Influence of structural and material property uncertainties on biomechanics of intervertebral discs - Implications for disc tissue engineering

This study investigated how variations of structural and material properties of human intervertebral discs (IVDs) affect the biomechanical responses of the IVDs under simulated physiological loading conditions using a stochastic finite element (SFE) model. An SFE method, which combined an anatomic FE model of human lumbar L34 segment and probabilistic analysis of its structural and material properties, was used to generate a dataset of 500 random disc samples with varying structural and material properties. The sensitivity of the biomechanical responses, including intervertebral displacements/rotations, intradiscal pressures (IDP), fiber stresses and matrix strains of annulus fibrosus (AF), were systematically quantified under various physiological loading conditions, including a 500N compression and 7.5Nm moments in the 3 primary rotations. Significant variations of the IDPs, IVD displacements/rotations, and stress/strain distributions were found using the dataset of 500 ramdom disc samples. Under all the loading conditions, the IDPs were positively correlated with the Poisson's ratio of the NP (r = 0.46 to 0.75, p = 0.004-0.001) and negatively with the Young's modulus of the annulus matrix (r = 0.48 to 0.65, p = 0.003-0.001). The primary intervertebral rotations were significantly affected by the Young's modulus of the annulus matrix (r = 0.44 to 0.71, p = 0.001-0.032) and the orientations of the annular fibers (r = 0.45 to 0.69, p = 0.001-0.029). The heterogeneity of structures and material properties of the IVD had distinct effects on the biomechanical performances of the IVD. These data could help improve our understanding of the intrinsic biomechanics of the IVD and provide references for optimal design of tissue engineered discs by controlling structural and material properties of the disc components.

Automated summary

This study investigated how variations in structural and material properties of human intervertebral discs affect biomechanical responses under simulated physiological loading conditions using a stochastic finite element model. Analysis of 500 random disc samples revealed significant variations in intradiscal pressures, IVD displacements/rotations, and stress/strain distributions under various loading conditions.