Role of Ghrelin in the Pathophysiology of Eating Disorders

Current and potential roles of ghrelin in clinical practice

(2014) G. Angelidis et al.   JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION

Effects of an Oral Ghrelin Mimetic on Body Composition and Clinical Outcomes in Healthy Older Adults

(2013) Ralf Nass et al.   ANNALS OF INTERNAL MEDICINE

Role of ghrelin in food reward: impact of ghrelin on sucrose self-administration and mesolimbic dopamine and acetylcholine receptor gene expression

(2011) Karolina P. Skibicka et al.   ADDICTION BIOLOGY

Women with bulimia nervosa exhibit attenuated secretion of glucagon-like peptide 1, pancreatic polypeptide, and insulin in response to a meal

(2011) Sabine Naessén et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

A small molecule antagonist of ghrelin O-acyltransferase (GOAT)

(2011) Amanda L. Garner et al.   CHEMICAL COMMUNICATIONS

Motivation to obtain preferred foods is enhanced by ghrelin in the ventral tegmental area

(2011) S.J. King et al.   HORMONES AND BEHAVIOR

Meal Anticipatory Rise in Acylated Ghrelin at Dark Onset is Blunted After Long-Term Fasting in Rats

(2011) P. Zizzari et al.   JOURNAL OF NEUROENDOCRINOLOGY

Ghrelin and cachexia: Will treatment with GHSR-1a agonists make a difference for patients suffering from chronic wasting syndromes?

(2011) Mark D. DeBoer   MOLECULAR AND CELLULAR ENDOCRINOLOGY

In adults with Prader–Willi syndrome, elevated ghrelin levels are more consistent with hyperphagia than high PYY and GLP-1 levels

(2011) Louise Purtell et al.   NEUROPEPTIDES

Ghrelin directly targets the ventral tegmental area to increase food motivation

(2011) K.P. Skibicka et al.   NEUROSCIENCE

6-Hydroxydopamine lesions of the ventral tegmental area suppress ghrelin's ability to elicit food-reinforced behavior

(2011) Zachary Y. Weinberg et al.   NEUROSCIENCE LETTERS

Long-Term Persistence of Hormonal Adaptations to Weight Loss

(2011) Priya Sumithran et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ghrelin and anorexia nervosa: A psychosomatic perspective

(2011) Kazuma Ogiso et al.   NUTRITION

Ghrelin and food reward: The story of potential underlying substrates

(2011) Karolina P. Skibicka et al.   PEPTIDES

Ghrelin increases intake of rewarding food in rodents

(2010) Emil Egecioglu et al.   ADDICTION BIOLOGY

The alcohol-induced locomotor stimulation and accumbal dopamine release is suppressed in ghrelin knockout mice

(2010) Elisabet Jerlhag et al.   ALCOHOL

Ghrelin Receptor Antagonism Decreases Alcohol Consumption and Activation of Perioculomotor Urocortin-Containing Neurons

(2010) Simranjit Kaur et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

MK-0677 (ibutamoren mesylate) for the treatment of patients recovering from hip fracture: A multicenter, randomized, placebo-controlled phase IIb study

(2010) Abraham Adunsky et al.   ARCHIVES OF GERONTOLOGY AND GERIATRICS

Acute and chronic suppression of the central ghrelin signaling system reveals a role in food anticipatory activity

(2010) Linda A.W. Verhagen et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Development of the eating behaviour in Prader–Willi Syndrome: advances in our understanding

(2010) C J McAllister et al.   INTERNATIONAL JOURNAL OF OBESITY

Ghrelin and Obestatin Circadian Levels Differentiate Bingeing-Purging from Restrictive Anorexia Nervosa

(2010) Natacha Germain et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The Metabolic Phenotype of Prader-Willi Syndrome (PWS) in Childhood: Heightened Insulin Sensitivity Relative to Body Mass Index

(2010) Andrea M. Haqq et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Oral sensory and cephalic hormonal responses to fat and non-fat liquids in bulimia nervosa

(2010) Nicholas T. Bello et al.   PHYSIOLOGY & BEHAVIOR

Peripheral ghrelin enhances sweet taste food consumption and preference, regardless of its caloric content

(2010) Emmanuel Disse et al.   PHYSIOLOGY & BEHAVIOR

Ghrelin receptor antagonism attenuates cocaine- and amphetamine-induced locomotor stimulation, accumbal dopamine release, and conditioned place preference

(2010) Elisabet Jerlhag et al.   PSYCHOPHARMACOLOGY

Glucose and Weight Control in Mice with a Designed Ghrelin O-Acyltransferase Inhibitor

(2010) B. P. Barnett et al.   SCIENCE

Ghrelin modulates electrical activity of area postrema neurons

(2009) Mark Fry et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Ghrelin Increases the Rewarding Value of High-Fat Diet in an Orexin-Dependent Manner

(2009) Mario Perello et al.   BIOLOGICAL PSYCHIATRY

Ghrelin Increases Hunger and Food Intake in Patients with Restricting-type Anorexia Nervosa: A Pilot Study

(2009) Mari HOTTA et al.   ENDOCRINE JOURNAL

In VivoCharacterization of High Basal Signaling from the Ghrelin Receptor

(2009) Pia Steen Petersen et al.   ENDOCRINOLOGY

Children with Prader–Willi syndrome exhibit more evident meal-induced responses in plasma ghrelin and peptide YY levels than obese and lean children

(2009) Carla Bizzarri et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

The validity and clinical utility of night eating syndrome

(2009) Ruth H. Striegel-Moore et al.   INTERNATIONAL JOURNAL OF EATING DISORDERS

Circadian Rhythm Profiles in Women with Night Eating Syndrome

(2009) Namni Goel et al.   JOURNAL OF BIOLOGICAL RHYTHMS

On the Central Mechanism Underlying Ghrelin’s Chronic Pro-Obesity Effects in Rats: New Insights from Studies Exploiting a Potent Ghrelin Receptor Antagonist

(2009) N. Salomé et al.   JOURNAL OF NEUROENDOCRINOLOGY

Impaired Ghrelin Response after High-Fat Meals Is Associated with Decreased Satiety in Obese and Lean Chinese Young Adults

(2009) Nianhong Yang et al.   JOURNAL OF NUTRITION

Ghrelin-a novel generation of anti-obesity drug: design, pharmacomodulation and biological activity of ghrelin analogues

(2009) Constance Chollet et al.   JOURNAL OF PEPTIDE SCIENCE

An Acyl-Ghrelin-Specific Neutralizing Antibody Inhibits the Acute Ghrelin-Mediated Orexigenic Effects in Mice

(2009) S.-C. Lu et al.   MOLECULAR PHARMACOLOGY

Reduced anticipatory locomotor responses to scheduled meals in ghrelin receptor deficient mice

(2009) I.D. Blum et al.   NEUROSCIENCE

Energy Homoeostasis: The Roles of Adipose Tissue-Derived Hormones, Peptide YY and Ghrelin

(2009) Jocelin Hall et al.   Obesity Facts

CCK, ghrelin, and PYY responses in individuals with binge eating disorder before and after a cognitive behavioral treatment (CBT)

(2009) Simone Munsch et al.   PHYSIOLOGY & BEHAVIOR

Requirement of central ghrelin signaling for alcohol reward

(2009) E. Jerlhag et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glucagon-like peptide-1 secretion in bulimia nervosa

(2009) Francesca Brambilla et al.   PSYCHIATRY RESEARCH

Enhanced ghrelin secretion in the cephalic phase of food ingestion in women with bulimia nervosa

(2009) Palmiero Monteleone et al.   PSYCHONEUROENDOCRINOLOGY

Possible entrainment of ghrelin to habitual meal patterns in humans

(2008) Julie M. Frecka et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Should Binge Eating Disorder Be Included in the DSM-V? A Critical Review of the State of the Evidence

(2008) Ruth H. Striegel-Moore et al.   Annual Review of Clinical Psychology

Peripheral injection of ghrelin induces Fos expression in the dorsomedial hypothalamic nucleus in rats

(2008) Peter Kobelt et al.   BRAIN RESEARCH

Identification of the Acyltransferase that Octanoylates Ghrelin, an Appetite-Stimulating Peptide Hormone

(2008) Jing Yang et al.   CELL

Ghrelin Gets Its GOAT

(2008) James Gardiner et al.   Cell Metabolism

Ghrelin Modulates Brain Activity in Areas that Control Appetitive Behavior

(2008) Saima Malik et al.   Cell Metabolism

Long-acting octreotide treatment causes a sustained decrease in ghrelin concentrations but does not affect weight, behaviour and appetite in subjects with Prader–Willi syndrome

(2008) Kathleen De Waele et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Plasma Obestatin, Ghrelin, and Ghrelin/Obestatin Ratio Are Increased in Underweight Patients with Anorexia Nervosa But Not in Symptomatic Patients with Bulimia Nervosa

(2008) Palmiero Monteleone et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Novel Ghrelin Assays Provide Evidence for Independent Regulation of Ghrelin Acylation and Secretion in Healthy Young Men

(2008) Jianhua Liu et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

UCP2 mediates ghrelin’s action on NPY/AgRP neurons by lowering free radicals

(2008) Zane B. Andrews et al.   NATURE

Systemic administration of ghrelin increases extracellular dopamine in the shell but not the core subdivision of the nucleus accumbens

(2008) Davide Quarta et al.   NEUROCHEMISTRY INTERNATIONAL

Appetite-related gut peptides, ghrelin, PYY, and GLP-1 in obese women with and without binge eating disorder (BED)

(2008) Allan Geliebter et al.   PHYSIOLOGY & BEHAVIOR

Ghrelin octanoylation mediated by an orphan lipid transferase

(2008) J. A. Gutierrez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ghrelin/obestatin ratio in two populations with low bodyweight: Constitutional thinness and anorexia nervosa

(2008) Natacha Germain et al.   PSYCHONEUROENDOCRINOLOGY

Introducing GOAT: a target for obesity and anti-diabetic drugs?

(2008) Oreste Gualillo et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Simultaneous deletion of ghrelin and its receptor increases motor activity and energy expenditure

(2007) Paul T. Pfluger et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Course and predictors of rehospitalization in adolescent anorexia nervosa in a multisite study

(2007) Hans-Christoph Steinhausen et al.   INTERNATIONAL JOURNAL OF EATING DISORDERS

Systemic ghrelin sensitizes cocaine-induced hyperlocomotion in rats

(2007) Paul J. Wellman et al.   REGULATORY PEPTIDES