Journal
CLINICAL ONCOLOGY
Volume 20, Issue 5, Pages 345-352Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.clon.2008.02.004
Keywords
clonogenic survival; IGF2; IGF1; IGF-1R; irradiation
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Funding
- Cancer Research UK [9891] Funding Source: researchfish
- Cancer Research UK [C429/ABH, 9891] Funding Source: Medline
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The insulin-like growth factor system is known to be associated with malignancy and represents a potential therapeutic target. This review discusses the evidence associating ligand and signalling receptor expression with malignancy and radioresistance, which may be relevant to tumour predisposition, growth and resistance to treatment. In particular, evidence relating to the less evaluated ligand insulin-like growth factor 2 is considered.
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