Article
Allergy
Grace C. Lee, Marcos I. Restrepo, Nathan Harper, Muthu Saravanan Manoharan, Alisha M. Smith, Justin A. Meunier, Sandra Sanchez-Reilly, Aamir Ehsan, Anne P. Branum, Caitlyn Winter, Lauryn Winter, Fabio Jimenez, Lavanya Pandranki, Andrew Carrillo, Graciela L. Perez, Antonio Anzueto, Hanh Trinh, Monica Lee, Joan M. Hecht, Celida Martinez-Vargas, Raj T. Sehgal, Jose Cadena, Elizabeth A. Walter, Kimberly Oakman, Raymond Benavides, Jacqueline A. Pugh, Scott Letendre, Maristella Steri, Valeria Orru, Edoardo Fiorillo, Francesco Cucca, Alvaro G. Moreira, Nu Zhang, Elizabeth Leadbetter, Brian K. Agan, Douglas D. Richman, Weijing He, Robert A. Clark, Jason F. Okulicz, Sunil K. Ahuja
Summary: The study found that differences in levels of immunologic resilience may lead to variations in mortality rates among COVID-19 patients. Females typically have higher immunologic resilience, while males are more susceptible to severe COVID-19.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Johannes R. Kratz, Jack Z. Li, Jessica Tsui, Jen C. Lee, Vivianne W. Ding, Arjun A. Rao, Michael J. Mann, Vincent Chan, Alexis J. Combes, Matthew F. Krummel, David M. Jablons
Summary: Recurrent stage I lung adenocarcinomas exhibit higher mutation and lower methylation burden, as well as widespread activation of known cancer and cell cycle pathways. Meanwhile, recurrent tumors demonstrate downregulation of immune response pathways including antigen presentation and Th1/Th2 activation. The depletion of adaptive immune populations and low cytolytic activity are predictive factors for stage I recurrence.
SCIENTIFIC REPORTS
(2021)
Editorial Material
Oncology
Hussein Issaoui, Jean-Ehrland Ricci
Summary: A new study has identified an IL-7 allelic variant-rs16906115-as a major risk factor for ICI-associated irAEs. This finding is significant as it suggests that germline genetic variants play a role in the occurrence of irAEs, providing a new avenue for better management of ICI therapy and associated irAEs by identifying high-risk patients.
MOLECULAR ONCOLOGY
(2023)
Review
Biology
Kazuyuki Hamada, Takuya Tsunoda, Kiyoshi Yoshimura
Summary: The gut microbiota has the potential to serve as a novel marker in predicting the therapeutic efficacy of immune checkpoint inhibitors (ICIs).
Article
Immunology
Youming Lei, Kun Wang, Yinqiang Liu, Xuming Wang, Xudong Xiang, Xiangu Ning, Wanbao Ding, Jin Duan, Dingbiao Li, Wei Zhao, Yi Li, Fujun Zhang, Xiaoyu Luo, Yunfei Shi, Ying Wang, Depei Huang, Yuezong Bai, Hushan Zhang
Summary: This study analyzed data from Chinese primary NSCLC patients and found that uncommon EGFR mutation subtypes have higher TMB and PD-L1 expression levels. Different subtypes are associated with different characteristics of the tumor immune microenvironment. Prognostic biomarkers for NSCLC patients vary depending on EGFR mutation status.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Lushan Peng, Dan Wang, Yingying Han, Tao Huang, Xiaoyun He, Junpu Wang, Chunlin Ou
Summary: CAF-derived exosomes play a crucial role in tumorigenesis, tumor progression, and clinical characteristics of cancer patients, and have the potential to serve as diagnostic biomarkers and therapeutic targets in human cancers.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Brandon M. Cope, Raymond S. Traweek, Rossana Lazcano, Emily Z. Keung, Alexander J. Lazar, Christina L. Roland, Elise F. Nassif
Summary: Immunotherapy has greatly improved cancer care, but leiomyosarcoma is not responsive to early immune-based therapies. This review discusses the results of immunotherapy trials in leiomyosarcoma and highlights the differences between soft-tissue and uterine leiomyosarcomas. It also explores the molecular subgroups of leiomyosarcomas and their impact on response to immune checkpoint blockade, proposing future directions for improving immunotherapy in leiomyosarcoma patients. Leiomyosarcoma is a rare and aggressive tumor with low tumor mutational burden, frequent alterations in certain genes, and a highly infiltrated immune microenvironment. This review provides insights for the development of biomarker-based immune therapies.
Review
Oncology
Ye Wang, Zhuang Tong, Wenhua Zhang, Weizhen Zhang, Anton Buzdin, Xiaofeng Mu, Qing Yan, Xiaowen Zhao, Hui-Hua Chang, Mark Duhon, Xin Zhou, Gexin Zhao, Hong Chen, Xinmin Li
Summary: The response to immune checkpoint inhibitors is a complex quantitative trait determined by multiple factors, for which FDA-approved biomarkers are used for patient selection. However, challenges in daily practice and the different factors captured by the biomarkers highlight the need for optimized use of current biomarkers and development of new predictive biomarkers. Various gene signature biomarkers and combined predictive biomarkers have shown improved performance compared to single predictors, suggesting a potential direction for robust predictive biomarker development for ICI response.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, Research & Experimental
Alice Mogenet, Pascal Finetti, Emilie Denicolai, Laurent Greillier, Pascaline Boudou-Rouquette, Francois Goldwasser, Gwenael Lumet, Michele Ceccarelli, Daniel Birnbaum, Davide Bedognetti, Emilie Mamessier, Fabrice Barlesi, Francois Bertucci, Pascale Tomasini
Summary: The ICR signature, a 20-gene expression signature, is independently associated with benefit from anti-PD1/PDL1 ICI in advanced NSCLC patients and has predictive value for treatment outcomes. Further validation in larger retrospective and prospective studies is needed.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Medical Laboratory Technology
Mina Yekani, Mohammad Yousef Memar
Summary: Meningitis is a severe inflammation of the meninges, caused by bacteria or viruses, with high mortality rates. Immunologic biomarkers, such as cytokines and acute phase proteins, have been identified as significant indicators for diagnosing bacterial meningitis. However, the sensitivity and specificity of these biomarkers are influenced by various factors. This study provides an overview of different immunologic biomarkers and their efficiency in diagnosing bacterial meningitis and differentiating it from viral meningitis.
CLINICA CHIMICA ACTA
(2023)
Review
Cell & Tissue Engineering
Tarek Ziad Arabi, Belal Nedal Sabbah, Amir Lerman, Xiang-Yang Zhu, Lilach O. Lerman
Summary: In order to address the organ shortage, xenotransplantation has been attempted for hearts, corneas, skin, and kidneys. However, the major obstacle is immune rejection, which involves both adaptive and innate immune systems. Biomarkers for identifying and predicting xenograft rejection still need standardization.
CELL TRANSPLANTATION
(2023)
Article
Surgery
HanZheng Zhao, Xingyu Chen, WenHui Zhang, Die Cheng, Yanjie Lu, Cheng Wang, JunHu Li, LiuPing You, JiaYong Yu, WenLong Guo, YuHong Li, YueNan Huang
Summary: This study investigated the clinical significance of preoperative pan-immune-inflammation value (PIV) in patients with colorectal cancer (CRC). The results showed that PIV was positively correlated with tumor size, carcinoembryonic antigen (CEA), and carbohydrate antigen 125 (CA-125), but negatively correlated with albumin (Alb). PIV was significantly different in patients with different tumor locations, surgical methods, and pathological stages of CRC. ROC curve analysis showed that PIV had better predictive efficacy when combined with CEA or carbohydrate antigen 19-9 (CA19-9).
FRONTIERS IN SURGERY
(2022)
Article
Oncology
Yue Chen, Jiayu Sun, Xinxin Dong, Deyu Sun, Yanli Qu
Summary: The prognosis and adjuvant chemotherapy of patients who underwent neoadjuvant chemoradiotherapy (nCRT) are currently based on pre-radiotherapy clinical TNM (cTNM) stage. However, the value of neoadjuvant pathologic TNM (ypTNM) stage is not clearly described.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Ramon Rami-Porta
Summary: The classification of lung cancer based on tumor, lymph node, and metastases has undergone several revisions since its proposal in 1966. The upcoming 9th edition is expected to combine this classification with other prognostic factors to provide a more personalized prognosis for individual patients. International collaboration is crucial in building a comprehensive database to achieve this objective.
Review
Immunology
Julie Y. Zhou, Brian A. Cobb
Summary: Glycans play essential roles in the immune system, participating in various immunological processes and impacting inflammatory, autoimmune, and cancer disease states.
ANNUAL REVIEW OF IMMUNOLOGY, VOL 39
(2021)
