Viral Hepatitis C Therapy: Pharmacokinetic and Pharmacodynamic Considerations
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Title
Viral Hepatitis C Therapy: Pharmacokinetic and Pharmacodynamic Considerations
Authors
Keywords
Sustained Virological Response, Sustained Virological Response Rate, Telaprevir, Sofosbuvir, Boceprevir
Journal
CLINICAL PHARMACOKINETICS
Volume 53, Issue 5, Pages 409-427
Publisher
Springer Nature America, Inc
Online
2014-04-10
DOI
10.1007/s40262-014-0142-5
References
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Note: Only part of the references are listed.- Meta-analysis: pegylated interferon α-2a achieves higher early virological responses than α-2b in chronic hepatitis C
- (2013) M. Romero-Gómez et al. ALIMENTARY PHARMACOLOGY & THERAPEUTICS
- The clinical significance of drug-drug interactions in the era of direct-acting anti-viral agents against chronic hepatitis C
- (2013) B. Maasoumy et al. ALIMENTARY PHARMACOLOGY & THERAPEUTICS
- Efficacy and Safety of Pegylated Interferon Alfa-2b and Ribavirin Combination Therapy Versus Pegylated Interferon Monotherapy in Hemodialysis Patients: A Comparison of 2 Sequentially Treated Cohorts
- (2013) Po-Lin Tseng et al. AMERICAN JOURNAL OF KIDNEY DISEASES
- Equal efficacy between the two types of peginterferon on HCV: A matter of relapse?
- (2013) Etienne Brochot et al. ANTIVIRAL RESEARCH
- Drug interactions between antiretrovirals and new or emerging direct-acting antivirals in HIV/hepatitis C virus coinfection
- (2013) Drosos E. Karageorgopoulos et al. CURRENT OPINION IN INFECTIOUS DISEASES
- The importance of drug–drug interactions in the DAA era
- (2013) David Back et al. DIGESTIVE AND LIVER DISEASE
- Pegylated Interferon-α2a and Ribavirin versus Pegylated Interferon-α2b and Ribavirin in Chronic Hepatitis C
- (2013) Nicolas Flori et al. DRUGS
- Population pharmacokinetics of peginterferon alfa-2b in pediatric patients with chronic hepatitis C
- (2013) C. Xu et al. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
- Decreasing mortality and changing patterns of causes of death in the Swiss HIV Cohort Study
- (2013) R Weber et al. HIV MEDICINE
- Therapeutic drug monitoring of telaprevir in chronic hepatitis C patients receiving telaprevir-based triple therapy is useful for predicting virological response
- (2013) N. Furusyo et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Triple therapy in treatment-experienced patients with HCV-cirrhosis in a multicentre cohort of the French Early Access Programme (ANRS CO20-CUPIC) – NCT01514890
- (2013) Christophe Hézode et al. JOURNAL OF HEPATOLOGY
- Boceprevir versus placebo with pegylated interferon alfa-2b and ribavirin for treatment of hepatitis C virus genotype 1 in patients with HIV: a randomised, double-blind, controlled phase 2 trial
- (2013) Mark Sulkowski et al. LANCET INFECTIOUS DISEASES
- The molecular and structural basis of advanced antiviral therapy for hepatitis C virus infection
- (2013) Ralf Bartenschlager et al. NATURE REVIEWS MICROBIOLOGY
- Current and Future Therapies for Hepatitis C Virus Infection
- (2013) T. Jake Liang et al. NEW ENGLAND JOURNAL OF MEDICINE
- Treatment of Genotype 1 HCV Infection in the HIV Coinfected Patient in 2014
- (2013) Cody A. Chastain et al. Current HIV/AIDS Reports
- The pharmacokinetics of peginterferon alfa-2a and ribavirin in African American, Hispanic and Caucasian patients with chronic hepatitis C
- (2012) B. J. Brennan et al. ALIMENTARY PHARMACOLOGY & THERAPEUTICS
- Telaprevir: pharmacokinetics and drug interactions
- (2012) Varun Garg et al. ANTIVIRAL THERAPY
- Interaction of the antiviral drug telaprevir with renal and hepatic drug transporters
- (2012) Annett Kunze et al. BIOCHEMICAL PHARMACOLOGY
- Single-Dose Pharmacokinetics of Boceprevir in Subjects with Impaired Hepatic or Renal Function
- (2012) Michelle Treitel et al. CLINICAL PHARMACOKINETICS
- Evaluation of the Absolute Bioavailability of Pegylated Interferon Alfa-2a After Subcutaneous Administration to Healthy Male Volunteers: An Open-Label, Randomized, Parallel-Group Study
- (2012) Barbara J. Brennan et al. CLINICAL THERAPEUTICS
- HIV and viral hepatitis coinfections: advances and challenges
- (2012) Karine Lacombe et al. GUT
- Review and management of drug interactions with boceprevir and telaprevir
- (2012) Jennifer J. Kiser et al. HEPATOLOGY
- Peginterferon alfa-2a Plus Ribavirin for HIV-HCV Genotype 1 Coinfected Patients: A Randomized International Trial
- (2012) Maribel Rodriguez-Torres et al. HIV CLINICAL TRIALS
- Erythrocyte and plasma ribavirin concentrations in the assessment of early and sustained virological responses to pegylated interferon-alpha 2a and ribavirin in patients coinfected with hepatitis C virus and HIV
- (2012) S. Dominguez et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Anti-viral triple therapy with telaprevir in haemodialysed HCV patients: Is it feasible?
- (2012) Jérôme Dumortier et al. JOURNAL OF CLINICAL VIROLOGY
- Clinical management of drug–drug interactions in HCV therapy: Challenges and solutions
- (2012) David Burger et al. JOURNAL OF HEPATOLOGY
- Sofosbuvir (GS-7977) plus peginterferon/ribavirin in treatment-naïve patients with HCV genotype 1: A randomized, 28-day, dose-ranging trial
- (2012) Maribel Rodriguez-Torres et al. JOURNAL OF HEPATOLOGY
- Role of the Equilibrative and Concentrative Nucleoside Transporters in the Intestinal Absorption of the Nucleoside Drug, Ribavirin, in Wild-Type and Ent1(−/−) Mice
- (2012) Aaron M. Moss et al. MOLECULAR PHARMACEUTICS
- Discovery of boceprevir, a direct-acting NS3/4A protease inhibitor for treatment of chronic hepatitis C infections
- (2012) Srikanth Venkatraman TRENDS IN PHARMACOLOGICAL SCIENCES
- Pharmacological exposure to ribavirin: A key player in the complex network of factors implicated in virological response and anaemia in hepatitis C treatment
- (2011) Véronique Loustaud-Ratti et al. DIGESTIVE AND LIVER DISEASE
- Pharmacokinetics, safety, and tolerability of ribavirin in hemodialysis-dependent patients
- (2011) Samir K. Gupta et al. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
- An update on treatment of genotype 1 chronic hepatitis C virus infection: 2011 practice guideline by the American Association for the Study of Liver Diseases
- (2011) Marc G. Ghany et al. HEPATOLOGY
- EASL Clinical Practice Guidelines: Management of hepatitis C virus infection
- (2011) JOURNAL OF HEPATOLOGY
- Contribution of ribavirin transporter gene polymorphism to treatment response in peginterferon plus ribavirin therapy for HCV genotype 1b patients
- (2011) Akihito Tsubota et al. LIVER INTERNATIONAL
- Boceprevir for Untreated Chronic HCV Genotype 1 Infection
- (2011) Fred Poordad et al. NEW ENGLAND JOURNAL OF MEDICINE
- Telaprevir for Previously Untreated Chronic Hepatitis C Virus Infection
- (2011) Ira M. Jacobson et al. NEW ENGLAND JOURNAL OF MEDICINE
- Evaluation of pharmacokinetics, user handling, and tolerability of peginterferon alfa-2a (40 kDa) delivered via a disposable autoinjector device
- (2011) Peter Varunok et al. Patient Preference and Adherence
- Ribavirin for the treatment of chronic hepatitis C virus infection: a review of the proposed mechanisms of action
- (2011) Jan Paeshuyse et al. Current Opinion in Virology
- Ribavirin monitoring in chronic hepatitis C therapy: anaemia versus efficacy
- (2010) Etienne Brochot et al. ANTIVIRAL THERAPY
- Plasma/erythrocyte ribavirin ×100 ratio as an indicator of sustained virological response in HCV genotype 1 patients with early virological response
- (2010) Leonardo Baiocchi et al. ANTIVIRAL THERAPY
- Evolving epidemiology of hepatitis C virus
- (2010) D. Lavanchy CLINICAL MICROBIOLOGY AND INFECTION
- Characterization of Human Liver Enzymes Involved in the Biotransformation of Boceprevir, a Hepatitis C Virus Protease Inhibitor
- (2010) A. Ghosal et al. DRUG METABOLISM AND DISPOSITION
- Telaprevir Is Effective Given Every 8 or 12 Hours With Ribavirin and Peginterferon Alfa-2a or -2b to Patients With Chronic Hepatitis C
- (2010) Patrick Marcellin et al. GASTROENTEROLOGY
- Characterization of ribavirin uptake systems in human hepatocytes
- (2010) Yukina Fukuchi et al. JOURNAL OF HEPATOLOGY
- High sustained virologic response rates in children with chronic hepatitis C receiving peginterferon alfa-2b plus ribavirin
- (2010) Stefan Wirth et al. JOURNAL OF HEPATOLOGY
- Seminal fluid ribavirin level and functional semen parameters in patients with chronic hepatitis C on antiviral combination therapy
- (2010) Harald Hofer et al. JOURNAL OF HEPATOLOGY
- Relationship between the hepatitis C viral load and the serum interferon concentration during the first week of peginterferon-alpha-2b-ribavirin combination therapy
- (2010) Catherine François et al. JOURNAL OF MEDICAL VIROLOGY
- Discovery of a β-d-2′-Deoxy-2′-α-fluoro-2′-β-C-methyluridine Nucleotide Prodrug (PSI-7977) for the Treatment of Hepatitis C Virus
- (2010) Michael J. Sofia et al. JOURNAL OF MEDICINAL CHEMISTRY
- ITPA gene variants protect against anaemia in patients treated for chronic hepatitis C
- (2010) Jacques Fellay et al. NATURE
- The Utility of Therapeutic Drug Monitoring for Ribavirin in Patients with Chronic Hepatitis C—A Critical Review
- (2009) Alice HW Chan et al. ANNALS OF PHARMACOTHERAPY
- In Vitro Activity and Preclinical Profile of TMC435350, a Potent Hepatitis C Virus Protease Inhibitor
- (2009) T.-I Lin et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Peginterferon-α-2a (40 kD) Plus Ribavirin
- (2009) Susan J Keam et al. DRUGS
- Rapid HCV-RNA Decline With Once Daily TMC435: A Phase I Study in Healthy Volunteers and Hepatitis C Patients
- (2009) Henk W. Reesink et al. GASTROENTEROLOGY
- Effect of Dietary Purines on the Pharmacokinetics of Orally Administered Ribavirin
- (2009) Linghui Li et al. JOURNAL OF CLINICAL PHARMACOLOGY
- The Role of Nucleoside Transporters in the Erythrocyte Disposition and Oral Absorption of Ribavirin in the Wild-Type and Equilibrative Nucleoside Transporter 1(-/-) Mice
- (2009) C. J. Endres et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Peginterferon Alfa-2b or Alfa-2a with Ribavirin for Treatment of Hepatitis C Infection
- (2009) John G. McHutchison et al. NEW ENGLAND JOURNAL OF MEDICINE
- Pharmacokinetics and dosage adjustment in patients with hepatic dysfunction
- (2008) Roger K. Verbeeck EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
- Ribavirin exposure after the first dose is predictive of sustained virological response in chronic hepatitis C
- (2008) Véronique Loustaud-Ratti et al. HEPATOLOGY
- Diagnosis, management, and treatment of hepatitis C: An update
- (2008) Marc G. Ghany et al. HEPATOLOGY
- Usefulness of monitoring ribavirin plasma concentrations to improve treatment response in patients with chronic hepatitis C
- (2008) J. Morello et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Differences in the pharmacokinetics of protease inhibitors between healthy volunteers and HIV-infected persons
- (2008) Laura Dickinson et al. Current Opinion in HIV and AIDS
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