Journal
CLINICAL PHARMACOLOGY & THERAPEUTICS
Volume 96, Issue 1, Pages 64-73Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/clpt.2014.76
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Cardiovascular disease (CVD) is the leading cause of mortality worldwide, and its prevalence is increasing worldwide. Statins are the mainstay of treatment but do not address all aspects of CVD risk. Other lipid-lowering therapies are available but are less effective than statins. New therapies to lower low-density-lipoprotein cholesterol (LDL-C) by as much as statins, to reduce triglycerides (TGs), and to modify the metabolism of high-density lipoproteins (HDLs) are in development.
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