Journal
ORGANIC LETTERS
Volume 13, Issue 4, Pages 816-818Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol103096u
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- National Science Foundation [CHE-08-09659]
- National Institute of General Medical Sciences [F32-GM080859]
- Novartis
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [0809659] Funding Source: National Science Foundation
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Mannich reactions with chiral silicon Lewis acid activated acylhydrazones and alpha-aryl silyl ketene acetals and alpha-aryl,alpha-alkyl silyl ketene imines proceed efficiently and with good to excellent levels of both diastereoselectivity and enantioselectivity. The reactions provide access to alpha-aryl, beta-hydrazido esters and alpha-aryl,alpha-alkyl,beta-hydrazido nitriles, which are valuable analogs of beta-amino acids.
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