Article
Gastroenterology & Hepatology
Sai Wang, Rilu Feng, Shan Shan Wang, Hui Liu, Chen Shao, Yujia Li, Frederik Link, Stefan Munker, Roman Liebe, Christoph Meyer, Elke Burgermeister, Matthias Ebert, Steven Dooley, Huiguo Ding, Honglei Weng
Summary: This study investigates the transcriptional regulation of multidrug resistance protein 2 (MRP2) under different pathophysiological conditions and identifies FOXA2 as a potential replacement for FXR in maintaining MRP2 expression in patients with acute liver failure (ALF). The findings suggest that by regulating the expression of FOXA2, it may be possible to prevent hyperbilirubinemia in ALF patients with sepsis.
Article
Pediatrics
Kanwar Saini, Rishi Bolia, Nowneet Kumar Bhat
Summary: Sepsis-associated liver injury (SALI) occurs as a result of systemic and microcirculatory changes caused by sepsis. This study found an association between SALI occurrence and higher pSOFA scores, and SALI development increases the risk of mortality in children with sepsis.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Medicine, Research & Experimental
Adrian T. Press, Petra Babic, Bianca Hoffmann, Tina Mueller, Wanling Foo, Walter Hauswald, Jovana Benecke, Martina Beretta, Zoltan Cseresnyes, Stephanie Hoeppener, Ivo Nischang, Sina M. Coldewey, Markus H. Graeler, Reinhard Bauer, Falk Gonnert, Nikolaus Gassler, Reinhard Wetzker, Marc Thilo Figge, Ulrich S. Schubert, Michael Bauer
Summary: Inhibition of PI3K gamma can protect against liver dysfunction, while targeted drug delivery to hepatic parenchymal cells using nanocarriers functionalized with DY-635 can improve survival in a sepsis model without impairing host defense mechanisms.
EMBO MOLECULAR MEDICINE
(2021)
Article
Veterinary Sciences
Lara Baptista, Danica Pollard, Andrea Di Bella
Summary: This study aimed to evaluate the differences in resting serum bile acid concentrations between septic and non-septic dogs. The results showed significantly higher resting serum bile acid concentrations in the septic group compared to the non-septic group. However, when comparing the septic group with a control group of dogs admitted for elective orthopedic procedures, no difference in bile acid concentrations was found.
VETERINARY SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Dustin Beyer, Jessica Hoff, Oliver Sommerfeld, Alexander Zipprich, Nikolaus Gassler, Adrian T. Press
Summary: This review investigates the impact of dysregulated host response on the liver, consequences for the immune response, and potential avenues for personalized therapeutics.
MOLECULAR MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Mingxia Shi, Li Sheng, Min Lian, Qi Miao, Qixia Wang, Xiao Xiao, Xiong Ma
Summary: Rifampicin could be a promising option for most PHSF patients, especially those with UGT1A1 deficiency. In this study, 14 out of 16 PHSF patients who received rifampicin treatment showed more than 20% improvement in TBIL levels after 4 weeks, with all 14 eventually returning to normal TBIL levels after 6-12 weeks.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Review
Medicine, General & Internal
Jacqueline A. G. M. Langedijk, Ulrich H. Beuers, Ronald P. J. Oude Elferink
Summary: This article discusses the debilitating symptom of pruritus in various cholestatic disorders, the unresolved molecular mechanisms, and the current guidelines-approved therapy. Experimental therapeutic approaches are also necessary to improve patients' quality of life.
FRONTIERS IN MEDICINE
(2021)
Article
Medicine, General & Internal
Beiyuan Zhang, Xiancheng Chen, Chenhang He, Ting Su, Ke Cao, Xiaoyao Li, Jianfeng Duan, Ming Chen, Zhanghua Zhu, Wenkui Yu
Summary: This study evaluated the associations between acute gastrointestinal injury (AGI), gut microbiota, and sepsis-associated liver dysfunction (SALD) in patients with intra-abdominal infection (IAI). The results showed a severity-dependent relationship between AGI grade and the occurrence of sepsis-induced cholestasis (SIC). Patients with SIC exhibited a significant gut microbiota disorder during the first week of their stay in the intensive care unit.
FRONTIERS IN MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Pin-Ho Pan, Ya-Yu Wang, Shih-Yi Lin, Su-Lan Liao, Yu-Fang Chen, Wei-Chi Huang, Chun-Jung Chen, Wen-Ying Chen
Summary: 18-β-Glycyrrhetinic acid has promising hepatoprotective effects against cholestatic liver injury, improving liver histology and reducing oxidative stress, inflammation, apoptosis, impaired autophagy, and fibrosis.
Article
Cell Biology
Maarten P. Bebelman, Matthew J. Bovyn, Carlotta M. Mayer, Julien Delpierre, Ronald Naumann, Nuno P. Martins, Alf Honigmann, Yannis Kalaidzidis, Pierre A. Haas, Marino Zerial
Summary: Bebelman and Bovyn et al. demonstrate that apical bulkheads are load-bearing mechanical elements that contribute to the ability of bile canaliculi to withstand elevated luminal pressure. Through their structure and function analysis, they found that apical bulkheads are sealed by tight junction loops, connected by adherens junctions, and contain contractile actomyosin. The study also revealed that apical bulkheads can double the pressure bile canaliculi can hold and protect the bile duct network against elevated pressure.
JOURNAL OF CELL BIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Li Wang, Yi-Ling Qiu, Hong-Mei Xu, Jing Zhu, Shuang-Jie Li, Wen-Xian OuYang, Yong-Feng Yang, Yi Lu, Xin-Bao Xie, Qing-He Xing, Jian-She Wang
Summary: The phenotype of MYO5B deficiency is associated with MYO5B genotypes, particularly null variants or affected domains. The severity of intestinal manifestation and cholestasis in FIC patients is correlated with specific variants of the MYO5B gene. Missense/in-frame variants affecting non-motor regions and IQ motifs in MYO5B are more common in FIC patients compared to MVID patients.
LIVER INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Shihong Zheng, Peichang Cao, Zequn Yin, Xuerui Wang, Yuanli Chen, Maoyun Yu, Baocai Xu, Chenzhong Liao, Yajun Duan, Shuang Zhang, Jihong Han, Xiaoxiao Yang
Summary: Apigenin can improve cholestasis induced by DDC by reducing inflammation and oxidative damage, and improving bile acid metabolism, indicating its potential application for cholestasis treatment.
Article
Gastroenterology & Hepatology
Debashis Haldar, Ashnila Janmohamed, Tim Plant, Matthew Davidson, Hannah Norman, Emily Russell, Olivia Serevina, Kenneth Chung, Kashif Qamar, Bridget Gunson, Bettina Hansen, Alex Richter, Palak J. Trivedi, Gideon M. Hirschfield
Summary: In patients with PBC, the presence of anti-gp210 autoantibodies is associated with adverse clinical manifestations, predicts treatment non-response, and independently predicts decreased transplant-free survival.
LIVER INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Bibiana Quirant-Sanchez, Oriol Plans-Galvan, Ester Lucas, Eduard Argudo, Eva Maria Martinez-Caceres, Fernando Armestar
Summary: The early identification and treatment of at-risk patients with sepsis is crucial for reducing mortality. This study assessed the correlation between HLA-DR expression on monocytes ((M)HLA-DR ratio), sepsis index (CD64 expression on neutrophils/(M)HLA-DR ratio), C-reactive protein (CRP), and sepsis development. Biomarkers were tested in 77 critically ill patients over a period of 15 days. Most patients (71%) developed sepsis within 4.2±1.3 days after admission. On day 3, patients who subsequently developed sepsis had lower (M)HLA-DR+ levels and higher sepsis indexes compared to those who did not develop sepsis. The (M)HLA-DR ratio recovered slowly before day 6, while the sepsis index remained elevated up to day 9 in septic patients. Optimal cut-offs for predicting sepsis development were CRP levels > 106.90 mg/mL and (M)HLA-DR expression rate < 72.80%. Periodic monitoring of (M)HLA-DR expression, CRP, and sepsis index may help identify high-risk sepsis patients in the ICU.
Article
Biochemistry & Molecular Biology
Tim Brecklinghaus, Wiebke Albrecht, Franziska Kappenberg, Julia Duda, Nachiket Vartak, Karolina Edlund, Rosemarie Marchan, Ahmed Ghallab, Cristina Cadenas, Georgia Gunther, Marcel Leist, Mian Zhang, Iain Gardner, Jorg Reinders, Frans G. M. Russel, Alison J. Foster, Dominic P. Williams, Amruta Damle-Vartak, Melanie Grandits, Gerhard Ecker, Naim Kittana, Jorg Rahnenfuehrer, Jan G. Hengstler
Summary: A method was introduced to assess the risk of human drug induced liver injury based on oral doses and blood concentrations of drugs using in vitro/in silico approaches. The addition of an assay that measures the inhibition of bile acid export carriers improved the differentiation of hepatotoxic and non-hepatotoxic compounds. Integration of the CMFDA assay with an in vitro test battery enhanced the separation of hepatotoxic from non-hepatotoxic compounds.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Gastroenterology & Hepatology
Zhou Yuming, Tang Ruqi, Merrill Eric Gershwin, Ma Xiong
CLINICS IN LIVER DISEASE
(2024)
Article
Gastroenterology & Hepatology
Inbal Houri, Gideon M. Hirschfield
CLINICS IN LIVER DISEASE
(2024)
Article
Gastroenterology & Hepatology
Yasameen Muzahim, Ali Wakil, Mehak Bassi, Nikolaos Pyrsopoulos
CLINICS IN LIVER DISEASE
(2024)
Article
Gastroenterology & Hepatology
Brian H. Horwich, Douglas T. Dieterich
CLINICS IN LIVER DISEASE
(2024)
Article
Gastroenterology & Hepatology
Aparna Goel, Paul Kwo
Summary: The goal of autoimmune hepatitis treatment is achieving clinical and biochemical remission. Standard care involves induction treatment with corticosteroids and gradual tapering of steroids. Alternatives to standard therapy can be considered for patients with intolerance or inadequate response. Treatment withdrawal is achievable in less than 20% of patients after 2 years of sustained remission, and liver transplantation should be considered for patients with progressive disease or complications.
CLINICS IN LIVER DISEASE
(2024)
Article
Gastroenterology & Hepatology
Mariana Zapata, Hendrick Pagan-Torres, Marlyn J. Mayo
CLINICS IN LIVER DISEASE
(2024)
Article
Gastroenterology & Hepatology
Aalam Sohal, Sanya Kayani, Kris Kowdley
Summary: Primary sclerosing cholangitis (PSC) is an immune-mediated liver disease characterized by inflammation and fibrosis of bile ducts. It is commonly associated with inflammatory bowel disease, especially ulcerative colitis. The natural history of the disease varies among patients, but most will develop cirrhosis.
CLINICS IN LIVER DISEASE
(2024)
