Ceramide as a target of chemotherapy: its role in apoptosis and autophagy

Bcl-2 family members: Dual regulators of apoptosis and autophagy

(2014) Beth Levine et al.   Autophagy

Regulation of Autophagy by Sphingolipids

(2012) Carmen Bedia et al.   Anti-Cancer Agents in Medicinal Chemistry

Combinatorial therapies improve the therapeutic efficacy of nanoliposomal ceramide for pancreatic cancer

(2011) Yixing Jiang et al.   CANCER BIOLOGY & THERAPY

Resveratrol, a Phytochemical Inducer of Multiple Cell Death Pathways: Apoptosis, Autophagy and Mitotic Catastrophe

(2011) D. Delmas et al.   CURRENT MEDICINAL CHEMISTRY

Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis

(2011) J. Y. Guo et al.   GENES & DEVELOPMENT

Acid Ceramidase Expression Modulates the Sensitivity of A375 Melanoma Cells to Dacarbazine

(2011) Carmen Bedia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Many Ceramides

(2011) Yusuf A. Hannun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ceramide in Redox Signaling and Cardiovascular Diseases

(2010) Xiang Li et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Caspase-8 and caspase-7 sequentially mediate proteolytic activation of acid sphingomyelinase in TNF-R1 receptosomes

(2010) Bärbel Edelmann et al.   EMBO JOURNAL

Subcellular compartmentalization of TNF receptor-1 and CD95 signaling pathways

(2010) Vladimir Tchikov et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Sphingolipids and cancer: ceramide and sphingosine-1-phosphate in the regulation of cell death and drug resistance

(2010) Suriyan Ponnusamy et al.   Future Oncology

Nanoliposomal ceramide prevents in vivo growth of hepatocellular carcinoma

(2010) H. R. S. Tagaram et al.   GUT

Syntaxin 4 Is Required for Acid Sphingomyelinase Activity and Apoptotic Function

(2010) Cristiana Perrotta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FAN (factor associated with neutral sphingomyelinase activation), a moonlighting protein in TNF-R1 signaling

(2010) Anne Montfort et al.   JOURNAL OF LEUKOCYTE BIOLOGY

A Novel Sphingosine Kinase Inhibitor Induces Autophagy in Tumor Cells

(2010) V. Beljanski et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Transcriptional regulation of neutral sphingomyelinase 2 gene expression of a human breast cancer cell line, MCF-7, induced by the anti-cancer drug, daunorubicin

(2009) Hiromi Ito et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Disruption of Sphingosine 1-Phosphate Lyase Confers Resistance to Chemotherapy and Promotes Oncogenesis through Bcl-2/Bcl-xL Upregulation

(2009) S. Colie et al.   CANCER RESEARCH

Antiapoptotic roles of ceramide-synthase-6-generated C16-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways

(2009) Can E. Senkal et al.   FASEB JOURNAL

Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells

(2009) María Salazar et al.   JOURNAL OF CLINICAL INVESTIGATION

Ceramide synthase 6 modulates TRAIL sensitivity and nuclear translocation of active caspase-3 in colon cancer cells

(2009) S White-Gilbertson et al.   ONCOGENE

Synthesis and biological properties of Pachastrissamine (jaspine B) and diastereoisomeric jaspines

(2008) Daniel Canals et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Ceramide induces p38 MAPK and JNK activation through a mechanism involving a thioredoxin-interacting protein-mediated pathway

(2008) C.-L. Chen et al.   BLOOD

The sphingolipid salvage pathway in ceramide metabolism and signaling

(2008) Kazuyuki Kitatani et al.   CELLULAR SIGNALLING

Combining Nanoliposomal Ceramide with Sorafenib Synergistically Inhibits Melanoma and Breast Cancer Cell Survival to Decrease Tumor Development

(2008) M. A. Tran et al.   CLINICAL CANCER RESEARCH

De novo ceramide synthesis is responsible for the anti-tumor properties of camptothecin and doxorubicin in follicular thyroid carcinoma

(2008) Geraldine Rath et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Role of JNK1-dependent Bcl-2 Phosphorylation in Ceramide-induced Macroautophagy

(2008) Sophie Pattingre et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

JNK1-Mediated Phosphorylation of Bcl-2 Regulates Starvation-Induced Autophagy

(2008) Yongjie Wei et al.   MOLECULAR CELL

Principles of bioactive lipid signalling: lessons from sphingolipids

(2008) Yusuf A. Hannun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ceramide starves cells to death by downregulating nutrient transporter proteins

(2008) G. G. Guenther et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of macroautophagy by mTOR and Beclin 1 complexes

(2007) Sophie Pattingre et al.   BIOCHIMIE

Novel analogs of d-e-MAPP and B13. Part 2: Signature effects on bioactive sphingolipids

(2007) Alicja Bielawska et al.   BIOORGANIC & MEDICINAL CHEMISTRY