Article
Andrology
Makoto Matsushita, Kazutoshi Fujita, Daisuke Motooka, Koji Hatano, Junya Hata, Mitsuhisa Nishimoto, Eri Banno, Kentaro Takezawa, Shinichiro Fukuhara, Hiroshi Kiuchi, Yue Pan, Toshifumi Takao, Akira Tsujimura, Shinichi Yachida, Shota Nakamura, Wataru Obara, Hirotsugu Uemura, Norio Nonomura
Summary: This study examined the relationship between gut microbiota and testosterone levels in elderly Japanese men. The results showed that certain bacteria belonging to the Firmicutes phylum were associated with higher levels of testosterone. This suggests that the gut microbiota may affect testosterone metabolism in elderly males.
WORLD JOURNAL OF MENS HEALTH
(2022)
Article
Endocrinology & Metabolism
Mark Ng Tang Fui, Rudolf Hoermann, Karen Bracken, David J. Handelsman, Warrick J. Inder, Bronwyn G. A. Stuckey, Bu B. Yeap, Ali Ghasem-Zadeh, Kristy P. Robledo, David Jesudason, Jeffrey D. Zajac, Gary A. Wittert, Mathis Grossmann
Summary: In men aged 50 and above, testosterone treatment for 2 years increased volumetric bone density, primarily through effects on cortical bone. The effects on trabecular bone architecture were minor.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Andrology
Julie Abildgaard, Jorgen Holm Petersen, Anne Kirstine Bang, Lise Aksglaede, Peter Christiansen, Anders Juul, Niels Jorgensen
Summary: Quarterly intramuscular injections with long-acting testosterone undecanoate (TU) provide stable serum testosterone concentrations over time and are preferred by many testosterone-deficient patients. However, the use of long-acting TU in elderly patients is limited due to lack of safety and feasibility studies. The study found that elderly patients require more adjustments in TU dose to reach treatment targets, but the risk of polycythemia in elderly patients does not increase compared to younger patients when age-adjusted treatment targets are achieved.
Article
Endocrinology & Metabolism
Shang-Rong Zhong, Han-Hsuan Yang, Cheng-Hsi Liao, Deng-Ho Yang, Shih-Kai Tu, Chia-Lien Hung, Chun-Cheng Liao
Summary: The study revealed a strong association between serum testosterone and metabolic syndrome in Taiwanese men, with the predictive value increasing with age.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2021)
Review
Endocrinology & Metabolism
Sara De Vincentis, Vincenzo Rochira
Summary: Hypogonadism is common in HIV-positive men and tends to occur earlier compared to the general male population. It can be easily underestimated due to non-specific symptoms and overlaps with symptoms of HIV infection. Laboratory examinations are necessary to accurately diagnose hypogonadism in this population.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Medicine, Research & Experimental
Marcelo Rodrigues dos Santos, Shalender Bhasin
Summary: The increase in life expectancy for men has drawn attention to quality-of-life issues related to reproductive aging. Testosterone levels decline with age and can be improved with treatment, although long-term effects on major cardiovascular events and prostate cancer risk remain unclear.
ANNUAL REVIEW OF MEDICINE, VOL 72, 2021
(2021)
Article
Endocrinology & Metabolism
Jean-Marc Kaufman
Summary: The diagnosis of hypogonadism in ageing men requires attention to symptom specificity and measurement of serum testosterone levels. The diagnostic approach to late onset hypogonadism is similar to other forms of hypogonadism, but with a focus on avoiding overdiagnosis.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2022)
Article
Cardiac & Cardiovascular Systems
Mengyuan Qu, Chenzhao Feng, Xiaotong Wang, Yiqun Gu, Xuejun Shang, Yuanzhong Zhou, Chengliang Xiong, Honggang Li
Summary: The study found that the decline in sex hormone levels due to aging may be an important factor in male aging and cardiovascular diseases. Testosterone levels were inversely associated with hypertension prevalence, but factors like age, weight, smoking, and family history can impact this association.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Review
Endocrinology & Metabolism
Shalender Bhasin, Noelle Ozimek
Summary: This narrative review provides a guideline-based approach for optimizing diagnostic evaluation and treatment decision making in men being evaluated for testosterone deficiency. The diagnosis of testosterone deficiency is made through ascertainment of symptoms and signs, blood tests, and additional evaluations. Testosterone replacement therapy should be carefully considered based on the burden of symptoms, potential benefits and risks, patient's values, and the cost and burden of long-term treatment and monitoring.
ENDOCRINE PRACTICE
(2021)
Article
Endocrinology & Metabolism
Robert Benson Jones Jr, Peter J. Snyder
Summary: This study aims to determine if testosterone treatment of men with unequivocal hypogonadism and organ-confined prostate cancer is associated with recurrence of the cancer. Previous studies on testosterone treatment of men with treated prostate cancer have not provided clear evidence that these men were truly hypogonadal.
ENDOCRINE PRACTICE
(2023)
Article
Endocrinology & Metabolism
David J. Handelsman, Mathis Grossmann, Bu B. Yeap, Bronwyn G. A. Stuckey, Nandini Shankara-Narayana, Ann J. Conway, Warrick J. Inder, Robert Mclachlan, Carolyn Allan, Alicia J. Jenkins, David Jesudason, Karen Bracken, Gary A. Wittert
Summary: The T4DM study shows that testosterone treatment for men with impaired glucose tolerance or newly diagnosed diabetes reduces the risk of diabetes and improves sleep apnea diagnosis during the study period, but these effects disappear after the study. There is also evidence of androgen dependence in some men receiving prolonged injectable testosterone treatment.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
J. A. Cauley, S. S. Ellenberg, A. V. Schwartz, K. E. Ensrud, T. M. Keaveny, P. J. Snyder
Summary: The study found that TBS is not clinically useful in monitoring the 1-year effect of testosterone treatment on bone structure in older hypogonadal men.
OSTEOPOROSIS INTERNATIONAL
(2021)
Review
Medicine, General & Internal
Ettore Caroppo, Giovanni M. Colpi
Summary: Preoperative hormonal stimulation has been tested to improve sperm retrieval rate in patients with nonobstructive azoospermia, but conflicting results exist. Patients with normal testosterone levels have a significantly higher chance of successful sperm retrieval, indicating potential benefit for those with hypogonadism. However, there is insufficient evidence to recommend hormonal therapy as a standard clinical practice to enhance sperm retrieval rate in these patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, Research & Experimental
Junke Chang, Yongming Wu, Sicheng Zhou, Ye Tian, Yan Wang, Jie Tian, Wenpeng Song, Yinxian Dong, Jue Li, Ziyi Zhao, Guowei Che
Summary: Genetically predicted BT level was significantly associated with an increased risk of prostate cancer, while TT was found to be the suggestive protective factor against stomach cancer, pancreatic cancer, and small intestine cancer in men.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Urology & Nephrology
Alex Zhu, Juan Andino, Stephanie Daignault-Newton, Zoey Chopra, Aruna Sarma, James M. M. Dupree
Summary: There is an age-related decline in male testosterone production. It is important to use age-specific cutoffs for low testosterone levels in the evaluation of young men presenting with testosterone deficiency.
JOURNAL OF UROLOGY
(2022)
Article
Geriatrics & Gerontology
Lisa Langsetmo, John T. Schousboe, Brent C. Taylor, Jane A. Cauley, Howard A. Fink, Peggy M. Cawthon, Marcia L. Stefanick, Deborah M. Kado, Allyson M. Kats, Kristine E. Ensrud
Summary: This study evaluated the risks of clinical fracture, hip fracture, and mortality prior to fracture among men aged at least 80 years. The results showed that fall history, hip bone mineral density, and recent fracture were strong predictors of clinical fracture and hip fracture. Age and multimorbidity were strong predictors of mortality before fracture. The study results have important implications for guiding osteoporosis drug treatment decisions.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Critical Care Medicine
Sobhan Salari Shahrbabaki, Dominik Linz, Susan Redline, Katie Stone, Kristine Ensrud, Mathias Baumert
Summary: Arousal during sleep triggers ventricular repolarization lability, which may increase the risk of long-term cardiovascular mortality. The QT variability index during arousal is independently associated with all-cause and cardiovascular mortality, indicating maladaptation of ventricular repolarization to the arousal stimulus. Further study is needed to determine if arousal suppression can reduce ventricular repolarization lability and subsequent mortality, and if arousal-related QT variability index can be used for more accurate risk stratification.
Article
Geriatrics & Gerontology
Alexandra Cours, Mei-Hua Huang, Howard Fink, Kristine E. Ensrud, John T. Schousboe, Wendy Katzman, Diane Schneider, Nancy E. Lane, Peggy Cawthon, Deborah M. Kado
Summary: This study found that increasing blocks-measured kyphosis is associated with a higher risk of mortality in older men, indicating that hyperkyphosis should be considered as a clinically significant problem.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Article
Cardiac & Cardiovascular Systems
Hyung-Bok Park, Jina Lee, Yongtaek Hong, So Byungchang, Wonse Kim, Byoung K. Lee, Fay Y. Lin, Martin Hadamitzky, Yong-Jin Kim, Edoardo Conte, Daniele Andreini, Gianluca Pontone, Matthew J. Budoff, Ilan Gottlieb, Eun Ju Chun, Filippo Cademartiri, Erica Maffei, Hugo Marques, Pedro de A. Goncalves, Jonathon A. Leipsic, Sanghoon Shin, Jung H. Choi, Renu Virmani, Habib Samady, Kavitha Chinnaiyan, Peter H. Stone, Daniel S. Berman, Jagat Narula, Leslee J. Shaw, Jeroen J. Bax, James K. Min, Woong Kook, Hyuk-Jae Chang
Summary: This study used the Bayesian quantile regression model to analyze the relationship between multiple cardiovascular risk factors and different stages of coronary artery disease. The results showed that the lumen diameter stenosis of different heart vessels ranged from 41% to 50% and the maximum stenosis change ranged from 5.6% to 7.3%. The study found that angina was associated with a high quantile (90%) of stenosis in the left anterior descending artery, diabetes was associated with higher quantiles (75% and 90%) of stenosis in the left circumflex artery, and dyslipidemia was associated with the highest quantile (90%) of stenosis in the right coronary artery. This study demonstrates the clinical utility of the Bayesian quantile regression model in evaluating the comprehensive relationship between risk factors and baseline-grade coronary artery disease and its progression.
CLINICAL CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Jeff Moore, Suvasini Lakshmanan, Venkat Sanjay Manubolu, April Kinninger, George Stojan, Daniel W. Goldman, Michelle Petri, Matthew Budoff, George A. Karpouzas
Summary: This study compared the baseline and progression of coronary plaques in patients with SLE and RA. The results showed that SLE patients had a greater increase in plaque volume, which may explain their higher cardiovascular risk.
CORONARY ARTERY DISEASE
(2023)
Review
Peripheral Vascular Disease
Samuel C. R. Sherratt, Peter Libby, Matthew J. Budoff, Deepak L. Bhatt, R. Preston Mason
Summary: This review examines the effects of omega-3 fatty acids (n3-FAs) on cardiovascular risk reduction. It has been found that high-purity EPA ethyl ester has significant benefits in reducing cardiovascular events and atherosclerosis progression compared to mixed EPA/DHA treatments. Mechanistic differences between n3-FAs, including membrane interactions, metabolic products, cholesterol efflux, antioxidant properties, and tissue distribution, have been explored.
CURRENT ATHEROSCLEROSIS REPORTS
(2023)
Article
Geriatrics & Gerontology
Brienne Miner, Margaret Doyle, Melissa Knauert, Henry Klar Yaggi, Katie L. Stone, Sonia Ancoli-Israel, Jane A. Cauley, Susan Redline, Terri Blackwell, Thomas M. Gill
Summary: ISSD, characterized by insomnia or poor sleep quality with short sleep duration, is common among older adults and is associated with various factors. Future research should focus on determining causal relationships and whether these factors are modifiable risk factors.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Article
Geriatrics & Gerontology
Natalia Festa, John Hsu, James K. K. Hammitt, Thomas M. M. Gill
Summary: Although environmental pollution and societal aging are concurrent public health challenges, the relationship between the two is rarely considered. The current approach to valuing public health benefits of environmental policy may not be suitable for aging populations. We describe the limitations of the age-invariant approach used by the US EPA for estimating public health benefits of environmental regulation. We offer an empirical framework that could address these limitations and improve the calibration of environmental regulatory analysis to the changing age distribution of the US population.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Article
Cardiac & Cardiovascular Systems
Lohendran Baskaran, Jing Kai Lee, Michelle Shi Min Ko, Subhi J. Al'Aref, Yu Pei Neo, Jien Sze Ho, Weiting Huang, Yeonyee Elizabeth Yoon, Donghee Han, Rine Nakanishi, Swee Yaw Tan, Mouaz Al-Mallah, Matthew J. Budoff, Leslee J. Shaw
Summary: This study compared the abilities of pooled cohort equations (PCE) and coronary artery calcium (CAC) assessment in predicting major adverse cardiovascular events (MACE) in an Asian population. Age, presence of CAC, and ln(Volume) were significantly associated with MACE in the overall subgroup, while age and PCE score were significantly associated with MACE in the CAC = 0 subgroup. No risk factors were associated with MACE in the CAC > 0 subgroup. The performance of PCE deteriorated in statin versus non-statin users, while the Agatston score performed consistently in both groups.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Clinical Neurology
Meiyuzhen Qi, Imke Janssen, Emma Barinas-Mitchell, Matthew Budoff, Maria M. Brooks, Arun S. Karlamangla, Carol A. Derby, Chung-Chou H. Chang, Kelly J. Shields, Samar R. El Khoudary
Summary: This study found that the quantity and quality of thoracic perivascular adipose tissue (PVAT) in middle age are related to cognitive performance in later years. Higher thoracic PVAT volume is associated with better future episodic memory, while higher thoracic PVAT radiodensity is related to poorer future working and episodic memories, particularly at higher thoracic PVAT volume.
ALZHEIMERS & DEMENTIA
(2023)
Article
Cardiac & Cardiovascular Systems
Ramzi Dudum, Zeina A. Dardari, David I. Feldman, Daniel S. Berman, Matthew J. Budoff, Michael D. Miedema, Khurram Nasir, Alan Rozanski, John A. Rumberger, Leslee Shaw, Omar Dzaye, Miguel Cainzos-Achirica, Jaideep Patel, Michael J. Blaha
Summary: Coronary artery calcium is useful for assessing subclinical atherosclerosis and improving risk stratification. The dispersion of calcified vessels and CAC phenotype have different impacts on cause-specific mortality. This study demonstrated that increasing calcium dispersion, characterized by multiple vessel involvement and less dense calcification, is associated with higher all-cause mortality and cardiovascular disease-specific mortality.
AMERICAN JOURNAL OF CARDIOLOGY
(2023)
Article
Clinical Neurology
Daniela Renedo, Julian N. Acosta, Andrew B. Koo, Cyprien Rivier, Nanthiya Sujijantarat, Adam de Havenon, Richa Sharma, Thomas M. Gill, Kevin N. Sheth, Guido J. Falcone, Charles C. Matouk
Summary: This study aims to investigate the relationship between the hospital frailty risk score (HFRS) and the risk of stroke, as well as to determine whether there is a significant association between genetically determined frailty and stroke. The results showed that frailty status is positively associated with the risk of stroke, and genetically determined frailty is independently associated with the risk of stroke.
Editorial Material
Cardiac & Cardiovascular Systems
Jairo Aldana-Bitar, Ronald P. Karlsberg, Matthew J. Budoff
EXPERT REVIEW OF CARDIOVASCULAR THERAPY
(2023)
Letter
Cardiac & Cardiovascular Systems
Jairo Aldana-Bitar, Ronald P. Karlsberg, Matthew J. Budoff
Article
Cardiac & Cardiovascular Systems
Ayman Abdelkarim, Sion K. Roy, April Kinninger, Azadeh Salek, Olivia Baranski, Daniele Andreini, Gianluca Pontone, Edoardo Conte, Rachael O'Rourke, Christian Hamilton-Craig, Matthew J. Budoff
Summary: This study evaluates the image quality in patients with heart rates above or equal to 70 bpm using a 16 cm scanner compared to a CT scanner with only 4 cm of coverage. The results show that the 16 cm scanner has superior image quality in terms of contrast-to-noise ratio and signal-to-noise ratio compared to the 4 cm scanner.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)