Article
Andrology
Makoto Matsushita, Kazutoshi Fujita, Daisuke Motooka, Koji Hatano, Junya Hata, Mitsuhisa Nishimoto, Eri Banno, Kentaro Takezawa, Shinichiro Fukuhara, Hiroshi Kiuchi, Yue Pan, Toshifumi Takao, Akira Tsujimura, Shinichi Yachida, Shota Nakamura, Wataru Obara, Hirotsugu Uemura, Norio Nonomura
Summary: This study examined the relationship between gut microbiota and testosterone levels in elderly Japanese men. The results showed that certain bacteria belonging to the Firmicutes phylum were associated with higher levels of testosterone. This suggests that the gut microbiota may affect testosterone metabolism in elderly males.
WORLD JOURNAL OF MENS HEALTH
(2022)
Article
Endocrinology & Metabolism
Mark Ng Tang Fui, Rudolf Hoermann, Karen Bracken, David J. Handelsman, Warrick J. Inder, Bronwyn G. A. Stuckey, Bu B. Yeap, Ali Ghasem-Zadeh, Kristy P. Robledo, David Jesudason, Jeffrey D. Zajac, Gary A. Wittert, Mathis Grossmann
Summary: In men aged 50 and above, testosterone treatment for 2 years increased volumetric bone density, primarily through effects on cortical bone. The effects on trabecular bone architecture were minor.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Andrology
Julie Abildgaard, Jorgen Holm Petersen, Anne Kirstine Bang, Lise Aksglaede, Peter Christiansen, Anders Juul, Niels Jorgensen
Summary: Quarterly intramuscular injections with long-acting testosterone undecanoate (TU) provide stable serum testosterone concentrations over time and are preferred by many testosterone-deficient patients. However, the use of long-acting TU in elderly patients is limited due to lack of safety and feasibility studies. The study found that elderly patients require more adjustments in TU dose to reach treatment targets, but the risk of polycythemia in elderly patients does not increase compared to younger patients when age-adjusted treatment targets are achieved.
Article
Endocrinology & Metabolism
Shang-Rong Zhong, Han-Hsuan Yang, Cheng-Hsi Liao, Deng-Ho Yang, Shih-Kai Tu, Chia-Lien Hung, Chun-Cheng Liao
Summary: The study revealed a strong association between serum testosterone and metabolic syndrome in Taiwanese men, with the predictive value increasing with age.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2021)
Review
Endocrinology & Metabolism
Sara De Vincentis, Vincenzo Rochira
Summary: Hypogonadism is common in HIV-positive men and tends to occur earlier compared to the general male population. It can be easily underestimated due to non-specific symptoms and overlaps with symptoms of HIV infection. Laboratory examinations are necessary to accurately diagnose hypogonadism in this population.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Medicine, Research & Experimental
Marcelo Rodrigues dos Santos, Shalender Bhasin
Summary: The increase in life expectancy for men has drawn attention to quality-of-life issues related to reproductive aging. Testosterone levels decline with age and can be improved with treatment, although long-term effects on major cardiovascular events and prostate cancer risk remain unclear.
ANNUAL REVIEW OF MEDICINE, VOL 72, 2021
(2021)
Article
Endocrinology & Metabolism
Jean-Marc Kaufman
Summary: The diagnosis of hypogonadism in ageing men requires attention to symptom specificity and measurement of serum testosterone levels. The diagnostic approach to late onset hypogonadism is similar to other forms of hypogonadism, but with a focus on avoiding overdiagnosis.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2022)
Article
Cardiac & Cardiovascular Systems
Mengyuan Qu, Chenzhao Feng, Xiaotong Wang, Yiqun Gu, Xuejun Shang, Yuanzhong Zhou, Chengliang Xiong, Honggang Li
Summary: The study found that the decline in sex hormone levels due to aging may be an important factor in male aging and cardiovascular diseases. Testosterone levels were inversely associated with hypertension prevalence, but factors like age, weight, smoking, and family history can impact this association.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Review
Endocrinology & Metabolism
Shalender Bhasin, Noelle Ozimek
Summary: This narrative review provides a guideline-based approach for optimizing diagnostic evaluation and treatment decision making in men being evaluated for testosterone deficiency. The diagnosis of testosterone deficiency is made through ascertainment of symptoms and signs, blood tests, and additional evaluations. Testosterone replacement therapy should be carefully considered based on the burden of symptoms, potential benefits and risks, patient's values, and the cost and burden of long-term treatment and monitoring.
ENDOCRINE PRACTICE
(2021)
Article
Endocrinology & Metabolism
Robert Benson Jones Jr, Peter J. Snyder
Summary: This study aims to determine if testosterone treatment of men with unequivocal hypogonadism and organ-confined prostate cancer is associated with recurrence of the cancer. Previous studies on testosterone treatment of men with treated prostate cancer have not provided clear evidence that these men were truly hypogonadal.
ENDOCRINE PRACTICE
(2023)
Article
Endocrinology & Metabolism
David J. Handelsman, Mathis Grossmann, Bu B. Yeap, Bronwyn G. A. Stuckey, Nandini Shankara-Narayana, Ann J. Conway, Warrick J. Inder, Robert Mclachlan, Carolyn Allan, Alicia J. Jenkins, David Jesudason, Karen Bracken, Gary A. Wittert
Summary: The T4DM study shows that testosterone treatment for men with impaired glucose tolerance or newly diagnosed diabetes reduces the risk of diabetes and improves sleep apnea diagnosis during the study period, but these effects disappear after the study. There is also evidence of androgen dependence in some men receiving prolonged injectable testosterone treatment.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
J. A. Cauley, S. S. Ellenberg, A. V. Schwartz, K. E. Ensrud, T. M. Keaveny, P. J. Snyder
Summary: The study found that TBS is not clinically useful in monitoring the 1-year effect of testosterone treatment on bone structure in older hypogonadal men.
OSTEOPOROSIS INTERNATIONAL
(2021)
Review
Medicine, General & Internal
Ettore Caroppo, Giovanni M. Colpi
Summary: Preoperative hormonal stimulation has been tested to improve sperm retrieval rate in patients with nonobstructive azoospermia, but conflicting results exist. Patients with normal testosterone levels have a significantly higher chance of successful sperm retrieval, indicating potential benefit for those with hypogonadism. However, there is insufficient evidence to recommend hormonal therapy as a standard clinical practice to enhance sperm retrieval rate in these patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, Research & Experimental
Junke Chang, Yongming Wu, Sicheng Zhou, Ye Tian, Yan Wang, Jie Tian, Wenpeng Song, Yinxian Dong, Jue Li, Ziyi Zhao, Guowei Che
Summary: Genetically predicted BT level was significantly associated with an increased risk of prostate cancer, while TT was found to be the suggestive protective factor against stomach cancer, pancreatic cancer, and small intestine cancer in men.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Urology & Nephrology
Alex Zhu, Juan Andino, Stephanie Daignault-Newton, Zoey Chopra, Aruna Sarma, James M. M. Dupree
Summary: There is an age-related decline in male testosterone production. It is important to use age-specific cutoffs for low testosterone levels in the evaluation of young men presenting with testosterone deficiency.
JOURNAL OF UROLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Bibinaz Eghtedari, Sion K. K. Roy, Matthew J. J. Budoff
Summary: Chronic inflammation plays a key role in the progression of atherosclerotic disease, and targeting inflammation has been shown to halt the development of coronary artery disease. Specific anti-inflammatory therapies, such as colchicine, canakinumab, VIA-2291, and methotrexate, have demonstrated efficacy in inhibiting atherosclerosis and cardiovascular disease progression. This review highlights the potential benefits of these anti-inflammatories, particularly for high-risk individuals already on optimal medical therapy.
CARDIOLOGY IN REVIEW
(2023)
Review
Cardiac & Cardiovascular Systems
Mahmoud Al Rifai, Alka M. Kanaya, Namratha R. Kandula, Jaideep Patel, Mouaz H. Al-Mallah, Matthew Budoff, Miguel Cainzos-Achirica, Michael H. Criqui, Salim S. Virani
Summary: Individuals of South Asian ancestry have a higher risk of atherosclerotic cardiovascular disease. Coronary artery calcium volume and density can identify unique plaque characteristics in this population, providing important prognostic information. Cardiovascular risk factors are associated with CAC density and volume.
CURRENT PROBLEMS IN CARDIOLOGY
(2023)
Article
Geriatrics & Gerontology
Mary E. Winger, Paolo Caserotti, Jane A. Cauley, Robert M. Boudreau, Sara R. Piva, Peggy M. Cawthon, Eric S. Orwoll, Kristine E. Ensrud, Deborah M. Kado, Elsa S. Strotmeyer
Summary: This study investigated the application of lower-extremity power and upper-extremity strength in fall injuries and found that lower leg power and grip strength predicted future fall injury risk in older men, independent of physical performance.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Oncology
Claire E. Thomas, Douglas C. Bauer, Jian-Min Yuan, Jane A. Cauley
Summary: This study assessed the associations between serum concentrations of cytokines and systemic immune biomarkers with the risk of prostate cancer. The results showed that the anti-inflammatory cytokine IL-10 was associated with a lower risk of prostate cancer. Further research on the relationship between IL-10, inflammation, and prostate cancer development is warranted.
CANCER CAUSES & CONTROL
(2023)
Review
Cardiac & Cardiovascular Systems
Ilana S. Golub, Orly G. Termeie, Stephanie Kristo, Lucia P. Schroeder, Suvasini Lakshmanan, Ahmed M. Shafter, Luay Hussein, Dhiran Verghese, Jairo Aldana-Bitar, Venkat S. Manubolu, Matthew J. Budoff
Summary: This review provides a summary of global guidelines on coronary artery calcium (CAC) for atherosclerotic cardiovascular disease risk assessment in both clinical and preventive settings. The review compares recommendations from different cardiovascular societies worldwide and identifies common features. Although there are some differences in specific intervals and cut points, international guidelines emphasize the importance of CAC in both primary and secondary prevention of atherosclerotic cardiovascular disease. Understanding the similarities among international guidelines is crucial for clinicians to make informed decisions about personalized treatment.
JACC-CARDIOVASCULAR IMAGING
(2023)
Article
Gastroenterology & Hepatology
Jacqueline B. B. Henson, Matthew J. J. Budoff, Andrew J. J. Muir
Summary: This study evaluated the performance of the Pooled Cohort Equations (PCE) in non-alcoholic fatty liver disease (NAFLD) patients and found that the PCE performed poorly in cardiovascular risk assessment in NAFLD, particularly in women and individuals with moderate-to-severe steatosis. Therefore, primary prevention may need to be considered at a lower risk threshold in these patients.
LIVER INTERNATIONAL
(2023)
Article
Cardiac & Cardiovascular Systems
Harpreet S. S. Bhatia, Robyn L. L. McClelland, Julie Denenberg, Matthew J. J. Budoff, Matthew A. A. Allison, Michael H. H. Criqui
Summary: This study evaluated the association between coronary artery calcium (CAC) density and cardiovascular disease risk across different levels of CAC volume. The combination of CAC density and volume improved risk prediction for coronary heart disease. Higher density was associated with lower risk at volume ≤ 130 mm(3), suggesting a potentially clinically useful cut point. Further research is needed to integrate these findings into a unified CAC scoring method.
CIRCULATION-CARDIOVASCULAR IMAGING
(2023)
Letter
Cardiac & Cardiovascular Systems
Charles Ginsberg, Andrew N. Hoofnagle, Ronit Katz, Jonathan H. Cheng, Simon Hsu, Matthew J. Budoff, Deborah M. Kado, Bryan Kestenbaum, David S. Siscovick, Erin D. Michos, Joachim H. Ix, Ian H. de Boer
CIRCULATION-CARDIOVASCULAR IMAGING
(2023)
Letter
Cardiac & Cardiovascular Systems
Yejin Mok, Yasuyuki Honda, Frances M. Wang, Candace M. Howard, Aaron R. Folsom, Josef Coresh, Matthew Budoff, Michael J. Blaha, Kunihiro Matsushita
CIRCULATION-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Mark G. Rabbat, Suvasini Lakshmanan, Mina M. Benjamin, Gheorghe Doros, April Kinninger, Matthew J. Budoff, Deepak L. Bhatt
Summary: The EVAPORATE trial demonstrated that IPE significantly reduced plaque burden. This study assessed the impact of IPE on coronary physiology using FFRCT. The results showed that IPE improved coronary distal segment FFRCT, providing mechanistic insight into the clinical benefit observed in the REDUCE-IT trial.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Sophie E. van Rosendael, A. Maxim Bax, Fay Y. Lin, Stephan Achenbach, Daniele Andreini, Matthew J. Budoff, Filippo Cademartiri, Tracy Q. Callister, Kavitha Chinnaiyan, Benjamin J. W. Chow, Ricardo C. Cury, Augustin J. DeLago, Gudrun Feuchtner, Martin Hadamitzky, Joerg Hausleiter, Philipp A. Kaufmann, Yong-Jin Kim, Jonathon A. Leipsic, Erica Maffei, Hugo Marques, Pedro de Araujo Goncalves, Gianluca Pontone, Gilbert L. Raff, Ronen Rubinshtein, Todd C. Villines, Hyuk-Jae Chang, Daniel S. Berman, James K. Min, Jeroen J. Bax, Leslee J. Shaw, Alexander R. van Rosendael
Summary: This study found that women develop coronary atherosclerosis approximately 12 years later than men, and post-menopausal women in the highest atherosclerotic burden group have a significantly higher risk for major adverse cardiovascular events (MACE) compared to men.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Review
Cardiac & Cardiovascular Systems
Keishi Ichikawa, Shriraj Susarla, Matthew J. Budoff
Summary: Although the overall incidence of atherosclerotic cardiovascular disease (ASCVD) is declining in the United States, the incidence of ASCVD events in young adults is increasing. The use of coronary artery calcium (CAC) scores can improve ASCVD risk assessment, but is not recommended for universal screening in young adults.
JOURNAL OF CARDIOVASCULAR COMPUTED TOMOGRAPHY
(2023)
Article
Endocrinology & Metabolism
Jane A. Cauley, Howard M. Kravitz, Kristine Ruppert, Yinjuan Lian, Martica J. Hall, Sioban D. Harlow, Joel S. Finkelstein, Gail Greendale
Summary: A study found that self-reported sleep disturbances were associated with an increased risk of fractures across the menopausal transition. However, after adjusting for confounding factors, this association was largely attenuated, suggesting that shared risk factors or other factors in the causal pathway may contribute to the observed relationship.
Review
Cardiac & Cardiovascular Systems
Pamela Pina, Daniel Lorenzatti, Rita Paula, Jonathan Daich, Aldo L. Schenone, Carlos Gongora, Mario J. Garcia, Michael J. Blaha, Matthew J. Budoff, Daniel S. Berman, Salim S. Virani, Leandro Slipczuk
Summary: Atherosclerotic cardiovascular disease (ASCVD) is a ongoing epidemic, primarily caused by lipid abnormalities. Despite being asymptomatic, most individuals who experience a first ASCVD event do not receive preventative therapies. Risk calculators based on traditional risk factors have been the cornerstone of primary prevention, but they often misclassify individuals, resulting in ineffective use of lipid-lowering medication or missed opportunities for prevention. The development of coronary artery calcium scoring (CAC) and CT coronary angiography (CCTA) provide tools to visualize coronary plaque and guide personalized lipid management.
AMERICAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Anandita Agarwala, Jaideep Patel, Michael Blaha, Miguel Cainzos-Achirica, Khurram Nasir, Matthew Budoff
Summary: South Asian individuals, especially those in the United States and other Westernized countries, have a higher risk of ASCVD and ASCVD-related mortality. The use of coronary artery calcium (CAC) scoring can improve risk stratification and the delivery of preventive therapies among South Asian individuals, as it is a cost-effective and highly reproducible marker of subclinical atherosclerosis.
AMERICAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)