Journal
NEUROSCIENCE LETTERS
Volume 450, Issue 3, Pages 246-251Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2008.11.070
Keywords
SIGN-R1; Rat CD209b; Microglia; Pattern-recognition receptors; Capsular polysaccharides; Pneumococcal meningitis
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Although Streptococcus pneumoniae is the major cause of meningitis, how it causes disease is poorly understood. The C-type lectin SIGN-R I mediates the recently described SIGN-RI complement activation pathway. which operates against capsular polysaccharides (CPSs) of S. pneumoniae in splenic marginal macrophages. Here, we demonstrate that SIGN-R1, as well as the rat SIGN-RI homologue CD209b are expressed in most regions of mouse or rat brain. respectively. Moreover, both C-type lectins are obviously expressed on microglia. but not on neurons or astrocytes. We also found that rat CD209b mediates the uptake of dextran or CPS 14 within the rat splenic marginal zone, similar to SIGN-R1 On microglia, rat CD209b also mediates the uptake of CPS 14 of S. pneumoniae. Our findings strongly suggest that both rat CD209b and SIGN-RI on microglia mediate the SIGN-RI complement activation pathway against S. pneumoniae, and thereby plays an important role in the pathogenesis of pneumococcal meningitis. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
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