Review
Biochemistry & Molecular Biology
Simona Serioli, Ludovico Agostini, Alberto Pietrantoni, Federico Valeri, Flavia Costanza, Sabrina Chiloiro, Barbara Buffoli, Amedeo Piazza, Pietro Luigi Poliani, Maria Peris-Celda, Federica Iavarone, Simona Gaudino, Marco Gessi, Giovanni Schinzari, Pier Paolo Mattogno, Antonella Giampietro, Laura De Marinis, Alfredo Pontecorvi, Marco Maria Fontanella, Liverana Lauretti, Guido Rindi, Alessandro Olivi, Antonio Bianchi, Francesco Doglietto
Summary: This article comprehensively reviews the principal pathways and potential target therapies for aggressive PitNETs. Through a search and analysis of English papers, the current understanding and future prospects of the molecular mechanisms and treatment methods for PitNETs are discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Elisabetta Tortorella, Sabrina Giantulli, Alessandro Sciarra, Ida Silvestri
Summary: Prostate cancer (PCa) is a common cancer in men, and the androgen receptor (AR) plays a crucial role in its development and progression. Although AR signaling inhibitors (ARSIs) have shown effectiveness in castration-sensitive PCa (CSPC) and improved survival, men with castration-resistant PCa (CRPC) still have a poor prognosis. Resistance to ARSIs in metastatic CRPC is commonly observed due to AR mutations and hyperactivation of the PI3K/AKT/mTOR pathway. The interaction between AR and the PI3K/AKT/mTOR signaling pathway in PCa has been well-documented.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Sushmaa Chandralekha Selvakumar, K. Auxzilia Preethi, Durairaj Sekar
Summary: Cancer is a global threat and current therapeutics lack specificity and have side effects. Researchers have been studying the PTEN/PI3K/AKT pathway and microRNAs as potential targets for novel cancer therapeutics. This review focuses on the role of miRNAs in regulating the PTEN/PI3K/AKT axis in various cancers.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2023)
Article
Biochemistry & Molecular Biology
Wentao Liu, Bin Yan, Haixin Yu, Jiannan Ren, Mou Peng, Liang Zhu, Yinhuai Wang, Xin Jin, Lu Yi
Summary: This study investigates the clinicopathological role of the OTUD family in ccRCC and identifies that the OTUD1-PTEN axis suppresses tumor growth and regulates the resistance of renal cancer to TKIs.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Review
Geriatrics & Gerontology
Chang Su, Yongzheng Lu, Zeyu Wang, Jiacheng Guo, Yachen Hou, Xiaofang Wang, Zhen Qin, Jiamin Gao, Zhaowei Sun, Yichen Dai, Yu Liu, Guozhen Liu, Xunde Xian, Xiaolin Cui, Jinying Zhang, Junnan Tang
Summary: This review discusses the inflammatory pathogenesis during the development of atherosclerosis, with a focus on blood cells, immune cells, smooth muscle cells, and endothelial cells. The latest progress in molecular-cellular based therapy for atherosclerosis is also discussed. The article provides valuable insights for the clinical management of atherosclerosis.
Article
Polymer Science
Wei Cao, Xinyan Li
Summary: The recycling and reuse of waste asphalt materials in the pavement industry has made significant contributions to infrastructure sustainability and environmental preservation. This study found that plasticizers, such as dibutyl phthalate (DBP) and tributyl citrate (TBC), showed great potential in rejuvenating oxidized asphalt. The rheological characterizations and molecular dynamics simulations demonstrated that both plasticizers were effective in restoring the stiffness, elasticity, and fatigue resistance of aged asphalt. TBC, with its high polarity and hydroxyl group, exhibited slightly higher efficiency in dissociating the asphaltene associations, leading to better restoration of the rheological properties compared to DBP. These findings suggest that the plasticizers rejuvenate the aged asphalt rather than simply softening it.
Review
Geriatrics & Gerontology
Chang Su, Yongzheng Lu, Zeyu Wang, Jiacheng Guo, Yachen Hou, Xiaofang Wang, Zhen Qin, Jiamin Gao, Zhaowei Sun, Yichen Dai, Yu Liu, Guozhen Liu, Xunde Xian, Xiaolin Cui, Jinying Zhang, Junnan Tang
Summary: Atherosclerosis, a major cardiovascular disease, contributes to coronary artery disease (CAD) and stroke. Endothelial injury is the initial step, leading to inflammation and lipid accumulation that promote acute and chronic inflammation. Molecular biological approaches, such as gene editing and nanotechnology, are being studied for therapeutic purposes in atherosclerosis.
Review
Biochemistry & Molecular Biology
Alexandrine Bertaud, Ahmad Joshkon, Xavier Heim, Richard Bachelier, Nathalie Bardin, Aurelie S. Leroyer, Marcel Blot-Chabaud
Summary: Cardiac fibrosis is a condition characterized by irreversible necrosis of the heart muscle, caused by various acute or chronic diseases, genetic alterations, or aging. Currently, there is no curative treatment available to prevent or attenuate cardiac fibrosis, which leads to progressive cardiac dysfunction and life-threatening outcomes. This review summarizes different targets and new strategies proposed to fight cardiac fibrosis, as well as discussing future directions, such as the use of exosomes or nanoparticles.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Paola Nobili, Weida Shen, Katarina Milicevic, Jelena Bogdanovic Pristov, Etienne Audinat, Ljiljana Nikolic
Summary: Epilepsy and multiple sclerosis, two common neurological diseases, have limited treatment options. This article discusses the potential of targeting astrocytes as a new therapeutic approach and explores their role in modulating neuroinflammatory responses.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Liqing Lu, Tian Fang, Tuo Pang, Ziyi Chen, Longhuai Cheng, Dejun Ma, Zhen Xi
Summary: Gene therapy using nanovectors carrying PTEN gene could restore PTEN function, inhibit cell proliferation, and induce cell apoptosis in lung cancer, suggesting promising therapeutic potential.
Article
Oncology
Yuanfeng Wei, Xi Yang, Limin Gao, Yong Xu, Cheng Yi
Summary: This study compared the differentially expressed genes between primary and secondary breast angiosarcoma and conducted enrichment analysis and protein-protein interaction network analysis. The results identified enrichment in metabolism, energy pathways, and protein metabolism in biological processes, as well as enrichment in signaling pathways such as transforming growth factor-beta, Wnt, Hippo, and PI3K-Akt. The study provides a foundation for the discovery of new biomarkers and therapeutic targets.
TRANSLATIONAL ONCOLOGY
(2022)
Review
Pharmacology & Pharmacy
Yaoxiang Tang, Ying Zhou, Songqing Fan, Qiuyuan Wen
Summary: This review article summarizes the importance of HSP60 in cancer, including its structure, functional cycle, regulatory mechanism, and its applications in diagnosis and therapy.
BIOCHEMICAL PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Ziyi Zhou, Zhaochen Feng, Xiaojia Sun, Yusheng Wang, Guorui Dou
Summary: This review examines the role of Galectin-3 in ocular diseases, its potential as a biomarker, and its potential as a therapeutic target.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Nastaran Karimi, Seyed Javad Moghaddam
Summary: RAS mutations, especially KRAS, are common in human cancers, particularly non-small-cell lung cancer (NSCLC). Despite numerous investigations and clinical trials, therapeutic agents targeting KRAS have encountered limited success due to co-mutations and other restrictive mechanisms.
Article
Biochemistry & Molecular Biology
Rohit Karn, Isaac Arnold Emerson
Summary: This study focused on the most frequently occurring PTEN mutation in breast cancer and found that frameshift mutations are the most damaging to the C2 domain. Substitution mutations D92H and R130Q were found to interfere with the dephosphorylation process of normal PTEN. The C2 domain is more frequently mutated and shows greater fluctuations in amino acid residues compared to other regions. The study provides a basis for selecting the frequently mutated C2 domain as a potential therapeutic marker.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Oncology
Elias E. Stratikopoulos, Meaghan Dendy, Matthias Szabolcs, Alan J. Khaykin, Celine Lefebvre, Ming-Ming Zhou, Ramon Parsons
Article
Oncology
Yilun Chen, Marc J. van de Vijver, Hanina Hibshoosh, Ramon Parsons, Lao H. Saal
PATHOLOGY & ONCOLOGY RESEARCH
(2016)
Article
Oncology
Qing-Bai She, Sofia K. Gruvberger-Saal, Matthew Maurer, Yilun Chen, Mervi Jumppanen, Tao Su, Meaghan Dendy, Ying-Ka Ingar Lau, Lorenzo Memeo, Hugo M. Horlings, Marc J. van de Vijver, Jorma Isola, Hanina Hibshoosh, Neal Rosen, Ramon Parsons, Lao H. Saal
Article
Oncology
Elias E. Stratikopoulos, Ramon E. Parsons
CLINICAL CANCER RESEARCH
(2016)
Article
Biochemistry & Molecular Biology
Douglas Barrows, John Z. He, Ramon Parsons
JOURNAL OF BIOLOGICAL CHEMISTRY
(2016)
Article
Cell Biology
Chi-Yeh Chung, Zhen Sun, Gavriel Mullokandov, Almudena Bosch, Zulekha A. Qadeer, Esma Cihan, Zachary Rapp, Ramon Parsons, Julio A. Aguirre-Ghiso, Eduardo F. Farias, Brian D. Brown, Alexandre Gaspar-Maia, Emily Bernstein
Article
Immunology
Sebastian A. Riquelme, Benjamin D. Hopkins, Andrew L. Wolfe, Emily DiMango, Kipyegon Kitur, Ramon Parsons, Alice Prince
Article
Oncology
Kyrie Pappas, Jia Xu, Sakellarios Zairis, Lois Resnick-Silverman, Francesco Abate, Nicole Steinbach, Sait Ozturk, Lao H. Saal, Tao Su, Pamela Cheung, Hank Schmidt, Stuart Aaronson, Hanina Hibshoosh, James Manfredi, Raul Rabadan, Ramon Parsons
MOLECULAR CANCER RESEARCH
(2017)
Article
Oncology
Shalini S. Yadav, Jinyi Li, Jennifer A. Stockert, Bryan Herzog, James O'Connor, Luis Garzon-Manco, Ramon Parsons, Ashutosh K. Tewari, Kamlesh K. Yadav
TRANSLATIONAL ONCOLOGY
(2017)
Article
Oncology
Deepti Mathur, Elias Stratikopoulos, Sait Ozturk, Nicole Steinbach, Sarah Pegno, Sarah Schoenfeld, Raymund Yong, Vundavalli V. Murty, John M. Asara, Lewis C. Cantley, Ramon Parsons
Article
Biochemistry & Molecular Biology
Elias E. Stratikopoulos, Nicole Kiess, Matthias Szabolcs, Sarah Pegno, Cheung Kakit, Xuewei Wu, Poulikos Poulikakos, Pamela Cheung, Hank Schmidt, Ramon Parsons
Article
Biochemistry & Molecular Biology
Nicole Steinbach, Dan Hasson, Deepti Mathur, Elias E. Stratikopoulos, Ravi Sachidanandam, Emily Bernstein, Ramon E. Parsons
NUCLEIC ACIDS RESEARCH
(2019)
Editorial Material
Multidisciplinary Sciences
Ramon Parsons
Article
Oncology
Sait Ozturk, Deepti Mathur, Royce W. Zhou, David Mulholland, Ramon Parsons
PROSTATE CANCER AND PROSTATIC DISEASES
(2020)
Article
Biology
Kyrie Pappas, Tiphaine C. Martin, Andrew L. Wolfe, Christie B. Nguyen, Tao Su, Jian Jin, Hanina Hibshoosh, Ramon Parsons
Summary: In breast cancer, downregulation of the PTEN tumor suppressor gene is common and associated with poor prognosis and triple-negative breast cancer. EZH2 and NOTCH1/2 alterations are correlated with decreased PTEN expression, possibly working together to suppress PTEN transcription.
COMMUNICATIONS BIOLOGY
(2021)