Article
Medicine, General & Internal
Norio Hanata, Yasuo Nagafuchi, Yusuke Sugimori, Satomi Kobayashi, Yumi Tsuchida, Yukiko Iwasaki, Hirofumi Shoda, Keishi Fujio
Summary: This study found that serum AREG levels were elevated in patients with IIM, especially in those with ILD. Additionally, HB-EGF expression was associated with muscle injury and regeneration in IIM.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Oncology
Maria Teresa Majorini, Mario Paolo Colombo, Daniele Lecis
Summary: This article reviews the role of mast cells in cancer, with a particular focus on breast cancer. Mast cells have an impact on the features and aggressiveness of cancer cells, but the eventual effect of mast cell infiltration is still controversial.
Review
Oncology
Tresa M. McGranahan, Alipi Bonm, Jennifer M. Specht, Vyshak Venur, Simon S. Lo
Summary: This paper reviews the treatment options for patients with HER2+ breast cancer brain metastasis and provides a simplified algorithm for when to consider delaying local treatments.
Article
Oncology
Tianyu Zeng, Hai Xu, Yincheng Liu, Chunxiao Sun, Fan Yang, Yan Liang, Xiang Huang, Ziyi Fu, Wei Li, Yongmei Yin
Summary: This study assessed the frequency of lung cancer following breast cancer diagnosis and the associations between the two types of cancer. The results showed that breast cancer patients, especially those with low-grade malignancy, have a higher risk of developing primary lung cancer. Close follow-up is recommended for patients with isolated ground-glass nodules and high-risk factors. Additionally, EGFR may play an important role in primary lung adenocarcinomas and breast cancer.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Laura A. Huppert, Ozge Gumusay, Dame Idossa, Hope S. Rugo
Summary: HR-positive/HER2-negative breast cancer is characterized by the presence of estrogen receptor and/or progesterone receptor and the absence of HER2 gene amplification. It accounts for a significant proportion of breast cancers and is treated with endocrine therapy. Combining endocrine therapy with cyclin-dependent kinase inhibitors has shown promising results in reducing recurrence and improving survival. Chemotherapy is used based on the stage and tumor biology. New therapies, such as novel endocrine agents and antibody-drug conjugates, are changing the treatment landscape.
CA-A CANCER JOURNAL FOR CLINICIANS
(2023)
Article
Immunology
Simon Melderis, Matthias T. Warkotsch, Julien Dang, Julia Hagenstein, Laura-Isabell Ehnold, Georg R. Herrnstadt, Christoph B. Niehus, Frederic C. Feindt, Dominik Kylies, Victor G. Puelles, Carmen Berasain, Matias A. Avila, Katrin Neumann, Gisa Tiegs, Tobias B. Huber, Pierre-Louis Tharaux, Oliver M. Steinmetz
Summary: Systemic lupus erythematosus (SLE) is a common autoimmune disorder, with lupus nephritis (LN) being a frequent and difficult to treat complication. This study identified the multifunctional cytokine AREG as an anti-inflammatory mediator in LN, suppressing pathogenic T cell immunity. These findings highlight the potential of the AREG/EGFR axis as a therapeutic target.
JOURNAL OF AUTOIMMUNITY
(2022)
Article
Biochemistry & Molecular Biology
Huiping Liu, Markus Muttenthaler
Summary: The high expression of oxytocin receptor (OTR) plays an important role in the metastasis process of triple-negative breast cancer (TNBC). OTR expression is highest in tumour-adjacent breast tissue and correlates with metastatic tumors and reduced survival in TNBC patients. High OTR expression enhances cell sensitivity to EGF and promotes cell migration through the EGF-mediated ERK1/2-RSK-rpS6 pathway.
Review
Oncology
Anastasia Alataki, Mitch Dowsett
Summary: Endocrine therapies are the main treatment for hormone-dependent breast cancer, but HER2 signaling contributes to resistance and affects treatment efficacy. HER2 overexpression plays a role in resistance to endocrine therapies in breast cancer patients, impacting their clinical outcomes.
ENDOCRINE-RELATED CANCER
(2022)
Review
Medicine, Research & Experimental
Nirali Shukla, Ankit Naik, Kamlesh Moryani, Molisha Soni, Jigna Shah, Heena Dave
Summary: This review focuses on the signaling pathways and biological activities of the TGF-beta family in breast cancer pathogenesis and highlights its potential as a biomarker and drug target. It is beneficial for early detection, disease monitoring, and treatment selection in breast cancer.
Article
Biochemistry & Molecular Biology
Rimma Sergeevna Kamentseva, Marianna Viktorovna Kharchenko, Gulnara Vladikovna Gabdrahmanova, Michael Alexandrovich Kotov, Vera Vladislavovna Kosheverova, Elena Sergeevna Kornilova
Summary: This study compared the effects of EGF, TGF-α, and AREG on physiological responses in endometrial MSCs and HeLa cells, and investigated the internalization and degradation of EGFR stimulated by these ligands. The study found that while EGF and TGF-α stimulated cell proliferation and prevented differentiation in enMSCs in an EGFR-dependent manner, AREG had no effect. Additionally, differences were observed in the degradation and recovery of EGFR in different cell lines.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Hae Hyun Jung, Ji-Yeon Kim, Eun Yoon Cho, Jung Min Oh, Jeong Eon Lee, Seok Won Kim, Seok Jin Nam, Yeon Hee Park, Jin Seok Ahn, Young-Hyuck Im
Summary: Exosomes and cytokines are important in tumor progression, with recent studies showing that cytokines can contribute to drug resistance when packaged in exosomes. This study evaluated the prognostic value of cytokines in both serum and exosomes for breast cancer patients undergoing neoadjuvant chemotherapy. Elevated levels of serum IP-10, serum MMP-1, and exosomal NGF were associated with poor overall survival, with exosomal NGF being an independent prognostic factor. These findings suggest that exosomal NGF can help identify patients with poorer survival outcomes.
Article
Oncology
Daichi Fujimoto, Hiroaki Akamatsu, Takeshi Morimoto, Kazushige Wakuda, Yuki Sato, Yoshitaka Kawa, Toshihide Yokoyama, Motohiro Tamiya, Ryota Hiraoka, Naoki Shingu, Hideki Ikeda, Akihiro Tamiya, Masaki Kanazu, Eisaku Miyauchi, Satoru Miura, Masaaki Yanai, Makiko Yomota, Ryotaro Morinaga, Takashi Yokoi, Akito Hata, Hidekazu Suzuki, Hirotaka Matsumoto, Shinya Sakata, Naoki Furuya, Yuhei Harutani, Ichiro Nakachi, Ayumu Otsuki, Shinya Uematsu, Satoshi Hara, Keiki Yokoo, Takeya Sugimoto, Nobuyuki Yamamoto
Summary: This study aimed to determine the incidence and clinical course of histologic transformation (HT) in lung cancer patients with epidermal growth factor receptor (EGFR) mutations. The study found that approximately 3% of EGFR-mutated patients developed HT after acquiring resistance to EGFR-tyrosine kinase inhibitors (TKIs). There was no significant difference in survival between patients with transformation to high-grade neuroendocrine carcinoma and those with transformation to another subtype of non-small cell lung cancer. Cytotoxic agents were likely to be effective in patients with HT, while the effectiveness of immune checkpoint inhibitors was limited.
EUROPEAN JOURNAL OF CANCER
(2022)
Article
Ophthalmology
Mukharram M. Bikbov, Timur A. Khalimov, Marc Cerrada-Gimenez, Symantas Ragauskas, Giedrius Kalesnykas, Jost B. Jonas
Summary: The study showed that intravitreal injections of EGF in rabbits and amphiregulin in guinea pigs did not cause intraocular specific inflammation or any observed intraocular destructive effects.
INTERNATIONAL OPHTHALMOLOGY
(2021)
Review
Immunology
Matthew B. Buechler, Wenxian Fu, Shannon J. Turley
Summary: Fibroblasts and macrophages are able to communicate directly in tissues, influencing the microenvironment and disease outcomes. Their interactions play a significant role in health, fibrosis, and cancer, with effects influenced by tissue and context, as well as cell origin and state.
Article
Psychiatry
Hsing-Ying Ho, Vincent Chin-Hung Chen, Bor-Show Tzang, Ching-Chuan Hsieh, Wen-Ke Wang, Yi-Ping Weng, Ya-Ting Hsu, Han-Pin Hsaio, Jun-Cheng Weng, Yi-Lung Chen
Summary: In this study, IL-2 and IL-5 were found to have good predictability for depression in patients with breast cancer, even after controlling for covariates. These circulating cytokines may serve as a valid laboratory diagnostic tool for depression in breast cancer due to their prediction ability and practical feasibility.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Oncology
Esther A. Peterson, Edmund C. Jenkins, Kristopher A. Lofgren, Natasha Chandiramani, Hui Liu, Evelyn Aranda, Maryia Barnett, Paraic A. Kenny
Article
Cell Biology
Maria E. Gonzalez, Olga Makarova, Esther A. Peterson, Lisa M. Privette, Elizabeth M. Petty
CELLULAR SIGNALLING
(2009)
Review
Genetics & Heredity
E. A. Peterson, E. M. Petty
Article
Oncology
Esther A. Peterson, Laura Stanbery, Christina Li, Hande Kocak, Olga Makarova, Elizabeth M. Petty
GENES CHROMOSOMES & CANCER
(2011)
Article
Biochemistry & Molecular Biology
Megan L. Landsverk, Elizabeth K. Ruzzo, Heather C. Mefford, Karen Buysse, Jillian G. Buchan, Evan E. Eichler, Elizabeth M. Petty, Esther A. Peterson, Dana M. Knutzen, Karen Barnett, Martin R. Farlow, Judy Caress, Gareth J. Parry, Dianna Quan, Kathy L. Gardner, Ming Hong, Zachary Simmons, Thomas D. Bird, Phillip F. Chance, Mark C. Hannibal
HUMAN MOLECULAR GENETICS
(2009)
Article
Chemistry, Inorganic & Nuclear
Gabriel Quinones Velez, Alexandra Paris Santiago, Diego Soto Nieves, Angelica Figueroa Guzman, Esther Peterson-Peguero, Vilmali Lopez-Mejias
Summary: Functionalization of rutile phase TiO2 particles with BPCC was achieved through in situ surface crystallization, resulting in a functionalized material with different shell thicknesses. Crystal phase assessment, morphological changes, and elemental composition of the functionalized material were analyzed. Cytotoxicity tests showed significant cell growth inhibition for the functionalized material against MDA-MB-231 cells, indicating its potential for treating osteolytic metastases.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Lesly Carmona-Sarabia, Gabriel Quinones Velez, Andrea M. Escalera-Joy, Darilys Mojica-Vazquez, Solimar Esteves-Vega, Esther A. Peterson-Peguero, Vilmali Lopez-Mejias
Summary: Extended bisphosphonate-based coordination polymers (BPCPs) exhibit higher binding affinity to bone, comparable drug loading/release, and cytotoxicity against triple-negative breast cancer cells without affecting osteoblast-like cells. These findings suggest the potential of BPCPs as bone-targeted drug delivery systems for treating bone-related diseases.
INORGANIC CHEMISTRY
(2023)
Article
Nanoscience & Nanotechnology
Gabriel Quinones Velez, Lesly Carmona-Sarabia, Alexandra Paris Santiago, Angelica F. Figueroa Guzman, Chunhua Hu, Esther Peterson-Peguero, Vilmali Lopez-Mejias
Summary: Clinically employed bisphospho-nate, risedronate (RISE), can form coordination complexes with bioactive metals, Ca2+, Mg2+, and Zn2+. The structures of three RISE-based coordination complexes, RISE-Ca, RISE-Mg, and RISE-Zn, were determined. The complexes showed pH-dependent structural stability, with lower solubility in neutral conditions and higher solubility in acidic conditions. By employing the phase inversion temperature (PIT)-nanoemulsion method, the particle size of RISE-Ca was reduced, resulting in nano-Ca@RISE. Nano-Ca@RISE showed higher binding to hydroxyapatite and significantly decreased viability of breast cancer cells, while not affecting normal osteoblast cells. This study expands the therapeutic potential of RISE through the design of pH-dependent BPCCs, specifically nano-Ca@RISE.
ACS APPLIED BIO MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Lesly Carmona-Sarabia, Gabriel Quinones Veelez, Darilys Mojica-Vazquez, Andrea M. Escalera-Joy, Solimar Esteves-Vega, Esther A. Peterson-Peguero, Vilmalii Loopez-Mejiias
Summary: Extended bisphosphonate-based coordination polymers (BPCPs) were synthesized by reacting BPBPA with bioactive metals Ca2+, Zn2+, and Mg2+. These BPCPs demonstrated pH-dependent degradation and had the ability to encapsulate the antineoplastic drug letrozole. The BPCPs showed significantly higher binding affinity to hydroxyapatite and higher cytotoxicity against breast cancer cells compared to commercial BPCPs.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Materials Science, Multidisciplinary
Gabriel Quinones Velez, Lesly Carmona-Sarabia, Alondra A. Rivera Raices, Tony Hu, Esther A. Peterson-Peguero, Vilmali Lopez-Mejias
Summary: The formation of bisphosphonate-based coordination complexes (BPCCs) through the reaction of bisphosphonate zoledronate (ZOLE) and bioactive metals resulted in materials with varying dissolution properties, showing lower solubility in phosphate buffered saline (PBS) but higher solubility in acidic media. The nanocrystals of ZOLE-Ca showed decreased crystal size and low aggregation in fetal bovine serum (FBS) : PBS, with increased binding to hydroxyapatite and significant cytotoxicity against the cancer cell model MDA-MB-231 while being non-toxic to the normal osteoblast-like cell model hFOB 1.19.
MATERIALS ADVANCES
(2022)
Article
Materials Science, Biomaterials
Gabriel Quinones Velez, Lesly Carmona-Sarabia, Waldemar A. Rodriguez-Silva, Alondra A. Rivera Raices, Lorraine Feliciano Cruz, Tony Hu, Esther Peterson, Vilmali Lopez-Mejias
JOURNAL OF MATERIALS CHEMISTRY B
(2020)
Article
Gastroenterology & Hepatology
Esther A. Peterson, Zsuzsanna Polgar, Gnanapackiam S. Devakanmalai, Yanfeng Li, Fadi L. Jaber, Wei Zhang, Xia Wang, Niloy J. Iqbal, John W. Murray, Namita Roy-Chowdhury, Wilber Quispe-Tintaya, Alexander Y. Maslov, Tatyana L. Tchaikovskaya, Yogeshwar Sharma, Leslie E. Rogler, Sanjeev Gupta, Liang Zhu, Jayanta Roy-Chowdhury, David A. Shafritz
HEPATOLOGY COMMUNICATIONS
(2019)
Article
Biochemistry & Molecular Biology
Esther A. Peterson, Linda M. Kalikin, Jonathan D. Steels, Mathew P. Estey, William S. Trimble, Elizabeth M. Petty
Article
Oncology
Maria E. Gonzalez, Esther A. Peterson, Lisa M. Privette, Janice L. Loffreda-Wren, Linda M. Kalikin, Elizabeth M. Petty
