Geranylgeranyl Diphosphate Synthase: An Emerging Therapeutic Target

The Intermediate Enzymes of Isoprenoid Metabolism as Anticancer Targets

(2012) Andrew Wiemer et al.   Anti-Cancer Agents in Medicinal Chemistry

Lipophilic Bisphosphonates Are Potent Inhibitors of Plasmodium Liver-Stage Growth

(2010) A. P. Singh et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Synthesis, Chiral High Performance Liquid Chromatographic Resolution and Enantiospecific Activity of a Potent New Geranylgeranyl Transferase Inhibitor, 2-Hydroxy-3-imidazo[1,2-a]pyridin-3-yl-2-phosphonopropionic Acid

(2010) Charles E. McKenna et al.   JOURNAL OF MEDICINAL CHEMISTRY

Effect of the Secretory Small GTPase Rab27B on Breast Cancer Growth, Invasion, and Metastasis

(2010) An Hendrix et al.   JNCI-Journal of the National Cancer Institute

Lovastatin inhibits EGFR dimerization and AKT activation in squamous cell carcinoma cells: potential regulation by targeting rho proteins

(2010) T T Zhao et al.   ONCOGENE

Pivaloyloxymethyl-modified isoprenoid bisphosphonates display enhanced inhibition of cellular geranylgeranylation

(2008) Andrew J. Wiemer et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Alendronate decreases orthotopic PC-3 prostate tumor growth and metastasis to prostate-draining lymph nodes in nude mice

(2008) Johanna M Tuomela et al.   BMC CANCER

Phase I pharmacokinetic and pharmacodynamic study of the prenyl transferase inhibitor AZD3409 in patients with advanced cancer

(2008) N M G M Appels et al.   BRITISH JOURNAL OF CANCER

Targeting a Uniquely Nonspecific Prenyl Synthase with Bisphosphonates to Combat Cryptosporidiosis

(2008) Jennifer D. Artz et al.   CHEMISTRY & BIOLOGY

Aminobisphosphonate-activated γδ T cells in immunotherapy of cancer: doubts no more

(2008) Nadia Caccamo et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Dual-Agent Molecular Targeting of the ErbB2 Receptor: Killing One Bird With Two Stones

(2008) Hal W. Hirte et al.   JOURNAL OF CLINICAL ONCOLOGY

Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging

(2008) Ignacio Varela et al.   NATURE MEDICINE

Mono- and dialkyl isoprenoid bisphosphonates as geranylgeranyl diphosphate synthase inhibitors

(2007) Andrew J. Wiemer et al.   BIOORGANIC & MEDICINAL CHEMISTRY