Article
Plant Sciences
M. Grassia, M. C. Messia, E. Marconi, O. Sakiyan Demirkol, F. Erdogdu, F. Sarghini, L. Cinquanta, O. Corona, D. Planeta
Summary: Polyphenols were recovered from cocoa bean shells using green extraction technologies, encapsulated with maltodextrin, and added to chocolate bars. The enriched chocolate bars showed a smaller reduction in polyphenol content after accelerated storage compared to the control bars, demonstrating successful enrichment of phenolic antioxidants without increasing bitterness and astringency.
PLANT FOODS FOR HUMAN NUTRITION
(2021)
Article
Physiology
Kathleen Cantow, Thomas Gladytz, Jason M. Millward, Sonia Waiczies, Thoralf Niendorf, Erdmann Seeliger
Summary: This study used dynamic MRI to monitor kidney size and provided physiological interpretation of changes in renal oxygenation. The results showed correlations between changes in kidney size and T-2* and T-2. Monitoring kidney size allows for a better understanding of renal pathophysiology.
Article
Cardiac & Cardiovascular Systems
Felix Mahfoud, Raymond R. Townsend, David E. Kandzari, Kazuomi Kario, Roland E. Schmieder, Konstantinos Tsiou, Stuart Pocock, Shukri David, Kiritkumar Patel, Anjani Rao, Antony Walton, Jason E. Bloom, Thomas Weber, Markus Suppan, Lucas Lauder, Sidney A. Cohen, Pamela McKenna, Martin Fahy, Michael Boehm, Michael A. Weber
Summary: The study aimed to evaluate the impact of renal denervation (RDN) on the renin-angiotensin-aldosterone system in blood pressure regulation. Results showed that plasma renin activity and aldosterone levels significantly decreased compared to baseline in RDN patients at 3 months, with higher baseline PRA levels associated with a more significant reduction in blood pressure.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Chu Hyun Kim, Ji Hyun Lee, Ji Won Lee, Eunju Kim, Sang-Hee Choi
Summary: This study aimed to evaluate the feasibility of using the BOLD technique to assess the response to NChT in osteosarcoma patients. The R2* values were found to have better correlation with the pathologic grade in the extraosseous portion. The BOLD MRI technique may be a useful biomarker for evaluating treatment response in osteosarcoma treated with NchT.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Food Science & Technology
Simona Jacimovic, Jelena Popovic-Djordjevic, Beka Saric, Aleksandar Krstic, Violeta Mickovski-Stefanovic, Nebojsa D. Pantelic
Summary: This study evaluated the antioxidant activity and nutritional composition of commercially available dark chocolate samples with different cocoa contents. The results showed that chocolates with higher cocoa percentage exhibited stronger antioxidant activity. The total polyphenol and total flavonoid content of the samples depended on the cocoa content and the addition of dried fruit pieces. Additionally, the chocolates were found to be a good source of minerals such as magnesium, iron, manganese, and copper.
Article
Food Science & Technology
Karen Souza dos Santos, Olavo Joao Frederico Ramos Junior, Isabela Ribeiro Grangeiro Tavares, Monica Volino-Souza, Gustavo Vieira de Oliveira, Thiago da Silveira Alvares
Summary: This study evaluated the potential of microencapsulated cocoa supplementation to reduce endothelial dysfunction caused by eccentric exercise. Thirteen healthy volunteers were enrolled in a double-blind, placebo-controlled, crossover study. Measures of flow-mediated dilatation, blood flow, and muscle oxygen saturation were obtained before and after microencapsulated cocoa supplementation. The findings showed that a single dose of microencapsulated cocoa ingestion attenuated the exercise-induced decrease in flow-mediated dilatation. These results suggest that microencapsulated cocoa may serve as an alternative nutritional strategy to mitigate vascular dysfunction caused by eccentric exercise in healthy individuals.
INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Kaixuan Zhao, Andreas Pohlmann, Qijian Feng, Yingjie Mei, Guixiang Yang, Peiwei Yi, Qianjin Feng, Wufang Chen, Lili Zhou, Ed X. Wu, Erdmann Seeliger, Thoralf Niendorf, Yanqiu Feng
Summary: This study investigates the feasibility of characterizing renal oxygenation regulation using high-temporal-resolution monitoring of the T2* response. The results suggest that the implemented system analysis approach may aid in understanding the regulation of renal oxygenation, potentially offering imaging means for diagnosis and therapy of renal diseases.
MAGNETIC RESONANCE IN MEDICINE
(2021)
Article
Neurosciences
Irene A. Garcia-Yu, Luis Garcia-Ortiz, Manuel A. Gomez-Marcos, Emiliano Rodriguez-Sanchez, Sara Mora-Simon, Jose A. Maderuelo-Fernandez, Jose I. Recio-Rodriguez
Summary: This study aimed to evaluate the effects of consuming 10 grams of cocoa-rich chocolate on cognitive performance in postmenopausal women. The findings suggest that adding cocoa-rich chocolate to the daily diet may lead to a slight improvement in cognitive flexibility and processing speed in postmenopausal women.
NUTRITIONAL NEUROSCIENCE
(2022)
Article
Physiology
Yizeng Xu, Jing Yang, Fang Lu, Chaoyang Ye, Chen Wang
Summary: This study explored the correlation between renal oxygenation evaluated by BOLD-MRI and renal function in patients with chronic kidney disease. The decline of T2* values in the cortex may be an effective diagnostic-marker for early detection of CKD.
KIDNEY & BLOOD PRESSURE RESEARCH
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zhong-Yuan Cheng, Qi-Ting Lin, Ping-Kang Chen, Ding-Kun Si-Tu, Long Qian, You-Zhen Feng, Xiang-Ran Cai
Summary: The study revealed the potential value of combined diffusion tensor imaging (DTI) and blood oxygenation level-dependent magnetic resonance imaging (BOLD-MRI) in detecting early renal alterations in patients with hyperuricemia, providing strong evidence for understanding renal changes caused by hyperuricemia.
ABDOMINAL RADIOLOGY
(2021)
Article
Medicine, General & Internal
Zhenjie Liu, Xiaohong Deng, Li Luo, Shaopeng Li, Man Li, Qinqin Deng, Weiguo Zhong, Qiang Luo
Summary: The meta-analysis results of this study indicate that aldosterone to renin ratio (ARR) calculated by plasma renin concentration (PRC) has higher diagnostic efficacy compared to ARR calculated by plasma renin activity (PRA). Additionally, within a certain range, a higher threshold for ARR leads to better diagnostic value.
CHINESE MEDICAL JOURNAL
(2022)
Article
Urology & Nephrology
Pottumarthi V. Prasad, Lu-Ping Li, Bradley Hack, Nondas Leloudas, Stuart M. Sprague
Summary: Kidney BOLD MRI has potential in assessing oxygen availability, but the relationship between R2* value and tissue oxygenation remains uncertain. This study found that fractional blood volume (fBV) was associated with oxygen saturation (StO2) and partial pressure of oxygen in blood (bloodPO2), while R2* value was not.
KIDNEY INTERNATIONAL REPORTS
(2023)
Article
Neurosciences
Sebastian Dresbach, Laurentius (Renzo) Huber, Omer Faruk Gulban, Rainer Goebel
Summary: Layers and columns are the dominant processing units in the human cortex, and the blood oxygenation dependent (BOLD) signal is biased towards unwanted signals from large veins. This study shows that the vascular space occupancy (VASO) contrast can enhance the interpretability of layer-fMRI results by capturing complementary information of locally specific changes in cerebral blood volume (CBV) without the unwanted sensitivity amplifications of large veins. The study also develops a VASO acquisition procedure with short acquisition time and high spatial resolution, demonstrating the ability to capture layer-specific hemodynamic responses with high spatio-temporal resolution.
Article
Biochemistry & Molecular Biology
Inna P. Gladysheva, Ryan D. Sullivan, Kodangudi Ramanathan, Guy L. Reed
Summary: Elevated plasma levels of soluble (pro)renin receptor (s(P)RR) are associated with edema in symptomatic heart failure patients with reduced ejection fraction, independent of renal dysfunction. This finding is consistent with observations in mice with dilated cardiomyopathy and heart failure with reduced ejection fraction.
Review
Pharmacology & Pharmacy
Ryan J. McNally, Luca Faconti, Marina Cecelja, Bushra Farukh, Christopher N. Floyd, Philip J. Chowienczyk
Summary: This study investigated the effects of diuretic therapy on plasma renin activity (PRA) and found that diuretics lead to a sustained increase in PRA, with similar effects across different classes of diuretic, and that this increase is unrelated to the reduction in blood pressure.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Transplantation
Matteo Bargagli, Andri Vetsch, Manuel A. Anderegg, Nasser A. Dhayat, Uyen Huynh-Do, Nicolas Faller, Bruno Vogt, Pietro Manuel Ferraro, Daniel G. Fuster
Summary: In this study, chronic tolvaptan treatment was found to be associated with increased femoral bone mineral density (BMD) and significant changes in mineral metabolism and acid-base parameters in patients with ADPKD.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Matthias Stuber, Aaron L. Baggish
Editorial Material
Cardiac & Cardiovascular Systems
Aurelien Bustin, Matthias Stuber, Maxime Sermesant, Hubert Cochet
EUROPEAN HEART JOURNAL
(2023)
Article
Urology & Nephrology
Frank B. Cortazar, John L. Niles, David R. W. Jayne, Peter A. Merkel, Annette Bruchfeld, Huibin Yue, Thomas J. Schall, Pirow Bekker
Summary: In the ADVOCATE trial, avacopan showed better improvement of eGFR compared to prednisone in treating ANCA-associated vasculitis, especially in patients with baseline eGFR <= 20 ml/min/1.73 m2.
KIDNEY INTERNATIONAL REPORTS
(2023)
Article
Pharmacology & Pharmacy
Paolo Mulatero, Michael Groessl, Bruno Vogt, Christoph Schumacher, Ronald Edward Steele, Ashley Brooks, Stuart Hossack, Hans-Rudolf Brunner
Summary: This study evaluated the safety and efficacy of a novel aldosterone synthase inhibitor in healthy participants. The results showed that the inhibitor effectively suppressed aldosterone production and improved sodium balance, making it a valuable option for managing aldosterone-dependent hypertension and primary aldosteronism.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mariana B. L. Falcao, Giulia M. C. Rossi, Tobias Rutz, Milan Prsa, Estelle Tenisch, Liliana Ma, Elizabeth K. Weiss, Justin J. Baraboo, Jerome Yerly, Michael Markl, Matthias Stuber, Christopher W. Roy
Summary: The study validated a respiratory motion correction method called focused navigation (fNAV) for free-running radial whole-heart 4D flow MRI. Using fNAV, respiratory signals were converted into three orthogonal displacements to correct respiratory motion. The difference between generated and fNAV displacement coefficients was calculated and compared to the motion-free ground-truth. Results showed that fNAV corrected respiratory motion and improved 4D flow measurements compared to uncorrected datasets.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Genetics & Heredity
Krzysztof Kiryluk, Elena Sanchez-Rodriguez, Xu-Jie Zhou, Francesca Zanoni, Lili Liu, Nikol Mladkova, Atlas Khan, Maddalena Marasa, Jun Y. Zhang, Olivia Balderes, Simone Sanna-Cherchi, Andrew S. Bomback, Pietro A. Canetta, Gerald B. Appel, Jai Radhakrishnan, Hernan Trimarchi, Ben Sprangers, Daniel C. Cattran, Heather Reich, York Pei, Pietro Ravani, Kresimir Galesic, Dita Maixnerova, Vladimir Tesar, Benedicte Stengel, Marie Metzger, Guillaume Canaud, Nicolas Maillard, Francois Berthoux, Laureline Berthelot, Evangeline Pillebout, Renato Monteiro, Raoul Nelson, Robert J. Wyatt, William Smoyer, John Mahan, Al-Akash Samhar, Guillermo Hidalgo, Alejandro Quiroga, Patricia Weng, Raji Sreedharan, David Selewski, Keefe Davis, Mahmoud Kallash, Tetyana L. Vasylyeva, Michelle Rheault, Aftab Chishti, Daniel Ranch, Scott E. Wenderfer, Dmitry Samsonov, Donna J. Claes, Oleh Akchurin, Dimitrios Goumenos, Maria Stangou, Judit Nagy, Tibor Kovacs, Enrico Fiaccadori, Antonio Amoroso, Cristina Barlassina, Daniele Cusi, Lucia Del Vecchio, Giovanni Giorgio Battaglia, Monica Bodria, Emanuela Boer, Luisa Bono, Giuliano Boscutti, Gianluca Caridi, Francesca Lugani, GianMarco Ghiggeri, Rosanna Coppo, Licia Peruzzi, Vittoria Esposito, Ciro Esposito, Sandro Feriozzi, Rosaria Polci, Giovanni Frasca, Marco Galliani, Maurizio Garozzo, Adele Mitrotti, Loreto Gesualdo, Simona Granata, Gianluigi Zaza, Francesco Londrino, Riccardo Magistroni, Isabella Pisani, Andrea Magnano, Carmelita Marcantoni, Piergiorgio Messa, Renzo Mignani, Antonello Pani, Claudio Ponticelli, Dario Roccatello, Maurizio Salvadori, Erica Salvi, Domenico Santoro, Guido Gembillo, Silvana Savoldi, Donatella Spotti, Pasquale Zamboli, Claudia Izzi, Federico Alberici, Elisa Delbarba, Michal Florczak, Natalia Krata, Krzysztof Mucha, Leszek Paczek, Stanislaw Niemczyk, Barbara Moszczuk, Malgorzata Panczyk-Tomaszewska, Malgorzata Mizerska-Wasiak, Agnieszka Perkowska-Ptasinska, Teresa Baczkowska, Magdalena Durlik, Krzysztof Pawlaczyk, Przemyslaw Sikora, Marcin Zaniew, Dorota Kaminska, Magdalena Krajewska, Izabella Kuzmiuk-Glembin, Zbigniew Heleniak, Barbara Bullo-Piontecka, Tomasz Liberek, Alicja Debska-Slizien, Tomasz Hryszko, Anna Materna-Kiryluk, Monika Miklaszewska, Maria Szczepanska, Katarzyna Dyga, Edyta Machura, Katarzyna Siniewicz-Luzenczyk, Monika Pawlak-Bratkowska, Marcin Tkaczyk, Dariusz Runowski, Norbert Kwella, Dorota Drozdz, Ireneusz Habura, Florian Kronenberg, Larisa Prikhodina, David van Heel, Bertrand Fontaine, Chris Cotsapas, Cisca Wijmenga, Andre Franke, Vito Annese, Peter K. Gregersen, Sreeja Parameswaran, Matthew Weirauch, Leah Kottyan, John B. Harley, Hitoshi Suzuki, Ichiei Narita, Shin Goto, Hajeong Lee, Dong Ki Kim, Yon Su Kim, Jin-Ho Park, BeLong Cho, Murim Choi, Ans Van Wijk, Ana Huerta, Elisabet Ars, Jose Ballarin, Sigrid Lundberg, Bruno Vogt, Laila-Yasmin Mani, Yasar Caliskan, Jonathan Barratt, Thilini Abeygunaratne, Philip A. Kalra, Daniel P. Gale, Ulf Panzer, Thomas Rauen, Juergen Floege, Pascal Schlosser, Arif B. Ekici, Kai-Uwe Eckardt, Nan Chen, Jingyuan Xie, Richard P. Lifton, Ruth J. F. Loos, Eimear E. Kenny, Iuliana Ionita-Laza, Anna Koettgen, Bruce A. Julian, Jan Novak, Francesco Scolari, Hong Zhang, Ali G. Gharavi
Summary: Genome-wide association analyses have identified 30 risk loci for IgA nephropathy, a progressive form of kidney disease. Functional annotations of potential causal genes suggest inflammatory signaling pathways and cytokine ligand-receptor pairs as potential new drug targets. These findings provide valuable insights into the genetic basis of IgA nephropathy and offer potential avenues for developing therapeutic interventions.
Article
Medicine, General & Internal
Nasser A. Dhayat, Olivier Bonny, Beat Roth, Andreas Christe, Alexander Ritter, Nilufar Mohebbi, Nicolas Faller, Lisa Pellegrini, Giulia Bedino, Reto M. Venzin, Philipp Grosse, Carina Husler, Irene Koneth, Christian Bucher, Rosaria Del Giorno, Luca Gabutti, Michael Mayr, Urs Odermatt, Florian Buchkremer, Thomas Ernandez, Catherine Stoermann-Chopard, Daniel Teta, Bruno Vogt, Marie Roumet, Luca Tamo, Grazia M. Cereghetti, Sven Trelle, Daniel G. Fuster
Summary: This study aimed to investigate the dose-response effect of hydrochlorothiazide agents for preventing the recurrence of kidney stones. The results showed that there was no significant difference in the incidence of recurrent stones among patients receiving hydrochlorothiazide at doses of 12.5 mg, 25 mg, or 50 mg compared to placebo. However, the use of hydrochlorothiazide was associated with a higher risk of adverse reactions.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Medicine, General & Internal
Antonio Ulpiano Trillig, Aikaterini Damianaki, Maielle Hendriks-Balk, Wendy Brito, Jonas Garessus, Michel Burnier, Gregoire Wuerzner, Menno Pruijm
Summary: In this study, contrast-enhanced ultrasound was used to quantitatively evaluate the cortical micro-perfusion, and it was found that females had higher cortical micro-perfusion index than males, but this difference was no longer significant after adjusting for covariates. The study also found that cortical micro-perfusion was associated with the renin-angiotensin system.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Virology
Damian T. Nydegger, Jonai Pujol-Gimenez, Palanivel Kandasamy, Bruno Vogt, Matthias A. Hediger
Summary: As new variants of SARS-CoV-2 continue to emerge during the COVID-19 pandemic, it is crucial to develop optimized tools for studying these variants and potential future coronaviruses. This report introduces microscale thermophoresis (MST) as a reliable and versatile tool for coronavirus research. The study demonstrates three applications of MST, including the binding of SARS-CoV-2 spike receptor binding domain (RBD) to peptides, the binding of RBD to the viral receptor ACE2, and the binding of RBD to ACE2 in complex with the amino acid transporter SLC6A20/SIT1 or its allelic variant rs61731475 (p.Ile529Val). The results highlight MST as a highly precise approach for studying protein interactions and developing antiviral agents in coronavirus research, particularly its advantage in measuring interactions with membrane proteins in their near-native plasma membrane environment.
Article
Medicine, General & Internal
Anne Zanchi, Andreas W. Jehle, Faiza Lamine, Bruno Vogt, Cecilia Czerlau, Stefan Bilz, Harald Seeger, Sophie de Seigneux
Summary: Diabetic kidney disease is highly prevalent in patients with type 2 diabetes and has become a major cause of end-stage renal disease in Switzerland. The consensus provides evidence-based guidance for the care of type 2 diabetic patients with diabetic kidney disease.
SWISS MEDICAL WEEKLY
(2023)
Article
Rheumatology
Duvuru Geetha, Anisha Dua, Huibin Yue, Jason Springer, Carlo Salvarani, David Jayne, Peter Merkel
Summary: This study evaluated the efficacy and safety of avacopan in a subgroup of patients with antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis receiving rituximab as background induction therapy. The results showed that avacopan was comparable to prednisone taper in achieving remission at week 26, but had greater efficacy at week 52. Additionally, avacopan was associated with improved renal outcomes and lower glucocorticoid toxicity.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Biochemistry & Molecular Biology
Emanuele Pignatti, Jakub Kollar, Evelyn Hafele, Daniela Schuster, Ronald E. Steele, Bruno Vogt, Christoph Schumacher, Michael Groessl
Summary: Aldosterone synthase is a promising drug target for cardiovascular disease, and its dysregulation can cause various diseases. A drug called dexfadrostat selectively inhibits aldosterone synthase and shows potential for clinical use. In clinical trials, dexfadrostat effectively reduces aldosterone levels without causing other side effects.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2023)
Meeting Abstract
Obstetrics & Gynecology
B. Vogt, N. Wolf, R. Faber, U. Thome, H. Stepan
GEBURTSHILFE UND FRAUENHEILKUNDE
(2023)
Article
Urology & Nephrology
Pietro Manuel Ferraro, Matteo Bargagli, Nicolas Faller, Manuel A. Anderegg, Uyen Huynh-Do, Bruno Vogt, Giovanni Gambaro, Daniel G. Fuster
Summary: This study identified uric acid supersaturation and several other urinary components as predictors of cyst growth in patients with ADPKD.
JOURNAL OF NEPHROLOGY
(2023)