Article
Biochemistry & Molecular Biology
Victor Lazarenko, Mikhail Churilin, Iuliia Azarova, Elena Klyosova, Marina Bykanova, Natalia Ob'edkova, Mikhail Churnosov, Olga Bushueva, Galina Mal, Sergey Povetkin, Stanislav Kononov, Yulia Luneva, Sergey Zhabin, Anna Polonikova, Alina Gavrilenko, Igor Saraev, Maria Solodilova, Alexey Polonikov
Summary: The study investigated the role of lipid-associated loci identified by GWAS in the molecular pathogenesis of CAD. Specific gene polymorphisms were found to be significantly associated with CAD risk, independent of demographic factors. Bioinformatics analysis revealed that these loci might act as allele-specific binding sites for transcription factors controlling atherosclerosis mechanisms.
Article
Cardiac & Cardiovascular Systems
Matthew K. Armstrong, Brooklyn J. Fraser, Olli Hartiala, Marie-Jeanne Buscot, Markus Juonala, Feitong Wu, Juha Koskinen, Nina Hutri-Kahonen, Mika Kahonen, Tomi P. Laitinen, Terho Lehtimaki, Jorma S. A. Viikari, Olli T. Raitakari, Costan G. Magnussen
Summary: The study shows that elevated non-HDL-C levels at different life stages are associated with coronary atherosclerosis in mid-adulthood, with adolescent non-HDL-C levels showing the strongest association.
Article
Pharmacology & Pharmacy
Stanislav Kononov, Galina Mal, Iuliia Azarova, Elena Klyosova, Marina Bykanova, Mikhail Churnosov, Alexey Polonikov
Summary: The study identified significant associations between polymorphisms in genes like MYLIP, APOC1, LDLR, and APOE with CAD susceptibility, CIMT regression, and changes in plasma lipids during rosuvastatin therapy. These findings demonstrate the important impact of genetic polymorphisms on disease development and treatment response in coronary artery disease patients.
Article
Biochemistry & Molecular Biology
Vaishali Narendra Naik, R. S. Gamad, P. P. Bansod
Summary: This study investigates the effects of three despeckle filters on the segmentation of carotid IMT in ultrasound images. The results show that the median filter performs better than the hybrid median and IACDF filters.
BIOMEDICAL JOURNAL
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Jean-Baptiste Moretti, Reinemary Michael, Sylvie Gervais, Emilie Alchourron, Nina Stein, Ziad Farhat, Chantal Lapierre, Josee Dubois, Ramy El-Jalbout
Summary: This study aimed to determine the normal pediatric values of carotid artery intima-media thickness (IMT) by conducting a systematic review of the literature. The results showed that the average IMT in children using B-mode and radiofrequency techniques were 0.43mm and 0.41mm respectively. No significant relationship was found between IMT and age or sex.
EUROPEAN RADIOLOGY
(2023)
Article
Environmental Sciences
Yue Leon Guo, Rosario D. Ampon, Ivan C. Hanigan, Luke D. Knibbs, Christy Geromboux, Ta-Chen Su, Kazuaki Negishi, Leanne Poulos, Geoffrey G. Morgan, Guy B. Marks, Bin Jalaludin
Summary: The study found that long-term exposure to low levels of PM2.5 in children may have measurable adverse impacts on cardiovascular risk marker, carotid intima-media thickness (CIMT), by age 11-12 years.
ENVIRONMENTAL POLLUTION
(2021)
Article
Multidisciplinary Sciences
Gustavo Lara Rezende, Leonel Alves Oliveira, Renata Oliveira Soares, Fabiana Pirani Carneiro, Marcio Nakanishi, Sonia Nair Bao, Andre Luiz Lopes Sampaio, Selma Aparecida Souza Kuckelhaus
Summary: This study demonstrates that arterial hypertension may cause structural lesions in the vascular layers, increasing the risk of vascular rupture. The histology of the microvasculature associated with the mucosa of the posterior nasal cavity shows changes related to hypertension, which may be particularly significant during hypertensive peaks.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Ji Bian, Man Zhang, Feng Li, Jie Gao, Zhexue Wei, Zijing Liu, Xiaoming Wang, Wen Jiang, Jianchao Bian
Summary: Excess iodine intake has been shown to increase the risk of carotid intima-media thickening, potentially leading to vascular injury and atherosclerosis.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Article
Medicine, General & Internal
Ettore Dinoto, Domenico Mirabella, Francesca Ferlito, Graziella Tortomasi, Davide Turchino, Salvatore Evola, Massimiliano Zingales, Emanuela Bologna, Felice Pecoraro
Summary: The intima-media thickness (IMT) and its irregularities or ulcerations in the common carotid artery (CCA) can serve as biomarkers for cardiovascular system integrity. Total homocysteine and lipoprotein levels are commonly used for cardiovascular risk stratification. Duplex ultrasound (DUS) combined with serum biomarkers can assess atherosclerotic disease and cardiovascular risk effectively.
Article
Public, Environmental & Occupational Health
Fred Stephen Sarfo, Jenifer Voeks, Sheila Adamu, Benedict Apaw Agyei, Manolo Agbenorku, Nyantakyi Adu-Darko, Mercy Adomah Oteng, Vida Obese, Rexford Adu Gyamfi, Nathaniel Adusei Mensah, Raelle Tagge, Michael Ampofo, Samuel Amoabeng Kontoh, Samuel Blay Nguah, Bruce Ovbiagele
Summary: The study compared the effects of a cardiovascular polypill with usual care on carotid intima-media thickness (CIMT) regression after ischaemic stroke. Results showed similar CIMT changes in both groups at 12 months, but more serious adverse events occurred in the polypill group. Larger, longer-term event-based studies are needed to further understand the impact of polypill regimens on stroke survivors.
LANCET GLOBAL HEALTH
(2023)
Article
Cardiac & Cardiovascular Systems
Mengyuan Miao, Guo Zhou, Anran Bao, Yaming Sun, Huaping Du, Liyan Song, Yongjun Cao, Shoujiang You, Chongke Zhong
Summary: This study found an association between TyG index and carotid atherosclerosis in patients with ischemic stroke, suggesting that TyG could be a promising marker for atherosclerosis.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Clinical Neurology
Yan Song, Jinru Yang, Qiaoling Zhao, Yunfei Bai, Litao Ruan
Summary: This study investigated the relationship between remnant cholesterol and carotid artery intima-media thickness (cIMT) in a community population with normal LDL-C levels. The results showed that as remnant cholesterol levels increased, the rate of abnormal cIMT also increased in the community population. This suggests that remnant cholesterol may be an important indicator for risk stratification in community population with normal LDL-C levels.
CEREBROVASCULAR DISEASES
(2023)
Article
Medicine, General & Internal
Daniel Goeder, Renate Oberhoffer-Fritz, Leon Brudy, Laura Willinger, Michael Meyer, Peter Ewert, Jan Mueller
Summary: The study found that patients with Tetralogy of Fallot (ToF) have reduced endothelial function, indicating cardiovascular risk, but no changes in vascular structure. Therefore, long-term management of these patients should include evaluation of vascular parameters.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Environmental Sciences
Johan Nilsson Sommar, Margareta Norberg, Christer Gronlund, David Segersson, Ulf Naslund, Bertil Forsberg
Summary: This study estimated the association between long-term exposure to particulate air pollution and sub-clinical atherosclerosis, finding that particle concentrations were related to plaque presence but not associated with plaque progression or carotid intima-media thickness.
ENVIRONMENTAL RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Joseph F. Polak, Jye-Yu C. Backlund, Matt Budoff, Philip Raskin, Ionut Bebu, John M. Lachin
Summary: In individuals with type 1 diabetes, common carotid artery IMT is weakly associated with subsequent coronary artery events, but this association disappears after adjusting for traditional cardiovascular risk factors. There is no significant association between internal carotid artery IMT and coronary artery disease events.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Geriatrics & Gerontology
Laura Kananen, Mikko Hurme, Alexander Buerkle, Maria Moreno-Villanueva, Jurgen Bernhardt, Florence Debacq-Chainiaux, Beatrix Grubeck-Loebenstein, Marco Malavolta, Andrea Basso, Francesco Piacenza, Sebastiano Collino, Efstathios S. Gonos, Ewa Sikora, Daniela Gradinaru, Eugene H. J. M. Jansen, Martijn E. T. Dolle, Michel Salmon, Wolfgang Stuetz, Daniela Weber, Tilman Grune, Nicolle Breusing, Andreas Simm, Miriam Capri, Claudio Franceschi, Eline Slagboom, Duncan Talbot, Claude Libert, Jani Raitanen, Seppo Koskinen, Tommi Harkanen, Sari Stenholm, Mika Ala-Korpela, Terho Lehtimaki, Olli T. Raitakari, Olavi Ukkola, Mika Kahonen, Marja Jylha, Juulia Jylhava
Summary: Circulating cell-free DNA (cf-DNA) levels are associated with age, sex, smoking, physical activity, vegetable consumption, ageing phenotypes, and various biomarkers. Higher cf-DNA levels were found in men, especially middle-aged men and women who smoke, and older frail individuals. Inflammatory markers, metabolites, and antioxidant levels were correlated with cf-DNA levels. These findings have implications for future studies on the epidemiology and biological mechanisms of cf-DNA and its potential as a clinical marker.
Article
Cardiac & Cardiovascular Systems
Olli Raitakari, Noora Kartiosuo, Katja Pahkala, Nina Hutri-Kahonen, Lydia A. Bazzano, Wei Chen, Elaine M. Urbina, David R. Jacobs Jr, Alan Sinaiko, Julia Steinberger, Trudy Burns, Stephen R. Daniels, Alison Venn, Jessica G. Woo, Terry Dwyer, Markus Juonala, Jorma Viikari
Summary: Elevated Lp(a) level in youth is associated with increased risk of adult atherosclerotic cardiovascular disease outcomes, but not with increased carotid intima-media thickness. This conclusion was derived from two similar studies.
Article
Multidisciplinary Sciences
Mitja Kurki, Juha Karjalainen, Priit Palta, Timo P. Sipila, Kati Kristiansson, Kati M. Donner, Mary P. Reeve, Hannele Laivuori, Mervi Aavikko, Mari A. Kaunisto, Anu Loukola, Elisa Lahtela, Hannele Mattsson, Paivi Laiho, Pietro Della Briotta Parolo, Arto A. Lehisto, Masahiro Kanai, Nina Mars, Joel Ramo, Tuomo Kiiskinen, Henrike O. Heyne, Kumar Veerapen, Sina Rueger, Susanna Lemmela, Wei Zhou, Sanni Ruotsalainen, Kalle Parn, Tero Hiekkalinna, Sami Koskelainen, Teemu Paajanen, Vincent Llorens, Javier Gracia-Tabuenca, Harri Siirtola, Kadri Reis, Abdelrahman G. Elnahas, Benjamin Sun, Christopher N. Foley, Katriina Aalto-Setala, Kaur Alasoo, Mikko Arvas, Kirsi Auro, Shameek Biswas, Argyro Bizaki-Vallaskangas, Olli Carpen, Chia-Yen Chen, Oluwaseun A. Dada, Zhihao Ding, Margaret G. Ehm, Kari Eklund, Martti Farkkila, Hilary Finucane, Andrea Ganna, Awaisa Ghazal, Robert R. Graham, Eric M. Green, Antti Hakanen, Marco Hautalahti, Asa K. Hedman, Mikko Hiltunen, Reetta Hinttala, Iiris Hovatta, Xinli Hu, Adriana Huertas-Vazquez, Laura Huilaja, Julie Hunkapiller, Howard Jacob, Jan-Nygaard Jensen, Heikki Joensuu, Sally John, Valtteri Julkunen, Marc Jung, Juhani Junttila, Kai Kaarniranta, Mika Kahonen, Risto Kajanne, Lila Kallio, Reetta Kalviainen, Jaakko Kaprio, Nurlan Kerimov, Johannes Kettunen, Elina Kilpelainen, Terhi Kilpi, Katherine Klinger, Veli-Matti Kosma, Teijo Kuopio, Venla Kurra, Triin Laisk, Jari Laukkanen, Nathan Lawless, Aoxing Liu, Simonne Longerich, Reedik Magi, Johanna Makela, Antti Makitie, Anders Malarstig, Arto Mannermaa, Joseph Maranville, Athena Matakidou, Tuomo Meretoja, Sahar Mozaffari, Mari E. K. Niemi, Marianna Niemi, Teemu Niiranen, George Okafo, Hanna M. Ollila, Antti Palomaki, Tuula Palotie, Jukka Partanen, Dirk S. Paul, Margit Pelkonen, Rion K. Pendergrass, Slave Petrovski, Anne Pitkaranta, Adam Platt, David Pulford, Eero Punkka, Pirkko Pussinen, Neha Raghavan, Fedik Rahimov, Deepak Rajpal, Nicole A. Renaud, Bridget Riley-Gillis, Rodosthenis Rodosthenous, Elmo Saarentaus, Aino Salminen, Eveliina Salminen, Veikko Salomaa, Johanna Schleutker, Raisa Serpi, Huei-yi Shen, Richard Siegel, Kaisa Silander, Sanna Siltanen, Sirpa Soini, Hilkka Soininen, Jae Hoon Sul, Ioanna Tachmazidou, Kaisa Tasanen, Pentti Tienari, Sanna Toppila-Salmi, Taru Tukiainen, Tiinamaija Tuomi, Joni A. Turunen, Jacob C. Ulirsch, Felix Vaura, Petri Virolainen, Jeffrey Waring, Dawn Waterworth, Robert Yang, Mari Nelis, Anu Reigo, Andres Metspalu, Lili Milani, Tonu Esko, Caroline Fox, Aki S. Havulinna, Markus Perola, Samuli Ripatti, Anu Jalanko, Tarja Laitinen, Tomi P. Makela, Robert Plenge, Mark McCarthy, Heiko Runz, Mark J. Daly, Aarno Palotie
Summary: Population isolates, like those in Finland, provide valuable insights for genetic research due to the concentration of deleterious alleles in low-frequency variants. FinnGen aims to study the genome and health data of 500,000 Finnish individuals, enabling the identification of new associations and the exploration of their implications for common diseases. The study identified 30 new associations and 2,733 genome-wide significant associations, highlighting the power of bottlenecked populations in uncovering disease biology.
Article
Psychology, Clinical
Amanda Nurmi, Laura Pulkki-Raback, Pia Salo, Katja Pahkala, Markus Juonala, Nina Hutri-Kahonen, Mika Kahonen, Terho Lehtimaki, Eero Jokinen, Liisa Keltikangas-Jarvinen, Tomi P. Laitinen, Paivi Tossavainen, Leena Taittonen, Jorma S. A. Viikari, Olli T. Raitakari, Suvi P. Rovio
Summary: The study found that adverse childhood psychosocial factors are associated with midlife learning ability and memory. Specifically, poor self-regulatory behavior and social adjustment in childhood are related to poorer learning ability and memory 30 years later.
Article
Pediatrics
Anna P. Tikkakoski, Antti Tikkakoski, Kalle Sipila, Juho E. Kivisto, Heini Huhtala, Mika Kahonen, Jussi Karjalainen, Lauri Lehtimaki
Summary: Long-term exposure to air pollution is associated with asthma morbidity in children. It has been found that even low concentrations of particulate matter (PM2.5) may have an effect on exercise-induced bronchoconstriction (EIB) in children.
PEDIATRIC PULMONOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Jyrki Taurio, Elina J. Hautaniemi, Jenni K. Koskela, Arttu Eraranta, Mari Hamalainen, Antti Tikkakoski, Jarkko A. Kettunen, Mika Kahonen, Onni Niemela, Eeva Moilanen, Jukka Mustonen, Ilkka Porsti
Summary: This study aimed to investigate the influence of abdominal fat content, as judged by waist:height ratio, on blood pressure and hemodynamic profile. The results showed that individuals with higher waist:height ratios had higher blood pressure, systemic vascular resistance, and arterial stiffness. These findings suggest that obesity-related hypertension has similar characteristics to primary hypertension.
BMC CARDIOVASCULAR DISORDERS
(2023)
Article
Biochemistry & Molecular Biology
Amen Keshawarz, Roby Joehanes, Jiantao Ma, Gha Young Lee, Ricardo Costeira, Pei-Chien Tsai, Olatz M. Masachs, Jordana T. Bell, Rory Wilson, Barbara Thorand, Juliane Winkelmann, Annette Peters, Jakob Linseisen, Melanie Waldenberger, Terho Lehtimaeki, Pashupati P. Mishra, Mika Kahonen, Olli Raitakari, Mika Helminen, Carol A. Wang, Phillip E. Melton, Rae-Chi Huang, Craig E. Pennell, Therese A. O'Sullivan, Carolina Ochoa-Rosales, Trudy Voortman, Joyce B. J. van Meurs, Kristin L. Young, Misa Graff, Yujie Wang, Douglas P. Kiel, Caren E. Smith, Paul F. Jacques, Daniel Levy
Summary: Through meta-analysis of epigenome-wide association studies, we found significant associations between dietary and supplemental intake of vitamins C and E with DNA methylation. Vitamin C intake was associated with 4,656 CpG sites, while vitamin E intake was associated with 160 CpG sites. Vitamin C intake was found to be related to systems development and the immune response, while no significant associations were found for vitamin E intake with any biological pathways investigated.
Article
Endocrinology & Metabolism
Ville-Petteri Makinen, Johannes Kettunen, Terho Lehtimaki, Mika Kahonen, Jorma Viikari, Markus Perola, Veikko Salomaa, Marjo-Riitta Jarvelin, Olli T. Raitakari, Mika Ala-Korpela
Summary: This observational study examines the complex temporal associations between body-mass index (BMI), waist-hip ratio (WHR), and circulating metabolomics. It uses longitudinal and cross-sectional population-based datasets and new systems epidemiology tools. The results show that age-associated weight variation in adults between 24 and 49 manifests as temporal divergence in BMI and uniform progression of WHR.
INTERNATIONAL JOURNAL OF OBESITY
(2023)
Article
Multidisciplinary Sciences
Miikael Lehtimaki, Binisha H. H. Mishra, Coral Del-Val, Leo-Pekka Lyytikainen, Mika Kahonen, C. Robert Cloninger, Olli T. T. Raitakari, Reijo Laaksonen, Igor Zwir, Terho Lehtimaki, Pashupati P. P. Mishra
Summary: This study used an unsupervised machine learning method called PGMRA to discover the genotype-lipidome relations in a Finnish population. The researchers found 93 statistically significant lipidome-genotype relations, which contained a total of 5977 SNPs across 3164 genes. Twenty nine of these relations represented distinct subgroups with unique SNPs and participants. Pathway enrichment analysis identified 30 significantly enriched biological processes related to plasma lipid metabolism. These findings have implications for precision medicine research.
SCIENTIFIC REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Juhani S. Koskinen, Ville Kyto, Markus Juonala, Jorma S. A. Viikari, Jaakko Nevalainen, Mika Kahonen, Terho Lehtimaki, Nina Hutri-Kahonen, Tomi P. Laitinen, Paivi Tossavainen, Eero Jokinen, Costan G. Magnussen, Olli T. Raitakari
Summary: This study examines the association between childhood and adult dyslipidemia and adult carotid atherosclerotic plaques, and found that childhood dyslipidemia, even if resolved by adulthood, is still a risk factor for adult carotid plaques.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Neurosciences
Simo-Pekko Salminen, Anssi Solismaa, Leo-Pekka Lyytikainen, Vesa Paavonen, Nina Mononen, Terho Lehtimaki, Esa Leinonen, Olli Kampman
Summary: This study examined the clustering of Cloninger's temperament dimensions and their association with single nucleotide polymorphisms (SNPs). The results showed that multiple SNPs from different genes were associated with different temperament clusters. Genetic risk scores (GRSs) were also found to be associated with individuals' temperament profiles. However, further research is needed to explore the clinical applicability of these clusters.
ACTA NEUROPSYCHIATRICA
(2023)
Article
Endocrinology & Metabolism
Satu Korpimaki, Suvi P. Rovio, Markus Juonala, Nina Hutri-Kahonen, Terho Lehtimaki, Tomi P. Laitinen, Paivi Tossavainen, Eero Jokinen, Britt-Marie Loo, Satu Mannisto, Tuija Tammelin, Atte Haarala, Heikki Aatola, Gaber Komar, Jorma Viikari, Olli Raitakari, Mika Kahonen, Katja Pahkala
Summary: This prospective study investigated the incidence and remission of nonalcoholic fatty liver disease (NAFLD) among a general Finnish population. The results showed that during the study period, every fifth participant without NAFLD at baseline developed NAFLD, and one-fifth of those with NAFLD at baseline achieved NAFLD remission. NAFLD became more prevalent during the follow-up period. From a clinical perspective, key predictors of NAFLD incidence and remission were BMI and waist circumference (WC) change independent of their baseline level.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Public, Environmental & Occupational Health
Naomi Priest, Shuaijun Guo, Dawid Gondek, Meredith O'Connor, Margarita Moreno-Betancur, Sarah Gray, Rebecca Lacey, David P. Burgner, Sue Woolfenden, Hannah Badland, Gerry Redmond, Markus Juonala, Katherine Lange, Sharon Goldfeld
Summary: Lower maternal education is associated with higher offspring BMI and chronic inflammation. Childhood adversity may mediate these associations. We examined the impact of addressing childhood adversity on reducing socioeconomic inequities in these outcomes.
JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH
(2023)
Article
Multidisciplinary Sciences
Yordi van de Vegte, Ruben P. Eppinga, M. Yldau van der Ende, Yanick Hagemeijer, Yuvaraj V. Mahendran, Elias Y. Salfati, Albert E. Smith, Vanessa Tan, Dan V. Arking, Ioanna Ntalla, Emil A. Appel, Claudia Schurmann, Jennifer Brody, Rico Rueedi, Ozren Polasek, Gardar Sveinbjornsson, Cecile Lecoeur, Claes Ladenvall, Jing Hua Zhao, Aaron Isaacs, Lihua Wang, Jian'an Luan, Shih-Jen Hwang, Nina U. Mononen, Kirsi F. Auro, Anne Jackson, Lawrence Bielak, Linyao Zeng, Nabi Shah, Maria Nethander, Archie Campbell, Tuomo Rankinen, Sonali Pechlivanis, Lu Qi, Wei Zhao, Federica Rizzi, Toshiko Tanaka, Antonietta Robino, Massimiliano Cocca, Leslie Lange, Martina Mueller-Nurasyid, Carolina E. Roselli, Weihua Zhang, Marcus J. Kleber, Xiuqing Guo, Henry E. Lin, Francesca Pavani, Tessel Galesloot, Raymond E. Noordam, Yuri Milaneschi, Katharina Schraut, Marcel den Hoed, Frauke E. Degenhardt, Stella Trompet, Marten van den Berg, Giorgio Pistis, Yih-Chung S. Tham, Stefan L. Weiss, Xueling J. Sim, Hengtong M. Li, Peter van der Most, Ilja Nolte, Leo-Pekka R. Lyytikaeinen, M. Abdullah Said, Daniel Witte, Carlos M. Iribarren, Lenore S. Launer, Susan Ring, Paul de Vries, Peter P. Sever, Allan Linneberg, Erwin M. Bottinger, Sandosh Padmanabhan, Bruce Psaty, Nona Sotoodehnia, Ivana Kolcic, Delnaz D. Roshandel, Andrew O. Paterson, David F. Arnar, Daniel Gudbjartsson, Hilma Holm, Beverley T. Balkau, Claudia H. Silva, Christopher Newton-Cheh, Kjell Nikus, Perttu L. Salo, Karen A. Mohlke, Patricia Peyser, Heribert Schunkert, Mattias Lorentzon, Jari C. Lahti, Dabeeru C. Rao, Marilyn D. Cornelis, Jessica A. Faul, Jennifer Smith, Katarzyna Stolarz-Skrzypek, Stefania Bandinelli, Maria Pina Concas, Gianfranco Sinagra, Thomas Meitinger, Melanie F. Waldenberger, Moritz Sinner, Konstantin E. Strauch, Graciela D. Delgado, Kent Taylor, Jie Yao, Luisa Foco, Olle Melander, Jacqueline de Graaf, Renee de Mutsert, Eco J. C. de Geus, Asa K. Johansson, Peter K. Joshi, Lars Lind, Andre W. Franke, Peter V. Macfarlane, Kirill Tarasov, Nicholas B. Tan, Stephan Felix, E-Shyong Q. Tai, Debra Quek, Harold Snieder, Johan Ormel, Martin Ingelsson, Cecilia P. Lindgren, Andrew T. Morris, Olli Raitakari, Torben Hansen, Themistocles Assimes, Vilmundur J. Gudnason, Nicholas C. Timpson, Alanna B. Morrison, Patricia P. Munroe, David Strachan, Niels Grarup, Ruth J. F. R. Loos, Susan Heckbert, Peter Vollenweider, Caroline Hayward, Kari Stefansson, Philippe Froguel, Leif J. Groop, Nicholas M. Wareham, Cornelia F. van Duijn, Mary J. Feitosa, Christopher O'Donnell, Mika Kaehoenen, Markus Perola, Michael Boehnke, Sharon L. R. Kardia, Jeanette Erdmann, Colin N. A. Palmer, Claes J. Ohlsson, David G. Porteous, Johan Eriksson, Claude Bouchard, Susanne Moebus, Peter R. Kraft, David Weir, Daniele Cusi, Luigi Ferrucci, Sheila Ulivi, Giorgia Girotto, Adolfo Correa, Stefan Kaeaeb, Annette C. Peters, John S. Chambers, Jaspal Kooner, Winfried I. Maerz, Jerome A. Rotter, Andrew Hicks, J. Gustav Smith, Lambertus A. L. M. O. Kiemeney, Dennis Mook-Kanamori, Brenda W. J. H. Penninx, Ulf F. Gyllensten, James Wilson, Stephen Burgess, Johan Sundstroem, Wolfgang Lieb, J. Wouter Jukema, Mark Eijgelsheim, Edward L. M. Lakatta, Ching-Yu Cheng, Marcus Doerr, Tien-Yin Wong, Charumathi J. Sabanayagam, Albertine Oldehinkel, Harriette Riese, Terho Lehtimaeki, Niek Verweij, Pim van der Harst
Summary: This study identifies new genetic variants associated with resting heart rate (RHR) and demonstrates that higher genetically predicted RHR is associated with a decreased risk of atrial fibrillation and ischemic stroke. Genome-wide analysis reveals multiple genetic variants in cardiomyocyte-related genes and provides insights into their electrocardiogram (ECG) signature. Mendelian randomization analyses indicate that higher genetically predicted RHR increases the risk of dilated cardiomyopathy, but reduces the risk of atrial fibrillation, ischemic stroke, and cardio-embolic stroke.
NATURE COMMUNICATIONS
(2023)
Article
Biotechnology & Applied Microbiology
Pashupati P. Mishra, Binisha H. Mishra, Emma Raitoharju, Nina Mononen, Jorma Viikari, Markus Juonala, Nina Hutri-Kahonen, Mika Kahonen, Olli T. Raitakari, Terho Lehtimaki
Summary: Advanced integrative analysis of DNA methylation and transcriptomics data reveals the effects of smoke-induced epigenetic alterations on gene expression and biological processes, linking smoking and related diseases.
OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY
(2023)