Editorial Material
Biochemistry & Molecular Biology
Etsuo Niki
Summary: This commentary describes a highly cited paper by Dahle, Hill, and Holman, which showed that the oxidation products of polyunsaturated fatty acids reacted with thiobarbituric acid to give a colored product, which might be used to assess lipid oxidation.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2022)
Article
Medicine, General & Internal
Xavier Heim, Daniel Bertin, Noemie Resseguier, Abdelouahab Beziane, Audrey Metral, Alexandre Brodovitch, Regis Guieu, Jean-Guillaume Steinberg, Marcel Blot-Chabaud, Pierre-Emmanuel Morange, Jean-Louis Mege, Nathalie Bardin
Summary: The detection of aPEs is valuable in exploring thrombosis in cases where conventional markers are negative, especially in cases of deep vein thrombosis. There is a significant association between aPE positivity and systemic ROS production, suggesting a potential mechanism of action of aPEs in thrombosis through signaling related to oxidative stress.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Environmental Sciences
Arun Dev Singh, Kanika Khanna, Jaspreet Kour, Shalini Dhiman, Tamanna Bhardwaj, Kamini Devi, Neerja Sharma, Pardeep Kumar, Nitika Kapoor, Priyanka Sharma, Priya Arora, Anket Sharma, Renu Bhardwaj
Summary: Mercury (Hg) is a natural heavy metal pollutant that is widely distributed in the environment in elemental, organic, and inorganic forms. It is found in high amounts in the atmosphere, soil, water, and plants, leading to contamination of food chains and posing risks to human health. Excessive levels of Hg can also be toxic to plants, affecting their physiological and metabolic processes. Therefore, it is important to study the interactions between Hg and plants and develop methods to detoxify and control its concentration for environmental protection.
Article
Veterinary Sciences
B. Perez-Montero, M. L. Fermin-Rodriguez, G. Miro, L. de Juan, F. Cruz-Lopez
Summary: This study evaluated the potential interference of hemolysis, icterus, and lipemia (HIL) in the determination of Thiobarbituric Acid Reactive Substances (TBARS) and Total Antioxidant Status (TAS) in canine serum. The results showed that HIL induced significant interferences on TBARS and TAS, with TBARS being more susceptible to interferences. Slight hemolysis, moderate icterus, and slight lipemia caused notable deviations in TBARS values, while TAS assay was also affected, although to a lesser extent.
BMC VETERINARY RESEARCH
(2023)
Article
Nutrition & Dietetics
Shih-Wei Lin, You-Shan Tsai, Yen-Lien Chen, Ming-Fu Wang, Chin-Chu Chen, Wen-Hsin Lin, Tony J. Fang
Summary: The study revealed that the probiotic Lactobacillus plantarum GKM3 has significant effects in delaying aging, alleviating age-related cognitive impairment, and reducing oxidative stress.
Article
Health Care Sciences & Services
Hung-Chen Wang, Yu-Tsai Lin, Chih-Cheng Huang, Meng-Chih Lin, Mei-Yun Liaw, Cheng-Hsien Lu
Summary: The study demonstrates that high-intensity home-based RMT has positive effects on pulmonary function and cardiovascular autonomic function in patients with acute cervical SCI, improving breathing difficulties. However, patients' quality of life decreased significantly after RMT, with no significant difference in clinical scores.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Plant Sciences
Muhammad Ahmad, Ejaz Ahmad Waraich, Usman Zulfiqar, Saddam Hussain, Muhammad Umair Yasin, Muhammad Farooq
Summary: This study evaluated the potential role of thiourea in alleviating heat stress in canola. The results showed that exogenous application of thiourea can improve plant growth and yield, reduce levels of reactive oxygen species and thiobarbituric acid reactive substances, and improve cell membrane stability, thereby mitigating heat-induced oxidative stress.
JOURNAL OF SOIL SCIENCE AND PLANT NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Nestor Vazquez-Agra, Anton Cruces-Sande, Estefania Mendez-Alvarez, Ramon Soto-Otero, Sergio Cinza-Sanjurjo, Jose-Enrique Lopez-Paz, Antonio Pose-Reino, Alvaro Hermida-Ameijeiras
Summary: This study aimed to investigate the markers of oxidative stress in hypertensive patients and compare their levels between individuals with dipper and non-dipper DBP profiles, as well as assess their correlation with nocturnal DBP dipping. The results showed that oxidative stress markers were weakly correlated with the percentage of nocturnal DBP dipping, and increased TBARS/Thiol ratio and serum Cu levels were associated with a higher risk of a non-dipper DBP profile.
Article
Biochemistry & Molecular Biology
Patrik Palacka, Jarmila Kucharska, Jana Obertova, Katarina Rejlekova, Jan Slopovsky, Michal Mego, Daniela Svetlovska, Boris Kollarik, Jozef Mardiak, Anna Gvozdjakova
Summary: Oxidative stress plays a significant role in cancer pathogenesis, and the level of thiobarbituric acid-reactive substances (TBARS)-a parameter of lipid peroxidation-has prognostic significance in chemotherapy-naive patients with metastatic urothelial carcinoma (mUC). The effect of cisplatin-based chemotherapy on oxidative stress, coenzyme Q(10), and antioxidants is still unknown.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Eva Varga-Visi, Ildiko Jocsak, Vanda Kozma, Katalin Loki, Omeralfaroug Ali, Andras Szabo
Summary: The application of thymol on the surface of sliced paprika salami effectively inhibits lipid oxidation and color change during refrigerated storage.
Review
Food Science & Technology
Benjamin W. B. Holman, David L. Hopkins
Summary: Various factors contribute to inconsistencies in consumer thresholds for acceptance or satisfaction with meat products, including laboratory methods, consumer panel procedures and demographics, statistical analysis approaches, sample type and representativeness, among others.
Article
Food Science & Technology
Lu Huang, Shuqi Liu, Yong Wang, He Li, Jinnuo Cao, Xinqi Liu
Summary: This study investigated the effect of grilling and frying as well as the addition of konjac glucomannan (KGM) on the characteristics of cubic fat substitutes (CFS). The results showed that grilling increased yellowness, lightness, and cooking yield, while KGM modified the distribution and migration of internal water. The addition of KGM improved the texture and taste of CFS, and the TBARS value was lower in CFS than in pork backfat.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Food Science & Technology
Gayathree Nidarshika Jayarathna, Dinesh Darshaka Jayasena, Deshani Chirajeevi Mudannayake
Summary: This study found that replacing vegetable oil with garlic inulin can improve the quality traits of chicken sausages. Sausages with 2% garlic inulin had higher flavor and overall acceptability scores. Increasing levels of inulin led to increased ash, moisture, and protein contents, and decreased fat content. Over a 28-day frozen storage period, brightness, pH, and water holding capacity decreased, while redness and yellowness values increased in all samples.
FOOD SCIENCE OF ANIMAL RESOURCES
(2022)
Article
Microbiology
Yuning Xu, Yinglian Zhu
Summary: This study demonstrates that replacing nitrite with Lactobacillus fermentum in Chinese fermented sausages can reduce the risk of nitrite and improve quality and safety. The strain enhances taste, flavor, and overall acceptability while increasing nutrition value of the sausages.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Nestor Vazquez-Agra, Ana-Teresa Marques-Afonso, Anton Cruces-Sande, Estefania Mendez-Alvarez, Ramon Soto-Otero, Jose-Enrique Lopez-Paz, Antonio Pose-Reino, Alvaro Hermida-Ameijeiras
Summary: This observational study compared the levels of redox markers in hypertensive patients with morning and bedtime use of renin-angiotensin-aldosterone system (RAAS) blockers. The results showed that bedtime use of RAAS blockers was associated with a better reduction in blood pressure and improved redox profile. This suggests that chronotherapy applied to hypertension treatment may have implications on oxidative stress.
Review
Neurosciences
Brendan M. Gabriel, Juleen R. Zierath
Summary: Metabolic health is influenced by innate physiology and environmental factors, with circadian physiology playing a key role in regulating diurnal hormones and metabolites. Skeletal muscle experiences significant diurnal variations due to physical activity and external Zeitgebers. The intricate orchestration of circadian metabolism in skeletal muscle involves molecular pathways with diurnal variation, including the central role of the mitochondrion in regulating metabolites.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Letter
Endocrinology & Metabolism
Matthew C. Gage, Deirdre Harrington, Gemma V. Brierley, Rachel M. Freathy, Brendan M. Gabriel, Rachel Gibson, Alison D. McNeilly, Claire L. Meek, Lee D. Roberts
Editorial Material
Neurosciences
Milena Schonke, Brendan M. Gabrie
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Geriatrics & Gerontology
Veronica Cabanas-Sanchez, Irene Esteban-Cornejo, Solange Parra-Soto, Fanny Petermann-Rocha, Stuart R. Gray, Fernando Rodriguez-Artalejo, Frederick K. Ho, Jill P. Pell, David Martinez-Gomez, Carlos Celis-Morales
Summary: Handgrip strength is inversely associated with incident depression and anxiety. It could be used as a simple, non-invasive, and inexpensive measure to stratify patients and identify those at elevated risk of mental health problems. Future research should investigate if resistance training can prevent the occurrence of mental health conditions.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Medicine, General & Internal
Jirapitcha Boonpor, Frederick K. Ho, Stuart R. Gray, Carlos A. Celis-Morales
Summary: The study found that self-reported average and slow walking pace were associated with a higher risk of developing type 2 diabetes. This association was consistent across different physical activity levels and walking time.
MAYO CLINIC PROCEEDINGS
(2022)
Article
Biology
Nicolas J. Pillon, Laura Sardon Puig, Ali Altintas, Prasad G. Kamble, Salvador Casani-Galdon, Brendan M. Gabriel, Romain Barres, Ana Conesa, Alexander Chibalin, Erik Naslund, Anna Krook, Juleen R. Zierath
Summary: Obesity and elevated circulating lipids can disrupt the molecular circadian clock and impair metabolism. This study shows that lipid overload interacts with the circadian clock in skeletal muscle and alters the rhythmicity of gene expression through epigenomic mechanisms. Specific histone modifications are responsive to lipid overload and contribute to the reprogramming of circadian genes and pathways involved in lipid biosynthesis.
LIFE SCIENCE ALLIANCE
(2022)
Article
Rheumatology
Huey Yi Chong, Paul McNamee, Eva-Maria Bachmair, Kathryn Martin, Lorna Aucott, Neeraj Dhaun, Emma Dures, Richard Emsley, Stuart. R. Gray, Elizabeth Kidd, Vinod Kumar, Karina Lovell, Graeme MacLennan, John Norrie, Lorna Paul, Jonathan Packham, Stuart. H. Ralston, Stefan Siebert, Alison Wearden, Gary Macfarlane, Neil Basu
Summary: This study estimated the cost-effectiveness of combining cognitive behavioural approach (CBA) or personalized exercise programme (PEP) with usual care (UC) for patients with inflammatory rheumatic diseases and chronic, moderate to severe fatigue. The results showed that PEP was more expensive but significantly more effective than UC, while CBA was more expensive but not significantly more effective. Therefore, combining PEP with UC is likely to be a cost-effective use of healthcare resources.
Article
Sport Sciences
Maryam Soltanisarvestani, Nathan Lynskey, Stuart Gray, Jason M. R. Gill, Jill P. Pell, Naveed Sattar, Paul Welsh, Frederick K. Ho, Carlos Celis-Morales, Fanny Peterman-Rocha
Summary: This study investigated the associations between walking pace, grip strength, and mortality in stroke survivors. The results showed that low grip strength and slow walking pace were associated with a higher risk of stroke and all-cause mortality. Improving physical capability among stroke survivors may potentially prolong survival.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2023)
Article
Clinical Neurology
Oussama Saidi, Paul Peyrel, Giovanna del Sordo, Brendan Gabriel, Freddy Maso, Eric Dore, Pascale Duche
Summary: This study aimed to examine the effect of the timing of high-intensity exercise (afternoon vs. evening) on adolescent athletes' bedtime psychological state, sleep quality, sleep staging, and next-day wellness/sleepiness according to chronotype. The results showed that the timing of high-intensity exercise significantly affected sleep efficiency and sleep onset latency. Additionally, differences were observed in the psychological state, objective sleep, and next day's wellness based on the participants' chronotype.
Article
Clinical Neurology
Panagiotis Giannos, Konstantinos Prokopidis, Darren G. Candow, Scott C. Forbes, Kamil Celoch, Masoud Isanejad, Vanja Pekovic-Vaughan, Oliver C. Witard, Brendan M. Gabriel, David Scott
Summary: Habitual declines in sleep duration and increased rates of obesity are significant concerns worldwide. This cross-sectional study examines the relationship between sleep duration and body fat distribution in US adults. The study finds a negative association between sleep duration and visceral fat mass accumulation, with no additional benefits beyond 8 hours of sleep per day. Further research is needed to understand the mechanism and causality of the relationship.
Editorial Material
Endocrinology & Metabolism
Milena Schonke, Karyn A. Esser, Brendan M. Gabriel
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Jirapitcha Boonpor, Jill P. Pell, Frederick K. Ho, Carlos Celis-Morales, Stuart R. Gray
Summary: Sarcopenia is associated with an increased risk of cardiovascular disease in people with type 2 diabetes, leading to earlier onset of the disease. Screening and prevention of sarcopenia in patients with type 2 diabetes may be useful in preventing complications of cardiovascular disease.
DIABETES OBESITY & METABOLISM
(2023)
Review
Nutrition & Dietetics
Maha Timraz, Ahmad Binmahfoz, Terry J. Quinn, Emilie Combet, Stuart R. Gray
Summary: The aim of this study was to examine the effects of LCn-3 PUFA supplementation on muscle strength in older individuals. A systematic literature review was conducted, and five relevant studies were included. The results showed that LCn-3 PUFA supplementation did not significantly improve grip strength compared to the control group.
Article
Oncology
Lian E. M. Stadhouders, Jonathon A. B. Smith, Brendan M. Gabriel, Sander A. J. Verbrugge, Tim D. Hammersen, Detmar Kolijn, Ilse S. P. Vogel, Abdalla D. Mohamed, Gerard M. J. de Wit, Carla Offringa, Willem M. H. Hoogaars, Sebastian Gehlert, Henning Wackerhage, Richard T. Jaspers
Summary: The Warburg effect, commonly associated with cancer, was investigated in relation to muscle hypertrophy, showing that glycolysis and non-essential amino acid synthesis play important roles in the process. Inhibiting glycolysis or key enzymes in the serine biosynthesis pathway decreased myotube size, while promoting glycolytic flux increased myotube size, suggesting a reprogramming of metabolism to facilitate anabolism in hypertrophying muscle cells.
EXPERIMENTAL CELL RESEARCH
(2023)
Article
Rheumatology
Sarah E. Bennett, Celia Almeida, Eva-Maria Bachmair, Stuart R. Gray, Karina Lovell, Lorna Paul, Alison Wearden, Gary J. Macfarlane, Neil Basu, Emma Dures
Summary: This study aimed to understand the perspectives of rheumatology health professionals in delivering interventions in the LIFT trial. Therapists improved their clinical skills and satisfaction through training, collaboration with patients, and clinical supervision. Insights from this trial can enhance clinical practice and service provision.
RHEUMATOLOGY ADVANCES IN PRACTICE
(2022)