Article
Multidisciplinary Sciences
Masao Yamaguchi, Masahiro Hoshino, Tomoyo Sugiyama, Yoshihisa Kanaji, Kai Nogami, Tatsuhiro Nagamine, Toru Misawa, Masahiro Hada, Makoto Araki, Rikuta Hamaya, Eisuke Usui, Tadashi Murai, Tetsumin Lee, Taishi Yonetsu, Tetsuo Sasano, Tsunekazu Kakuta
Summary: This study aimed to investigate the predictive ability of preprocedural transthoracic Doppler echocardiography (TDE) for increased coronary flow. The study found that pre-PCI FFR and hDPV were independent predictors of a significant coronary flow increase.
SCIENTIFIC REPORTS
(2022)
Article
Peripheral Vascular Disease
Marina Gaeta, Armin Nowroozpoor, James Dziura, Gail D'Onofrio, Albert J. Sinusas, Basmah Safdar
Summary: The study assessed the utility of EndoPAT in identifying low coronary flow reserve (CFR), but found that peripheral RHI was insufficient as a screening tool for low CFR as measured by cardiac PET/CT. Differences in vascular pathology assessed by each method may explain the lack of correlation between peripheral RHI and CFR.
MICROVASCULAR RESEARCH
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Shi-hai Zhao, Wei-feng Guo, Zhi-feng Yao, Shan Yang, Hong Yun, Yin-yin Chen, Tong-tong Han, Xiao-yue Zhou, Cai-xia Fu, Meng-su Zeng, Chen-guang Li, Cui-zhen Pan, Hang Jin
Summary: In this study, a fully automated pixel-wise post-processing framework was used to evaluate quantitative cardiovascular magnetic resonance myocardial perfusion imaging (CMR-MPI). The study aimed to assess the additional value of coronary magnetic resonance angiography (CMRA) in the diagnostic performance of fully automated pixel-wise quantitative CMR-MPI for detecting hemodynamically significant coronary artery disease (CAD). The results showed that the fully automated pixel-wise quantitative CMR-MPI can accurately detect hemodynamically significant CAD, but the integration of CMRA did not provide significantly additive value.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Weifeng Guo, Yuru Lin, Akira Taniguchi, Yaxin Zhu, Pratik Tripathi, Shan Yang, Junzhen Liu, Hong Yun, Hang Jin, Jie Zhang, Jing Yang, Mengsu Zeng
Summary: The study compared the diagnostic power of on-site CT-FFR combined with CCTA versus using CCTA alone in detecting patients with flow-limiting CAD. The results showed that CT-FFR provided significant incremental diagnostic improvement over CCTA in identifying patients with flow-limiting CAD.
EUROPEAN RADIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
K. Lance Gould, Nils P. Johnson, Amanda E. Roby, Linh Bui, Danai Kitkungvan, Monica B. Patel, Tung Nguyen, Richard Kirkeeide, Mary Haynie, Salman A. Arain, Konstantinos Charitakis, Abhijeet Dhoble, Richard Smalling, Angelo Nascimbene, Marwan Jumean, Sachin Kumar, Biswajit Kar, Stefano Sdringola, Anthony Estrera, Igor Gregoric, Dejian Lai, Ruosha Li, David Mcpherson, Jagat Narula
Summary: Coronary flow capacity (CFC) is associated with long-term survival probability in coronary artery disease (CAD) patients. Patients with severely reduced CFC have lower survival probability, but this can be improved by revascularization procedures. Repeat revascularization can further improve survival probability in post-revascularization patients with severely reduced CFC.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Lijuan Lyu, Jichen Pan, Dumin Li, Xinhao Li, Wei Yang, Mei Dong, Chenghu Guo, Peixin Lin, Yeming Han, Yongfeng Liang, Junyan Sun, Dexin Yu, Pengfei Zhang, Mei Zhang
Summary: This study investigated the distribution and normal range of hyperemic MBF in healthy subjects using dynamic CT-MPI, and validated its accuracy in identifying functional myocardial ischemia, providing insights for understanding myocardial ischemia in CAD patients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medicine, General & Internal
Xuelian Gao, Rui Wang, Zhonghua Sun, Hongkai Zhang, Kairui Bo, Xiaofei Xue, Junjie Yang, Lei Xu
Summary: This study found that the CTP-FFR model has promising value in improving the diagnostic accuracy of CCTA in detecting coronary ischemia. The feasibility of using CTP-FFR to detect coronary artery ischemia in patients with suspected CAD was proven.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Jeremy A. Slivnick, Karolina M. Zareba, Vien T. Truong, Ellen Liu, Alexis Barnes, Wojciech Mazur, Philip Binkley
Summary: This study assessed the prevalence of microvascular dysfunction (MVD) in patients with non-ischemic cardiomyopathy (NICM) compared to subjects with preserved ejection fraction (EF) using stress cardiovascular magnetic resonance (CMR). The results showed that MVD is highly prevalent in NICM patients as compared to subjects with preserved EF, even after controlling for covariates. Semiquantitative methods are able to detect a greater number of instances of MVD compared to visual methods alone.
Article
Radiology, Nuclear Medicine & Medical Imaging
Yan Yi, Cheng Xu, Wei Wu, Zhu-Jun Shen, Whal Lee, Chun-Ho Yun, Bin Lu, Jia-Yin Zhang, Zheng-Yu Jin, Yi-Ning Wang
Summary: The study aimed to investigate the diagnostic performance of 70-kVp stress dynamic myocardial CT perfusion as a low-dose, one-stop cardiac CT examination in clinical application. The results showed that CTP-derived SP-CTA significantly improved the diagnostic accuracy compared to CTP and SP-CTA alone, with high sensitivity and specificity for identifying ischemia.
EUROPEAN RADIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Diana M. Lopez, Sanjay Divakaran, Ankur Gupta, Navkaranbir S. Bajaj, Michael T. Osborne, Wunan Zhou, Jon Hainer, Courtney F. Bibbo, Hicham Skali, Sharmila Dorbala, Viviany R. Taqueti, Ron Blankstein, Marcelo F. Di Carli
Summary: This study aimed to evaluate the sensitivity and specificity of exercise treadmill testing (ETT) in the diagnosis of coronary microvascular disease (CMD) and the prognostic implications of ETT results in CMD patients. The study found that ETT has limited sensitivity in detecting CMD, but a positive ETT with ischemic changes lasting at least 1 minute into recovery and the absence of obstructive coronary artery disease may indicate the presence of CMD.
JACC-CARDIOVASCULAR IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mihaly Karolyi, Alexander Gotschy, Malgorzata Polacin, Sven Plein, Ingo Paetsch, Cosima Jahnke, Michael Frick, Rolf Gebker, Hatem Alkadhi, Sebastian Kozerke, Robert Manka
Summary: This study aimed to test the accuracy of 3D cardiac magnetic resonance stress perfusion in the elderly population compared to reference standard fractional flow reserve (FFR). The results showed that 3D CMR perfusion has excellent diagnostic accuracy for the detection of hemodynamically relevant coronary stenosis, independent of patient age.
EUROPEAN RADIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Itta Kawamura, Toru Tanigaki, Hiroyuki Omori, Takuya Mizukami, Tetsuo Hirata, Jun Kikuchi, Hideaki Ota, Yoshihiro Sobue, Taiji Miyake, Yoshiaki Kawase, Munenori Okubo, Hiroki Kamiya, Masanori Kawasaki, Kunihiko Tsuchiya, Masayasu Nakagawa, Takeshi Kondo, Takahiko Suzuki, Hitoshi Matsuo
Summary: The study found a good correlation between MPI and FFR in detecting myocardial ischemia, but the positive predictive value of FFR in identifying MPI-positive lesions was not high. Some lesions with normal MPI results may also have low FFR values.
CIRCULATION JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Signe Hojstrup, Kim W. Hansen, Ulrik Talleruphuus, Lisbeth Marner, Soren Galatius, Maira Rauf, Louise H. Bjerking, Lars Jakobsen, Evald H. Christiansen, Kirsten Bouchelouche, Hanne Christensen, Eva I. B. Prescott
Summary: This study is the first large-scale cohort study to establish a link between coronary microvascular disease (CMD) and small vessel disease in the kidney and brain. The data support the hypothesis that CMD is part of a systemic vascular disorder.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Mathematical & Computational Biology
Jucheng Zhang, Minwen Ma, Huajun Li, Zhaoxia Pu, Haipeng Liu, Tianhai Huang, Huan Cheng, Yinglan Gong, Yonghua Chu, Zhikang Wang, Jun Jiang, Ling Xia
Summary: This study investigates the diagnostic performance of myocardial contrast echocardiography (MCE) for coronary microvascular dysfunction (CMD). It finds that MCE has high sensitivity and specificity in diagnosing CMD, showing strong agreement with thermodilution. However, the correlation coefficient is not high.
MATHEMATICAL BIOSCIENCES AND ENGINEERING
(2023)
Article
Cardiac & Cardiovascular Systems
Seokhun Yang, Masahiro Hoshino, Taishi Yonetsu, Jinlong Zhang, Doyeon Hwang, Eun-Seok Shin, Joon-Hyung Doh, Chang-Wook Nam, Jianan Wang, Shaoliang Chen, Nobuhiro Tanaka, Hitoshi Matsuo, Takashi Kubo, Hyuk-Jae Chang, Tsunekazu Kakuta, Bon -Kwon Koo
Summary: The integrative implications of quantitative and qualitative plaque characteristics on clinical outcomes and therapeutic guidance have been investigated in this study. It has been found that these measures are closely associated with treatment and prognosis of the lesions. Therefore, they should be included in risk assessment and optimization of treatment strategies.
Article
Critical Care Medicine
Anna Gard, Ali Al-Husseini, Evgenios N. Kornaropoulos, Alessandro De Maio, Yelverton Tegner, Isabella Bjoerkman-Burtscher, Karin Markenroth Bloch, Markus Nilsson, Mans Magnusson, Niklas Marklund
Summary: Symptoms of vestibular dysfunction are common after sports-related concussions and can be caused by impairment of the peripheral or central neural parts of the vestibular system. This study found that athletes with persisting symptoms after SRC had vestibular dysfunction, which was associated with injury to the inferior vestibular nerve.
JOURNAL OF NEUROTRAUMA
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Johannes Toger, Mads Andersen, Olle Haglund, Tekla Maria Kylkilahti, Iben Lundgaard, Karin Markenroth Bloch
Summary: In this study, a real-time flow MRI method was developed to quantify respiratory-related variations of cerebrospinal fluid (CSF) flow in the cerebral aqueduct. The method showed good repeatability and a relationship between flow and respiration in both phantom and in vivo experiments.
MAGNETIC RESONANCE IN MEDICINE
(2022)
Article
Multidisciplinary Sciences
Per M. Arvidsson, Anders Nelsson, Martin Magnusson, J. Gustav Smith, Marcus Carlsson, Hakan Arheden
Summary: Hemodynamic force analysis was investigated as a tool for distinguishing between healthy subjects and heart failure patients with different degrees of systolic dysfunction. Results showed that volume-normalized hemodynamic forces were positively correlated with ejection fraction (EF) and were significantly lower in heart failure with reduced ejection fraction compared to controls. There was no significant difference between controls and heart failure patients with preserved ejection fraction (HFpEF). Non-normalized forces did not show any differences between controls and HFpEF patients and did not correlate with EF. Left ventricular hemodynamic force analysis, regardless of volume normalization, is not ready for clinical trials to assess HFpEF.
SCIENTIFIC REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
Jonathan Berg, Julius Akesson, Robert Jablonowski, Kristian Solem, Einar Heiberg, Rasmus Borgquist, Hakan Arheden, Marcus Carlsson
Summary: This study found that low ventricular longitudinal function is associated with an increase in the number of cardiovascular events as well as longer in-hospital stays. Additionally, both AVPD and GLS have independent prognostic value for cardiovascular mortality and morbidity in HFrEF patients.
Article
Physiology
Per M. Arvidsson, Anders Nelsson, Jonathan Edlund, J. Gustav Smith, Martin Magnusson, Ning Jin, Einar Heiberg, Marcus Carlsson, Katarina Steding-Ehrenborg, Hakan Arheden
Summary: This study presents the first investigation of left ventricular kinetic energy in individuals with subclinical diastolic dysfunction and in heart failure patients with preserved or impaired systolic function. Kinetic energy differs between groups during diastole, indicating altered filling and emptying processes. Kinetic energy analysis should be considered in studies seeking to comprehensively characterize myocardial energetics.
JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Article
Biophysics
Anina Seidemo, Ronnie Wirestam, Gunther Helms, Karin Markenrot Bloch, Xiang Xu, Johan Bengzon, Pia C. Sundgren, Peter C. M. van Zijl, Linda Knutsson
Summary: This study aims to develop a DGE analysis method based on tissue response curve shapes and investigate whether DGE MRI provides similar or complementary information to DCE MRI. Eleven patients with suspected gliomas were studied and the results showed that DGE AUC values were significantly higher in lesions than in normal tissue, and the distribution of curve types differed between lesions and normal tissue for both DGE and DCE.
NMR IN BIOMEDICINE
(2023)
Article
Medicine, General & Internal
Elin Tragardh, Olof Enqvist, Johannes Ulen, Jonas Jogi, Ulrika Bitzen, Fredrik Hedeer, Kristian Valind, Sabine Garpered, Erland Hvittfeldt, Pablo Borrelli, Lars Edenbrandt
Summary: The aim of this study was to develop an artificial intelligence (AI)-based method for the detection and quantification of prostate tumours, local recurrence, lymph node metastases, and bone metastases. The AI method was compared to manual segmentations performed by nuclear medicine physicians. The results showed that the AI method had a sensitivity comparable to that of the physicians.
Article
Cardiac & Cardiovascular Systems
Jonathan Berg, Robert Jablonowski, David Nordlund, Daniel Ryd, Einar Heiberg, Marcus Carlsson, Hakan Arheden
Summary: In this study, we used non-invasive pressure-volume (PV) loops to analyze cardiac performance and found that mild hypothermia reduces infarct size and preserves cardiac function in a pig model of ischemia/reperfusion injury.
CARDIOVASCULAR RESEARCH
(2023)
Article
Physiology
Kristian Valind, Jonas Jogi, David Minarik, Elin Tragardh
Summary: This study aimed to investigate the relationship between renal uptake of [F-18]PSMA-1007 and estimated glomerular filtration rate (eGFR). PET image analysis revealed a significant correlation between standardized uptake value (SUVmean) and segmentation volume of the kidneys with eGFR, indicating that [F-18]PSMA-1007 uptake parameters can serve as indicators of renal cortical function.
CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Alexander F. Santillo, Antoine Leuzy, Michael Honer, Maria Landqvist Waldo, Pontus Tideman, Luke Harper, Tomas Ohlsson, Svenja Moes, Lucia Giannini, Jonas Jogi, Colin Groot, Rik Ossenkoppele, Olof Strandberg, John van Swieten, Ruben Smith, Oskar Hansson
Summary: The uptake of [F-18]RO948 is not significantly increased in the majority of FTD patients, with the exception of specific MAPT mutations. The observed tracer retention does not overlap with the cortical atrophy, expected pattern of atrophy, or verified protein pathology distribution.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Biochemistry & Molecular Biology
Rik Ossenkoppele, Alexa Pichet Binette, Colin Groot, Ruben Smith, Olof Strandberg, Sebastian Palmqvist, Erik Stomrud, Pontus Tideman, Tomas Ohlsson, Jonas Jogi, Keith Johnson, Reisa Sperling, Vincent Dore, Colin L. Masters, Christopher Rowe, Denise Visser, Bart N. M. van Berckel, Wiesje M. van der Flier, Suzanne Baker, William J. Jagust, Heather J. Wiste, Ronald C. Petersen, Clifford R. Jack, Oskar Hansson
Summary: Abnormal amyloid and tau PET in cognitively unimpaired individuals is strongly associated with short-term cognitive decline and subsequent development of dementia.
Article
Clinical Neurology
Birgitta Ramgren, Johan Wasselius, Boel Hansson, Karin Markenroth Bloch
Summary: Perforator aneurysms of the basilar artery (PABA) can be diagnosed and monitored using 7T MRI, a novel non-invasive method. Two patients with SAH were imaged with CBCTA and 7T MRA, and 7T MRI provided fully diagnostic images without any remaining aneurysms at 3-month follow-up. In conclusion, 7T MRI is an important non-invasive tool for diagnosing and monitoring PABA.
INTERVENTIONAL NEURORADIOLOGY
(2023)
Article
Clinical Neurology
Ruben Smith, Douglas Hagerstrom, Daria Pawlik, Gregory Klein, Jonas Jogi, Tomas Ohlsson, Erik Stomrud, Oskar Hansson
Summary: This study aimed to determine the clinical value of tau positron emission tomography (PET) in the diagnosis of Alzheimer's disease (AD). The results showed that the addition of tau PET to the diagnostic workup led to changes in diagnosis and medication, and significantly increased the certainty of underlying etiology.
Article
Cardiac & Cardiovascular Systems
Martin Johansson, Edem Binka, Benjamin Barnes, Lasya Gaur, Erik Hedstrom, Shelby Kutty, Marcus Carlsson
Summary: This study aimed to investigate the relationship between right ventricular longitudinal function assessed by cardiovascular magnetic resonance (CMR) and left ventricular filling pressure in patients with repaired Tetralogy of Fallot (rToF). The study found that there is an association between right ventricular longitudinal pumping and left ventricular filling pressure in rToF-patients, which may explain the underfilling of the left ventricle in patients with pulmonary regurgitation and rToF, and may be useful in determining right ventricular dysfunction. However, the direction of septal movement cannot be used to assess right ventricular systolic pressure in these patients.
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Kristian Valind, David Minarik, Sabine Garpered, Eva Persson, Jonas Jogi, Elin Tragardh
Summary: This study aimed to compare [F-18]PSMA-1007 PET with [(99)mTc]Tc-DMSA SPECT in patients with prostate cancer regarding split renal uptake and renal uptake defects. The results showed that [F-18]PSMA-1007 PET is comparable to [(99)mTc]Tc-DMSA SPECT in detecting uptake defects and the measurements of split renal function are strongly correlated between the two imaging modalities.
EUROPEAN JOURNAL OF HYBRID IMAGING
(2023)
