期刊
CLINICAL ONCOLOGY
卷 20, 期 5, 页码 345-352出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.clon.2008.02.004
关键词
clonogenic survival; IGF2; IGF1; IGF-1R; irradiation
类别
资金
- Cancer Research UK [9891] Funding Source: researchfish
- Cancer Research UK [C429/ABH, 9891] Funding Source: Medline
The insulin-like growth factor system is known to be associated with malignancy and represents a potential therapeutic target. This review discusses the evidence associating ligand and signalling receptor expression with malignancy and radioresistance, which may be relevant to tumour predisposition, growth and resistance to treatment. In particular, evidence relating to the less evaluated ligand insulin-like growth factor 2 is considered.
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