Article
Endocrinology & Metabolism
Lars Lind, Samira Salihovic, Johan Sundstrom, Solve Elmstahl, Ulf Hammar, Koen Dekkers, Johan Arnlov, J. Gustav Smith, Gunnar Engstrom, Tove Fall
Summary: This study compared the plasma metabolome in obese subjects with and without metabolic syndrome (MetS) to normal-weight subjects without MetS. The results showed significant differences in metabolite profiles between obese and normal-weight individuals without MetS, with a gradual deterioration in metabolite profile from lean to obese to MetS. The pathways highlighted in this study, such as amino acid synthesis/metabolism and sphingolipid metabolism, may play a role in this metabolic deterioration, with insulin resistance as a potential mediator.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Medicine, General & Internal
Luiz Carlos Holanda Torres Pinheiro, Marcelo Rossi, Carlos Andre Freitas dos Santos, Luis Vicente Franco Oliveira, Sergio Vencio, Rodolfo de Paula Vieira, Yara Juliano, Jane Armond, Carlos Hassel Mendes Silva, Adriano Luis Fonseca, Carolina Nunes Franca, Andre Luis Lacerda Bachi
Summary: This study investigated the prevalence of obesity, sarcopenia, and metabolic syndrome in an older adult population in Sao Paulo, Brazil. The results showed that obesity was more closely associated with metabolic syndrome than sarcopenia, especially in women. The prevalence ratio calculated using the C index was 2.3 times higher than the values obtained using the BMI classification.
FRONTIERS IN MEDICINE
(2023)
Article
Multidisciplinary Sciences
Maysa Alves Rodrigues Brandao-Rangel, Renilson Moraes-Ferreira, Manoel Carneiro Oliveira-Junior, Alana Santos-Dias, Andre Luis Lacerda Bachi, Giovana Gabriela-Pereira, Simone de Oliveira Freitas, Amanda Cristina Araujo-Rosa, Luis Vicente Franco Oliveira, Claudio Ricardo Frison, Wagner Luiz do Prado, Raghavan Pillai Raju, P. Babu Balagopal, Rodolfo P. Vieira
Summary: Metabolic syndrome affects lung mechanics, function, and immunological response in older adults, leading to abnormal respiratory system resistance and increased levels of pro- and anti-inflammatory cytokines as well as fibrotic factors.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Aki Juhani Karajamaki, Arto Korkiakoski, Janne Hukkanen, Y. Antero Kesaniemi, Olavi Ukkola
Summary: The presence of metabolic syndrome (MetS), but not obesity only, entails a greater risk of mortality and cardiovascular diseases. The risk of atrial fibrillation is increased only in subjects with both obesity and MetS. Obesity without MetS tends to progress eventually to obesity with MetS.
ANNALS OF MEDICINE
(2022)
Article
Engineering, Chemical
Teresa Auguet, Miguel Lopez-Dupla, Jessica Ramos, Laia Bertran, David Riesco, Carmen Aguilar, Anna Ardevol, Montserrat Pinent, Fatima Sabench, Daniel Del Castillo, Cristobal Richart
Summary: This study aimed to determine whether adipocytokines and microbiota-derived metabolites can be used as predictive biomarkers for metabolic improvement post-surgery in women with clinically severe obesity. The results showed that levels of certain cytokines and microbiota-derived metabolites changed after surgery, correlating with improvements in glucose, insulin, and lipid levels.
Article
Nutrition & Dietetics
Virginia Boccardi, Francesca Mancinetti, Marta Baroni, Roberta Cecchetti, Patrizia Bastiani, Carmelinda Ruggiero, Patrizia Mecocci
Summary: The study found that plasma levels of EGF, Eotaxin, and MCP-1 are closely associated with insulin resistance in women, with BMI being a significant mediator. This suggests that the association between cytokines and insulin resistance is gender-specific.
Review
Nutrition & Dietetics
Mariana Duarte Bona, Carlos Henrique de Medeiros Torres, Severina Carla Vieira Cunha Lima, Ana Heloneida de Araujo Morais, Aldo Angelo Moreira Lima, Bruna Leal Lima Maciel
Summary: This systematic review assessed the association between obesity with or without MetS and alteration of intestinal barrier permeability in humans. A total of eight studies were included and categorized as moderate to high quality. The findings suggested that impaired intestinal barrier permeability was positively associated with obesity with MetS. However, the evidence quality was assessed to be very low to low according to the GRADE framework.
Review
Cell Biology
Pamela A. Nono Nankam, Matthias Blueher
Summary: Excessive adipose tissue in obesity is associated with various comorbid disorders, with adipose tissue secreting adipocytokines playing a significant role in regulating energy balance and metabolism. Among these molecules, RBP4 is associated with systemic insulin resistance and metabolic diseases.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Article
Nutrition & Dietetics
Anh Kim Dang, Mai Tuyet Truong, Huong Thi Le, Khan Cong Nguyen, Mai Bach Le, Lam Thi Nguyen, Khanh Nam Do, Lan Huong Thi Nguyen, Abdullah A. Mamun, Dung Phung, Phong K. Thai
Summary: Recent studies have shown that using international guidelines to diagnose metabolic syndrome (MetS) may underestimate its prevalence in different Asian populations. This study aims to determine the validity of anthropometric indicators and appropriate cut-off values to predict MetS for Vietnamese adults. The results suggest that health personnel in Vietnam should apply lower thresholds of anthropometry, which are more suitable for the local population, in order to avoid under-diagnosis.
Article
Geriatrics & Gerontology
Chaojun Yang, Xiaocan Jia, Yuping Wang, Jingwen Fan, Chenyu Zhao, Yongli Yang, Xuezhong Shi
Summary: This study examines the prevalence, intervention, and control of metabolic syndrome (MetS) among US adults from 1999 to 2018, finding a significant increase in MetS prevalence during this time period. Factors such as smoking and vigorous activity were found to influence MetS prevalence. Elevated blood glucose and obesity were identified as the main causes of MetS burden. The study suggests that targeting specific populations for treatment and lifestyle modification could improve the control of blood glucose and obesity.
Article
Nutrition & Dietetics
Chi-Hua Yen, Po-Sheng Chang, Ching-Ju Chiu, Yu-Yun Huang, Ping-Ting Lin
Summary: In this study, obese osteoarthritis patients showed higher rates of metabolic syndrome, abdominal obesity, and lower beta-carotene status compared to non-obese patients and controls. A higher beta-carotene status was found to be inversely associated with the risk of metabolic syndrome and inflammation, particularly in cases with low-grade inflammation. This suggests that beta-carotene status could potentially predict the risk of metabolic syndrome and inflammation in patients with or without osteoarthritis.
Article
Endocrinology & Metabolism
Sang Youl Rhee, Dong Keon Yon, Mi Jung Kwon, Ji Hee Kim, Joo-Hee Kim, Woo Jin Bang, Jung Woo Lee, Bong-Cheol Kwon, Hyo Geun Choi, Chanyang Min
Summary: This study found that there was an inverse association between metabolic syndrome (MetS) and osteoporosis in normal weight men, premenopausal women with all obesity statuses, and postmenopausal underweight and normal weight women. However, there was a positive association between MetS and osteoporosis in obese men and postmenopausal obese women.
ARCHIVES OF OSTEOPOROSIS
(2022)
Review
Biochemistry & Molecular Biology
Franziska Hornung, Julia Rogal, Peter Loskill, Bettina Loeffler, Stefanie Deinhardt-Emmer
Summary: Obesity affects lung function and increases susceptibility to infectious pathogens. Patients with obesity may have more severe outcomes in viral infections, but potentially have a survival advantage in bacterial infections.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Perpetua Modjadji, Mulalo Caroline Salane, Kebogile Elizabeth Mokwena, Tshimangadzo Selina Mudau, Peter Modupi Mphekgwana
Summary: This study investigates the predictive ability of obesity indicators for hypertension among older persons in South Africa and finds that body mass index, waist circumference, and waist-to-height ratio are better predictors of hypertension, particularly waist circumference in older South African women.
APPLIED SCIENCES-BASEL
(2022)
Article
Cardiac & Cardiovascular Systems
Kamila Osadnik, Tadeusz Osadnik, Marek Gierlotka, Adam Windak, Tomasz Tomasik, Miroslaw Mastej, Agnieszka Kuras, Kacper Jozwiak, Peter E. Penson, Gregory Y. H. Lip, Dimitri P. Mikhailidis, Peter P. Toth, Alberico L. Catapano, Kausik K. Ray, George Howard, Maciej Tomaszewski, Fadi J. Charchar, Naveed Sattar, Bryan Williams, Thomas M. MacDonald, Maciej Banach, Jacek Jozwiak
Summary: This study examined the association between metabolic syndrome (MetS) and long-term all-cause mortality. The findings showed that MetS was associated with increased mortality risk in both obese and non-obese individuals. The concept of metabolically healthy obesity should be reconsidered, and maintaining normal body weight is important for overall health.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Clinical Neurology
Nathan R. DeJong, Jacobus F. A. Jansen, Martin P. J. van Boxtel, Miranda T. Schram, Coen D. A. Stehouwer, Pieter C. Dagnelie, Carla J. H. van der Kallen, Abraham A. Kroon, Anke Wesselius, Annemarie Koster, Walter H. Backes, Sebastian Koehler
Summary: This study examined the associations between white matter connectivity, brain damage markers, and cognition in middle-aged individuals. The results showed that increasing connectivity moderated the negative association between brain damage and cognition, supporting the reserve hypothesis.
ALZHEIMERS & DEMENTIA
(2023)
Article
Nutrition & Dietetics
Nuno M. P. Mendonca, Linda M. Hengeveld, Nancy Presse, Helena Canhao, Eleanor Simonsick, Stephen B. Kritchevsky, Samaneh Farsijani, Pierrette Gaudreau, Carol Jagger, Marjolein Visser
Summary: This study aimed to investigate the relationship between protein intake and grip strength, as well as the interaction between protein intake and physical activity, in relation to the rate of grip strength decline in older adults. The findings showed no evidence to support the hypothesis that higher protein intake, alone or in combination with higher physical activity, slowed the rate of grip strength decline in older adults.
BRITISH JOURNAL OF NUTRITION
(2023)
Article
Geriatrics & Gerontology
Katri Saaksjarvi, Tommi Harkanen, Sari Stenholm, Laura Schaap, Annamari Lundqvist, Seppo Koskinen, Katja Borodulin, Marjolein Visser
Summary: Conflicting evidence exists regarding the relationship between sarcopenic obesity and mortality risk. This study examined the associations between obesity, probable sarcopenia, and all-cause mortality in individuals aged 70 years and over. The results showed that probable sarcopenia, with or without obesity, was associated with increased mortality, while obesity alone did not increase mortality risk. Maintaining muscle strength and identifying individuals at risk of sarcopenia are important for preventing premature death.
Article
Public, Environmental & Occupational Health
L. D. Sialino, H. A. H. Wijnhoven, S. H. van Oostrom, H. S. J. Picavet, W. M. M. Verschuren, M. Visser, S. Vader, L. A. Schaap
Summary: This study investigates motivators and barriers for healthy lifestyles and perspectives on determinants of healthy aging of older women. The research found that personal health is the most common motivator for a healthy lifestyle, while culture and religion are specific barriers and motivations for women with a migration background. Therefore, strategies to improve lifestyle among older women should have a tailored, culture sensitive approach.
Article
Cardiac & Cardiovascular Systems
Frank C. T. van der Heide, Simone J. P. M. Eussen, Alfons J. H. M. Houben, Ronald M. A. Henry, Abraham A. Kroon, Carla J. H. van der Kallen, Pieter C. Dagnelie, Martien C. J. M. van Dongen, Tos T. J. M. Berendschot, Jan S. A. G. Schouten, Carroll A. B. Webers, Marleen M. J. van Greevenbroek, Anke Wesselius, Casper G. Schalkwijk, Annemarie Koster, Jacobus F. A. Jansen, Walter H. Backes, Joline W. J. Beulens, Coen D. A. Stehouwer
Summary: This study examined the association between alcohol consumption and microvascular dysfunction (MVD). The results showed a significant relationship between moderate alcohol consumption and less severe MVD. The findings suggest that dietary interventions may be effective in preventing MVD.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Endocrinology & Metabolism
Rianneke de Ritter, Simone J. S. Sep, Carla J. H. van der Kallen, Marleen M. J. van Greevenbroek, Annemarie Koster, Simone J. P. M. Eussen, Pieter C. Dagnelie, Martin van Boxtel, Miranda T. Schram, Sebastian Kohler, Jordi A. J. Martens, Lucia Snobl, Rimke C. Vos, Coen D. A. Stehouwer, Sanne A. E. Peters
Summary: There are sex differences in the excess risk of diabetes-associated cardiovascular disease. However, whether these sex differences exist with regard to other complications like mental health aspects is unclear. Therefore, this study investigated sex differences in the association of prediabetes and T2D with cognitive function, depression, and QoL, and found that T2D was associated with worse cognitive function, depression, and poorer QoL in both women and men.
Article
Endocrinology & Metabolism
Rianneke de Ritter, Simone J. S. Sep, Marleen M. J. van Greevenbroek, Yvo H. A. M. Kusters, Rimke C. Vos, Michiel L. Bots, M. Eline Kooi, Pieter C. Dagnelie, Simone J. P. M. Eussen, Miranda T. Schram, Annemarie Koster, Martijn C. G. Brouwers, Niels M. R. van der Sangen, Sanne A. E. Peters, Carla J. H. van der Kallen, Coen D. A. Stehouwer
Summary: This study investigates the association between body composition and type 2 diabetes, and examines whether this association is influenced by sex. The results show that women and men with type 2 diabetes or prediabetes have higher levels of body fat and lean mass compared to those with normal glucose metabolism. Sex differences exist in body composition, and further research is needed to understand the significance of these differences.
Article
Nutrition & Dietetics
Pia Scheufele, Anja Rappl, Marjolein Visser, Eva Kiesswetter, Dorothee Volkert
Summary: This study aims to characterize older adults with poor appetite. The results show that factors such as gender, chewing problems, unintentional weight loss, polypharmacy, and depressive symptoms are associated with an increased likelihood of having poor appetite.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Review
Nutrition & Dietetics
Richard M. Pulsford, Laura Brocklebank, Sally A. M. Fenton, Esmee Bakker, Gregore I. Mielke, Li-Tang Tsai, Andrew J. Atkin, Danielle L. Harvey, Joanna M. Blodgett, Matthew Ahmadi, Le Wei, Alex Rowlands, Aiden Doherty, Vegar Rangul, Annemarie Koster, Lauren B. Sherar, Andreas Holtermann, Mark Hamer, Emmanuel Stamatakis
Summary: This study examined the influence of accelerometer placement and other methodological factors on participant recruitment, adherence, and data loss in observational studies of adult physical behaviors. The findings showed that in-person distribution of accelerometers was associated with higher participant consent and adherence rates compared to postal distribution. Wrist-worn accelerometers were more likely to meet minimum wear criteria compared to waist-worn accelerometers.
INTERNATIONAL JOURNAL OF BEHAVIORAL NUTRITION AND PHYSICAL ACTIVITY
(2023)
Article
Multidisciplinary Sciences
Francis Q. S. Dzakpasu, Annemarie Koster, Neville Owen, Bastiaan E. de Galan, Alison Carver, Christian J. Brakenridge, Annelies Boonen, Hans Bosma, Pieter C. Dagnelie, Simone J. P. M. Eussen, Parneet Sethi, Coen D. A. Stehouwer, Nicolaas C. Schaper, David W. Dunstan
Summary: This study found a significant association between daily sitting time and knee pain in middle-aged and older adults with type 2 diabetes. However, no significant association was observed between sitting time and neck, shoulder, or low back pain in any of the models. Further studies are needed to examine the relationship between sitting time and different types of pain, as well as other aspects of sedentary behavior.
Article
Cardiac & Cardiovascular Systems
Ioannis Bellos, Smaragdi Marinaki, Pagona Lagiou, Ioannis N. Boletis, Coen D. A. Stehouwer, Marleen M. J. van Greevenbroek, Simone J. P. M. Eussen, Bastiaan E. de Galan, Hans H. C. M. Savelberg, Annemarie Koster, Anke Wesselius, Vassiliki Benetou
Summary: This study examined the association of physical activity (PA) and sedentary behavior (SB) with endothelial dysfunction (ED) in individuals with different kidney function status. The results showed that PA duration was inversely associated with ED in both individuals with normal kidney function and those with chronic kidney disease, while longer sedentary bouts were associated with greater endothelial dysfunction in chronic kidney disease.
Article
Nutrition & Dietetics
C. Thogersen-Ntoumani, M. Kritz, A. Grunseit, J. Chau, M. Ahmadi, A. Holtermann, A. Koster, C. Tudor-Locke, N. Johnson, C. Sherrington, S. Paudel, C. Maher, E. Stamatakis
Summary: This study examined the barriers and enablers of Vigorous Intermittent Lifestyle Physical Activity (VILPA) among physically inactive adults. The barriers include physical limitations, perceptions of aging, need for knowledge, environmental constraints, perceptions of effort and energy, and fear. The enablers include convenience, reframing physical activity as purposeful movement, use of prompts and reminders, normalization of taking the active option, gamification, sense of achievement, health improvements, identity fit, and changing from effortful deliberation to habitual action.
INTERNATIONAL JOURNAL OF BEHAVIORAL NUTRITION AND PHYSICAL ACTIVITY
(2023)
Article
Nutrition & Dietetics
Kristina Fluitman, Tim van den Broek, Ilse Reinders, Hanneke Wijnhoven, Max Nieuwdorp, Marjolein Visser, Richard Ijzerman, Bart Keijser
Summary: Nutrition and oral health are closely related, especially in older adults. Increasing protein intake has certain effects on oral health and oral microbial composition, but the impact on individual bacterial taxa is minor.
Review
Endocrinology & Metabolism
Aurelie Ladang, Charlotte Beaudart, Jean-Yves Reginster, Nasser Al-Daghri, Olivier Bruyere, Nansa Burlet, Matteo Cesari, Antonio Cherubini, Mario Coelho da Silva, Cyrus Cooper, Alfonso J. Cruz-Jentoft, Francesco Landi, Andrea Laslop, Stefania Maggi, Ali Mobasheri, Sif Ormarsdottir, Regis Radermecker, Marjolein Visser, Maria Concepcion Prieto Yerro, Rene Rizzoli, Etienne Cavalier
Summary: Biochemical markers in clinical trials provide useful information on drug's mode of action, therapeutic response, and side effect monitoring. Identifying biomarkers for sarcopenia management is urgently needed for future clinical practice. A consensus paper from a working group of the ESCEO proposed a list of biochemical markers for musculoskeletal health and aging in Phase II and III clinical trials for sarcopenia treatment, and suggested classifying them into two series based on their evaluation of musculoskeletal status and causal factors.
CALCIFIED TISSUE INTERNATIONAL
(2023)
Review
Geriatrics & Gerontology
Charlotte Beaudart, Jean-Yves Reginster, Jotheeswaran Amuthavalli Thiyagarajan, Ivan Bautmans, Juergen Bauer, Nansa Burlet, Matteo Cesari, Antonio Cherubini, Cyrus Cooper, Alfonso J. Cruz-Jentoft, Bess Dawson-Hughes, Roger A. Fielding, Nicholas C. Harvey, Francesco Landi, Andrea Laslop, Stefania Maggi, Beatriz Montero-Errasquin, Prieto Yerro Maria Concepcion, Yves Rolland, Rene Rizzoli, Marjolein Visser, Olivier Bruyere
Summary: Patient perspectives are crucial in evaluating health interventions, and the availability of specific Patient Reported Outcome Measures is important. The SarQoL questionnaire is the only validated instrument for assessing health-related quality of life in sarcopenia patients. It has been widely studied and shown to be reliable, valid, and responsive to change. However, more research is needed to measure its responsiveness in interventional studies and to establish a cut-off score for defining low quality of life. Furthermore, the questionnaire should be studied in different populations, not just community-dwelling older individuals with sarcopenia.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
