Applying Physiological and Biochemical Concepts to Optimize Biological Drug Development

Relationship between omalizumab pharmacokinetics, IgE pharmacodynamics and symptoms in patients with severe persistent allergic (IgE-mediated) asthma

(2009) Philip J. Lowe et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Asthma symptom re-emergence after omalizumab withdrawal correlates well with increasing IgE and decreasing pharmacokinetic concentrations

(2009) Raymond G. Slavin et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

In vivo regulation of interleukin 1β in patients with cryopyrin-associated periodic syndromes

(2009) Helen J. Lachmann et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Numerical validation and properties of a rapid binding approximation of a target-mediated drug disposition pharmacokinetic model

(2009) Anshu Marathe et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Use of Canakinumab in the Cryopyrin-Associated Periodic Syndrome

(2009) Helen J. Lachmann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Use of pharmacokinetic/ pharmacodynamic modelling for starting dose selection in first-in-human trials of high-risk biologics

(2008) Balaji M. Agoram   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Approximations of the target-mediated drug disposition model and identifiability of model parameters

(2008) Leonid Gibiansky et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Motor performance and functional ability in preschool- and early school-aged children with Juvenile Idiopathic Arthritis: a cross-sectional study

(2008) Janjaap van der Net et al.   Pediatric Rheumatology

Pharmacokinetic and Pharmacodynamic Modeling of a Humanized Anti-IL-13 Antibody in Naive and Ascaris-Challenged Cynomolgus Monkeys

(2008) Yulia Vugmeyster et al.   PHARMACEUTICAL RESEARCH

Tumor Regression in Cancer Patients by Very Low Doses of a T Cell-Engaging Antibody

(2008) R. Bargou et al.   SCIENCE