Article
Chemistry, Multidisciplinary
Yudi Song, Wei Wang, Xinyang Liu, Jingsi Chen, Dunjin Chen, Xiaoyi Wang, Wei Li, Defang Ouyang
Summary: A physiologically-based pharmacokinetics (PBPK) model was established to evaluate the dosage regimens of labetalol in pregnant women. The study found that the maximum daily dosage in the Chinese guideline may be insufficient for severe HDP patients and that there was a similar steady-state plasma concentration between the maximum daily dosage in the ACOG guideline and a regimen of 200 mg Q6h. Differences in labetalol exposure between pregnant and non-pregnant women were dependent on the CYP2C19 metabolic phenotype.
PHARMACEUTICAL RESEARCH
(2023)
Article
Medicine, General & Internal
Ethan K. Gough, Thaddeus J. Edens, Hyun Min Geum, Iman Baharmand, Sandeep K. Gill, Ruairi C. Robertson, Kuda Mutasa, Robert Ntozini, Laura E. Smith, Bernard Chasekwa, Florence D. Majo, Naume Tavengwa, Batsirai Mutasa, Freddy Francis, Lynnea Carr, Joice Tome, Rebecca J. Stoltzfus, Lawrence H. Moulton, Andrew J. Prendergast, Jean H. Humphrey, Amee R. Manges
Summary: The study in rural Zimbabwe found that the maternal intestinal microbiome composition and functions during pregnancy are closely related to infant birth weight and growth outcomes, with resistant starch-degrading bacteria playing a key role in predicting birth outcomes.
Article
Medicine, General & Internal
Qiuhong Zhang, Chee Shin Lee, Lixia Zhang, Qi Wu, Yunyan Chen, Danqing Chen, Lu Qi, Zhaoxia Liang
Summary: Different factors, such as advanced age and high pre-pregnancy BMI, contribute to elevated HbA1c levels in pregnant women with GDM. Monitoring and controlling blood glucose levels have shown effectiveness in reducing adverse pregnancy outcomes, especially in cases of excessive GWG.
FRONTIERS IN MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Andrea Maugeri, Roberta Magnano San Lio, Maria Clara La Rosa, Giuliana Giunta, Marco Panella, Antonio Cianci, Maria Anna Teresa Caruso, Antonella Agodi, Martina Barchitta
Summary: Inadequate gestational weight gain could affect fetal health and is associated with DNA telomere length.
Article
Nutrition & Dietetics
Martina Barchitta, Roberta Magnano San Lio, Maria Clara La Rosa, Claudia La Mastra, Giuliana Favara, Giuliana Ferrante, Fabiola Galvani, Elisa Pappalardo, Carla Ettore, Giuseppe Ettore, Antonella Agodi, Andrea Maugeri
Summary: Limited evidence exists on the effects of maternal dietary patterns on birth weight, and most studies conducted so far did not adjust their findings for gestational age and sex, leading to potentially biased conclusions. In this study, a novel method was applied to derive dietary patterns among pregnant women and evaluate the associations with birth weight for gestational age. The findings suggest that adherence to an unhealthy dietary pattern is associated with an increased likelihood of having a large for gestational age newborn.
Article
Oncology
Britt B. M. Suelmann, Carmen van Dooijeweert, Carsten F. J. Bakhuis, Sabine Linn, Elsken van der Wall, Paul J. van Diest
Summary: This study assesses the influence of gestational age and lactation on the histopathologic features of pregnancy-associated breast cancer (PABC). The results show that most PABC cases were diagnosed during pregnancy, and tumors in the second and third trimesters were more often estrogen receptor (ER)-negative. In postpartum patients, Grade III tumors were common, and lactating patients had a higher proportion of ER-negative tumors.
ENDOCRINE-RELATED CANCER
(2022)
Review
Biochemistry & Molecular Biology
Ian R. Mulrenin, Julian E. Garcia, Muluneh M. Fashe, Matthew Shane Loop, Melissa A. Daubert, Rachel Peragallo Urrutia, Craig R. Lee
Summary: With the increasing prevalence of HDP, physiological changes during pregnancy can affect the pharmacokinetics of antihypertensive drugs, highlighting the need for further research to develop more precise dosing strategies.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
(2021)
Article
Medicine, General & Internal
Kamini Dangat, Sanjay Gupte, Girija Wagh, Sanjay Lalwani, Karuna Randhir, Shweta Madiwale, Hemlata Pisal, Vrushali Kadam, Shridevi Gundu, Nomita Chandhiok, Bharati Kulkarni, Sadhana Joshi, Caroline Fall, Harshpal Singh Sachdev
Summary: This study aimed to evaluate the trimester specific gestational weight gain (GWG) in Indian pregnant women and compare it with international and Indian reference data. The study found that Indian women had lower GWG compared to international standards, but higher GWG compared to Indian reference data. Maternal BMI, age, parity, hemoglobin concentrations, and height were found to be associated with GWG.
FRONTIERS IN MEDICINE
(2022)
Article
Multidisciplinary Sciences
Max T. Aung, Pahriya Ashrap, Deborah J. Watkins, Bhramar Mukherjee, Zaira Rosario, Carmen M. Velez-Vega, Akram N. Alshawabkeh, Jose F. Cordero, John D. Meeker
Summary: Maternal lipidomic signatures associated with preterm birth and neonatal anthropometric parameters were characterized, revealing potential biomarkers for pregnancy outcomes. Fine omics-scale analysis of the maternal lipidome may offer more informative insights compared to whole class level lipid analysis.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Xiaoli Gong, Jiaxin Li, Yuanhui Jiang, Pengbo Yuan, Lian Chen, Yike Yang, You Li, Mengxing Sun, Yangyu Zhao, Huifeng Shi, Yuan Wei
Summary: This study aimed to evaluate the impact of gestational weight gain (GWG) on the risk of preeclampsia among women with different prepregnancy body mass index (BMI). The findings showed that high prepregnancy BMI and excessive GWG were associated with an increased risk of preeclampsia.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Aiqi Yin, Fuying Tian, Xiaoxia Wu, Yixuan Chen, Kan Liu, Jianing Tong, Xiaonian Guan, Huafan Zhang, Linlin Wu, Jianmin Niu
Summary: This study evaluated the effect of weight gain in different trimesters on the risk of gestational diabetes mellitus (GDM). The results showed that insufficient weight gain in early pregnancy and excessive weight gain in middle pregnancy were associated with an increased risk of GDM. Strict control of weight gain in early pregnancy and sufficient nutrition in middle pregnancy are necessary.
CHINESE MEDICAL JOURNAL
(2022)
Article
Endocrinology & Metabolism
Li-Rong He, Li Yu, Yong Guo
Summary: There has been a decrease in birth weight and prevalence of large for gestational age (LGA) among offspring of women with gestational diabetes mellitus (GDM) in southern China. However, the risk of LGA remains stable at a relatively high level for GDM women over the past 10 years.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Nutrition & Dietetics
Reyna Samano, Hugo Martinez-Rojano, Luis Ortiz-Hernandez, Oralia Najera-Medina, Gabriela Chico-Barba, Ricardo Gamboa, Maria Eugenia Mendoza-Flores
Summary: About 56% to 84% of pregnant adolescents experience inappropriate gestational weight gain. This scoping review aimed to synthesize the available scientific evidence on the association of individual, family, and social factors with gestational weight gain in pregnant adolescents. The evidencesuggests that pre-pregnancy body mass index (pBMI) is positively associated with gestational weight gain, but insufficient evidence exists for other factors.
Article
Public, Environmental & Occupational Health
Camila Honorato A. Torres, Lidiane F. Schultz, Paul J. Veugelers, Silmara S. B. S. Mastroeni, Marco F. Mastroeni
Summary: The study found that maternal pre-pregnancy overweight and simultaneous excessive GWG were positively associated with elevated BP in 6-year-old children. Mothers with pre-pregnancy BMI ≥ 25 kg/m(2) and excessive GWG were more likely to have children with elevated diastolic blood pressure.
JOURNAL OF PUBLIC HEALTH
(2021)
Article
Pediatrics
Giulia Vizzari, Daniela Morniroli, Valentina Tiraferri, Marta Macchi, Silvana Gangi, Alessandra Consales, Federica Ceroni, Jacopo Cerasani, Fabio Mosca, Maria Lorella Gianni
Summary: This study examined the growth outcomes of late preterm infants and identified factors associated with failure to recover growth. The results showed that 34% of children did not regain weight at 36 months. Infants who did not regain weight at 12 months were at a higher risk of not regaining weight at 36 months. The same risk factor was also associated with length catch-up growth. Additionally, infants fed any human milk at discharge were protected from failure to achieve weight and length catch-up growth at 36 months.
PEDIATRIC RESEARCH
(2023)