Review
Cardiac & Cardiovascular Systems
Alexia Rouland, David Masson, Laurent Lagrost, Bruno Verges, Thomas Gautier, Benjamin Bouillet
Summary: ApoC1 is a small apolipoprotein with significant roles in lipoprotein metabolism. It affects the metabolism of triglycerides and cholesterol and is involved in inflammation regulation. However, further studies are needed to fully understand its precise functions and its relationship with cardiometabolic diseases.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Endocrinology & Metabolism
Marietta Rottenkolber, Christina Gar, Cornelia Then, Lorena Wanger, Vanessa Sacco, Friederike Banning, Anne L. Potzel, Stefanie Kern-Matschilles, Claudia Nevinny-Stickel-Hinzpeter, Harald Grallert, Nina Hesse, Jochen Seissler, Andreas Lechner
Summary: This study re-evaluated the prevailing hypothesis that metabolic syndrome components are central to all cases of T2DM. Results showed that a significant proportion of T2DM cases did not display any components of metabolic syndrome, indicating the existence of a second, unrelated pathophysiology.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Multidisciplinary Sciences
Fiona Bragg, Christiana Kartsonaki, Yu Guo, Michael Holmes, Huaidong Du, Canqing Yu, Pei Pei, Ling Yang, Donghui Jin, Yiping Chen, Dan Schmidt, Daniel Avery, Jun Lv, Junshi Chen, Robert Clarke, Michael R. Hill, Liming Li, Iona Y. Millwood, Zhengming Chen
Summary: Diverse metabolic biomarkers are associated with the risk of type 2 diabetes (T2D) among Chinese adults and can help improve established risk prediction models.
SCIENTIFIC REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
Hiroki Yuge, Hiroshi Okada, Masahide Hamaguchi, Kazushiro Kurogi, Hiroaki Murata, Masato Ito, Michiaki Fukui
Summary: The ratio of TG/HDL-C is strongly associated with the risk of developing type 2 diabetes, and it can be a better predictor than LDL-C, HDL-C, or TG alone.
CARDIOVASCULAR DIABETOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Gracia Fahed, Laurence Aoun, Morgan Bou Zerdan, Sabine Allam, Maroun Bou Zerdan, Youssef Bouferraa, Hazem I. Assi
Summary: Metabolic syndrome is a cluster of metabolic dysregulations associated with insulin resistance and chronic low-grade inflammation. If left untreated, it significantly increases the risk of developing diabetes and cardiovascular diseases. However, many aspects of Metabolic syndrome are still not completely understood, and many questions remain unanswered. This review provides a comprehensive overview of the historical background, epidemiology, histopathology, pathophysiology, management, and prevention of Metabolic syndrome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Lars Lind, Samira Salihovic, Johan Sundstrom, Solve Elmstahl, Ulf Hammar, Koen Dekkers, Johan Arnlov, J. Gustav Smith, Gunnar Engstrom, Tove Fall
Summary: This study compared the plasma metabolome in obese subjects with and without metabolic syndrome (MetS) to normal-weight subjects without MetS. The results showed significant differences in metabolite profiles between obese and normal-weight individuals without MetS, with a gradual deterioration in metabolite profile from lean to obese to MetS. The pathways highlighted in this study, such as amino acid synthesis/metabolism and sphingolipid metabolism, may play a role in this metabolic deterioration, with insulin resistance as a potential mediator.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Biochemistry & Molecular Biology
Lowell Dilworth, Aldeam Facey, Felix Omoruyi
Summary: Adipose tissues, particularly brown and white adipose tissues, play key roles in communication and insulin sensitivity in the development and treatment of type 2 diabetes. Adipocytokines produced by adipose tissues, like leptin and adiponectin, vary in conditions such as metabolic dysfunction, diabetes, and inflammation. The regulation of satiety, energy metabolism, and insulin release by adipose tissues indicates their significance in the pathogenesis of diabetes mellitus and its complications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Endocrinology & Metabolism
Bashir Ahmad Laway, Mohammad Salem Baba
Summary: Sheehan syndrome caused by postpartum hemorrhage leads to pituitary hormone deficiency, resulting in various abnormalities including lipid and glucose abnormalities, increased body fat, insulin resistance, coagulation abnormalities, increased leptin concentration, low-grade inflammation, and endothelial dysfunction. Replacement with growth hormone in addition to standard hormone replacement improves the cardiometabolic profile of patients with Sheehan syndrome.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Charles D. Nicoli, April P. Carson, Timothy B. Plante, D. Leann Long, Leslie A. McClure, Janin Schulte, Mary Cushman
Summary: The stable precursor pro-neurotensin/neuromedin N (pro-NT/NMN) is associated with metabolic syndrome and diabetes mellitus, likely explained by insulin resistance.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Cardiac & Cardiovascular Systems
Joungyoun Kim, Sang-Jun Shin, Ye-Seul Kim, Hee-Taik Kang
Summary: The study investigated the relationship between TG/HDL-C ratio and diabetes incidence in Korean adults. Results showed that higher TG/HDL-C ratio was significantly associated with an increased risk of new-onset diabetes in both men and women.
CARDIOVASCULAR DIABETOLOGY
(2021)
Article
Endocrinology & Metabolism
Charles D. Nicoli, April P. Carson, Timothy B. Plante, D. Leann Long, Leslie A. McClure, Janin Schulte, Mary Cushman
Summary: The study demonstrates an association between the peptide neurotensin's stable precursor, pro-neurotensin/neuromedin N (pro-NT/NMN), and metabolic syndrome, specifically with dysglycemia and low density lipoprotein, likely attributable to insulin resistance.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Hematology
Karin E. Bornfeldt
Summary: Both type 1 and type 2 diabetes are associated with an increased risk of atherosclerotic cardiovascular disease. Recent findings suggest that increased levels of circulating remnant lipoproteins in people with diabetes could be the missing link between diabetes and CVD.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Review
Pediatrics
Dario Iafusco, Roberto Franceschi, Alice Maguolo, Salvatore Guercio Nuzio, Antonino Crino, Maurizio Delvecchio, Lorenzo Iughetti, Claudio Maffeis, Valeria Calcaterra, Melania Manco
Summary: Type 2 diabetes develops within the context of metabolic syndrome and is influenced by a continuum of risk factors, including visceral obesity, high blood pressure, abnormal blood lipids, and impaired glucose control. This condition places a significant burden on beta-cell function during puberty, leading to irreversible deterioration and the onset of diabetes. This review aims to identify age-specific risk factors for type 2 diabetes in youth, summarize screening and diagnostic criteria, and explore potential treatment options. Visceral obesity and disrupted lipid metabolism are key factors in disease development. Genetic susceptibility to impaired beta-cell function in the presence of obesity and insulin resistance explains why some obese adolescents develop diabetes at a young age while others do not. Lifestyle interventions focusing on a healthy diet and physical activity remain the primary treatment approach for youth with type 2 diabetes. However, pharmacological management using common drugs, such as dipeptidyl peptidase-4 inhibitors and sodium-dependent glucose transport inhibitors, as well as new weight-reducing medications, like glucagon-like peptide 1 receptor agonists, could revolutionize the management of this disease. These medications have the potential to not only treat diabetes but also alleviate the burden of metabolic abnormalities associated with the syndrome and lead to significant weight loss.
Article
Medicine, Research & Experimental
Maryam Farahmand, Maryam Rahmati, Fereidoun Azizi, Fahimeh Ramezani Tehrani
Summary: This study compared the effect of breastfeeding (BF) in women with and without gestational diabetes mellitus (GDM) on metabolic syndrome (MetS) incidence. The findings showed that BF, especially exclusive BF, has a protective effect on MetS incidence risk, and it is more effective in reducing the risk of MetS among women with a history of GDM.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Nutrition & Dietetics
Hiroki Nishikawa, Akira Asai, Shinya Fukunishi, Shuhei Nishiguchi, Kazuhide Higuchi
Summary: Skeletal muscle plays a crucial role in insulin-induced glucose metabolism, with muscle loss and intramuscular fat accumulation closely linked. Skeletal muscle loss and fat accumulation are associated with various pathologies through factors such as oxidative stress, inflammatory cytokines, mitochondrial dysfunction, insulin resistance, and inactivity. The relationship between Metabolic Syndrome (Met-S) and sarcopenia is attracting attention, with persistent inflammation, fat deposition, and insulin resistance thought to play important roles in their association.
Article
Nutrition & Dietetics
Giorgio Gargari, Valentina Taverniti, Cristian Del Bo', Stefano Bernardi, Nicole Hidalgo-Liberona, Tomas Merono, Cristina Andres-Lacueva, Paul A. Kroon, Antonio Cherubini, Patrizia Riso, Simone Guglielmetti
Summary: This study demonstrates that older subjects with higher bacterial DNAemia can benefit from a polyphenol-rich diet. Bacterial DNAemia may be a useful marker for identifying populations that could benefit more from a protective dietary intervention.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Article
Geriatrics & Gerontology
Tomas Merono, Raul Zamora-Ros, Nicole Hidalgo-Liberona, Montserrat Rabassa, Stefania Bandinelli, Luigi Ferrucci, Massimiliano Fedecostante, Antonio Cherubini, Cristina Andres-Lacueva
Summary: Animal protein intake is inversely associated with all-cause and cardiovascular mortality in older adults, while plant protein intake is not associated with mortality.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Public, Environmental & Occupational Health
Fabian Lanuza, Fanny Petermann-Rocha, Carlos Celis-Morales, Yeny Concha-Cisternas, Gabriela Nazar, Claudia Troncoso-Pantoja, Nicole Lassere-Laso, Maria Adela Martinez-Sanguinetti, Solange Parra-Soto, Raul Zamora-Ros, Cristina Andres-Lacueva, Tomas Merono
Summary: The study investigated the relationship between healthy eating score and depression in Chilean older adults, finding that those with higher healthy eating scores had better education, physical activity, and sleep patterns. Participants with healthier eating scores were inversely associated with depression, mainly due to high consumption of legumes and seafood.
PUBLIC HEALTH NUTRITION
(2022)
Review
Nutrition & Dietetics
Valentina Vinelli, Paola Biscotti, Daniela Martini, Cristian Del Bo', Mirko Marino, Tomas Merono, Olga Nikoloudaki, Francesco Maria Calabrese, Silvia Turroni, Valentina Taverniti, Andrea Union Caballero, Cristina Andres-Lacueva, Marisa Porrini, Marco Gobbetti, Maria De Angelis, Patrizia Brigidi, Mariona Pinart, Katharina Nimptsch, Simone Guglielmetti, Patrizia Riso
Summary: This systematic review investigates the effects of dietary fibers on the gut microbial ecosystem and their potential impact on human health. The results suggest that although dietary fibers can influence the composition and metabolites of the gut microbiota, they may not consistently lead to significant increases in short chain fatty acid (SCFA) levels in apparently healthy adults. Factors such as study protocols and analytical methods may have influenced the results obtained.
Article
Biochemistry & Molecular Biology
Inken Behrendt, Isabella Roeder, Frank Will, Hamza Mostafa, Raul Gonzalez-Dominguez, Tomas Merono, Cristina Andres-Lacueva, Mathias Fasshauer, Silvia Rudloff, Sabine Kuntz
Summary: Physiological concentrations of anthocyanins and their metabolites (PAM) inhibit colon cancer cell migration, potentially enhancing the effectiveness of chemotherapy.
Article
Food Science & Technology
Tomas Merono, Gregorio Peron, Giorgio Gargari, Raul Gonzalez-Dominguez, Antonio Minarro, Esteban Vegas-Lozano, Nicole Hidalgo-Liberona, Cristian Del Bo, Stefano Bernardi, Paul Antony Kroon, Barbara Carrieri, Antonio Cherubini, Patrizia Riso, Simone Guglielmetti, Cristina Andres-Lacueva
Summary: A polyphenol-rich diet can reduce intestinal permeability in older adults. Participants categorized according to urolithin metabotypes (UMs) exhibited different responses in the improvement of intestinal permeability after the diet. UMs identified as metabotype B showed higher improvement in intestinal permeability and exhibited changes in fatty acid metabolism, the kynurenine pathway of tryptophan catabolism, and microbial metabolization of phenolic acids. These findings are important for tailoring personalized nutrition interventions.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Geriatrics & Gerontology
Andrea Union-Caballero, Tomas Merono, Cristina Andres-Lacueva, Nicole Hidalgo-Liberona, Montserrat Rabassa, Stefania Bandinelli, Luigi Ferrucci, Massimiliano Fedecostante, Raul Zamora-Ros, Antonio Cherubini
Summary: This study aimed to examine the association between dietary fibre intake and cognitive decline in older adults. The results showed that dietary fibre intake was not associated with cognitive decline over a 15-year period. However, there was a significant interaction between fibre intake and the APOE-e4 haplotype, with a 30% lower risk of cognitive decline in participants with this genetic variant.
Article
Medicine, Research & Experimental
Hamza Mostafa, Inken Behrendt, Tomas Merono, Raul Gonzalez-Dominguez, Mathias Fasshauer, Silvia Rudloff, Cristina Andres-Lacueva, Sabine Kuntz
Summary: This study aimed to investigate whether plasma-isolated anthocyanins and their metabolites (PAMs) modulate pancreatic cancer cell migration and to identify molecular targets of PAMs in this process. A 28-day intervention trial involving 35 healthy subjects was conducted to compare the effects of daily anthocyanin-rich juice intake versus placebo. Plasma extracts were used for migration and mechanistic in vitro studies as well as metabolomic analysis. The intake of anthocyanin-rich juice significantly reduced PANC-1 migration, and also decreased the expression of adhesion molecules in PANC-1 and endothelial cells.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Cardiac & Cardiovascular Systems
Fabian Lanuza, Raul Zamora-Ros, Nicola P. Bondonno, Tomas Merono, Agnetha Linn Rostgaard-Hansen, Gabriele Riccardi, Anne Tjonneland, Rikard Landberg, Jytte Halkjaer, Cristina Andres-Lacueva
Summary: This study aimed to investigate the relationship between dietary polyphenol intake and metabolic syndrome and its components. The results showed that higher polyphenol intake was associated with a lower risk of metabolic syndrome and a lower risk of high blood pressure and low HDL cholesterol.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Article
Nutrition & Dietetics
Hamza Mostafa, Tomas Merono, Antonio Minarro, Alex Sanchez-Pla, Fabian Lanuza, Raul Zamora-Ros, Agnetha Linn Rostgaard-Hansen, Nuria Estanyol-Torres, Marta Cubedo-Cullere, Anne Tjonneland, Rikard Landberg, Jytte Halkjaer, Cristina Andres-Lacueva
Summary: This observational study explored the association between anthocyanin intake and cardiometabolic risk. Results revealed specific associations between anthocyanins and certain plasma metabolites, some of which were inversely correlated with visceral adipose tissue. These findings suggest a potential link between anthocyanin intake and cardiometabolic health benefits.
Article
Cardiac & Cardiovascular Systems
Fabian Lanuza, Tomas Merono, Raul Zamora-Ros, Nicola P. Bondonno, Agnetha Linn Rostgaard-Hansen, Alex Sanchez-Pla, Berta Miro, Francesc Carmona-Pontaque, Gabriele Riccardi, Anne Tjonneland, Rikard Landberg, Jytte Halkjaer, Cristina Andres-Lacueva
Summary: This study found that metabolites associated with plant-based dietary patterns were inversely associated with metabolic syndrome and its components. These findings may partially explain the effects of plant-based diets on cardiometabolic risk factors.
Review
Agriculture, Multidisciplinary
Hamza Mostafa, Alex Cheok, Tomas Merono, Cristina Andres-Lacueva, Ana Rodriguez-Mateos
Summary: Berries are rich in (poly)phenols, which may benefit human health. Estimating berry consumption using self-reported questionnaires is difficult due to compliance issues and lack of accuracy. Using biomarkers derived from food as an alternative method for estimation has been proposed. This review aimed to update the evidence on biomarkers of intake for six types of berries. A systematic literature search identified 18 eligible studies out of 42 papers. Multimetabolite panels are suggested for blueberry and cranberry intake, while no new candidates were found for raspberries, strawberries, blackcurrants, and blackberries. Further studies are needed to validate these panels for improving estimation of berry consumption.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Cardiac & Cardiovascular Systems
Maximiliano Martin, Belen Davico, Maria Florencia Verona, Walter Francisco Tetzlaff, Ezequiel Lozano Chiappe, Lisandro Gilligan, Graciela Jimenez, Leonardo Gomez Rosso, Gabriela Ballerini, Laura Boero, Julian Verona, Fernando Brites
Summary: Weight alterations are associated with modifications in lipoprotein-associated enzymes and proteins. Novel cardiometabolic indexes such as TyG, VAI, and HLAP can better assess the atherogenic risk related to weight changes. Both underweight and overweight/obesity show decreased antioxidant activity. TyG, VAI, and HLAP can predict alterations in key regulators of lipoprotein metabolism and vascular inflammation.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Correction
Endocrinology & Metabolism
Maria Paz Barbier, Evelin Mingote, Noelia Sforza, Yanina Morosan Allo, Maximiliano Lotartaro, Leonardo Serrano, Maria Pia Fossati, Tomas Merono, Cristina Faingold, Claudia Sedlinsky, Gabriela Brenta
Article
Endocrinology & Metabolism
Barbier Maria Paz, Mingote Evelin, Sforza Noelia, Morosan Allo Yanina, Lotartaro Maximiliano, Serrano Leonardo, Fossati Maria Pia, Merono Tomas, Faingold Cristina, Sedlinsky Claudia, Brenta Gabriela
Summary: The study revealed that postsurgical hypocalcaemia is common in elderly patients undergoing thyroid surgery, with a higher occurrence in total thyroidectomy patients at 24 hours post-surgery. Lower magnesium levels were associated with 24-hour hypocalcaemia in total thyroidectomy patients, while preoperative 25OHD deficiency predicted lower postsurgical calcium levels in hemithyroidectomy patients.
