Journal
JOURNAL OF LEUKOCYTE BIOLOGY
Volume 88, Issue 5, Pages 897-903Publisher
WILEY
DOI: 10.1189/jlb.0410188
Keywords
NSMAF; ceramide; apoptosis; inflammation; immune response
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Funding
- INSERM
- Paul Sabatier University
- Genopole Toulouse-Midi-Pyrenees
- Association pour la Recherche sur le Cancer (ARC) [3417]
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TNF-alpha is a pleiotropic cytokine involved in the regulation of various biological effects, including cell survival and proliferation, cell differentiation, and cell death. Moreover, TNF-alpha triggers proinflammatory responses, essentially through its ability to promote the expression of various proinflammatory genes. Most of the biological effects initiated by TNF-alpha rely on its ability to bind to and activate TNF-R1. As a consequence, molecular complexes are being formed, resulting from the recruitment of multiple adaptor proteins to the intracellular TNF-R1 DD. The adaptor protein FAN constitutively binds to a proximal membrane domain of TNF-R1 called NSD. Herein, the role of FAN in TNF-alpha-induced cell signaling and biological responses is discussed. J. Leukoc. Biol. 88: 897-903; 2010.
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