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A novel prodrug-based strategy to increase effects of bumetanide in epilepsy

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Local Impermeant Anions Establish the Neuronal Chloride Concentration

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Cortical GABAergic excitation contributes to epileptic activities around human glioma

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Consequences of inhibition of bumetanide metabolism in rodents on brain penetration and effects of bumetanide in chronic models of epilepsy

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PI3K-Akt Signaling Activates mTOR-Mediated Epileptogenesis in Organotypic Hippocampal Culture Model of Post-Traumatic Epilepsy

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Chloride extrusion enhancers as novel therapeutics for neurological diseases

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Bumetanide Enhances Phenobarbital Efficacy in a Rat Model of Hypoxic Neonatal Seizures

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Traumatic Alterations in GABA Signaling Disrupt Hippocampal Network Activity in the Developing Brain

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Too Many Cooks? Intrinsic and Synaptic Homeostatic Mechanisms in Cortical Circuit Refinement

(2011) Gina Turrigiano   Annual Review of Neuroscience

Neuronal chloride accumulation and excitatory GABA underlie aggravation of neonatal epileptiform activities by phenobarbital

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Early Post-Traumatic Seizures in Moderate to Severe Pediatric Traumatic Brain Injury: Rates, Risk Factors, and Clinical Features

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Interictal spikes, seizures and ictal cell death are not necessary for post-traumatic epileptogenesis in vitro

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Role of NKCC1 and KCC2 in the development of chronic neuropathic pain following spinal cord injury

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Interictal Spikes Precede Ictal Discharges in an Organotypic Hippocampal Slice Culture Model of Epileptogenesis

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Progressive NKCC1-Dependent Neuronal Chloride Accumulation during Neonatal Seizures

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Prevention or Modification of Epileptogenesis after Brain Insults: Experimental Approaches and Translational Research

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Preventing and treating posttraumatic seizures: The human experience

(2009) Nancy R. Temkin   EPILEPSIA

Bumetanide, an NKCC1 Antagonist, Does Not Prevent Formation of Epileptogenic Focus but Blocks Epileptic Focus Seizures in Immature Rat Hippocampus

(2009) Romain Nardou et al.   JOURNAL OF NEUROPHYSIOLOGY

Compensatory Enhancement of Intrinsic Spiking upon NKCC1 Disruption in Neonatal Hippocampus

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Brain extracellular matrix affects AMPA receptor lateral mobility and short-term synaptic plasticity

(2009) Renato Frischknecht et al.   NATURE NEUROSCIENCE

Cation-Chloride Cotransporters and Neuronal Function

(2009) Peter Blaesse et al.   NEURON

Roles of the cation–chloride cotransporters in neurological disease

(2008) Kristopher T Kahle et al.   Nature clinical practice. Neurology

Bumetanide enhances phenobarbital efficacy in a neonatal seizure model

(2007) Volodymyr I. Dzhala et al.   ANNALS OF NEUROLOGY