Article
Pharmacology & Pharmacy
Madhuri Dandamudi, Peter McLoughlin, Gautam Behl, Sweta Rani, Lee Coffey, Anuj Chauhan, David Kent, Laurence Fitzhenry
Summary: The study developed a nanoparticulate system for topically applied corticosteroids, aiming to reduce the treatment burden for patients and doctors. Surface-modified nanoparticles showed controlled drug release and improved bioavailability, making them potential candidates for treating acquired retinal vasculopathies.
Article
Instruments & Instrumentation
Alaa H. Salama, Mona M. AbouSamra, Ghada E. A. Awad, Soheir S. Mansy
Summary: This study developed an ocular drug delivery system for treating ocular inflammation by utilizing the advantages of nanotechnology and bioadhesive gel properties. The optimized LPCL-NP2 formulation showed superior antibacterial activity, making it a potential candidate for ocular therapy.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2021)
Article
Polymer Science
Xuan-Ling Hsu, Lien-Chen Wu, Jui-Yang Hsieh, Yi-You Huang
Summary: The study developed a composite drug delivery system using nanoparticles and hyaluronan hydrogel, which can reduce the dosing frequency for intravitreal injections. The system showed sustained release of the model drug for over two months, with potential to be a better treatment option for ocular neovascular diseases like wet AMD.
Article
Biochemistry & Molecular Biology
Zhishu Bao, Ailing Yu, Hui Shi, Yuhan Hu, Bo Jin, Dan Lin, Mali Dai, Lei Lei, Xingyi Li, Yuqin Wang
Summary: In this study, a glycol chitosan/oxidized hyaluronic acid hydrogel film for dual ophthalmic drug delivery was fabricated successfully. The hydrogel films exhibited a stepwise release of levofloxacin and dexamethasone, demonstrating potent antibacterial and anti-inflammatory activities.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Pharmacology & Pharmacy
Jun Wu, Xinyu Wang, Haiwen Li, Mingyue Qu, Wenbin Sun, Xu Yan, Zheng Zhao, Binbin Li
Summary: In this study, chitosan-coated PLGA microspheres with rough surface and hollow structure were successfully prepared using a modified method. These microspheres can be used as drug carriers to improve drug loading efficiency and anticancer effect, and reduce drug administration frequency. The chitosan-modified microspheres showed prolonged anticancer activity and promoted apoptosis, suggesting their potential application in liver cancer treatment.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Feipeng Yang, Maleen Cabe, Hope A. Nowak, Kelly A. Langert
Summary: In this study, different size groups of poly(lactic-co-glycolic) acid (PLGA) nanoparticles and chitosan-PLGA nanoparticle counterparts were prepared by adjusting key formulation parameters. The effects of size and surface modification on drug loading and release were investigated, and changes in mucoadhesion were quantified.
Article
Pharmacology & Pharmacy
Simise S. Sikhondze, Pedzisai A. Makoni, Roderick B. Walker, Sandile M. M. Khamanga
Summary: In this study, a once-daily-dosed chitosan-coated metronidazole (MTZ)-loaded solid lipid nanoparticles (SLNs) for ocular delivery were developed to improve the residence time and release of the drug in the eye, which may reduce patient non-adherence.
Review
Pharmacology & Pharmacy
Vernon LaLone, Doug Smith, Jennifer Diaz-Espinosa, Gus R. Rosania
Summary: Raman confocal microscopes are used to visualize the distribution of small molecule drugs within cells, providing insights into their transport phenomena. Chemical imaging techniques reveal the formation of stable complexes or precipitates of lipophilic drugs inside cells. Raman chemical imaging methods allow measurement and mapping of drug molecules at a microscopic, subcellular level.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Article
Pharmacology & Pharmacy
Fatima Fernandez-Alvarez, Gracia Garcia-Garcia, Jose L. Arias
Summary: The study successfully constructed a maghemite/PLGA/chitosan nanostructure with good stability, magnetism, and drug release behavior, showing significant anti-lung adenocarcinoma effect of cisplatin loading on the matrix.
Article
Pharmacology & Pharmacy
Minoo Ghanavi, Ali Khoshandam, Shaghayegh Aslzad, Marziyeh Fathi, Abolfazl Barzegari, Elaheh Dalir Abdolahinia, Khosro Adibkia, Jaleh Barar, Yadollah Omidi
Summary: Due to the unique structure of the human eye, ocular drug delivery faces challenges such as low bioavailability. In-situ gel-forming mucoadhesive hydrogels can improve ocular bioavailability. Chitosan has been used in the preparation of these hydrogels. Water-soluble chitosan was obtained and gel formation was accomplished using sodium beta-glycerophosphate and sodium bicarbonate. The prepared hydrogel showed sustained-release and antibacterial activity in vitro.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Jeffrey Momoh, Dimitrios Kapsokalyvas, Michael Vogt, Sjoerd Hak, Fabian Kiessling, Marc van Zandvoort, Twan Lammers, Alexandros Marios Sofias
Summary: Intravital microscopy (IVM) has broad applications in various fields, including biology, physiology, immunology, and drug development. This review provides an overview of the modalities, methods, and model organisms used in IVM, as well as its applications in nanomedicine and biological process studies.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Review
Pharmacology & Pharmacy
Dmitriy Berillo, Zharylkasyn Zharkinbekov, Yevgeniy Kim, Kamila Raziyeva, Kamila Temirkhanova, Arman Saparov
Summary: Despite the conventional use of oral and intravenous routes for drug administration, they face limitations such as reduced bioavailability and invasiveness. Therefore, alternative delivery routes and modifications to drug formulations using stimuli-responsive polymers can improve drug release and bioavailability.
Review
Biotechnology & Applied Microbiology
Lianfei Fang, Jin Liu, Zeyang Liu, Huifang Zhou
Summary: Ocular diseases are increasingly affecting people's quality of life. Nanoparticles, with their advantages in tissue permeability, controlled drug release, and tissue targeting ability, have attracted attention as a potential therapy for ocular diseases.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Saeem Ahmad, Iram Khan, Jayamanti Pandit, Nasr A. Emad, Shahnaj Bano, Khalid Imtiyaz Dar, M. Moshahid Alam Rizvi, Mohd Danish Ansari, Mohd. Aqil, Yasmin Sultana
Summary: This study successfully developed chitosan-coated PLGA nanoparticles for nose-to-brain delivery of carmustine. The optimized nanoparticles showed satisfactory levels in terms of particle size, entrapment efficiency, drug release, and permeability. The results suggested that chitosan-coated nanoparticles could be a promising approach for delivering carmustine to treat Glioblastoma multiforme via intranasal administration.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Pharmacology & Pharmacy
Abdullah Alshememry, Mohd Abul Kalam, Abdulhadi Almoghrabi, Abdulwahab Alzahrani, Mudassar Shahid, Azmat Ali Khan, Anzarul Haque, Raisuddin Ali, Musaed Alkholief, Ziyad Binkhathlan, Aws Alshamsan
Summary: The present study investigates the simultaneous encapsulation and delivery of DOX and NAR using PLGA-NPs and CS-coated PLGA-NPs to enhance their efficacy and synergistic anticancer activity, while reducing toxicity. The results demonstrate that F4 exhibits the best drug release and cytotoxicity, indicating its potential as an effective nano-carrier for DOX and NAR.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Review
Environmental Sciences
Sima Singh, Arshid Numan, Dinesh Sharma, Rahul Shukla, Amit Alexander, Gaurav Kumar Jain, Farhan Jalees Ahmad, Prashant Kesharwani
Summary: The outbreak of the COVID-19 pandemic in 2019 and 2020 has led to a new era of communicable infectious diseases, with the emergence of Hantavirus infection posing a new public health emergency. Hantavirus, a zoonotic pathogen, causes two major clinical manifestations - HFRS and HCPS. Despite the lack of effective treatments or vaccines, public awareness and precautionary measures can help reduce the spread of the virus.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH
(2022)
Article
Biochemical Research Methods
S. M. Kawish, Abdul Qadir, Suma Saad, Sarwar Beg, Gaurav K. Jain, Mohd Aqil, Amer M. Alanazi, Azmat Ali Khan, Md Abdur Rashid, Rehan A. Rab, Waleed H. Almalki, Farhan J. Ahmad
Summary: A cost-effective, reliable, and rapid HPTLC method was developed for estimating GLA in borage oil, utilizing aluminum plates precoated with silica gel as the stationary phase and a hexane:toulene:glacial acetic acid mixture as the mobile phase. The method showed well-resolved spots for GLA and was validated for parameters like linearity, accuracy, specificity, and precision. The method demonstrated high sensitivity for GLA estimation in herbal oil samples and formulations.
JOURNAL OF CHROMATOGRAPHIC SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Mansi Budhiraja, Sobiya Zafar, Sohail Akhter, Majed Alrobaian, Md Abdur Rashid, Md. Abul Barkat, Sarwar Beg, Farhan J. Ahmad
Summary: This study developed a combinational drug delivery system by embedding mupirocin-loaded chitosan microspheres in a collagen scaffold containing Piper betle extract, aiming to improve wound healing. The results showed that this method effectively promoted wound healing and exhibited good antibacterial effects.
Article
Food Science & Technology
Sarushi Rastogi, Vinita Kumari, Vasudha Sharma, F. J. Ahmad
Summary: The use of gold nanoparticles (AuNP) in food safety is crucial due to their unique properties. Nanosensors are emerging as key technologies to detect various contaminants in food industries. Research is ongoing in the food industry to explore the applications of AuNP-based nanosensors and nanobiosensors.
FOOD ANALYTICAL METHODS
(2022)
Article
Engineering, Electrical & Electronic
Shafaque Rahman, Farhan Ahmad, Jyoti Bansal, Rana Tabassum, A. K. Hafiz
Summary: This study reports on the fabrication and characterization of tricomposite nanostructures of silicon-doped titanium dioxide and multiwalled carbon nanotubes. The fabricated nanostructures possess typical nanoflower shape and show an increase in bandgap with increasing silicon concentration. The tricomposite nanostructures exhibit superior performance in specific capacitance, quantum efficiency, responsivity, and detectivity compared to reported data.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
(2022)
Article
Chemistry, Analytical
Nazeer Hasan, Mohammad Imran, Dhara Jain, Athar Shamim, Sarwar Beg, Prashant Kesharwani, Gaurav Jain, Farhan J. Ahmad
Summary: The paper describes the development and validation of a simple and reliable HPLC method for simultaneous estimation of 5-FU and CBD. The method showed good linearity, precision, specificity, and robustness. It could be effectively used for quantification of these drugs in various in vitro and in vivo studies.
CURRENT ANALYTICAL CHEMISTRY
(2022)
Article
Education, Scientific Disciplines
Tej Pratap Singh, Navneet Verma, Farhan Jalees Ahmad, Phool Chandra, Gaurav Kumar Jain
Summary: This study evaluated the wound healing potential of raloxifene nanoemulsion gel in a rat model. The results showed that the raloxifene nanoemulsion gel can enhance breaking strength, tensile strength, and wound contraction in incision wounds, as well as promote re-epithelialization, neo-vascularization, fibroblast proliferation, and collagen deposition. It demonstrates significant wound healing potential.
INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH
(2022)
Article
Education, Scientific Disciplines
Anjna Rani, Sunil Kumar, Roop K. Khar
Summary: This study successfully formulated, optimized, and characterized phytosomes of Murraya koenigii extract, which showed improved antidiabetic and hypolipidemic activities compared to crude extract.
INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Nazeer Hasan, Mohammad Imran, Afsana Sheikh, Suma Saad, Gaurav Chaudhary, Gaurav Kumar Jain, Prashant Kesharwani, Farhan J. Ahmad
Summary: This review discusses the potential of cannabis in treating cancer, its safety profile, and the advancements in using nanotechnology to improve its therapeutic efficacy. It also explores the role of cannabinoids in different cancers and provides information on completed and ongoing clinical trials.
JOURNAL OF DRUG TARGETING
(2022)
Article
Multidisciplinary Sciences
Bharti Vyas, Ratul Bhowmik, Mymoona Akhter, Farhan Jalees Ahmad
Summary: This study used computational analysis to identify potential mutations associated with hereditary glutathione reductase deficiency and other diseases. Structural and evolutionary analyses suggested that the mutations may alter the structure and function of the GSR protein. Additionally, genetic studies found that certain variations were associated with obstructive heart defects and hereditary anemia.
SCIENTIFIC REPORTS
(2022)
Article
Pharmacology & Pharmacy
S. M. Kawish, Nazeer Hasan, Sarwar Beg, Abdul Qadir, Gaurav K. Jain, Mohd Aqil, Farhan J. Ahmad
Summary: In this study, a novel docetaxel-nanoemulsion was developed to improve therapeutic effectiveness and reduce side effects through targeted delivery. The optimized nanoemulsion demonstrated excellent characteristics in terms of drug encapsulation, drug release kinetics, and in vivo pharmacokinetics.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Instruments & Instrumentation
Pavitra Solanki, Mohd Danish Ansari, Mohd Iqbal Alam, Mohd Aqil, Farhan J. Ahmad, Yasmin Sultana
Summary: This study developed an orally effective nanoformulation of disodium pamidronate for the treatment of osteoporosis. Through rational design and optimization, a commercially potential self nano-emulsifying drug delivery system (SNEDDS) was developed, which showed improved oral bioavailability and enhanced anti-osteoporotic activity. The study provided significant achievements in the treatment of postmenopausal osteoporosis and may lead to the use of nanotherapeutic-driven emerging biodegradable carriers-based drug delivery.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Biophysics
Neha Parveen, Mohammed A. S. Abourehab, Punniyakoti Veeraveedu Thanikachalam, Roop K. Khar, Prashant Kesharwani
Summary: Skin conditions have a significant impact on individuals and society. The barrier mechanism of the skin and physicochemical characteristics of drugs often limit drug penetration, leading to the need for innovative drug delivery methods. Nanocrystals have been investigated as a method to enhance skin penetration and this review explores the barriers of skin penetration, modern methods for topical distribution enhancement, and the use of nanocrystals to overcome these barriers. Researchers working on challenging topical drug delivery may find this research relevant.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Biochemistry & Molecular Biology
Manisha Malani, Manthan S. Hiremath, Surbhi Sharma, Manisha Jhunjhunwala, Shovanlal Gayen, Chittaranjan Hota, Jayabalan Nirmal
Summary: Patients with chronic diseases undergo long-term systemic drug treatment, but ocular barriers can falsely recognize these drugs and allow them to enter the eye from the bloodstream, leading to toxicity. Understanding the role of organic cation transporter (OCT1) in ocular barriers is important for the entry of systemic drugs into the eye. Machine learning and computer simulation models were used to predict potential OCT1 substrates from various systemic drugs causing ocular toxicity. The accuracy of the machine learning model was around 80%, and it identified previously unknown potential OCT1 substrates.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Review
Clinical Neurology
Namish Manchanda, Akanksha Aggarwal, Sonal Setya, Sushama Talegaonkar
Summary: Alzheimer's disease is a global health crisis with limited therapeutic options. Digital therapeutics, a novel therapy driven by internet and software, provides evidence-based interventions and tools for managing and treating neurological abnormalities and chronic diseases. It shows potential in improving memory, cognition, and functional abilities in Alzheimer's disease.
CURRENT ALZHEIMER RESEARCH
(2022)
Article
Biophysics
Cristina Potrich, Anna Pedrotti, Cecilia Pederzolli, Lorenzo Lunelli
Summary: This study developed different functional surfaces for capturing exosomes and verified their effectiveness through experiments. Among them, the negatively-charged surface performed the best, capturing a large number of exosomes and successfully analyzing their biomarkers.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Brojendra Nath Saren, Srushti Mahajan, Mayur Aalhate, Rahul Kumar, Essha Chatterjee, Indrani Maji, Ujala Gupta, Santosh Kumar Guru, Pankaj Kumar Singh
Summary: This study developed P-selectin-targeted dasatinib nanoparticles coated with chitosan and fucoidan (DST-CH-FUC-NPs), which showed sustained release, reduced hemolytic potential, increased cytotoxicity and cellular uptake compared to free dasatinib. These nanoparticles also demonstrated enhanced ROS production, mitochondrial membrane potential damage, apoptosis induction, cell migration inhibition, and disruption of lysosomal membrane integrity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Weiping Deng, Xiaohui Li, Ya Li, Zhongbing Huang, Yulin Wang, Ning Mu, Juan Wang, Tunan Chen, Ximing Pu, Guangfu Yin, Hua Feng
Summary: This study demonstrates the importance of chirality in nerve repair by constructing a GO-phenylalanine derivative hydrogel system. In vivo experiments show that the dextro group significantly improves functional recovery and histological restoration in rat sciatic nerve repair models. The doped GO promotes angiogenesis and myelination. These results suggest that chirality plays a crucial role in promoting nerve regeneration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xiaoyan Wang, Jin Gao, Yu Gao, Linlin Zhang, Congchao Xu, Qintong Li, Lin Li, Jianliang Xue
Summary: In this study, a highly effective surfactant producer strain, Bacillus Cereus GX7, was isolated from the oil tank bottom sludge of Shengli Oil Field in China. The biosurfactant produced by GX7 was identified as surfactin, a lipopeptide surfactant, through TLC, FT-IR, and LC-MS/MS analysis. The fermentation process of GX7 was optimized using single-factor experiments, focusing on the composition of fermentation medium and fermentation conditions. Glucose and peptone were found to be the best carbon and nitrogen sources, and the optimum temperature, inoculum amount, pH, rotation speed, and fermentation time for the strain were determined to be 30°C, 1%, 7.5, 150 rpm, and 48 h, respectively. After optimization, the surface tension and emulsification index of the fermentation broth were 26.84 mN/m and 57.84%, respectively. Furthermore, the biosurfactant produced by GX7 demonstrated good stability over a wide range of temperature, pH, and salt concentration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Rodney Marcelo do Nascimento, Christine Grauby-Heywang, Houssem Kahli, Nesrine Debez, Laure Beven, Ivan Helmuth Bechtold, Touria Cohen Bouhacina
Summary: This article presents a theoretical model based on thermodynamic rules to assess the early stages of bacterial biofilm formation on different material surfaces. By utilizing morphological characteristics of bacteria and Atomic Force Microscopy images, the model generates a dataset of energetically minimized states, which can be correlated with bacterial adhesion states.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Filipa A. L. S. Silva, Licinia Timochenco, Raquel Costa-Almeida, Jose Ramiro Fernandes, Susana G. Santos, Fernao D. Magalhaes, Artur M. Pinto
Summary: The study demonstrates that by photoreducing nanosized graphene oxide using ultraviolet radiation, nanometric particles with high light-to-heat conversion efficiency and water stability can be obtained. These nanomaterials exhibit high absorption in the near-infrared region and show no cytotoxicity towards human cells, indicating their potential for safe therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
D. Costa, V. De Matteis, F. Treso, G. Montani, M. Martino, R. Rinaldi, M. Corrado, M. Cascione
Summary: This review primarily discusses the relationship between contact lens discomfort (CLD) and the surface properties of contact lenses (CLs), specifically the coefficient of friction (CoF). The review emphasizes the importance of introducing a standardized protocol for measuring CoF and calls for a more precise evaluation of the relationship between surface properties and comfort in CLs users.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Debdip Brahma, Tamal Sarkar, Rupal Kaushik, Akshay Narayan Sarangi, Amar Nath Gupta
Summary: This in-vitro study evaluates the effect of reactive oxygen species (ROS) on the structural rearrangement of elastin. The results show that oxidative stress leads to a decrease in protein size and changes in secondary structure, potentially promoting protein aggregation. This study is important for therapeutics aiming to prevent elastin degradation and aging.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xin Yang, Qiang Wang, Chaoxi Yan, Degang Huang, Yinchang Zhang, Huazheng He, Shouliang Xiong, Congming Li, Pingbo Chen, Tingjun Ye, Dan Hu, Lei Wang
Summary: This study presents a practical and effective strategy to improve osseointegration in patients with osteoporosis. By coating titanium implants with polydopamine followed by strontium modification, the bi-functional implants promote bone regeneration and immune regulation. The results show good biocompatibility, sustained release of strontium ions, and stable osseointegration between bone tissues and implants.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Sengwang Fu, Jianping Zhu, Zhijun Jiang, Yue Cao, Yufei Chen, Lihao Zhang, Sunlong Li, Weipeng Lu, Chengbin Miao, Qing He, Qi Li, Weixing Zhang, Lehao Ren, Yachun Li, Hongchao Shi, Cihui Liu
Summary: Effective management of biofluids is crucial for in vivo surgical interventions. Recent advances include self-sealing needles, drug-eluting stents, and shear-thinning hydrogels. However, complications associated with intestinal mucosal injury and secondary damage still persist. In this study, researchers developed an interpenetrating Janus wettability stent coating that enables unidirectional draining of excessive biofluid. They also demonstrated directional biofluid movement using a self-pumping dressing with potential applications in biofluid collection and disease diagnosis through metal ion detection. This integrated system presents an opportunity for designing wound dressings with effective biofluid management and metal ion detection capabilities.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Maryam Hassani, Mojtaba Kamankesh, Mazda Rad-Malekshahi, Kobra Rostamizadeh, Farhad Rezaee, Ismaeil Haririan, Seyed Mojtaba Daghighi
Summary: Bacterial adhesion and biofilm formation on the surface of biomaterial implants is a critical problem, and a polymer brush coating with antiadhesive and antimicrobial properties has proven to be highly effective in resolving this issue.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Huaihong Zhang, Na Liu, Yuting Zhang, Hui Cang, Zhaosheng Cai, Ziqun Huang, Jun Li
Summary: A functionalized cationic polymer, CR-PQAC, was designed and synthesized for photothermal enhanced antimicrobial therapy. The CR-PQAC nanoparticles exhibited significant antibacterial activity and low cytotoxicity against mammalian cells.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Ipsita Sahu, Priyadarshi Chakraborty
Summary: Peptide nanotechnology bridges the gap between materials and biological worlds by utilizing self-assembly of short-peptide building blocks. Hydrogels engineered from these short peptides show great potential in biomedical applications, but their weak mechanical properties and limited functional diversity need to be addressed. Nanoengineering the networks of these hydrogels by incorporating small molecules, polymers, and inorganic/carbon nanomaterials can enhance their mechanical properties and expand their functional diversity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Hao Wei, Yajun Gu, Ao Li, Panpan Song, Dingding Liu, Feihu Sun, Xiaofeng Ma, Xiaoyun Qian
Summary: In this study, a stable three-dimensional conductive hydrogel was prepared by cross-linking MXenes to Matrigel hydrogel. The conductive hydrogel promotes the proliferation and differentiation of NSCs, providing new strategies for neural tissue engineering.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Yue Zhong, Xiaoli Ge, Juan Zhang, Qun Wei, Feng Wang, Yongke Zhong
Summary: The effect of oxygenic groups on the hemocompatibility of activated carbon was studied through liquid-phase oxidation and subsequent heat treatment. Results showed that the presence of oxygenic groups improved hemocompatibility, while their removal decreased it.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
