Cyanoalkylation: Alkylnitriles in Catalytic CC Bond-Forming Reactions

Direct Coupling of Arylacetonitriles and Primary Alcohols to α-Alkylated Arylacetamides with Complete Atom Economy Catalyzed by a Rhodium Complex-Triphenylphosphine- Potassium Hydroxide System

(2015) Feng Li et al.   ADVANCED SYNTHESIS & CATALYSIS

Catalytic Asymmetric Mannich-Type Reaction ofN-Alkylidene-α-Aminoacetonitrile with Ketimines

(2015) Shaoquan Lin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Enantioselective Reaction of α-Aminoacetonitriles Using Chiral Bis(imidazoline) Palladium Catalysts

(2015) Masaru Kondo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Copper-Catalyzed Cyanomethylation of Allylic Alcohols with Concomitant 1,2-Aryl Migration: Efficient Synthesis of Functionalized Ketones Containing an α-Quaternary Center

(2015) Ala Bunescu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Copper-Catalyzed Intermolecular Carboetherification of Unactivated Alkenes by Alkyl Nitriles and Alcohols

(2015) Claire Chatalova-Sazepin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective α-Alkylation of Aldehydes by Photoredox Organocatalysis: Rapid Access to Pharmacophore Fragments from β-Cyanoaldehydes

(2015) Eric R. Welin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Silver(i) NHC mediated C–C bond activation of alkyl nitriles and catalytic efficiency in oxazoline synthesis

(2015) Rachael Heath et al.   CHEMICAL COMMUNICATIONS

A radical anti-Markovnikov addition of alkyl nitriles to simple alkenes via selective sp3 C–H bond functionalization

(2015) Zejiang Li et al.   CHEMICAL COMMUNICATIONS

Oxidative radical 1,2-alkylarylation of alkenes with α-C(sp3)–H bonds of acetonitriles involving 1,2-aryl migration

(2015) Yang Li et al.   CHEMICAL COMMUNICATIONS

Catalytic Asymmetric 1,4-Addition Reactions of Simple Alkylnitriles

(2015) Yasuhiro Yamashita et al.   Chemistry-An Asian Journal

α-Alkyl-α-aryl (Trimethyltin) Nitriles: Versatile Nucleophilic Intermediates in Aldol-Like Reactions

(2015) Wenling Qin et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Enantioselective Rhodium-Catalyzed Allylic Substitution with a Nitrile Anion: Construction of Acyclic Quaternary Carbon Stereogenic Centers

(2015) Ben W. H. Turnbull et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of Functionalized Epoxides by Copper-Catalyzed Alkylative Epoxidation of Allylic Alcohols with Alkyl Nitriles

(2015) Ala Bunescu et al.   ORGANIC LETTERS

DIAD as a promoter for cyanomethylation of alkenes by Cu catalysis

(2015) Shi Tang et al.   TETRAHEDRON LETTERS

Enantioselective Construction of Vicinal Tetrasubstituted Stereocenters by the Mannich Reaction of Silyl Ketene Imines with Isatin-Derived Ketimines

(2014) Jiannan Zhao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Radical cascade cyanomethylation of activated alkenes to construct cyano substituted oxindoles

(2014) Juan Li et al.   CHEMICAL COMMUNICATIONS

Direct Catalytic Addition of Alkylnitriles to Aldehydes by Transition-Metal/NHC Complexes

(2014) Devarajulu Sureshkumar et al.   CHEMISTRY-A EUROPEAN JOURNAL

Cover Picture: Direct Catalytic Addition of Alkylnitriles to Aldehydes by Transition-Metal/NHC Complexes (Chem. Eur. J. 48/2014)

(2014) Devarajulu Sureshkumar et al.   CHEMISTRY-A EUROPEAN JOURNAL

Ureidopeptide-Based Brønsted Bases: Design, Synthesis and Application to the Catalytic Enantioselective Synthesis of β-Amino Nitriles from (Arylsulfonyl)acetonitriles

(2014) Saioa Diosdado et al.   CHEMISTRY-A EUROPEAN JOURNAL

Copper-Mediated/Catalyzed Oxyalkylation of Alkenes with Alkylnitriles

(2014) Ala Bunescu et al.   CHEMISTRY-A EUROPEAN JOURNAL

POP–Pincer Ruthenium Complexes: d6 Counterparts of Osmium d4 Species

(2014) Joaquín Alós et al.   INORGANIC CHEMISTRY

Organocatalytic asymmetric decarboxylative cyanomethylation of isatins using l-proline derived bifunctional thiourea

(2014) V. Pratap Reddy Gajulapalli et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Activation of Alcohols with Carbon Dioxide: Intermolecular Allylation of Weakly Acidic Pronucleophiles

(2014) Simon B. Lang et al.   ORGANIC LETTERS

Copper-Catalyzed Aerobic Oxidative Coupling of Aromatic Alcohols and Acetonitrile to β-Ketonitriles

(2014) Jiaxuan Shen et al.   ORGANIC LETTERS

Nucleophilic Addition Reactions of Nitriles to Nitrones under Mild Silylation Conditions

(2014) Fumihiko Yoshimura et al.   SYNLETT

Concise enantioselective synthesis of δ,δ-disubstituted δ-valerolactones

(2014) Akira Saito et al.   TETRAHEDRON LETTERS

Copper-catalyzed cyanoalkylarylation of activated alkenes with AIBN: a convenient and efficient approach to cyano-containing oxindoles

(2014) Wei Wei et al.   RSC Advances

Remarkable Configurational Stability of Magnesiated Nitriles

(2013) Graeme Barker et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric Synthesis of β-Amino Nitriles through a ScIII-Catalyzed Three-Component Mannich Reaction of Silyl Ketene Imines

(2013) Jiannan Zhao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Robust Nickel Catalyst for Cyanomethylation of Aldehydes: Activation of Acetonitrile under Base-Free Conditions

(2013) Sumit Chakraborty et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Direct catalytic asymmetric addition of acetonitrile to N-thiophosphinoylimines

(2013) Yuji Kawato et al.   CHEMICAL COMMUNICATIONS

Metalated nitriles: N- and C-coordination preferences of Li, Mg, and Cu cations

(2013) Matthew Purzycki et al.   CHEMICAL COMMUNICATIONS

A Strategy Enabling Enantioselective Direct Conjugate Addition of Inert Aryl Methane Nucleophiles to Enals with a Chiral Amine Catalyst under Mild Conditions

(2013) Tengfei Li et al.   CHEMISTRY-A EUROPEAN JOURNAL

Catalytic Enantioselective Decarboxylative Cyanoalkylation of Imines by Using Palladium Pincer Complexes withC2-Symmetric Chiral Bis(imidazoline)s

(2013) Kengo Hyodo et al.   CHEMISTRY-A EUROPEAN JOURNAL

Quantification of the Nucleophilic Reactivities of Ethyl Arylacetate Anions

(2013) Francisco Corral-Bautista et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

p-Nitrophenyl Ethylthioester in Enantioselective Organocatalytic Michael Additions: Different Behaviour of β-Aryl and β-Alkyl Enals

(2013) Sara Duce et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Asymmetric Organocatalytic Benzylation of α,β-Unsaturated Aldehydes with Toluenes

(2013) Luca Dell'Amico et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Catalytic Asymmetric Protonation of Silyl Ketene Imines

(2013) Joyram Guin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Palladium-Catalyzed sp2 and sp3 C–H Bond Activation and Addition to Isatin toward 3-Hydroxy-2-oxindoles

(2013) Gang-Wei Wang et al.   ORGANIC LETTERS

Nucleophilic Addition of α-(Dimethylsilyl)nitriles to Aldehydes and Ketones

(2013) Takaaki Jinzaki et al.   ORGANIC LETTERS

Osmium Catalyst for the Borrowing Hydrogen Methodology: α-Alkylation of Arylacetonitriles and Methyl Ketones

(2013) María L. Buil et al.   ACS Catalysis

Silyl Ketene Imines: Highly Versatile Nucleophiles for Catalytic, Asymmetric Synthesis

(2012) Scott E. Denmark et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective Aza-Morita-Baylis-Hillman Reactions of Acrylonitrile Catalyzed by Palladium(II) Pincer Complexes havingC2-Symmetric Chiral Bis(imidazoline) Ligands

(2012) Kengo Hyodo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Lewis Base Catalyzed Enantioselective Additions of an N-Silyl Vinylketene Imine

(2012) Scott E. Denmark et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Palladium-Catalyzed Cross-Coupling: A Historical Contextual Perspective to the 2010 Nobel Prize

(2012) Carin C. C. Johansson Seechurn et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Role of quaternary ammonium salts as new additives in the enantioselective organocatalytic β-benzylation of enals

(2012) Sara Duce et al.   CHEMICAL COMMUNICATIONS

Direct Catalytic Asymmetric Addition of Allylic Cyanides to Aldehydes for Expeditious Access to Enantioenriched Unsaturated δ-Valerolactones

(2012) Yasunari Otsuka et al.   Chemistry-An Asian Journal

First Intramolecular Alkylation of Nitriles with Primary and Secondary Alcohols Catalyzed by Iridium Complexes

(2012) Bruno Anxionnat et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Intramolecular Conjugate Addition of α,β-Unsaturated Lactones Having an Alkanenitrile Side Chain: Stereocontrolled Construction of Carbocycles with Quaternary Carbon Atoms

(2012) Fumihiko Yoshimura et al.   SYNLETT

Catalytic Mannich-type reactions of α-aminoacetonitrile using fluorenylidene as a protecting and activating group

(2012) Yasuhiro Yamashita et al.   TETRAHEDRON

N-Heterocyclic carbene-catalyzed cyanomethylation of aldehydes with TMSAN

(2012) Ye-Cheng Fan et al.   TETRAHEDRON LETTERS

Enantioselective Reaction of Imines and Benzyl Nitriles Using Palladium Pincer Complexes withC2-Symmetric Chiral Bis(imidazoline)s

(2011) Kengo Hyodo et al.   ADVANCED SYNTHESIS & CATALYSIS

Asymmetric Synthesis of Isothiazoles through Cu Catalysis: Direct Catalytic Asymmetric Conjugate Addition of Allyl Cyanide to α,β-Unsaturated Thioamides

(2011) Yuka Yanagida et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Palladium-Catalyzed Oxidative Arylalkylation of Activated Alkenes: Dual CH Bond Cleavage of an Arene and Acetonitrile

(2011) Tao Wu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Decarboxylative benzylation and arylation of nitriles

(2011) Antonio Recio et al.   CHEMICAL COMMUNICATIONS

Organocatalytic trifluoromethylation of imines using phase-transfer catalysis with phenoxides. A general platform for catalytic additions of organosilanes to imines

(2011) Luca Bernardi et al.   CHEMICAL COMMUNICATIONS

Iridium-catalyzed α-Alkylation of Acetonitrile with Primary and Secondary Alcohols

(2011) Takuya Sawaguchi et al.   CHEMISTRY LETTERS

One-Pot Nitrile Aldolization/Hydration Operation Giving β-Hydroxy Carboxamides

(2011) Akihiro Goto et al.   Chemistry-An Asian Journal

Palladium-Catalyzed Cyanomethylation of Aryl Halides through Domino Suzuki Coupling–Isoxazole Fragmentation

(2011) Juraj Velcicky et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

An organocatalytic approach to enantiomerically enriched α-arylcyclohexenones and cyclohexanones

(2011) Sara Duce et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Highly Enantioselective Mannich Reactions with α-Aryl Silyl Ketene Acetals and Imines

(2011) Gregory T. Notte et al.   ORGANIC LETTERS

A New Synthesis of Pyrrolidines by Way of an Enantioselective Mannich/Diastereoselective Hydroamination Reaction Sequence

(2011) Jenny M. Baxter Vu et al.   ORGANIC LETTERS

Pd-Catalyzed α-Arylation of Nitriles and Esters and γ-Arylation of Unsaturated Nitriles with TMPZnCl·LiCl

(2011) Stéphanie Duez et al.   ORGANIC LETTERS

Coordinating Sulfonyl Substrates in Metal-Catalyzed Reactions

(2011) Jorge Hernández et al.   PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS

Cu(I)-catalyzed decarboxylative aldol-type and Mannich-type reactions for asymmetric construction of contiguous trisubstituted and quaternary stereocenters

(2011) Liang Yin et al.   TETRAHEDRON

Organocatalytic conjugate addition of 2-arylacetates and 2-arylacetonitriles having an electron-withdrawing group to α,β-unsaturated ketones

(2011) Jungho Do et al.   TETRAHEDRON LETTERS

Metal-Catalyzed α-Arylation of Carbonyl and Related Molecules: Novel Trends in CC Bond Formation by CH Bond Functionalization

(2010) Carin C. C. Johansson et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Asymmetric 1,3-Dipolar Cycloaddition of α-Iminonitriles

(2010) Rocío Robles-Machín et al.   CHEMISTRY-A EUROPEAN JOURNAL

Nitrile-Containing Pharmaceuticals: Efficacious Roles of the Nitrile Pharmacophore

(2010) Fraser F. Fleming et al.   JOURNAL OF MEDICINAL CHEMISTRY

Direct Catalytic Asymmetric Addition of Allyl Cyanide to Ketones via Soft Lewis Acid/Hard Brønsted Base/Hard Lewis Base Catalysis

(2010) Ryo Yazaki et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

N-silyl oxyketene imines are underused yet highly versatile reagents for catalytic asymmetric synthesis

(2010) Scott E. Denmark et al.   Nature Chemistry

Nitrophenylacetonitriles as Versatile Nucleophiles in Enantioselective Organocatalytic Conjugate Additions

(2010) M. Belén Cid et al.   ORGANIC LETTERS

Construction of Quaternary Stereogenic Carbon Centers by the Lewis Base Catalyzed Conjugate Addition of Silyl Ketene Imines to α,β-Unsaturated Aldehydes and Ketones

(2010) Scott Denmark et al.   SYNLETT

Dialkylamino cyclopentadienyl ruthenium(ii) complex-catalyzed α-alkylation of arylacetonitriles with primary alcohols

(2009) Hung Wai Cheung et al.   DALTON TRANSACTIONS

Product-Catalyzed Addition of Alkyl Nitriles to Unactivated Imines Promoted by Sodium Aryloxide/Ethyl(trimethylsilyl)acetate (ETSA) Combination

(2009) Thomas Poisson et al.   JOURNAL OF ORGANIC CHEMISTRY

Nucleophile Generation via Decarboxylation: Asymmetric Construction of Contiguous Trisubstituted and Quaternary Stereocenters through a Cu(I)-Catalyzed Decarboxylative Mannich-Type Reaction

(2009) Liang Yin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Direct Catalytic Asymmetric Addition of Allyl Cyanide to Ketones

(2009) Ryo Yazaki et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

RhI-catalyzed aldol-type reaction of organonitriles under mild conditions

(2008) Akihiro Goto et al.   CHEMICAL COMMUNICATIONS

Asymmetric organocatalysis by chiral Brønsted bases: implications and applications

(2008) Claudio Palomo et al.   CHEMICAL SOCIETY REVIEWS

Direct Catalytic Asymmetric Addition of Allylic Cyanides to Ketoimines

(2008) Ryo Yazaki et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stereoselective Pincer-Complex Catalyzed C-H Functionalization of Benzyl Nitriles under Mild Conditions. An Efficient Route to β-Aminonitriles

(2008) Juhanes Aydin et al.   ORGANIC LETTERS

Catalytic cyanomethylation of carbonyl compounds and imines with highly basic phosphine

(2008) Satoru Matsukawa et al.   TETRAHEDRON LETTERS