Article
Neurosciences
Xin-Rui Wu, Kai-Min Wu, Yue-Ting Deng, Shu-Yi Huang, Liu Yang, Qiang Dong, Jian-Feng Feng, Wei Cheng, Jin-Tai Yu
Summary: This study found impaired kidney function to be a critical risk factor for dementia, with the use of cystatin C strengthening the relationship between CKD and dementia. It highlights the significant value of preserving kidney function to reduce the risk of dementia and suggests considering cystatin C measurement as part of clinical practice in evaluating dementia risk.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Nutrition & Dietetics
Cristina Valle-Hita, Andres Diaz-Lopez, Nerea Becerra-Tomas, Estefania Toledo, Isabel Cornejo-Pareja, Itziar Abete, Antoni Sureda, Maira Bes-Rastrollo, J. Alfredo Martinez, Francisco J. Tinahones, Josep A. Tur, Tany E. Garciduenas-Fimbres, Francisco Paris-Palleja, Albert Goday, Nuria Goni-Ruiz, Jordi Salas-Salvado, Nancy Babio
Summary: The consumption of ultra-processed food (UPF) is associated with a decline in kidney function, particularly among older adults. Therefore, reducing the intake of UPF is important for maintaining kidney function.
CLINICAL NUTRITION
(2023)
Article
Medical Laboratory Technology
W. Greg Miller, Harvey W. Kaufman, Andrew S. Levey, Joely A. Straseski, Kelly W. Wilhelms, Hoi-Ying Elsie Yu, J. Stacey Klutts, Lee H. Hilborne, Gary L. Horowitz, John Lieske, Jennifer L. Ennis, James L. Bowling, Mary J. Lewis, Elizabeth Montgomery, Joseph A. Vassalotti, Lesley A. Inker
Summary: Recognizing that race is a social construct, there is a push to remove race from clinical algorithms for diagnosing kidney diseases. The Task Force recommends using the newly published CKD-EPI 2021 equation for eGFR calculations without a race coefficient.
CLINICAL CHEMISTRY
(2022)
Article
Medical Laboratory Technology
Etienne Mondesert, Anne-Sophie Bargnoux, Florence Portet, Dalila Laoudj-Chenivesse, Sandrine Arbogast, Stephanie Badiou, Jean-Frederic Brun, Nils Kuster, Eric Raynaud de Mauverger, Jean -Paul Cristol
Summary: Muscle mass impairment in FSHD may affect the accuracy of eGFR based on creatinine. eGFR based on cystatin C, which is independent of muscle mass, may be a promising alternative. This study found that using eGFRcys instead of eGFRcreat resulted in reclassification towards more severe stages of CKD. Creatinine was correlated with muscle mass, while cystatin C was correlated with age. Using eGFRcys can provide more accurate detection of renal function decline in FSHD patients.
CLINICA CHIMICA ACTA
(2023)
Review
Urology & Nephrology
Pierre Delanaye, Etienne Cavalier, Hans Pottel, Thomas Stehle
Summary: Glomerular filtration rate (GFR) is estimated using equations based on serum biomarker concentration and demographic data. The 2009 creatinine-based CKD-EPI equation (CKD-EPI2009) was widely used until 2021 when it was recalibrated. However, both CKD-EPI2009 and the recalibrated version overestimate GFR in adults aged 18-30 years, with a particularly significant overestimation at age 18. Alternative equations like EKFC and EKFCCC provide better performance in diverse populations, with EKFCCC being a sex-free and race-free equation.
CLINICAL KIDNEY JOURNAL
(2023)
Review
Medicine, General & Internal
Ana Maria Cusumano, Carmen Tzanno-Martins, Guillermo Javier Rosa-Diez
Summary: The prevalence of chronic kidney disease is increasing globally, with diagnosis based on eGFR and urine analysis. Knowledge about renal physiology is essential for accurate measurement of GFR and CrCl. While various equations exist to calculate CrCl or estimate GFR, the accuracy remains controversial in certain patient subgroups.
FRONTIERS IN MEDICINE
(2021)
Article
Medicine, General & Internal
Richard Mayanja, Tafadzwa Machipisa, Opeyemi Soremeku, Abram B. Kamiza, Christopher Kintu, Allan Kalungi, Robert Kalyesubula, Obondo J. Sande, Daudi Jjingo, June Fabian, Cassianne Robinson-Cohen, Nora Franceschini, Dorothea Nitsch, Moffat Nyirenda, Eleftheria Zeggini, Andrew P. Morris, Tinashe Chikowore, Segun Fatumo
Summary: Chronic kidney disease is on the rise in Africa, but the genetic factors behind it are not well understood. While creatinine-based estimated glomerular filtration rate (eGFR) is commonly used to estimate kidney function, it has been shown to be inadequate in detecting low kidney function in Sub-Saharan Africa. On the other hand, eGFR based on cystatin-C (eGFRcys) has shown significantly better performance. Therefore, this study aimed to conduct a GWAS for eGFRcys.
Review
Urology & Nephrology
Natalie Ebert, Sebastjan Bevc, Arend Boekenkamp, Francois Gaillard, Mads Hornum, Kitty J. Jager, Christophe Mariat, Bjon Odvar Eriksen, Runolfur Palsson, Andrew D. Rule, Marco van Londen, Christine White, Elke Schaeffner
Summary: The article discusses the limitations of estimating glomerular filtration rate (GFR) using serum creatinine and proposes possible solutions such as using cystatin C or an exogenous marker for direct measurement. Various clinical scenarios where creatinine-based GFR estimation may be invalid are highlighted, emphasizing the importance of personalized medicine and the need for standardized GFR procedures.
CLINICAL KIDNEY JOURNAL
(2021)
Article
Medicine, General & Internal
Orlando M. Gutierrez, Yingying Sang, Morgan E. Grams, Shoshana H. Ballew, Aditya Surapaneni, Kunihiro Matsushita, Alan S. Go, Michael G. Shlipak, Lesley A. Inker, Nwamaka D. Eneanya, Deidra C. Crews, Neil R. Powe, Andrew S. Levey, Josef Coresh
Summary: This retrospective analysis compared the racial differences in risk of KFRT and mortality between Black and non-Black participants with kidney disease. The study found that the eGFR equation that included both creatinine and cystatin C without considering race demonstrated racial differences in risk across the range of eGFR. The eGFRcr-cys equation may be preferable for assessing racial differences in the risk of KFRT and mortality associated with low eGFR.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Editorial Material
Urology & Nephrology
Borja Quiroga, Javier Diez
Summary: The progressive reduction in estimated glomerular filtration rate (eGFR) resulting in chronic kidney disease (CKD) is associated with increased risk of cardiovascular disease (CVD). Creatinine plus cystatin C-based eGFR and cystatin C-based eGFR can better assess the risk of adverse cardiovascular outcomes. It is suggested to use cystatin C and/or creatinine plus cystatin C-based eGFR for routine clinical practice in cardiorenal patients to accurately stratify cardiovascular risk and evaluate the kidney and cardiovascular protective effects of SGLT2 inhibitors.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Medicine, General & Internal
Bjorn Kaijun Betzler, Rehena Sultana, Feng He, Yih Chung Tham, Cynthia Ciwei Lim, Ya Xing Wang, Vinay Nangia, E. Shyong Tai, Tyler Hyungtaek Rim, Mukharram M. M. Bikbov, Jost B. B. Jonas, Se Woong Kang, Kyu Hyung Park, Ching-Yu Cheng, Charumathi Sabanayagam
Summary: This study evaluated the impact of a new equation for estimated glomerular filtration rate (eGFR) on the prevalence of chronic kidney disease (CKD) in multiple Asian cohorts. The results showed that the new equation reduced the prevalence of CKD and provided higher estimations of GFR among Asian populations. Reclassifying patients to lower-risk GFR categories could potentially reduce inappropriate care and its adverse effects.
FRONTIERS IN MEDICINE
(2022)
Article
Urology & Nephrology
Anna C. van der Burgh, Bruno H. Stricker, Dimitris Rizopoulos, M. Arfan Ikram, Ewout J. Hoorn, Layal Chaker
Summary: This study investigated the association between kidney function and sudden cardiac death (SCD) in a general population. The results showed that reduced kidney function, particularly as measured by eGFRcys, was associated with an increased risk of SCD. These findings suggest that eGFRcys could be incorporated into prediction models and screening programs for SCD prevention.
CLINICAL KIDNEY JOURNAL
(2022)
Article
Multidisciplinary Sciences
Jieun Kang, Sangwon Hwang, Tae Sic Lee, Jooyoung Cho, Dong Min Seo, Seong Jin Choi, Young Uh
Summary: This study reveals the relationship between serum creatinine level and adverse pregnancy outcomes, taking into account the pregnancy-related biological changes. The analysis shows that the gestational age-specific distribution of serum creatinine can be used to predict adverse pregnancy outcomes.
SCIENTIFIC REPORTS
(2022)
Article
Urology & Nephrology
Cynthia Delgado, Mukta Baweja, Deidra C. Crews, Nwamaka D. Eneanya, Crystal A. Gadegbeku, Lesley A. Inker, Mallika L. Mendu, W. Greg Miller, Marva M. Moxey-Mims, Glenda V. Roberts, Wendy L. St. Peter, Curtis Warfield, Neil R. Powe
Summary: The National Kidney Foundation and the American Society of Nephrology have made recommendations regarding the consideration of race in GFR estimation. They suggest implementing the CKD-EPI creatinine equation without the race variable in all US laboratories and promoting the use of cystatin C for more accurate estimation. They also encourage research on new filtration markers and interventions to eliminate racial disparities. The unified approach should be adopted nationwide.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2022)
Article
Medicine, General & Internal
Mads Hornum, Morten Baltzer Houlind, Esben Iversen, Esteban Porrini, Sergio Luis-Lima, Peter Oturai, Martin Iversen, Pia Bredahl, Jorn Carlsen, Christian Holdflood Moller, Mads Jonsson Andersen, Bo Feldt-Rasmussen, Michael Perch
Summary: Patients undergoing lung transplantation (LTx) experience a rapid decline in glomerular filtration rate (GFR) in the acute postoperative period. This study compared different equations for estimating GFR in LTx patients and found that equations based on plasma creatinine underestimated GFR decline, while equations based on plasma cystatin C overestimated GFR decline after LTx. The 2021 CKD-EPI combination equation had the most accurate estimation of GFR in both pre-LTx and post-LTx periods. Therefore, caution should be exercised when interpreting renal function based on GFR estimation equations in the acute postoperative period following LTx.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
C. Viecceli, L. R. Remonti, V. N. Hirakata, L. S. Mastella, V. Gnielka, M. L. R. Oppermann, S. P. Silveiro, A. J. Reichelt
Article
Medicine, General & Internal
Angela Jacob Reichelt, Leticia Schwerz Weinert, Livia Silveira Mastella, Vanessa Gnielka, Maria Amelia Campos, Vania Naomi Hirakata, Maria Lucia Rocha Oppermann, Sandra Pinho Silveiro, Maria Ines Schmidt
SAO PAULO MEDICAL JOURNAL
(2017)
Article
Medicine, Research & Experimental
Ana Marina Moreira, Roberta Marobin, Dimitris Varvaki Rados, Camila Bergonsi de Farias, Sabrina Coelli, Barbara Luiza Bernardi, Livia de Almeida Faller, Laura Ferraz dos Santos, Ana Maria Matzenbacher, Natan Katz, Erno Harzheim, Sandra Pinho Silveiro
Article
Medical Laboratory Technology
Julia Dauernheimer Machado, Eduardo Guimaraes Camargo, Roberta Boff, Lais da Silva Rodrigues, Joiza Lins Camargo, Ariana Aguiar Soares, Sandra Pinho Silveiro
CLINICAL BIOCHEMISTRY
(2018)
Review
Medical Laboratory Technology
Sofia M. Dick, Marina Queiroz, Barbara L. Bernardi, Angelica Dall'Agnol, Leticia A. Brondani, Sandra P. Silveiro
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2018)
Letter
Medical Laboratory Technology
Sofia Michele Dick, Marina Queiroz, Leticia Almeida Brondani, Angelica Dall'Agnol, Barbara Luisa Bernardi, Sandra Pinho Silveiro
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2018)
Article
Endocrinology & Metabolism
Livia S. Mastella, Leticia S. Weinert, Vanessa Gnielka, Vania N. Hirakata, Maria Lucia R. Oppermann, Sandra P. Silveiro, Angela J. Reichelt
ARCHIVES OF ENDOCRINOLOGY METABOLISM
(2018)
Article
Multidisciplinary Sciences
Amanda Veiga Cheuiche, Marina Queiroz, Andre Luis Ferreira Azeredo-da-Silva, Sandra Pinho Silveiro
SCIENTIFIC REPORTS
(2019)
Article
Multidisciplinary Sciences
Leticia de Almeida Brondani, Ariana Aguiar Soares, Mariana Recamonde-Mendoza, Angelica Dall'Agnol, Joiza Lins Camargo, Karina Mariante Monteiro, Sandra Pinho Silveiro
SCIENTIFIC REPORTS
(2020)
Review
Health Care Sciences & Services
Ana Marina Moreira, Roberta Marobin, Gustavo Monteiro Escott, Dimitris Varvaki Rados, Sandra Pinho Silveiro
Summary: This study systematically evaluated the effect of telephone call intervention on glycemic control in patients with type 2 diabetes, showing that it can improve glycemic control, particularly when combined with pharmacological treatment modification and delivered by nurses.
JOURNAL OF TELEMEDICINE AND TELECARE
(2022)
Article
Endocrinology & Metabolism
Angelica Dall'Agnol, Leticia de Almeida Brondani, Vitor da Agostim Cancelier, Eduardo Guimaraes Camargo, Sandra Pinho Silveiro
THERAPEUTIC ADVANCES IN ENDOCRINOLOGY AND METABOLISM
(2020)
Article
Medical Laboratory Technology
Sabrina Coelli, Camila Bergonsi Farias, Ariana Aguiar Soares, Gabriele Martins Crescente, Vania Naomi Hirakata, Luiza Barboza Souza, Mauro Antonio Czepielewski, Joiza Lins Camargo, Sandra Pinho Silveiro
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2017)
Article
Endocrinology & Metabolism
Fernando M. A. Giuffrida, Regina S. Moises, Leticia S. Weinert, Luis E. Calliari, Thais Della Manna, Renata P. Dotto, Luciana F. Franco, Lilian A. Caetano, Milena G. Teles, Renata Andrade Lima, Cresio Alves, Sergio A. Dib, Sandra P. Silveiro, Magnus R. Dias-da-Silva, Andre F. Reis
DIABETES RESEARCH AND CLINICAL PRACTICE
(2017)