4.5 Article

Association of serum ferritin with coronary artery disease

Journal

CLINICAL BIOCHEMISTRY
Volume 45, Issue 16-17, Pages 1336-1341

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.clinbiochem.2012.06.013

Keywords

Ferritin; Iron; Coronary artery disease; Meta-analysis

Funding

  1. National Natural Science Foundation of China [81072357]

Ask authors/readers for more resources

Background: Published results regarding the association of serum ferritin with coronary artery disease (CAD) were conflicting, thus a case-control study and a meta-analysis were performed to assess the association between serum ferritin and CAD risk. Methods: A hospital-based case-control study was conducted with 258 CAD cases and 282 healthy controls. The restricted cubic spline (RCS) function with three knots was used to assess the concentration-risk association between serum ferritin and CAD risk. A meta-analysis was performed including 20 outcomes. Fixed or random effect pooled measure was selected on the basis of homogeneity test among studies. Results: In our case-control study, compared with serum ferritin concentrations less than 200 mu g/L as the reference, the trend of CAD risk increased by 4.2% for every 50 mu g/L increase in serum ferritin (OR = 1.042, 95% CI = 0.946-1.147). In the meta-analysis and after excluding articles that were the key contributors to between-study heterogeneity, the standardized mean difference (SMD) of serum ferritin was associated with increased CAD risk (FEM: SMD = 0.119, 95% CI = 0.073-0.165). And the concentration-risk meta-analysis suggested that, for every 50 mu g/L increase of serum ferritin, the risk of CAD increases by 2.4% (OR = 1.024, 95% CI = 1.001-1.048). Conclusion: These findings indicate that serum ferritin is weakly positively associated with CAD risk. This risk needs to be confirmed by further studies. (c) 2012 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.5
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

Article Environmental Sciences

Peanut/sorghum intercropping drives specific variation in peanut rhizosphere soil properties and microbiomes under salt stress

Xiaolong Shi, Yufei Zhou, Pei Guo, Jingyao Ren, He Zhang, Qiqi Dong, Chunji Jiang, Chao Zhong, Zheng Zhang, Shubo Wan, Xinhua Zhao, Haiqiu Yu

Summary: Intercropping of peanut and sorghum can improve soil properties and microbial community structure, enhancing nutrient availability, enzymatic activities, and plant adaptability under salt stress conditions.

LAND DEGRADATION & DEVELOPMENT (2023)

Article Computer Science, Artificial Intelligence

Automatic detection of indoor occupancy based on improved YOLOv5 model

Chao Wang, Yunchu Zhang, Yanfei Zhou, Shaohan Sun, Hanyuan Zhang, Yepeng Wang

Summary: This paper proposes a novel algorithm DFV-YOLOv5 for occupancy detection, which tackles the problems of slow model convergence and poor detection performance for densely occluded targets. The proposed algorithm uses the anchor-free mechanism and decoupled detection heads to improve the detection accuracy and robustness. Experimental results show the practicality and superiority of the algorithm in occupancy detection compared to mainstream target detection models.

NEURAL COMPUTING & APPLICATIONS (2023)

Article Engineering, Geological

Seismic behavior of prefabricated reinforced concrete stair isolated by high damping rubber bearings

Chao Zhang, Chao Ding, Yun Zhou, Guangyu Wang, Fei Shi, Weiyuan Huang

Summary: A novel stair system is proposed in this study, which is a prefabricated reinforced concrete staircase isolated by high damping rubber (HDR) bearings that can alleviate the detrimental diagonal bracing effect of traditional staircases under lateral inputs. The remarkable properties of HDR bearings are verified through material tests, and a parametric study is conducted to understand the behavior of the developed system. The results confirm that the proposed system can mitigate the detrimental effect and improve the seismic performance, with the rubber thickness of the HDR bearings playing a significant role.

BULLETIN OF EARTHQUAKE ENGINEERING (2023)

Article Environmental Sciences

Trophic interactions regulate microbial responses to environmental conditions and partially counteract nitrogen transformation potential in urban river bends

Haolan Wang, Wenlong Zhang, Yi Li, Yu Gao, Nan Yang, Lihua Niu, Huanjun Zhang, Longfei Wang

Summary: This study investigates the impact of trophic interactions on the assembly of multi-trophic microbial communities and nitrogen transformation potential in typical urban river bends. The results indicate that trophic interactions strongly shape microbial communities, leading to increased abundance in multitrophic microbial communities and enhanced nitrogen transformation potential. This research provides a theoretical basis for the regulation and restoration of urban rivers.

JOURNAL OF ENVIRONMENTAL MANAGEMENT (2023)

Article Biochemical Research Methods

Novel Green Fluorescent Probe Stem From Carbon Quantum Dots for Specific Recognition of Tyrosinase in Serum and Living Cells

Wenxian Wang, Dan Yang, Yufei Zhou, Yuding Zhang, Lijiao Guan, Xianfen Zhang, Weiming Xue, Saipeng Huang

Summary: This study successfully constructed highly sensitive and functional carbon quantum dots for the detection of tyrosinase activity. These carbon quantum dots showed excellent linear relationship and broad linear range with high accuracy and recovery in human serum samples. Furthermore, they demonstrated good cellular imaging capability and biocompatibility, making them suitable for intracellular tyrosinase detection. This research holds potential biomedical applications in early diagnosis of melanoma and other tyrosinase-related diseases.

JOURNAL OF FLUORESCENCE (2023)

Article Surgery

Salvianolic Acid B Reduces the Inflammation of Fat Grafts by Inhibiting the NF-Kb Signalling Pathway in Macrophages

Jia-Ming Sun, Chia-Kang Ho, Ya Gao, Chio-Hou Chong, Yang-Dan Liu, Yu-Xin Liu, Dan-Ning Zheng, Yi-Fan Zhang, Li Yu

Summary: Sal-B could improve the effect of fat transplantation by inhibiting the polarization of M1 macrophages through NF-kappa B signaling. The results showed that Sal-B significantly improved fat graft survival and attenuated adipose tissue fibrosis and inflammation. In addition, Sal-B had an inhibitory effect on NF-kappa B signaling.

AESTHETIC SURGERY JOURNAL (2023)

Article Computer Science, Information Systems

Robust Hierarchical Federated Learning with Anomaly Detection in Cloud-Edge-End Cooperation Networks

Yujie Zhou, Ruyan Wang, Xingyue Mo, Zhidu Li, Tong Tang

Summary: This study proposes a robust hierarchical federated learning (R-HFL) framework that utilizes cloud-edge cooperation to enhance communication efficiency and system resistance to abnormal behaviors in distributed machine learning training.

ELECTRONICS (2023)

Article Management

Full-time homemakers and economic disadvantage: The case of Japan

James M. Raymo, Yanfei Zhou

Summary: A significant number of impoverished mothers in Japan do not work, which defies conventional theories of labor supply and the expectation of gender equality. Unlike in the United States and other countries, well-known barriers to employment for low-income mothers do not seem to apply in Japan. This study seeks to understand this phenomenon by examining the reasons given by these mothers for not working and the factors influencing maternal employment based on their husbands' income. The prioritization of childrearing and traditional gender roles were found to be strong predictors of non-employment among all mothers, regardless of their husbands' income level.

GENDER WORK AND ORGANIZATION (2023)

Article Plant Sciences

Soil metagenome and metabolome of peanut intercropped with sorghum reveal a prominent role of carbohydrate metabolism in salt-stress response

Xiaolong Shi, Yufei Zhou, Xinhua Zhao, Pei Guo, Jingyao Ren, He Zhang, Qiqi Dong, Zheng Zhang, Haiqiu Yu, Shubo Wan

Summary: Soil metabolomics and metagenome sequencing were used to investigate the salt-stress response in peanuts intercropped with sorghum. The study found that carbohydrate metabolism was the most differentially expressed pathway, with certain metabolites more abundant in intercropped peanuts under salt stress. In addition, there was a higher abundance of specific microbial taxa in intercropped peanuts under salt stress. These findings suggest that intercropping can indirectly influence beneficial microbial communities and potentially enhance peanut's salt tolerance.

ENVIRONMENTAL AND EXPERIMENTAL BOTANY (2023)

Article Environmental Sciences

Inter-basin water diversion homogenizes microbial communities mainly through stochastic assembly processes

Nan Yang, Xing Hou, Yi Li, Huanjun Zhang, Jun Wang, Xiaodong Hu, Wenlong Zhang

Summary: This study investigates the effects of water diversion on microbial communities in different habitats. It finds that increased connectivity between aquatic habitats due to water diversion can homogenize microbial communities and reduce heterogeneity. Stochastic processes play an important role in shaping microbial community assembly, with dispersal limitation and variable selection being the dominant mechanisms in isolated lakes. The study provides important insights for water resource allocation and project management.

ENVIRONMENTAL RESEARCH (2023)

Article Oncology

Apolipoprotein E mimetic peptide COG1410 alleviates blood-brain barrier injury in a rat model of ischemic stroke

Yunwen Xue, Minhua Gu, Cuilan Chen, Yujian Yao, Yuzhen Li, Guohu Weng, Yong Gu

Summary: The ApoE mimetic peptide COG1410 can alleviate blood-brain barrier (BBB) damage and neuroinflammation caused by cerebral ischemia-reperfusion injury.

MOLECULAR MEDICINE REPORTS (2023)

Article Plant Sciences

Integrated Analysis of microRNA and RNA-Seq Reveals Phenolic Acid Secretion Metabolism in Continuous Cropping of Polygonatum odoratum

Yan Wang, Kaitai Liu, Yunyun Zhou, Yong Chen, Chenzhong Jin, Yihong Hu

Summary: This study investigated the relationship between phenolic acid biosynthesis and continuous cropping (CC) in Polygonatum odoratum roots through miRNA-seq and RNA-seq analysis. Several key DEGs and DEMs involved in phenolic acid synthesis were identified, providing a foundation for further understanding phenolic acid biosynthesis during CC of P. odoratum roots.

PLANTS-BASEL (2023)

Article Education & Educational Research

The influence of social capital on primary school teachers? creative teaching behavior: Mediating effects of knowledge sharing and creative teaching self-efficacy

Leishan Shi, Shuzhen Chen, Yanfang Zhou

Summary: Based on social capital theory, this study investigates the relationship between social capital and teachers' Creative Teaching Behavior (CTB) in school organizations. The results show that social capital positively predicts primary school teachers' CTB. It is found that social capital influences CTB through the mediating effects of knowledge sharing and creative teaching self-efficacy. The findings have theoretical and empirical implications for teachers' CTB.

THINKING SKILLS AND CREATIVITY (2023)

Article Area Studies

Raising Dogs that Bite: How Pastoralists and Breeders Care for Tibetan Mastiffs

Yufei Zhou

Summary: This paper discusses the commodification of Tibetan Mastiffs and the care relationship between humans and dogs. Tibetan pastoralists and dogs have a reciprocal yet distanced care relationship, while breeders of Tibetan Mastiffs focus on their ferociousness, resulting in a more dedicated but unilateral and dangerous care approach. The unintended consequence of breeders' care is that they raise dogs that sometimes bite, due to the transformation of dogs' guarding abilities from ethical virtue to commercial value.

CHINA QUARTERLY (2023)

Review Biochemistry & Molecular Biology

Advances in Ion Channel, Non-Desmosomal Variants and Autophagic Mechanisms Implicated in Arrhythmogenic Cardiomyopathy

Kexin Li, Yufeng Jiang, Yiyao Zeng, Yafeng Zhou

Summary: Arrhythmogenic cardiomyopathy (ACM) is a heterogeneous disorder characterized by the replacement of cardiac myocytes with fibro-fatty tissues, leading to abnormal excitation-contraction (EC) coupling and a range of malignant events. The pathogenesis of ACM involves mutation variants in desmosomal or non-desmosomal gene loci, as well as various external factors. Ion channel alterations, autophagy and non-desmosomal variants are also important components in the development of ACM. Reviewing recent studies on these topics is crucial for better diagnosing and treating the molecular phase of ACM.

CURRENT ISSUES IN MOLECULAR BIOLOGY (2023)

No Data Available