Linking genetics to epigenetics: The role of folate and folate-related pathways in neurodevelopmental disorders

Gene-specific DNA methylation in newborns in response to folic acid supplementation during the second and third trimesters of pregnancy: epigenetic analysis from a randomized controlled trial

(2018) Aoife Caffrey et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Genetic variants of the folate metabolic system and mild hyperhomocysteinemia may affect ADHD associated behavioral problems

(2018) Tanusree Saha et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Association Study of Polymorphisms in Genes Relevant to Vitamin B12 and Folate Metabolism with Childhood Autism Spectrum Disorder in a Han Chinese Population

(2018) Zengyu Zhang et al.   MEDICAL SCIENCE MONITOR

Components of the folate metabolic pathway and ADHD core traits: an exploration in eastern Indian probands

(2017) Tanusree Saha et al.   JOURNAL OF HUMAN GENETICS

Epigenetic Etiology of Intellectual Disability

(2017) Shigeki Iwase et al.   JOURNAL OF NEUROSCIENCE

Reelin (RELN) DNA methylation in the peripheral blood of schizophrenia

(2017) Rahim Mohd Nabil Fikri et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Functional convergence of histone methyltransferases EHMT1 and KMT2C involved in intellectual disability and autism spectrum disorder

(2017) Tom S. Koemans et al.   PLoS Genetics

Moderate folic acid supplementation and MTHFD1-synthetase deficiency in mice, a model for the R653Q variant, result in embryonic defects and abnormal placental development

(2016) Karen E Christensen et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

The metabolic basis for developmental disorders due to defective folate transport

(2016) Ankuri Desai et al.   BIOCHIMIE

Genetic and environmental modulation of neurodevelopmental disorders: Translational insights from labs to beds

(2016) Judith R. Homberg et al.   BRAIN RESEARCH BULLETIN

Differential methylation at the RELN gene promoter in temporal cortex from autistic and typically developing post-puberal subjects

(2016) Carla Lintas et al.   Journal of Neurodevelopmental Disorders

Association of methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism with autism: evidence of genetic susceptibility

(2016) Vandana Rai   METABOLIC BRAIN DISEASE

Epigenetic profiling of ADHD symptoms trajectories: a prospective, methylome-wide study

(2016) E Walton et al.   MOLECULAR PSYCHIATRY

The landscape of DNA methylation amid a perfect storm of autism aetiologies

(2016) Annie Vogel Ciernia et al.   NATURE REVIEWS NEUROSCIENCE

DNA methylation in the gene body influences MeCP2-mediated gene repression

(2016) Benyam Kinde et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clinical utility of folate pathway genetic polymorphisms in the diagnosis of autism spectrum disorders

(2016) Naushad Shaik Mohammad et al.   PSYCHIATRIC GENETICS

Epigenetic RELN Dysfunction in Schizophrenia and Related Neuropsychiatric Disorders

(2016) Alessandro Guidotti et al.   Frontiers in Cellular Neuroscience

The interplay between DNA methylation, folate and neurocognitive development

(2016) Rachelle E Irwin et al.   Epigenomics

Genes with high penetrance for syndromic and non-syndromic autism typically function within the nucleus and regulate gene expression

(2016) Emily L. Casanova et al.   Molecular Autism

DNA Methylation Profiling at Single-Base Resolution Reveals Gestational Folic Acid Supplementation Influences the Epigenome of Mouse Offspring Cerebellum

(2016) Subit Barua et al.   Frontiers in Neuroscience

Maternal folate status as a risk factor for autism spectrum disorders: a review of existing evidence

(2015) Elizabeth A. DeVilbiss et al.   BRITISH JOURNAL OF NUTRITION

Methylomic trajectories across human fetal brain development

(2015) Helen Spiers et al.   GENOME RESEARCH

Multiple epigenetic factors predict the attention deficit/hyperactivity disorder among the Chinese Han children

(2015) Yi Xu et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Disruption of DNA-methylation-dependent long gene repression in Rett syndrome

(2015) Harrison W. Gabel et al.   NATURE

Mapping DNA methylation across development, genotype and schizophrenia in the human frontal cortex

(2015) Andrew E Jaffe et al.   NATURE NEUROSCIENCE

Insights into Autism Spectrum Disorder Genomic Architecture and Biology from 71 Risk Loci

(2015) Stephan J. Sanders et al.   NEURON

MeCP2 binds to non-CG methylated DNA as neurons mature, influencing transcription and the timing of onset for Rett syndrome

(2015) Lin Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Diverse Genetic Landscape of Neurodevelopmental Disorders

(2014) Wen F. Hu et al.   Annual Review of Genomics and Human Genetics

Mutations in the DNA methyltransferase gene DNMT3A cause an overgrowth syndrome with intellectual disability

(2014) Katrina Tatton-Brown et al.   NATURE GENETICS

A Pilot Study on the Contribution of Folate Gene Variants in the Cognitive Function of ADHD Probands

(2014) T. Saha et al.   NEUROCHEMICAL RESEARCH

B vitamin polymorphisms and behavior: Evidence of associations with neurodevelopment, depression, schizophrenia, bipolar disorder and cognitive decline

(2014) E. Siobhan Mitchell et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Determinants of maternal pregnancy one-carbon metabolism and newborn human DNA methylation profiles

(2014) Nina H van Mil et al.   REPRODUCTION

Whole-genome analysis of 5-hydroxymethylcytosine and 5-methylcytosine at base resolution in the human brain

(2014) Lu Wen et al.   GENOME BIOLOGY

DNA methylation analysis of the autistic brain reveals multiple dysregulated biological pathways

(2014) S Nardone et al.   Translational Psychiatry

Genome-wide DNA methylation analysis of human brain tissue from schizophrenia patients

(2014) L F Wockner et al.   Translational Psychiatry

Folic Acid for the Prevention of Neural Tube Defects: U.S. Preventive Services Task Force Recommendation Statement

(2013)   ANNALS OF INTERNAL MEDICINE

Gene-Environment Interactions and Epigenetic Pathways in Autism: The Importance of One-Carbon Metabolism

(2013) L. R. Schaevitz et al.   ILAR JOURNAL

Association Between Maternal Use of Folic Acid Supplements and Risk of Autism Spectrum Disorders in Children

(2013) Pål Surén et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Charting a dynamic DNA methylation landscape of the human genome

(2013) Michael J. Ziller et al.   NATURE

MTHFR 1298A>C is a risk factor for autism spectrum disorder in the Korean population

(2013) JungWon Park et al.   PSYCHIATRY RESEARCH

Global Epigenomic Reconfiguration During Mammalian Brain Development

(2013) R. Lister et al.   SCIENCE

Maternal periconceptional folic acid intake and risk of autism spectrum disorders and developmental delay in the CHARGE (CHildhood Autism Risks from Genetics and Environment) case-control study

(2012) Rebecca J Schmidt et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Methylenetetrahydrofolate Reductase Polymorphisms C677T and Risk of Autism in the Chinese Han Population

(2012) Tianyou Guo et al.   Genetic Testing and Molecular Biomarkers

Methylenetetrahydrofolate Reductase Gene Polymorphisms in Children with Attention Deficit Hyperactivity Disorder

(2012) Cem Gokcen et al.   International Journal of Medical Sciences

Folate and DNA Methylation: A Review of Molecular Mechanisms and the Evidence for Folate's Role

(2012) Krista S. Crider et al.   Advances in Nutrition

Prenatal Vitamins, One-carbon Metabolism Gene Variants, and Risk for Autism

(2011) Rebecca J. Schmidt et al.   EPIDEMIOLOGY

Excess folate during adolescence suppresses thyroid function with permanent deficits in motivation and spatial memory

(2011) L. J. Sittig et al.   GENES BRAIN AND BEHAVIOR

Methylenetetrahydrofolate Reductase Gene Polymorphisms in Turkish Children with Attention-Deficit/Hyperactivity Disorder

(2011) Emel Ergul et al.   Genetic Testing and Molecular Biomarkers

Tissue-specific distribution of aberrant DNA methylation associated with maternal low-folate status in human neural tube defects

(2011) Huibo Chang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Importance of gene variants and co-factors of folate metabolic pathway in the etiology of idiopathic intellectual disability

(2011) Samikshan Dutta et al.   NUTRITIONAL NEUROSCIENCE

Tet Proteins Can Convert 5-Methylcytosine to 5-Formylcytosine and 5-Carboxylcytosine

(2011) S. Ito et al.   SCIENCE

Association of folate receptor (folr1, folr2, folr3) and reduced folate carrier (slc19a1) genes with meningomyelocele

(2010) Michelle R. O'Byrne et al.   BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY

Folate regulation of axonal regeneration in the rodent central nervous system through DNA methylation

(2010) Bermans J. Iskandar et al.   JOURNAL OF CLINICAL INVESTIGATION

Higher Maternal Plasma Folate but Not Vitamin B-12 Concentrations during Pregnancy Are Associated with Better Cognitive Function Scores in 9- to 10- Year-Old Children in South India

(2010) Sargoor R. Veena et al.   JOURNAL OF NUTRITION

MTHFR C677T is not a risk factor for autism spectrum disorders in South Brazil

(2010) Pollyanna Almeida Costa dos Santos et al.   PSYCHIATRIC GENETICS

Genomic and epigenetic evidence for oxytocin receptor deficiency in autism

(2009) Simon G Gregory et al.   BMC Medicine

Lower maternal folate status in early pregnancy is associated with childhood hyperactivity and peer problems in offspring

(2009) Wolff Schlotz et al.   JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY

Human DNA methylomes at base resolution show widespread epigenomic differences

(2009) Ryan Lister et al.   NATURE

Novel variants identified in methyl-CpG-binding domain genes in autistic individuals

(2009) Holly N. Cukier et al.   NEUROGENETICS

Correlation between cystathionine beta synthase gene polymorphisms, plasma homocysteine and idiopathic mental retardation in Indian individuals from Kolkata

(2009) Samikshan Dutta et al.   NEUROSCIENCE LETTERS

Aberrations in folate metabolic pathway and altered susceptibility to autism

(2009) Naushad Shaik Mohammad et al.   PSYCHIATRIC GENETICS

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

(2009) M. Tahiliani et al.   SCIENCE

One carbon metabolism disturbances and the C677T MTHFR gene polymorphism in children with autism spectrum disorders

(2008) Sergiu P. Paşca et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Screening for methylenetetrahydrofolate reductase C677T and A1298C polymorphisms in Indian patients with idiopathic mental retardation

(2008) Samikshan Dutta et al.   NUTRITIONAL NEUROSCIENCE