Article
Multidisciplinary Sciences
Tyler Bland, Jing Wang, Lijuan Yin, Tianjie Pu, Jingjing Li, Jin Gao, Tzu-Ping Lin, Allen C. Gao, Boyang Jason Wu
Summary: Experimental studies revealed that the Wnt secretion mediator Wnt less (WLS) plays a major role in NEPC pathogenesis and aggressive tumor growth, being suppressed by AR and activating the ROR2/PKC delta/ERK signaling pathway. Clinical sample analysis showed high expression of WLS in CRPC and NEPC tumors, and treatment with WLS inhibitor LGK974 can restrict NE prostate tumor growth.
Article
Multidisciplinary Sciences
Ziwei Wang, Tao Wang, Danni Hong, Baijun Dong, Yan Wang, Huaqiang Huang, Wenhui Zhang, Bijun Lian, Boyao Ji, Haoqing Shi, Min Qu, Xu Gao, Daofeng Li, Colin Collins, Gonghong Wei, Chuanliang Xu, Hyung Joo Lee, Jialiang Huang, Jing Li
Summary: This study characterized ADPC and NEPC in prostate tumors using scRNA-seq and identified NEPC-specific gene expression signatures. The findings revealed different paths by which NEPC diverges from ADPC and inferred a hierarchical transcription factor network involved in NEPC progression.
Article
Genetics & Heredity
YouZhi Wang, Ning Wu, KeKe Wang, YiHao Liao, JiaNing Guo, BoQiang Zhong, Tao Guo, JiaMing Liang, Ning Jiang
Summary: This study aims to explore whether NEDPC is an intermediate stage in the progression of HRPC to NEPC and identify risk factors and new targets associated with survival in the treatment of NEPC.
FRONTIERS IN GENETICS
(2022)
Review
Urology & Nephrology
Beshara Sheehan, Christina Guo, Antje Neeb, Alec Paschalis, Shahneen Sandhu, Johann S. de Bono
Summary: PSMA is a promising theranostic target in advanced prostate cancer (PCa) and multiple PSMA-targeted therapies have shown antitumour activity. PSMA expression is associated with disease progression, worse clinical outcomes, and DNA damage repair defects. Recent studies have shed light on the complex regulation of PSMA and its interactions with androgen receptor, PI3K/Akt, and DDR signalling. Clinical trials have shown that 177Lu-PSMA-617 can shrink tumours and delay disease progression in metastatic castration-resistant PCa. There are also novel PSMA-targeting immunotherapies, small molecules, and antibody therapies in clinical development.
EUROPEAN UROLOGY FOCUS
(2022)
Article
Multidisciplinary Sciences
Paloma Cejas, Yingtian Xie, Alba Font-Tello, Klothilda Lim, Sudeepa Syamala, Xintao Qiu, Alok K. Tewari, Neel Shah, Holly M. Nguyen, Radhika A. Patel, Lisha Brown, Ilsa Coleman, Wenzel M. Hackeng, Lodewijk Brosens, Koen M. A. Dreijerink, Leigh Ellis, Sarah Abou Alaiwi, Ji-Heui Seo, Sylvan Baca, Himisha Beltran, Francesca Khani, Mark Pomerantz, Alessandra Dall'Agnese, Jett Crowdis, Eliezer M. Van Allen, Joaquim Bellmunt, Colm Morrisey, Peter S. Nelson, James DeCaprio, Anna Farago, Nicholas Dyson, Benjamin Drapkin, X. Shirley Liu, Matthew Freedman, Michael C. Haffner, Eva Corey, Myles Brown, Henry W. Long
Summary: Neuroendocrine carcinomas (NECs) arise from different anatomic sites, but share similar histological and clinical features. The epigenetic landscape of NECs converges towards a common state, while distinct subtypes occur within neuroendocrine prostate cancer, contributing to intratumor heterogeneity in clinical samples.
NATURE COMMUNICATIONS
(2021)
Article
Oncology
Nanwei Xu, Jinge Zhao, Fengnian Zhao, Haoyang Liu, Wenlian Yin, Sha Zhu, Ling Nie, Guangxi Sun, Linmao Zheng, Zhenhua Liu, Diming Cai, Junru Chen, Jindong Dai, Yuchao Ni, Zhipeng Wang, Xingming Zhang, Jiayu Liang, Yuntian Chen, Xu Hu, Xiuyi Pan, Xiaoxue Yin, Xudong Zhu, Yaowen Zhang, Zilin Wang, Yuhao Zeng, Minghao Wang, Pengfei Shen, Ni Chen, Hao Zeng
Summary: This study aimed to explore the predictive value of neuroendocrine differentiation (NED) in patients with metastatic castration-resistant prostate cancer (mCRPC) receiving abiraterone or docetaxel as first-line therapy. The results showed that NED was associated with shorter survival in both abiraterone and docetaxel treatment, suggesting that NED detection may help predict treatment outcomes and optimize treatment decisions for mCRPC patients.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xue Shui, Xuehua Ren, Rong Xu, Qinghua Xie, Yaohua Hu, Jing Qin, Han Meng, Caiqin Zhang, Jumei Zhao, Changhong Shi
Summary: Neuroendocrine transdifferentiation (NED) is the main cause of failure of androgen receptor inhibitor treatment in prostate cancer (PCa), and elevated monoamine oxidase A (MAOA) plays a significant role in this process. Enzalutamide induces NED via the MAOA/mTOR/HIF-1a signaling axis, and the MAOA inhibitor clorgyline shows potential benefits in treating CRPC patients by improving therapeutic effects and delaying NED.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Oncology
Shiqin Liu, Busola Ruth Alabi, Qingqing Yin, Tanya Stoyanova
Summary: Prostate cancer is a common cancer in men in the United States and often leads to cancer-related deaths. Androgen deprivation therapy is the standard treatment for advanced prostate cancer, but some patients develop castration-resistant prostate cancer and even neuroendocrine prostate cancer. Neuroendocrine prostate cancer is characterized by the expression of neuroendocrine markers and the absence of androgen receptor, and is often associated with aggressive tumors, therapy resistance, and poor clinical outcomes.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Cell Biology
Zhi Long, Liang Deng, Chao Li, Qiangrong He, Yao He, Xiheng Hu, Yi Cai, Yu Gan
Summary: The study found that EHF expression is significantly reduced in t-NEPC, and ADT promotes NED by regulating the binding of AR to EHF. Restoring EHF expression or using EZH2 inhibitors can alleviate the aggressive properties of CRPC.
CELL DEATH & DISEASE
(2021)
Review
Oncology
Yuchen Xie, Songyi Ning, Jianpeng Hu
Summary: This review focuses on the molecular characteristics and relevant genes and molecular mechanisms that contribute to the transformation of neuroendocrine differentiation in prostate cancer, aiming to discover new methods for accurate diagnosis and targeted therapy.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yohei Sekino, Quoc Thang Pham, Kohei Kobatake, Hiroyuki Kitano, Kenichiro Ikeda, Keisuke Goto, Shogo Inoue, Tetsutaro Hayashi, Masaki Shiota, Wataru Yasui, Jun Teishima
Summary: HOXB5 plays a role in prostate cancer progression and may serve as a promising prognostic marker after prostatectomy. Its overexpression promotes cell growth and invasion in PCa cell lines, and it may be involved in the progression to neuroendocrine prostate cancer.
Article
Biochemistry & Molecular Biology
Jing Wang, Jingjing Li, Lijuan Yin, Tianjie Pu, Jing Wei, Varsha Karthikeyan, Tzu-Ping Lin, Allen C. Gao, Boyang Jason Wu
Summary: This study reveals that neuropilin 2 (NRP2) is upregulated in NEPC and plays a role in driving NEPC development and resistance. NRP2 interacts with AR to suppress AR signaling, and activates STAT3 phosphorylation by interacting with VEGFR2, promoting NEPC differentiation and growth.
Article
Oncology
Kenji Unno, Zachary R. Chalmers, Sahithi Pamarthy, Rajita Vatapalli, Yara Rodriguez, Barbara Lysy, Hanlin Mok, Vinay Sagar, Huiying Han, Young A. Yoo, Sheng-Yu Ku, Himisha Beltran, Yue Zhao, Sarki A. Abdulkadir
Summary: The coactivation of ALK and N-Myc induces NEPC through stimulation of the Wnt/beta-catenin pathway. Inhibition of ALK and Wnt pathways represents a potential therapeutic strategy for NEPC and neuroblastoma.
Review
Oncology
James G. Nicholson, Howard A. Fine
Summary: Diffuse gliomas are characterized by high levels of genetic, epigenetic, and environmental heterogeneity, leading to extreme phenotypic heterogeneity at the cellular level and resistance to various therapies. The intratumoral heterogeneity and malignant cell state plasticity in gliomas pose significant challenges to the development of novel targeted therapies.
Article
Biochemistry & Molecular Biology
Sijie Wang, Aktan Alpsoy, Surbhi Sood, Sandra Carolina Ordonez-Rubiano, Alisha Dhiman, Yixing Sun, Guanming Jiao, Casey J. Krusemark, Emily C. Dykhuizen
Summary: Polycomb group (PcG) proteins regulate embryonic development and cancer progression by forming Polycomb repressive complexes. Among them, CBX2 is upregulated in various cancers, especially advanced prostate cancer. A selective CBX2 chromodomain probe, SW2_152F, has been discovered to inhibit CBX2 chromatin binding and block neuroendocrine differentiation in prostate cancer cells.
Article
Oncology
Elias E. Stratikopoulos, Meaghan Dendy, Matthias Szabolcs, Alan J. Khaykin, Celine Lefebvre, Ming-Ming Zhou, Ramon Parsons
Article
Oncology
Yilun Chen, Marc J. van de Vijver, Hanina Hibshoosh, Ramon Parsons, Lao H. Saal
PATHOLOGY & ONCOLOGY RESEARCH
(2016)
Article
Oncology
Qing-Bai She, Sofia K. Gruvberger-Saal, Matthew Maurer, Yilun Chen, Mervi Jumppanen, Tao Su, Meaghan Dendy, Ying-Ka Ingar Lau, Lorenzo Memeo, Hugo M. Horlings, Marc J. van de Vijver, Jorma Isola, Hanina Hibshoosh, Neal Rosen, Ramon Parsons, Lao H. Saal
Article
Oncology
Elias E. Stratikopoulos, Ramon E. Parsons
CLINICAL CANCER RESEARCH
(2016)
Article
Biochemistry & Molecular Biology
Douglas Barrows, John Z. He, Ramon Parsons
JOURNAL OF BIOLOGICAL CHEMISTRY
(2016)
Article
Cell Biology
Chi-Yeh Chung, Zhen Sun, Gavriel Mullokandov, Almudena Bosch, Zulekha A. Qadeer, Esma Cihan, Zachary Rapp, Ramon Parsons, Julio A. Aguirre-Ghiso, Eduardo F. Farias, Brian D. Brown, Alexandre Gaspar-Maia, Emily Bernstein
Article
Immunology
Sebastian A. Riquelme, Benjamin D. Hopkins, Andrew L. Wolfe, Emily DiMango, Kipyegon Kitur, Ramon Parsons, Alice Prince
Article
Oncology
Kyrie Pappas, Jia Xu, Sakellarios Zairis, Lois Resnick-Silverman, Francesco Abate, Nicole Steinbach, Sait Ozturk, Lao H. Saal, Tao Su, Pamela Cheung, Hank Schmidt, Stuart Aaronson, Hanina Hibshoosh, James Manfredi, Raul Rabadan, Ramon Parsons
MOLECULAR CANCER RESEARCH
(2017)
Article
Oncology
Deepti Mathur, Elias Stratikopoulos, Sait Ozturk, Nicole Steinbach, Sarah Pegno, Sarah Schoenfeld, Raymund Yong, Vundavalli V. Murty, John M. Asara, Lewis C. Cantley, Ramon Parsons
Article
Biochemistry & Molecular Biology
Elias E. Stratikopoulos, Nicole Kiess, Matthias Szabolcs, Sarah Pegno, Cheung Kakit, Xuewei Wu, Poulikos Poulikakos, Pamela Cheung, Hank Schmidt, Ramon Parsons
Article
Biochemistry & Molecular Biology
Nicole Steinbach, Dan Hasson, Deepti Mathur, Elias E. Stratikopoulos, Ravi Sachidanandam, Emily Bernstein, Ramon E. Parsons
NUCLEIC ACIDS RESEARCH
(2019)
Editorial Material
Multidisciplinary Sciences
Ramon Parsons
Article
Oncology
Sait Ozturk, Deepti Mathur, Royce W. Zhou, David Mulholland, Ramon Parsons
PROSTATE CANCER AND PROSTATIC DISEASES
(2020)
Article
Biology
Kyrie Pappas, Tiphaine C. Martin, Andrew L. Wolfe, Christie B. Nguyen, Tao Su, Jian Jin, Hanina Hibshoosh, Ramon Parsons
Summary: In breast cancer, downregulation of the PTEN tumor suppressor gene is common and associated with poor prognosis and triple-negative breast cancer. EZH2 and NOTCH1/2 alterations are correlated with decreased PTEN expression, possibly working together to suppress PTEN transcription.
COMMUNICATIONS BIOLOGY
(2021)
Article
Oncology
Xiaofan Pu, Chaolei Zhang, Guoping Ding, Hongpeng Gu, Yang Lv, Tao Shen, Tianshu Pang, Liping Cao, Shengnan Jia
Summary: This study demonstrated the potential utility of the sEV-miRNA d-signature in the diagnosis of PDAC via machine learning methods. A novel sEV biomarker, miR-664a-3p, was identified for the diagnosis of PDAC. It can also potentially promote angiogenesis and metastasis, provide insight into PDAC pathogenesis, and reveal novel regulators of this disease.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Jiaping Wang, Zhijuan Xu, Yanli Lai, Yanli Zhang, Ping Zhang, Qitian Mu, Shujun Yang, Yongcheng Sun, Lixia Sheng, Guifang Ouyang
Summary: This study demonstrates the significance of PD-1 in EBV-infected lymphoma cells. Silencing PD-1 enhances the tumor targeting effect of EBV-specific killer T cells on B lymphocytes and attenuates the immune escape effect.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Qiliang Peng, Jialong Tao, Yingjie Xu, Yi Shen, Yong Wang, Yang Jiao, Yiheng Mao, Yaqun Zhu, Yulong Liu, Ye Tian
Summary: This study investigates the potential role of lipid metabolism-associated genes (LMAGs) in neoadjuvant chemoradiotherapy (nCRT) and immunotherapy for rectal cancer. The results suggest that the SREBF2 gene is a highly predictive factor for nCRT in rectal cancer and is associated with favorable prognosis. SREBF2 is also closely associated with immune cell infiltration and immunotherapy-related genes.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Shiquan Li, Nan Zhang, Yongping Yang, Tongjun Liu
Summary: This study investigated the potential molecular mechanism of SPDEF in immune evasion of colorectal cancer (CRC) and found that it suppresses immune evasion by activating CCL28 through the modulation of M2 polarization of macrophages. These findings provide a new research direction and potential therapeutic target for immunotherapy in CRC.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Manas Sehgal, Soundharya Ramu, Joel Markus Vaz, Yogheshwer Raja Ganapathy, Srinath Muralidharan, Sankalpa Venkatraghavan, Mohit Kumar Jolly
Summary: This study investigates the relationship between gene expression patterns and phenotypic plasticity and heterogeneity in colorectal cancer (CRC). The results demonstrate the interconnectedness between different Consensus Molecular Subtypes (CMS) of CRC and specific phenotypes such as epithelial and mesenchymal characteristics. Additionally, the study reveals correlations between metabolic pathways and phenotypic scores, as well as between PD-L1 activity and mesenchymal phenotype. Single-cell RNA sequencing analysis further confirms the heterogeneity of different CMS subtypes. These findings have important implications for understanding CRC heterogeneity and developing targeted therapies.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Yutong Zou, Siyao Guo, Yan Liao, Weidong Chen, Ziyun Chen, Junkai Chen, Lili Wen, Xianbiao Xie
Summary: This study found that ceramide metabolism is associated with the progression and clinical outcome of osteosarcoma by analyzing data from osteosarcoma patients. The gene ST3GAL1 plays an important role in osteosarcoma, regulating the tumor immune microenvironment and affecting T cell function. It may become a new target for the treatment of osteosarcoma.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Chuanhui Chen, Mengzhi Wan, Xiong Peng, Qing Zhang, Yu Liu
Summary: This study examines the function and mechanism of the ceRNA network centered around GPR37 in LUAD. The findings show that high expression of GPR37 in LUAD tissue samples is associated with poor prognosis, and it may regulate the expression of downstream target genes by competitively binding to lncRNA DLEU1 and miR-4458.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Junping Li, Hong Hu, Jinping He, Yuling Hu, Manting Liu, Bihui Cao, Dongni Chen, Xiaodie Ye, Jian Zhang, Zhiru Zhang, Wen Long, Hui Lian, Deji Chen, Likun Chen, Lili Yang, Zhenfeng Zhang
Summary: Sequential administration of CDC7 inhibitor XL413 after carboplatin enhances the chemotherapeutic effect of carboplatin on ovarian cancer cells, possibly by inhibiting homologous recombination repair activity and increasing the accumulation of chemotherapy-induced DNA damage.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Madison Catalanotto, Joel Markus Vaz, Camille Abshire, Reneau Youngblood, Min Chu, Herbert Levine, Mohit Kumar Jolly, Ana -Maria Dragoi
Summary: The study demonstrates that loss of FLASH in cancer cells leads to a hybrid E/M phenotype with high epithelial scores, suggesting FLASH acts as a repressor of the epithelial phenotype. Additionally, FLASH expression is inversely correlated with the epithelial score and subsets of mesenchymal markers are distinctly up-regulated in FLASH, NPAT, or SLBP-depleted cells.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Xiaorui Wang, Na Li, Minying Zheng, Yongjun Yu, Shiwu Zhang
Summary: Adipocytes are derived from pluripotent mesenchymal stem cells and histone modifications play a key role in their differentiation. Recent studies have shown that cancer stem cells can differentiate into adipocytes, reducing the malignancy of cancer cells.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Hana Q. Sadida, Alanoud Abdulla, Sara Al Marzooqi, Sheema Hashem, Muzafar A. Macha, Ammira S. Al-Shabeeb Akil, Ajaz A. Bhat
Summary: Cancer heterogeneity and drug resistance are major obstacles to effective cancer treatment, and epigenetic modifications play a pivotal role in these processes. This review explores essential epigenetic modifications, including DNA methylation, histone modifications, and chromatin remodeling, and discusses their complex contributions to cancer biology. However, the interplay of epigenetic and genetic changes in cancer cells presents unique challenges that must be addressed to fully exploit the potential of epigenetic modifications.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Pedro De Marchi, Leticia Ferro Leal, Luciane Sussuchi da Silva, Rodrigo de Oliveira Cavagna, Flavio Augusto Ferreira da Silva, Vinicius Duval da Silva, Eduardo C. A. da Silva, Augusto O. Saito, Vladmir C. Cordeiro de Lima, Rui Manuel Reis
Summary: The TIS and IFN-gamma signatures are predictive biomarkers for identifying NSCLC patients who could potentially benefit from immune checkpoint inhibitor therapies.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Giovanni Marchi, Anna Rajavuori, Mai T. N. Nguyen, Kaisa Huhtinen, Sinikka Oksa, Sakari Hietanen, Sampsa Hautaniemi, Johanna Hynninen, Jaana Oikkonen
Summary: The study shows that ctDNA can adequately represent high-grade serous ovarian carcinoma (HGSC), and the mutations observed at relapse suggest personalized therapy options.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Yuncang Yuan, Jiawei Fan, Dandan Liang, Shijie Wang, Xu Luo, Yongjie Zhu, Nan Liu, Tingxiu Xiang, Xudong Zhao
Summary: This study demonstrates that csGRP78-directed CAR-T cells can selectively kill pancreatic cancer cells, and the combination with chemotherapy enhances cytotoxicity.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Niyati Piplani, Tanusri Roy, Neha Saxena, Shamik Sen
Summary: The glycocalyx, a protective barrier surrounding cells, has been found to play a role in cancer cell proliferation, survival, and metastasis. However, its function in maintaining DNA/nuclear integrity during migration through dense matrices has not been explored. This study shows that the bulkiness of the glycocalyx is inversely associated with nuclear stresses, and highlights its mechanical role in shielding migration-associated stresses.
TRANSLATIONAL ONCOLOGY
(2024)