Review
Chemistry, Medicinal
Hanne Belien, Lize Evens, Marc Hendrikx, Virginie Bito, Annelies Bronckaers
Summary: Myocardial infarction, the leading cause of heart failure worldwide, has sparked interest in stem cell therapy for cardiac repair. While some successful results have been achieved in animal models, the overall outcome of clinical trials has been disappointing, mainly due to limited stem cell survival and retention. Combinational use of stem cells and various priming strategies may hold promise for improving regenerative cell therapy efficacy.
MEDICINAL RESEARCH REVIEWS
(2022)
Editorial Material
Multidisciplinary Sciences
David J. J. Glass
Summary: Senescent cells in skeletal muscle promote inflammation and hinder regeneration, potentially causing harmful changes in aged muscle.
Review
Biochemistry & Molecular Biology
Maria Csobonyeiova, Nikoleta Beerova, Martin Klein, Michaela Debreova-Cehakova, L'ubos Danisovic
Summary: Heart failure is a major cause of morbidity and mortality in modern society due to cardiomyocyte death or dysfunction caused by myocardial infarction. Current therapies for heart failure or myocardial infarction are limited and non-curative. Therefore, research has focused on developing cell-based approaches, such as multipotent stem cells and induced pluripotent stem cells, for myocardial regeneration. Other potential sources for cardiac regeneration include telocytes and cell-free approaches, such as gene therapy and exosomes released from stem cells. This review provides insights into the novel strategies for myocardial repair based on different cell types and cell-free approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Emilia Manole, Cristina Niculite, Ioana Maria Lambrescu, Gisela Gaina, Octavian Ioghen, Laura Cristina Ceafalan, Mihail Eugen Hinescu
Summary: Macrophages play a crucial role in maintaining tissue homeostasis and repair, displaying heterogeneity in response to environmental cues. Their diverse functions as M1 and M2 phenotypes contribute to tissue damage and wound healing, emphasizing the importance of understanding their intervention in stem cell behavior and niche regulation for developing novel therapeutic strategies in different diseases.
Article
Biology
Gustavo Gavazzoni Blume, Paulo Andre Bispo Machado-Junior, Rossana Baggio Simeoni, Giovana Paludo Bertinato, Murilo Sgarbossa Tonial, Seigo Nagashima, Ricardo Aurino Pinho, Lucia de Noronha, Marcia Olandoski, Katherine Athayde Teixeira de Carvalho, Julio Cesar Francisco, Luiz Cesar Guarita-Souza
Summary: The study suggests that cell-based therapies using bone marrow stem cells and human amniotic membrane can effectively improve ventricular function and volume in heart failure rat models after myocardial infarction, increasing angiogenesis and cardiomyocyte expression.
Article
Biochemistry & Molecular Biology
Woo-Sup Sim, Bong-Woo Park, Kiwon Ban, Hun-Jun Park
Summary: The study explored a novel therapeutic platform called in situ preconditioning to enhance the therapeutic potential of BM-MSCs in a rat myocardial infarction model. Results showed that this approach significantly improved the survival and retention of BM-MSCs in the heart, leading to enhanced cardiac function and repair in myocardial infarction hearts. This suggests that in situ preconditioning could be an effective strategy for cardiac regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Emergency Medicine
Xin Yuan, Li Li, Haofan Liu, Jing Luo, Yongchao Zhao, Cheng Pan, Xue Zhang, Yuwen Chen, Maling Gou
Summary: This article reviews emerging strategies to improve the therapeutic efficacy of adipose-derived stem cells (ADSCs) in tissue regeneration. These strategies include advanced cell expansion technologies, enhancing regenerative functions of ADSCs, and improving cell delivery efficiency. Critical issues about the sources, effectiveness, and safety of ADSCs are also pointed out.
Review
Biochemistry & Molecular Biology
Lulu Liu, Lu Qiu, Yaqian Zhu, Lei Luo, Xinpei Han, Mingwu Man, Fuguang Li, Maozhi Ren, Yadi Xing
Summary: Regeneration is the process of repairing and replacing lost tissues and organs in organisms. Stem cells play a crucial role in animal and plant regeneration, with developmental processes involving totipotent, pluripotent, and unipotent stem cells. Stem cells and their products have diverse applications in agriculture, animal husbandry, environmental protection, and regenerative medicine. This review explores the similarities and differences in animal and plant tissue regeneration, as well as the regulation of regeneration through signaling pathways and key genes, aiming to provide insights for practical applications in agriculture and human organ regeneration, and to expand the future application of regeneration technology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Biomedical
Zain Siddiqui, Amanda M. Acevedo-Jake, Alexandra Griffith, Nurten Kadincesme, Kinga Dabek, Dana Hindi, Ka Kyung Kim, Yoshifumi Kobayashi, Emi Shimizu, Vivek Kumar
Summary: Pulp capping and dental pulp regeneration are evolving techniques to regenerate pulp tissue and maintain tooth vitality, with various methods and materials being used in regenerative endodontics.
BIOACTIVE MATERIALS
(2022)
Review
Cell Biology
Vineeta Sharma, Sanat Kumar Dash, Kavitha Govarthanan, Rekha Gahtori, Nidhi Negi, Mahmood Barani, Richa Tomar, Sudip Chakraborty, Santosh Mathapati, Dillip Kumar Bishi, Poonam Negi, Kamal Dua, Sachin Kumar Singh, Rohit Gundamaraju, Abhijit Dey, Janne Ruokolainen, Vijay Kumar Thakur, Kavindra Kumar Kesari, Niraj Kumar Jha, Piyush Kumar Gupta, Shreesh Ojha
Summary: Myocardium Infarction (MI) is a leading cause of death worldwide, with pharmacological interventions not being the forefront in improving outcomes. Stem cell-based tissue engineering approaches have shown promise in regenerating the infarcted myocardium. Research using microfluidic devices has provided insights into the pathophysiology of MI, aiding in the differentiation of stem cells and engineering of scaffolds mimicking native cardiac conditions. Delivery of stem cell-loaded engineered scaffolds to the infarction site remains a challenge for future clinical translation.
Article
Cell & Tissue Engineering
Pauline Cheng, Ahmad Rashad, Ankit Gangrade, Natan Roberto de Barros, Ali Khademhosseini, Jonathan Tam, Padmini Varadarajan, Devendra K. Agrawal, Finosh G. Thankam
Summary: Myocardial infarction leads to the loss of cardiomyocytes, but stem cell therapy shows promise in restoring cardiac function. This article discusses the application of different stem cell phenotypes and strategies to promote their differentiation into cardiomyocytes.
TISSUE ENGINEERING PART B-REVIEWS
(2023)
Review
Chemistry, Multidisciplinary
Anna Andrzejewska, Sylwia Dabrowska, Barbara Lukomska, Miroslaw Janowski
Summary: Neurological disorders pose a growing burden as society ages, with stem cell-based regenerative medicine offering a promising approach. Researchers are studying the application of MSCs to various neurological diseases and focusing on the delivery of stem cells to the brain as an essential and understudied challenge.
Article
Gastroenterology & Hepatology
Cambrian Y. Liu, Nandini Girish, Marie L. Gomez, Philip E. Dube, M. Kay Washington, Benjamin D. Simons, D. Brent Polk
Summary: In this study, it was found that a large squamous epithelium called squamous neo-epithelium of the colon (SNEC) exists near the anus during colitis. Squamous cells from the anus can migrate into the ulcerated colon and establish a permanent epithelium with crypt-like morphology. These squamous cells originate from a small transition zone outside the border of colonic and anal epithelium. Further research on these cells may provide new approaches for directing mucosal healing in inflammation and disease.
Review
Biotechnology & Applied Microbiology
Naoki Nakayama, Sudheer Ravuri, Johnny Huard
Summary: Adult articular cartilage lacks self-repair capacity due to deficiency of reparative cells, while fetal joints exhibit scar-less repair activity potentially involving chondrocytes, chondroprogenitors, or skeletal stem cells. Pluripotent stem cells offer a promising avenue for obtaining cells with similar cartilage self-repair potential, although their use in cartilage repair is still in the early stages of research.
BIOENGINEERING-BASEL
(2021)
Article
Biochemistry & Molecular Biology
Veronika Smolinska, Michaela Debreova, Martina Culenova, Maria Csobonyeiova, Andrey Svec, Lubos Danisovic
Summary: Healing of articular cartilage defects is challenging and traditional reparative approaches are limited. Mesenchymal stromal cells have been extensively studied and proven to have therapeutic effects on articular cartilage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
