The Stuttering Progress of Cell Therapy for Heart Disease

Cardiac cell therapy: where we've been, where we are, and where we should be headed

(2011) K. Malliaras et al.   BRITISH MEDICAL BULLETIN

Intramyocardial Injection of Autologous Cardiospheres or Cardiosphere-Derived Cells Preserves Function and Minimizes Adverse Ventricular Remodeling in Pigs With Heart Failure Post-Myocardial Infarction

(2011) Shuo-Tsan Lee et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Somatic coding mutations in human induced pluripotent stem cells

(2011) Athurva Gore et al.   NATURE

Immunogenicity of induced pluripotent stem cells

(2011) Tongbiao Zhao et al.   NATURE

Diagnostic and prognostic value of 3D NOGA mapping in ischemic heart disease

(2011) Mariann Gyöngyösi et al.   Nature Reviews Cardiology

Transient Regenerative Potential of the Neonatal Mouse Heart

(2011) E. R. Porrello et al.   SCIENCE

Final results of a phase IIa, randomised, open-label trial to evaluate the percutaneous intramyocardial transplantation of autologous skeletal myoblasts in congestive heart failure patients: the SEISMIC trial

(2011) Henricus Duckers et al.   EuroIntervention

Results of Intracoronary Stem Cell Therapy After Acute Myocardial Infarction

(2010) Jochen Wöhrle et al.   AMERICAN JOURNAL OF CARDIOLOGY

Direct Reprogramming of Fibroblasts into Functional Cardiomyocytes by Defined Factors

(2010) Masaki Ieda et al.   CELL

Heart Disease and Stroke Statistics—2011 Update

(2010) Véronique L. Roger et al.   CIRCULATION

Cardiomyogenesis in the Adult Human Heart

(2010) Jan Kajstura et al.   CIRCULATION RESEARCH

Assessment and Optimization of Cell Engraftment After Transplantation Into the Heart

(2010) John V. Terrovitis et al.   CIRCULATION RESEARCH

Magnetic Targeting Enhances Engraftment and Functional Benefit of Iron-Labeled Cardiosphere-Derived Cells in Myocardial Infarction

(2010) Ke Cheng et al.   CIRCULATION RESEARCH

Relative Roles of Direct Regeneration Versus Paracrine Effects of Human Cardiosphere-Derived Cells Transplanted Into Infarcted Mice

(2010) Isotta Chimenti et al.   CIRCULATION RESEARCH

Intracoronary infusion of mononuclear cells from bone marrow or peripheral blood compared with standard therapy in patients after acute myocardial infarction treated by primary percutaneous coronary intervention: results of the randomized controlled HEBE trial

(2010) Alexander Hirsch et al.   EUROPEAN HEART JOURNAL

Intracoronary autologous mononucleated bone marrow cell infusion for acute myocardial infarction: results of the randomized multicenter BONAMI trial

(2010) Jérôme Roncalli et al.   EUROPEAN HEART JOURNAL

Guided Cardiopoiesis Enhances Therapeutic Benefit of Bone Marrow Human Mesenchymal Stem Cells in Chronic Myocardial Infarction

(2010) Atta Behfar et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation

(2010) Chris Jopling et al.   NATURE

Dedifferentiation and Proliferation of Mammalian Cardiomyocytes

(2010) Yiqiang Zhang et al.   PLoS One

Intracoronary administration of bone marrow-derived progenitor cells improves left ventricular function in patients at risk for adverse remodeling after acute ST-segment elevation myocardial infarction: Results of the Reinfusion of Enriched Progenitor cells And Infarct Remodeling in Acute Myocardial Infarction study (REPAIR-AMI) cardiac Magnetic Resonance Imaging substudy

(2009) Thorsten Dill et al.   AMERICAN HEART JOURNAL

Engraftment, Differentiation, and Functional Benefits of Autologous Cardiosphere-Derived Cells in Porcine Ischemic Cardiomyopathy

(2009) Peter V. Johnston et al.   CIRCULATION

Clinical Outcome 2 Years After Intracoronary Administration of Bone Marrow–Derived Progenitor Cells in Acute Myocardial Infarction

(2009) Birgit Assmus et al.   Circulation-Heart Failure

Intracoronary bone marrow cell transfer after myocardial infarction: 5-year follow-up from the randomized-controlled BOOST trial

(2009) G. P. Meyer et al.   EUROPEAN HEART JOURNAL

Intracoronary infusion of bone marrow-derived selected CD34+CXCR4+ cells and non-selected mononuclear cells in patients with acute STEMI and reduced left ventricular ejection fraction: results of randomized, multicentre Myocardial Regeneration by Intracoronary Infusion of Selected Population of Stem Cells in Acute Myocardial Infarction (REGENT) Trial

(2009) Michał Tendera et al.   EUROPEAN HEART JOURNAL

Percutaneous intramyocardial stem cell injection in patients with acute myocardial infarction: first-in-man study

(2009) K Krause et al.   HEART

Determinants of functional recovery after myocardial infarction of patients treated with bone marrow-derived stem cells after thrombolytic therapy

(2009) J. A Miettinen et al.   HEART

Intramyocardial Bone Marrow Cell Injection for Chronic Myocardial Ischemia

(2009) Jan van Ramshorst et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Prospects for pluripotent stem cell-derived cardiomyocytes in cardiac cell therapy and as disease models

(2009) Christian Freund et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Promise of Blood- and Bone Marrow-Derived Stem Cell Transplantation for Functional Cardiac Repair

(2009) Thorsten Reffelmann et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

A Randomized, Double-Blind, Placebo-Controlled, Dose-Escalation Study of Intravenous Adult Human Mesenchymal Stem Cells (Prochymal) After Acute Myocardial Infarction

(2009) Joshua M. Hare et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Noninvasive Quantification and Optimization of Acute Cell Retention by In Vivo Positron Emission Tomography After Intramyocardial Cardiac-Derived Stem Cell Delivery

(2009) John Terrovitis et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Validation of the Cardiosphere Method to Culture Cardiac Progenitor Cells from Myocardial Tissue

(2009) Darryl R. Davis et al.   PLoS One

Allogeneic mesenchymal stem cells restore cardiac function in chronic ischemic cardiomyopathy via trilineage differentiating capacity

(2009) H. C. Quevedo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evidence for Cardiomyocyte Renewal in Humans

(2009) Olaf Bergmann et al.   SCIENCE

Donor-Derived Brain Tumor Following Neural Stem Cell Transplantation in an Ataxia Telangiectasia Patient

(2009) Ninette Amariglio et al.   PLOS MEDICINE

Cell Therapy of Acute Myocardial Infarction: Open Questions

(2008) Stefanie Dimmeler et al.   CARDIOLOGY

Differentiation of Embryonic Stem Cells to Clinically Relevant Populations: Lessons from Embryonic Development

(2008) Charles E. Murry et al.   CELL

The Myoblast Autologous Grafting in Ischemic Cardiomyopathy (MAGIC) Trial

(2008) Philippe Menasché et al.   CIRCULATION

Aging and Disease as Modifiers of Efficacy of Cell Therapy

(2008) Stefanie Dimmeler et al.   CIRCULATION RESEARCH

Paracrine Mechanisms in Adult Stem Cell Signaling and Therapy

(2008) Massimiliano Gnecchi et al.   CIRCULATION RESEARCH

Autologous bone marrow stem cells to treat acute myocardial infarction: a systematic review

(2008) Enca Martin-Rendon et al.   EUROPEAN HEART JOURNAL

Effects of intracoronary injection of mononuclear bone marrow cells on left ventricular function, arrhythmia risk profile, and restenosis after thrombolytic therapy of acute myocardial infarction

(2008) H. V. Huikuri et al.   EUROPEAN HEART JOURNAL

Cell therapy for ischaemic heart disease

(2008) S. L M A Beeres et al.   HEART

Stem cells in the heart: What's the buzz all about?—Part 1: Preclinical considerations

(2008) Rachel Ruckdeschel Smith et al.   HEART RHYTHM

Bone Marrow-Derived Mesenchymal Stromal Cells Express Cardiac-Specific Markers, Retain the Stromal Phenotype, and Do Not Become Functional Cardiomyocytes In Vitro

(2008) Robert A. Rose et al.   STEM CELLS