Metabolic remodelling in obesity and type 2 diabetes: pathological or protective mechanisms in response to nutrient excess?

The Intrinsic Apoptosis Pathway Mediates the Pro-Longevity Response to Mitochondrial ROS in C. elegans

(2014) Callista Yee et al.   CELL

Mitohormesis

(2014) Jeanho Yun et al.   Cell Metabolism

Metabolic Crosstalk: Molecular Links Between Glycogen and Lipid Metabolism in Obesity

(2014) B. Lu et al.   DIABETES

The architect who never sleeps: Tumor-induced plasticity

(2014) Julia Varga et al.   FEBS LETTERS

Association Between Intensification of Metformin Treatment With Insulin vs Sulfonylureas and Cardiovascular Events and All-Cause Mortality Among Patients With Diabetes

(2014) Christianne L. Roumie et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

A Role for Mitochondrial Phosphoenolpyruvate Carboxykinase (PEPCK-M) in the Regulation of Hepatic Gluconeogenesis

(2014) Romana Stark et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Obesity-associated mechanisms of hepatocarcinogenesis

(2014) Raffi Karagozian et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Diabetes and gastric cancer: The potential links

(2014) Chin-Hsiao Tseng   WORLD JOURNAL OF GASTROENTEROLOGY

Pompe disease: from pathophysiology to therapy and back again

(2014) Jeong-A Lim et al.   Frontiers in Aging Neuroscience

Mitochondrial dysfunction has divergent, cell type-dependent effects on insulin action

(2014) Sheree D. Martin et al.   Molecular Metabolism

Insulin resistance protects the heart from fuel overload in dysregulated metabolic states

(2013) Heinrich Taegtmeyer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

A Noncanonical, GSK3-Independent Pathway Controls Postprandial Hepatic Glycogen Deposition

(2013) Min Wan et al.   Cell Metabolism

Oleic Acid Stimulates Complete Oxidation of Fatty Acids through Protein Kinase A-dependent Activation of SIRT1-PGC1α Complex

(2013) Ji-Hong Lim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mice Deficient in the Respiratory Chain Gene Cox6a2 Are Protected against High-Fat Diet-Induced Obesity and Insulin Resistance

(2013) Roel Quintens et al.   PLoS One

The prevalence of overweight and obesity in a breast clinic population: Consideration for weight loss as a therapeutic intervention

(2013) Angela Kim et al.   Surgery for Obesity and Related Diseases

High-carbohydrate diets induce hepatic insulin resistance to protect the liver from substrate overload

(2012) Loranne Agius   BIOCHEMICAL PHARMACOLOGY

Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

(2012) Patrick S. Ward et al.   CANCER CELL

Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure

(2012) Chutima Talchai et al.   CELL

Mechanisms for Insulin Resistance: Common Threads and Missing Links

(2012) Varman T. Samuel et al.   CELL

Insulin Resistance in the Defense against Obesity

(2012) Alan R. Saltiel   Cell Metabolism

Insulin resistance improves metabolic and contractile efficiency in stressed rat heart

(2012) Romain Harmancey et al.   FASEB JOURNAL

Insulin resistance: An adaptive mechanism becomes maladaptive in the current environment — An evolutionary perspective

(2012) Agathocles Tsatsoulis et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Linking mitochondrial bioenergetics to insulin resistance via redox biology

(2012) Kelsey H. Fisher-Wellman et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The evolution of insulin resistance in muscle of the glucose infused rat

(2011) Amanda E. Brandon et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Mitochondrial respiratory chain complexes: apoptosis sensors mutated in cancer?

(2011) A Lemarie et al.   ONCOGENE

Deficiency of the Mitochondrial Electron Transport Chain in Muscle Does Not Cause Insulin Resistance

(2011) Dong-Ho Han et al.   PLoS One

Myocardial insulin resistance induced by high fat feeding in heart failure is associated with preserved contractile function

(2010) Bridgette A. Christopher et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Prolonged Fasting Identifies Skeletal Muscle Mitochondrial Dysfunction as Consequence Rather Than Cause of Human Insulin Resistance

(2010) J. Hoeks et al.   DIABETES

Hormonal regulation of gluconeogenic gene transcription in the liver

(2010) Nirmala Yabaluri et al.   JOURNAL OF BIOSCIENCES

Targeted deletion of liver glucose-6 phosphatase mimics glycogen storage disease type 1a including development of multiple adenomas

(2010) Elodie Mutel et al.   JOURNAL OF HEPATOLOGY

Glycogen storage disease type I and G6Pase-β deficiency: etiology and therapy

(2010) Janice Y. Chou et al.   Nature Reviews Endocrinology

Lipid and insulin infusion-induced skeletal muscle insulin resistance is likely due to metabolic feedback and not changes in IRS-1, Akt, or AS160 phosphorylation

(2009) Andrew J. Hoy et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Reactive Oxygen Species Enhance Insulin Sensitivity

(2009) Kim Loh et al.   Cell Metabolism

Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans

(2009) Ethan J. Anderson et al.   JOURNAL OF CLINICAL INVESTIGATION

Examination of ‘lipotoxicity’ in skeletal muscle of high-fat fed andob/obmice

(2009) S. M. Turpin et al.   JOURNAL OF PHYSIOLOGY-LONDON

Insulin resistance is a cellular antioxidant defense mechanism

(2009) K. L. Hoehn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial Overload and Incomplete Fatty Acid Oxidation Contribute to Skeletal Muscle Insulin Resistance

(2008) Timothy R. Koves et al.   Cell Metabolism

Hepatic Insulin Resistance Is Sufficient to Produce Dyslipidemia and Susceptibility to Atherosclerosis

(2008) Sudha B. Biddinger et al.   Cell Metabolism

STORING UP TROUBLE: DOES ACCUMULATION OF INTRAMYOCELLULAR TRIGLYCERIDE PROTECT SKELETAL MUSCLE FROM INSULIN RESISTANCE?

(2008) Matthew J Watt   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Moderate exercise is an antioxidant: Upregulation of antioxidant genes by training

(2007) Mari-Carmen Gomez-Cabrera et al.   FREE RADICAL BIOLOGY AND MEDICINE