Journal
ANNUAL REVIEW OF IMMUNOLOGY, VOL 39
Volume 39, Issue -, Pages 511-536Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-immunol-101819-074237
Keywords
glycan; glycan-binding protein; immune regulation; host-pathogen interactions; immune evasion; self/nonself; autoimmunity; cancer
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Funding
- NIH [GM115234, AI089474]
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Glycans play essential roles in the immune system, participating in various immunological processes and impacting inflammatory, autoimmune, and cancer disease states.
The surfaces of all living organisms and most secreted proteins share a common feature: They are glycosylated. As the outermost-facing molecules, glycans participate in nearly all immunological processes, including driving host-pathogen interactions, immunological recognition and activation, and differentiation between self and nonself through a complex array of pathways andmechanisms. These fundamental immunologic roles are further cast into sharp relief in inflammatory, autoimmune, and cancer disease states in which immune regulation goes awry. Here, we review the broad impact of glycans on the immune system and discuss the changes and clinical opportunities associated with the onset of immunologic disease.
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