Review
Chemistry, Multidisciplinary
Seid Reza Falsafi, Yong Wang, Tolulope Joshua Ashaolu, Minaxi Sharma, Shruti Rawal, Kaushika Patel, Gholamreza Askari, Shaghayegh Haghjooy Javanmard, Hadis Rostamabadi
Summary: Cancer, being the second leading cause of death globally, has been addressed using natural anticancer agents due to their pharmacological activities. The oral administration of these agents is limited due to their inherent features. However, the development of nano-driven encapsulation strategies using polymeric vehicles, especially those of natural origin, has shown promise in effectively delivering these agents to the site of action. This review summarizes the challenges of orally delivering natural anticancer agents and the solutions offered by biopolymer matrices, as well as discusses in vitro/in vivo results of oral delivery using various biopolymer vehicles found in literature. It also highlights the challenges and new opportunities in the field.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Polymer Science
Zhenyu Xu, Long Chen, Xiaoya Duan, Xueming Li, Hao Ren
Summary: A novel oral delivery system of insulin called NiM, based on a three-dimensional system of biocompatible chitosan/alginate/casein, has been developed to overcome the GI barriers. NiM showed stable hydrodynamic parameters and effectively controlled the release of insulin in gastric and intestinal tracts, demonstrating promising results for diabetic patients.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2021)
Review
Chemistry, Applied
Chuan-he Tang
Summary: This review discusses the utilization of naturally occurring protein architectures as nanovehicles for hydrophobic nutraceuticals or drugs, through a disassembly and reassembly strategy. Various strategies and techniques for mediating the disassembly and reassembly of these architectures are comprehensively reviewed. Reassembled protein nanoparticles have been shown to be outstanding nanovehicles for improving water dispersion and bioactivities of nutraceuticals or drugs.
FOOD HYDROCOLLOIDS
(2021)
Review
Polymer Science
Iyyakkannu Sivanesan, Shadma Tasneem, Nazim Hasan, Juhyun Shin, Manikandan Muthu, Judy Gopal, Jae-Wook Oh
Summary: Chitosan has made significant progress in biomedical applications, particularly in the field of drug delivery. Modified chitosan derivatives have overcome limitations and advanced drug delivery. This article reviews the current chitosan derivatives used in biomedical applications and discusses their importance in oral drug delivery. It points out the limited use of chitosan resources in oral drug delivery and possible reasons for this.
Review
Pharmacology & Pharmacy
Tanikan Sangnim, Divya Dheer, Nitin Jangra, Kampanart Huanbutta, Vivek Puri, Ameya Sharma
Summary: Nanoformulations have become increasingly important in drug delivery technologies. Chitosan, a natural polymer with various properties, plays a crucial role in drug encapsulation and transport. Synthesizing chitosan nanoparticles can significantly enhance oral administration.
Article
Biochemistry & Molecular Biology
Li Ming Lim, Kunn Hadinoto
Summary: This study found that hydroxypropyl starch is a suitable mucoadhesive polysaccharide for high-payload buccal film applications, with excellent CUR release characteristics and stability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Yvonne Lerchbammer-Kreith, Nadine S. Sommerfeld, Klaudia Cseh, Xian Weng-Jiang, Uchechukwu Odunze, Andreas G. Schaetzlein, Ijeoma F. Uchegbu, Mathea S. Galanski, Michael A. Jakupec, Bernhard K. Keppler
Summary: A new class of anticancer prodrugs was developed by combining platinum(IV) complexes with glycol chitosan polymers as drug carriers. The platinum(IV) complexes were synthesized and conjugated with degraded glycol chitosan (dGC) polymers of different chain lengths. These conjugates exhibited higher cytotoxicity and antiproliferative activity in cancer cell lines compared to platinum(IV) counterparts. In particular, a cisplatin(IV)-dGC conjugate showed the highest cytotoxicity, being 33 times more potent than the corresponding platinum(IV) complex and twice as potent as cisplatin. Biodistribution studies of an oxaliplatin(IV)-dGC conjugate also showed increased accumulation in the lung, suggesting potential for further activity studies.
Review
Pharmacology & Pharmacy
Flavia Castro, Claudia Martins, Maria Jose Silveira, Rui Pedro Moura, Catarina Leite Pereira, Bruno Sarmento
Summary: Erythrocyte-mimicking nanovehicles (EM-NVs) have been extensively studied as biomimetic coating on artificial nanocarriers due to their upgraded biocompatibility, biodegradability, non-immunogenicity, and long-term blood circulation. These EM-NVs have a wide range of applications in drug delivery, imaging, phototherapy, and other areas, showing great potential for therapeutic and diagnostic applications in various diseases.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Review
Chemistry, Multidisciplinary
Yu Zhang, Il Kim, Yixin Xu, Deng-Guang Yu, Wenliang Song
Summary: Stimuli-responsive drug delivery systems based on polymeric nanovehicles can release drugs according to the acidic tumor microenvironment, improving treatment specificity and efficacy.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Biochemistry & Molecular Biology
Haibin Zhang, Zhiyang Gu, Wenya Li, Lili Guo, Litong Wang, Lan Guo, Saibo Ma, Baoqin Han, Jing Chang
Summary: Oral drug delivery is the most preferred mode of treatment due to its convenience and non-invasiveness. However, delivering protein drugs orally has been a challenge. This study developed a novel OCMC/SA nanohydrogel that solves this problem, with high drug loading capacity and passive drug targeting function.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Materials Science, Ceramics
Hamed Tabasi, Fatemeh Oroojalian, Majid Darroudi
Summary: Clays as nanocarriers have high drug loading capacity and show great potential in nano-vaccine technology for disease prevention.
CERAMICS INTERNATIONAL
(2021)
Article
Chemistry, Multidisciplinary
Gokce D. Kalaycioglu, Arwa A. Elamin, Hurmet Kinali, Nihal Aydogan
Summary: The study aimed to develop a pH-sensitive polymeric system for oral insulin delivery, utilizing chitosan and alginate shells on a poly (epsilon-caprolactone) core to enhance nanoparticle stability and achieve pH-responsive release. The results showed that the nanoparticles had pH-responsive release patterns and followed the Korsmeyer-Peppas kinetic model for insulin release.
Article
Chemistry, Physical
Rajaram Rajamohan, Mika Sillanpaa, Angaiah Subramania
Summary: Nanofibrous mats and cyclodextrins are essential components in drug releasing systems, with cyclodextrins playing a key role in enhancing drug release profile by forming inclusion complexes. This study focused on analyzing the drug release profile of benzocaine using electrospun PVdF nanofibrous mats, with and without beta-cyclodextrin, demonstrating enhanced drug release ability with the presence of beta-CD due to increased solubility of benzocaine.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Review
Nanoscience & Nanotechnology
Hazem Choukaife, Salma Seyam, Batoul Alallam, Abd Almonem Doolaanea, Mulham Alfatama
Summary: This article summarizes the pathology and therapy of colorectal cancer (CRC), as well as the challenges faced by oral drug delivery. It emphasizes the role of nanotechnology in oral drug targeted delivery systems and the significance of chitosan and its derivatives.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Biochemistry & Molecular Biology
NorulNazilah Ab 'lah, Chong Yu Lok Yusuf, Pornchai Rojsitthisak, Tin Wui Wong
Summary: Starch, a polysaccharide, has varying amylose-to-amylopectin ratios depending on its biological sources. Modifying starch composition through genetic engineering or chemical and enzymatic methods can alter its properties for oral drug delivery. These modified starches can sustain drug release, form hydrogels, and protect drug molecules from degradation. The use of modified starches has shown promises for specific and controlled oral drug delivery.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Cell & Tissue Engineering
Hossein Derakhshankhah, Soraya Sajadimajd, Fatemeh Jahanshahi, Zakieh Samsonchi, Hassan Karimi, Ensiyeh Hajizadeh-Saffar, Samira Jafari, Mahdieh Razmi, Soroor Sadegh Malvajerd, Gholamreza Bahrami, Mehdi Razavi, Zhila Izadi
Summary: Cell encapsulation technology has shown promising potential in preventing immune responses and rejection of islets or beta-cells, and innovative materials and immunomodulation have provided new approaches in encapsulation technology. Immunoengineering strategies combined with encapsulation technologies can overcome the challenges of cell replacement therapy in type 1 diabetes.
TISSUE ENGINEERING PART B-REVIEWS
(2022)
Review
Chemistry, Multidisciplinary
Suliman Khan, Arif Hussain, Hossein Fahimi, Fakhteh Aliakbari, Samir Haj Bloukh, Zehra Edis, Mohammad Mahdi Nejadi Babadaei, Zhila Izadi, Behrang Shiri Varnamkhasti, Fatemeh Jahanshahi, Yueting Lin, Xiao Hao, Rizwan Hasan Khan, Behnam Rasti, Gholamreza Vaghar-Lahijani, Linlin Hua, Hossein Derakhshankhah, Majid Sharifi, Mojtaba Falahati
Summary: The advancement in early diagnosis and precise treatments lead to more predictable healthcare modalities. Aptamers, nucleic acid structures that selectively bind target sites, play a crucial role in the development of drug delivery systems. Conjugating aptamers with nanoparticles and understanding their internalization process have significant implications in theranostics applications for various diseases.
ARABIAN JOURNAL OF CHEMISTRY
(2022)
Article
Engineering, Environmental
Zakieh Samsonchi, Hassan Karimi, Zhila Izadi, Payam Baei, Mostafa Najarasl, Mohammad Kazemi Ashtiani, Javad Mohammadi, Maedeh Moazenchi, Yaser Tahamtani, Hossein Baharvand, Ensiyeh Hajizadeh-Saffar, Hamed Daemi
Summary: Type 1 diabetes, an autoimmune disease, is increasing in prevalence worldwide. Pancreatic islet encapsulation using biocompatible alginate hydrogels is a potential cell-based therapy to control blood glucose levels. In this study, different stereoisomers of sulfated alginate were synthesized and evaluated for their biocompatibility. The best samples were used to coat three-layer microcapsules containing pancreatic islets, which were transplanted into diabetic mice. The results showed reduced blood glucose levels and improved function of the transplanted islets, indicating the potential of this approach for treating type 1 diabetes.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Pharmacology & Pharmacy
Yaser Yousefpoor, Amir Amani, Adeleh Divsalar, Seyyedeh Elaheh Mousavi, Abbas Shakeri, Javad Torkamannejad Sabzevari
Summary: This study developed a stable nanoemulsion that helps the transdermal application of bee venom and reduces inflammation caused by rheumatoid arthritis.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2022)
Article
Food Science & Technology
Leila Zolghadr, Gholamreza Rezaei Behbehani, Babak PakBin, Seied Ali Hosseini, Adeleh Divsalar, Nematollah Gheibi
Summary: The study investigates the inhibitory impact of kaempferol on urease enzyme using a variety of methods, including molecular dynamics simulations and docking software. The results confirm the inhibitory potential of kaempferol and its ability to form stable complexes with urease. However, further in vivo investigations are recommended to validate these findings.
FOOD SCIENCE & NUTRITION
(2022)
Article
Pharmacology & Pharmacy
Faeze Kazemi-Andalib, Maryam Mohammadikish, Unes Sahebi, Adeleh Divsalar
Summary: This study aimed to design and develop a slow, targeted drug delivery system for curcumin and gemcitabine. The use of core-shell and yolk-shell structures allowed for high loading and efficient controlled release of the drugs. The yolk-shell structure exhibited higher loading capacity and released more drugs in acidic pH conditions.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Review
Oncology
Elmira Gheytanchi, Fatemeh Tajik, Mahdieh Razmi, Sadegh Babashah, William Chi Shing Cho, Kiarash Tanha, Maryam Sahlolbei, Roya Ghods, Zahra Madjd
Summary: This meta-analysis suggests that circulating exosomal microRNAs have prognostic value in gastrointestinal cancers. Both up-regulated and down-regulated exomiRs are associated with differentiation, TNM stage, lymph node metastasis, distant metastasis, overall survival, and disease/relapse/progression-free survival in GI cancer patients. These findings indicate that circulating exomiRs could serve as potential prognostic biomarkers in GI cancers.
CANCER CELL INTERNATIONAL
(2023)
Article
Chemistry, Multidisciplinary
Manizheh Poodat, Adeleh Divsalar, Behafarid Ghalandari, Ramezanali Khavarinezhad
Summary: This study aims to develop a new drug delivery system using green synthetic and modified iron oxide nanoparticles (IONPs) combined with the methanolic extract of Artemisia Persica loaded with cisplatin. The synthesized IONPs showed no cytotoxicity on normal cells but exhibited significant cytotoxicity on cancer cells. Additionally, the interaction between the nanoparticles and DNA did not cause any structural changes, indicating good biocompatibility. The IONP complexed cisplatin holds promise as a potential candidate in overcoming challenges of conventional chemotherapy for breast cancer treatment.
JOURNAL OF THE IRANIAN CHEMICAL SOCIETY
(2023)
Review
Cell & Tissue Engineering
Farideh Hashemi, Mahdieh Razmi, Fatemeh Tajik, Margot Zoeller, Masoumeh Dehghan Manshadi, Forough Mahdavinezhad, Amir Tiyuri, Roya Ghods, Zahra Madjd
Summary: Despite the challenges in cancer treatment, the use of whole CSC-based vaccines shows promise in inhibiting tumor development, metastasis, and improving survival rate. This review provides an overview of the methods used to assess the efficacy of these vaccines and offers recommendations for designing high-quality clinical studies.
Article
Chemistry, Multidisciplinary
Zhila Izadi, Ebrahim Barzegari, Amin Iranpanah, Soraya Sajadimajd, Hossein Derakhshankhah
Summary: This study demonstrates that aminoglycosidic antibiotics, gentamycin and neomycin, can bind to miR-34a and protect PC12 cells from oxidative stress induced by H2O2. The findings provide further insight into the role of miR-34a in stroke-induced cell viability.
Article
Chemistry, Physical
Sarvenaz Moradi Taklimi, Adeleh Divsalar, Behafarid Ghalandari, Xianting Ding, Maria Luisa Di Gioia, Karzan A. Omar, Ali Akbar Saboury
Summary: Since their introduction in 2003, deep eutectic solvents (DESs) have gained attention in various technological fields, especially biocatalysis, due to their unique properties such as low melting points, safety, low cost of raw materials, availability, sustainability, and biodegradability. Recent research has shown that enzymes can maintain and even improve their activity and stability when used in DES-based media. Therefore, DESs have emerged as promising alternatives to conventional organic solvents. This study reviews the effects of different DESs on the function and stability of various enzymes.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Chemistry, Multidisciplinary
Farhad Sanginabadi, Nematollah Gheibi, Adeleh Divsalar, Ali Akbar Saboury, Parichehreh Yaghmaei, Morteza Sadeghi
Summary: In this study, the inhibitory ability and mechanism of omega 3-nicotinic acid (omega 3-NA) and omega 3-Picolinic acid (omega 3-PA) complexes on mushroom tyrosinase (MT) activity were investigated. The complexes showed significant inhibition on MT activity, with K-i values of 5.2 mM and 5.1 mM for omega 3-NA and omega 3-PA, respectively. Fluorescence quenching experiments confirmed the interaction between omega 3-NA, omega 3-PA, and MT. Molecular docking and dynamics simulations revealed that hydrogen bonding with Trp136, His263, and Val299 residues is involved in the formation of ligand-MT complexes. These findings suggest that omega 3-NA and omega 3-PA have the potential to be used as MT inhibitors for treating hyperpigmentation.
Article
Chemistry, Physical
Mohammad Reza Abolhassan, Adeleh Divsalar, Farideh Badalkhani-Khamseh, Nejat Kheiripour, Mahboubeh Eslami-Moghadam, Hamed Mirzaei
Summary: The present study investigated the interaction of new Schiff base-platinum complexes with human serum albumin and their toxicity effects on cancer cell lines. Fluorescence and circular dichroism spectroscopy revealed the quenching mechanisms and structural changes of the albumin caused by the complexes. Molecular docking and molecular dynamics simulations identified the main interactions between the complexes and albumin. The IC50 values of the complexes on the cancer cell lines demonstrated their anti-cancer activities.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Physical
Liana Ghasemi, Maryam Hasanzadeh Esfahani, Unes Sahebi, Adeleh Divsalar, Alireza Abbasi, Mahdi Behzad
Summary: This study synthesized and characterized a series of new mixed-ligand Cu(II) complexes, and investigated their anticancer activity. Through experimental and computational analysis, the complexes showed potent cytotoxic effects on three human carcinoma cell lines. The highest cytotoxicity was observed in complex (2), making it a promising candidate for developing new anticancer drugs.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Pathology
Mahdieh Razmi, Ayna Yazdanpanah, Shahroo Etemad-Moghadam, Mojgan Alaeddini, Sabrina Angelini, Leila Eini
Summary: Enhanced expression of SMYD2/3 may serve as an unfavorable clinical prognostic factor in different solid cancer types, with SMYD2 showing a more significant association with survival outcomes and SMYD3 having a stronger relationship with various clinicopathologic factors.
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
(2022)
Article
Biophysics
Cristina Potrich, Anna Pedrotti, Cecilia Pederzolli, Lorenzo Lunelli
Summary: This study developed different functional surfaces for capturing exosomes and verified their effectiveness through experiments. Among them, the negatively-charged surface performed the best, capturing a large number of exosomes and successfully analyzing their biomarkers.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Brojendra Nath Saren, Srushti Mahajan, Mayur Aalhate, Rahul Kumar, Essha Chatterjee, Indrani Maji, Ujala Gupta, Santosh Kumar Guru, Pankaj Kumar Singh
Summary: This study developed P-selectin-targeted dasatinib nanoparticles coated with chitosan and fucoidan (DST-CH-FUC-NPs), which showed sustained release, reduced hemolytic potential, increased cytotoxicity and cellular uptake compared to free dasatinib. These nanoparticles also demonstrated enhanced ROS production, mitochondrial membrane potential damage, apoptosis induction, cell migration inhibition, and disruption of lysosomal membrane integrity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Weiping Deng, Xiaohui Li, Ya Li, Zhongbing Huang, Yulin Wang, Ning Mu, Juan Wang, Tunan Chen, Ximing Pu, Guangfu Yin, Hua Feng
Summary: This study demonstrates the importance of chirality in nerve repair by constructing a GO-phenylalanine derivative hydrogel system. In vivo experiments show that the dextro group significantly improves functional recovery and histological restoration in rat sciatic nerve repair models. The doped GO promotes angiogenesis and myelination. These results suggest that chirality plays a crucial role in promoting nerve regeneration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xiaoyan Wang, Jin Gao, Yu Gao, Linlin Zhang, Congchao Xu, Qintong Li, Lin Li, Jianliang Xue
Summary: In this study, a highly effective surfactant producer strain, Bacillus Cereus GX7, was isolated from the oil tank bottom sludge of Shengli Oil Field in China. The biosurfactant produced by GX7 was identified as surfactin, a lipopeptide surfactant, through TLC, FT-IR, and LC-MS/MS analysis. The fermentation process of GX7 was optimized using single-factor experiments, focusing on the composition of fermentation medium and fermentation conditions. Glucose and peptone were found to be the best carbon and nitrogen sources, and the optimum temperature, inoculum amount, pH, rotation speed, and fermentation time for the strain were determined to be 30°C, 1%, 7.5, 150 rpm, and 48 h, respectively. After optimization, the surface tension and emulsification index of the fermentation broth were 26.84 mN/m and 57.84%, respectively. Furthermore, the biosurfactant produced by GX7 demonstrated good stability over a wide range of temperature, pH, and salt concentration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Rodney Marcelo do Nascimento, Christine Grauby-Heywang, Houssem Kahli, Nesrine Debez, Laure Beven, Ivan Helmuth Bechtold, Touria Cohen Bouhacina
Summary: This article presents a theoretical model based on thermodynamic rules to assess the early stages of bacterial biofilm formation on different material surfaces. By utilizing morphological characteristics of bacteria and Atomic Force Microscopy images, the model generates a dataset of energetically minimized states, which can be correlated with bacterial adhesion states.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Filipa A. L. S. Silva, Licinia Timochenco, Raquel Costa-Almeida, Jose Ramiro Fernandes, Susana G. Santos, Fernao D. Magalhaes, Artur M. Pinto
Summary: The study demonstrates that by photoreducing nanosized graphene oxide using ultraviolet radiation, nanometric particles with high light-to-heat conversion efficiency and water stability can be obtained. These nanomaterials exhibit high absorption in the near-infrared region and show no cytotoxicity towards human cells, indicating their potential for safe therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
D. Costa, V. De Matteis, F. Treso, G. Montani, M. Martino, R. Rinaldi, M. Corrado, M. Cascione
Summary: This review primarily discusses the relationship between contact lens discomfort (CLD) and the surface properties of contact lenses (CLs), specifically the coefficient of friction (CoF). The review emphasizes the importance of introducing a standardized protocol for measuring CoF and calls for a more precise evaluation of the relationship between surface properties and comfort in CLs users.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Debdip Brahma, Tamal Sarkar, Rupal Kaushik, Akshay Narayan Sarangi, Amar Nath Gupta
Summary: This in-vitro study evaluates the effect of reactive oxygen species (ROS) on the structural rearrangement of elastin. The results show that oxidative stress leads to a decrease in protein size and changes in secondary structure, potentially promoting protein aggregation. This study is important for therapeutics aiming to prevent elastin degradation and aging.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xin Yang, Qiang Wang, Chaoxi Yan, Degang Huang, Yinchang Zhang, Huazheng He, Shouliang Xiong, Congming Li, Pingbo Chen, Tingjun Ye, Dan Hu, Lei Wang
Summary: This study presents a practical and effective strategy to improve osseointegration in patients with osteoporosis. By coating titanium implants with polydopamine followed by strontium modification, the bi-functional implants promote bone regeneration and immune regulation. The results show good biocompatibility, sustained release of strontium ions, and stable osseointegration between bone tissues and implants.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Sengwang Fu, Jianping Zhu, Zhijun Jiang, Yue Cao, Yufei Chen, Lihao Zhang, Sunlong Li, Weipeng Lu, Chengbin Miao, Qing He, Qi Li, Weixing Zhang, Lehao Ren, Yachun Li, Hongchao Shi, Cihui Liu
Summary: Effective management of biofluids is crucial for in vivo surgical interventions. Recent advances include self-sealing needles, drug-eluting stents, and shear-thinning hydrogels. However, complications associated with intestinal mucosal injury and secondary damage still persist. In this study, researchers developed an interpenetrating Janus wettability stent coating that enables unidirectional draining of excessive biofluid. They also demonstrated directional biofluid movement using a self-pumping dressing with potential applications in biofluid collection and disease diagnosis through metal ion detection. This integrated system presents an opportunity for designing wound dressings with effective biofluid management and metal ion detection capabilities.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Maryam Hassani, Mojtaba Kamankesh, Mazda Rad-Malekshahi, Kobra Rostamizadeh, Farhad Rezaee, Ismaeil Haririan, Seyed Mojtaba Daghighi
Summary: Bacterial adhesion and biofilm formation on the surface of biomaterial implants is a critical problem, and a polymer brush coating with antiadhesive and antimicrobial properties has proven to be highly effective in resolving this issue.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Huaihong Zhang, Na Liu, Yuting Zhang, Hui Cang, Zhaosheng Cai, Ziqun Huang, Jun Li
Summary: A functionalized cationic polymer, CR-PQAC, was designed and synthesized for photothermal enhanced antimicrobial therapy. The CR-PQAC nanoparticles exhibited significant antibacterial activity and low cytotoxicity against mammalian cells.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Ipsita Sahu, Priyadarshi Chakraborty
Summary: Peptide nanotechnology bridges the gap between materials and biological worlds by utilizing self-assembly of short-peptide building blocks. Hydrogels engineered from these short peptides show great potential in biomedical applications, but their weak mechanical properties and limited functional diversity need to be addressed. Nanoengineering the networks of these hydrogels by incorporating small molecules, polymers, and inorganic/carbon nanomaterials can enhance their mechanical properties and expand their functional diversity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Hao Wei, Yajun Gu, Ao Li, Panpan Song, Dingding Liu, Feihu Sun, Xiaofeng Ma, Xiaoyun Qian
Summary: In this study, a stable three-dimensional conductive hydrogel was prepared by cross-linking MXenes to Matrigel hydrogel. The conductive hydrogel promotes the proliferation and differentiation of NSCs, providing new strategies for neural tissue engineering.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Yue Zhong, Xiaoli Ge, Juan Zhang, Qun Wei, Feng Wang, Yongke Zhong
Summary: The effect of oxygenic groups on the hemocompatibility of activated carbon was studied through liquid-phase oxidation and subsequent heat treatment. Results showed that the presence of oxygenic groups improved hemocompatibility, while their removal decreased it.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
