Review
Environmental Sciences
Sukhbir Singh, Ishrat Zahoor, Neelam Sharma, Tapan Behl, Neha Kanojia, Aayush Sehgal, Syam Mohan, Yosif Almoshari, Ahmad Salawi, Lotfi Aleya, Simona Bungau
Summary: Hyperlipidemia, characterized by high levels of lipids and lipoproteins in blood circulation, is the primary cause of heart disorders. Pharmacologic therapy and lifestyle adjustments can be used for both primary and secondary prophylaxis of heart disease. Statins, particularly HMG-CoA reductase inhibitors, are preferred for primary prevention. Recent advancements in nanoparticle drug carriers for statins in hyperlipidemia therapy are discussed in this review.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Review
Ophthalmology
Laura Posch-Pertl, Monja Michelitsch, Gernot Wagner, Brigitte Wildner, Guenther Silbernagel, Gudrun Pregartner, Andreas Wedrich
Summary: The study indicated that patients with glaucoma showed significantly higher total cholesterol levels and lower HDL levels compared to those without glaucoma. Although LDL levels were slightly higher in patients with glaucoma, the difference was not significant.
ACTA OPHTHALMOLOGICA
(2022)
Review
Biochemistry & Molecular Biology
Panagiotis Anagnostis, Matilda Florentin, Sarantis Livadas, Irene Lambrinoudaki, Dimitrios G. Goulis
Summary: Dyslipidemia, especially elevated total and low-density lipoprotein cholesterol concentrations, is associated with low bone mass and increased fracture risk, possibly due to increased oxidative stress and systemic inflammation caused by dyslipidemia leading to increased osteoclastic activity and reduced bone formation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Lina Zhang, Weihao Wang, Fuli Man, Qi Pan, Lixin Guo
Summary: Long-term statin adherence among T2DM patients after PCI in Beijing is still low, and improving statin adherence can reduce the rate of all-cause readmission, revascularization, and cerebrovascular disease.
CARDIOVASCULAR DRUGS AND THERAPY
(2023)
Review
Chemistry, Medicinal
Sai Kumar Gadidala, Ebin Johny, Christy Thomas, Mounika Nadella, Krishna Undela, Ramu Adela
Summary: A systematic review and meta-analysis found that garlic can significantly improve cardiovascular disease risk factors such as blood lipids, inflammation markers, and coronary artery calcification in CAD patients. Garlic was shown to reduce LDL levels, increase HDL levels, decrease inflammation, and reduce coronary artery calcification. Subgroup analysis indicated that garlic is particularly effective in reducing cardiovascular risk factors in high-risk patients. The study findings provide consistent evidence that garlic intake reduces CVD risk factors and can be considered a safe natural medicine to alleviate inflammation in CAD patients.
PHYTOTHERAPY RESEARCH
(2023)
Article
Medicine, General & Internal
Douglas Drak, Jordan Fulcher, Jens Kilian, James J. H. Chong, Rominder Grover, Andrew P. Sindone, Mark Adams, Jo-Dee Lattimore, Anthony C. Keech
Summary: This study examined the adherence of physicians to heart failure treatment guidelines in Australian hospitals. The results showed that there were discrepancies between the actual use of therapies and the recommended use, particularly for ACEI/ARB and aldosterone antagonists.
INTERNAL MEDICINE JOURNAL
(2023)
Review
Biochemistry & Molecular Biology
Juan Pedro-Botet, Elisenda Climent, David Benaiges
Summary: CVD in HeFH is driven by LDL cholesterol concentrations, but other classical risk factors also contribute to the high cardiovascular risk. Alterations in the phenotype and functionality of HDL particles in HeFH patients are also associated with the presence and severity of CVD.
Article
Cardiac & Cardiovascular Systems
Cyril Camaro, Goaris W. A. Aarts, Eddy M. M. Adang, Roger van Hout, Gijs Brok, Anouk Hoare, Laura Rodwell, Frank de Pooter, Walter de Wit, Gilbert E. Cramer, Roland R. J. van Kimmenade, Peter Damman, Eva Ouwendijk, Martijn Rutten, Erwin Zegers, Robert-Jan M. van Geuns, Marc E. R. Gomes, Niels van Royen, ARTICA Invest
Summary: The study assessed the safety and healthcare costs of a pre-hospital rule-out strategy using a point-of-care troponin measurement in low-risk suspected NSTE-ACS patients. The results showed that the pre-hospital strategy significantly reduced healthcare costs and the incidence of major adverse cardiac events (MACE) was low in both strategies.
EUROPEAN HEART JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
David G. Thomas, Ying Wei, Alan R. Tall
Summary: The study assessed the pleiotropic effects of lipid trait genetic variants and conducted multivariable Mendelian randomization (MR) analysis in coronary artery disease. Results indicated that 30% of lipid trait genetic variants have effects on metabolic syndrome traits, yet the associations of LDL-C, HDL-C, TGs, BMI, T2D, and SBP with CAD remained independent and robust to adjustment for directional pleiotropy. MR at loci linked to direct effects on HDL-C and TGs suggested specific causal effects of these factors on CAD.
JOURNAL OF LIPID RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Daniel E. Harris, Arron Lacey, Ashley Akbari, Fatemeh Torabi, Dave Smith, Geraint Jenkins, Daniel Obaid, Alex Chase, Mike Gravenor, Julian Halcox
Summary: The European Society of Cardiology/European Atherosclerosis Society 2019 guidelines recommend more aggressive lipid targets and the addition of adjuvant treatments to statins for high- and very high-risk patients. A study found that the majority of patients did not achieve these lipid targets, and there were relatively low rates of prescribing intensive lipid-lowering therapy.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Junhong Xu, Qiongrui Zhao, Juan Li, Youhua Yuan, Xingguo Cao, Xueyan Zhang, Jia Fang, Wenjuan Yan, Baoya Wang, Yi Li, Yingjie Chu
Summary: A model was developed and validated to predict the occurrence of coronary artery disease (CAD) in patients with diabetes, incorporating predictors such as sex, diabetes duration, lipoprotein levels, creatinine, hypertension, and heart rate.
JOURNAL OF CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Akash H. Adhia, Joseph M. Feinglass, Cary Jo R. Schlick, Ryan P. Merkow, Karl Y. Bilimoria, David D. Odell
Summary: This study aimed to evaluate the quality of management of stage III esophageal cancer nationally and found variations in adherence rates in different aspects. Academic and high-volume institutions showed higher adherence rates in some aspects of quality, but had lower adherence rates in nodal staging.
ANNALS OF THORACIC SURGERY
(2022)
Article
Multidisciplinary Sciences
Anna Borowiec, Patrycja Ozdowska, Magdalena Rosinska, Agnieszka Jagiello-Gruszfeld, Slawomir Jasek, Joanna Waniewska, Beata Kotowicz, Hanna Kosela-Paterczyk, Elzbieta Lampka, Agata Makowka, Malgorzata Fuksiewicz, Magdalena Chojnacka, Agnieszka Zebrowska, Katarzyna Gepner, Aleksandra Kapala, Andrzej Cieszanowski, Zbigniew Nowecki, Jan Walewski
Summary: This study aims to assess the prognostic value of coronary atherosclerosis burden and CAC score on the onset of cardiac dysfunction associated with cancer therapy. It will include 80 cancer patients who will undergo coronary computed tomographic angiography before high-dose chemotherapy and be followed up for 12 months. The occurrence of cancer therapy-related cardiovascular toxicity will be evaluated, and new biomarkers of atherosclerosis will be measured.
Article
Pharmacology & Pharmacy
Nick S. R. Lan, Archna Bajaj, Gerald F. Watts, Marina Cuchel
Summary: Familial hypercholesterolaemia (FH) is a common genetic disorder characterized by elevated LDL-C levels and increased risk of ASCVD. Many patients with FH do not achieve LDL-C goals despite treatment with statins and ezetimibe. New therapies targeting PCSK9 and ANGPTL3 have shown promising results in closing the treatment gap. This review discusses current and emerging treatment strategies for FH and emphasizes the importance of risk-stratification and implementation strategies for patient care.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Clinical Neurology
Joni J. Sairanen, Anne-Mari Kantanen, Harri T. Hyppola, Reetta K. Kalviainen
Summary: Prompt and effective pharmacotherapy is crucial for the treatment of status epilepticus. Subtherapeutic doses of first-line benzodiazepines should be avoided, and benzodiazepine-resistant SE must be recognized early for rapid treatment escalation. The quality of second-line treatment is hindered by excessive delays and inadequate dosing of antiseizure medications.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Kay F. Weipert, Timm Bauer, Holger M. Nef, Helge Moellmann, Matthias Hochadel, Jean Marco, Franz Weidinger, Uwe Zeymer, Anselm K. Gitt, Christian W. Hamm
Article
Cardiac & Cardiovascular Systems
Alberico L. Catapano, Dominik Lautsch, Lale Tokgozoglu, Jean Ferrieres, Martin Horack, Michel Farnier, Peter P. Toth, Philippe Brudi, Joanne E. Tomassini, Baishali Ambegaonkar, Anselm K. Gitt
Article
Cardiac & Cardiovascular Systems
Tobias Heer, Matthias Hochadel, Karin Schmidt, Julinda Mehilli, Ralf Zahn, Karl-Heinz Kuck, Christian Hamm, Michael Boehm, Georg Ertl, Hans Martin Hoffmeister, Stefan Sack, Jochen Senges, Steffen Massberg, Anselm K. Gitt, Uwe Zeymer
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2017)
Article
Endocrinology & Metabolism
Jean Ferrieres, Dominik Lautsch, Anselm K. Gitt, Gaetano De Ferrari, Hermann Toplak, Moses Elisaf, Heinz Drexel, Martin Horack, Carl Baxter, Baishali Ambegaonkar, Philippe Brudi, Peter P. Toth
DIABETES OBESITY & METABOLISM
(2018)
Article
Cardiac & Cardiovascular Systems
Anselm K. Gitt, Peter Baumgart, Peter Bramlage, Felix Mahfoud, Sebastian A. Potthoff, Jochen Senges, Steffen Schneider, Hartmut Buhck, Roland E. Schmieder
BMC CARDIOVASCULAR DISORDERS
(2013)
Article
Cardiac & Cardiovascular Systems
A. K. Gitt, P. Bramlage, C. Binz, M. Krekler, E. Deeg, D. Tschoepe
Meeting Abstract
Cardiac & Cardiovascular Systems
Anselm K. Gitt, Timm Bauer, Uwe Zeymer, Ralf Zahn, Christian Hamm
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2012)
Meeting Abstract
Cardiac & Cardiovascular Systems
Anselm K. Gitt, Uwe Zeymer, Andrea Papp, Ralf Zahn, Jochen Senges
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2012)
Meeting Abstract
Cardiac & Cardiovascular Systems
Anselm K. Gitt, Uwe Zeymer, Andrea Papp, Ralf Zahn, Jochen Senges
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2012)
Meeting Abstract
Cardiac & Cardiovascular Systems
Anselm K. Gitt, Uwe Zeymer, Jochen Senges, Ralf Zahn
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2012)
Article
Cardiac & Cardiovascular Systems
Jean Ferrieres, Dominik Lautsch, Peter Bramlage, Martin Horack, Carl A. Baxter, Baishali Ambegaonkar, Peter P. Toth, Kian-Keong Poh, Gaetano Maria De Ferrari, Anselm K. Gitt
ARCHIVES OF CARDIOVASCULAR DISEASES
(2020)
Article
Medicine, General & Internal
Anselm K. Gitt, Ulrich Laufs, Winfried Marz, W. Dieter Paar, Peter Bramlage, Nikolaus Marx, Klaus G. Parhofer
Summary: This study provides insights into the clinical characteristics and current treatment status of patients with FH in Germany. Many patients with FH fail to achieve recommended lipid levels.
JOURNAL OF CLINICAL MEDICINE
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
A. K. Gitt, D. Lautsch, M. Horack, P. H. Brudi, K. K. Poh, G. De Ferrari, J. Ferrieres
EUROPEAN HEART JOURNAL
(2017)
Meeting Abstract
Cardiac & Cardiovascular Systems
A. K. Gitt, D. Lautsch, M. Horack, P. H. Brudi, K. K. Poh, G. De Ferrari, J. Ferrieres
EUROPEAN HEART JOURNAL
(2017)
Meeting Abstract
Cardiac & Cardiovascular Systems
A. K. Gitt, D. Lautsch, M. Horack, P. H. Brudi, K. K. Poh, G. De Ferrari, J. Ferrieres
EUROPEAN HEART JOURNAL
(2017)