Article
Biochemistry & Molecular Biology
Caren Weinhouse
Summary: Redox-active environmental pollutants can disrupt cellular redox status and induce specific and general stress responses in cells. Exposure to these pollutants can affect chromatin modifications and lead to transcriptional memory, predisposing cells to stronger transcriptional responses upon secondary challenge.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Physiology
Magdalena Solich-Talanda, Aleksandra Zebrowska, Rafal Mikolajczyk, Sabina Kostorz-Nosal, Dariusz Ziora, Dariusz Jastrzebski, Piotr Siermontowski
Summary: This study examined the impact of static and dynamic breath-holding on elite freedivers, revealing a significant increase in oxidative stress levels and positive effects on heat shock protein 27, with no significant impact on total antioxidant status, HSP90, HSP70, and nitric oxide levels. The findings show a significant positive correlation between heat shock proteins and total antioxidant status, as well as nitric oxide levels, suggesting a beneficial effect on cardiovascular adaptation in elite freedivers. Further research is needed to explore the exact mechanisms of cardiovascular adaptation during breath-holding training in elite divers.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Anastasia V. Poznyak, Varvara A. Orekhova, Vasily N. Sukhorukov, Victoria A. Khotina, Mikhail A. Popov, Alexander N. Orekhov
Summary: Atherosclerosis is a global health problem, leading to increased morbidity and mortality from cardiovascular diseases. Effective measures for prevention and treatment have not been developed yet. Understanding molecular interactions and the role of heat shock proteins in the progression of atherosclerosis is crucial. Some heat shock proteins have antiatherosclerotic effects, while others' roles are unclear. This review focuses on the antiatherosclerotic activity of specific heat shock proteins.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Yuhao Liu, Meijin Yu, Jiawen Cui, Ye Du, Xiaohua Teng, Zuozhong Zhang
Summary: This study aimed to investigate the mechanism of damage caused by excess Mn in chicken livers and found that Mn exposure led to inflammatory injury via NF-kappa B pathway. Additionally, Mn exposure induced oxidative stress and up-regulated HSPs expression, which mediated inflammatory damage. Time- and dose-dependent effects were observed on Mn-induced chicken liver inflammatory injury.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Plant Sciences
Qianqian Qin, Yujun Zhao, Jiajun Zhang, Li Chen, Weina Si, Haiyang Jiang
Summary: In this study, an HSF gene ZmHsf11 was cloned from maize and found to negatively regulate the expression of oxidative stress-related genes, increase ROS levels, and decrease proline content, thereby reducing plant tolerance to heat stress.
Article
Dermatology
Ling Li, Xudong Chen, Chang Liu, Ziying He, Qiyan Shen, Yue Zhu, Xin Wang, Shuanglin Cao, Shengju Yang
Summary: This study investigated the roles and mechanisms of hydrogen sulphide (H2S) on primary mice skin fibroblasts proliferation. The study found that H2S can inhibit the proliferation of skin fibroblasts and attenuate skin fibrosis by inhibiting necroptosis. These findings provide new insights into the prevention and treatment of skin fibrotic diseases.
EXPERIMENTAL DERMATOLOGY
(2023)
Article
Medicine, Research & Experimental
Mahsa Aeeni, Mazdak Razi, Alireza Alizadeh, Arash Alizadeh
Summary: The study demonstrated that insulin treatment enhances testicular antioxidant capacity, improves the expression of Hsp70-2a, TP-1, and TP-2, and boosts the Hsp90-mediated DNA repair process, thereby maintaining DNA integrity induced by hyperglycemia.
Article
Environmental Sciences
Yeyu Chen, Xiaoyun Wu, Jiansheng Lai, Ya Liu, Mingjiang Song, Feiyang Li, Quan Gong
Summary: Temperature fluctuations caused by climate change and global warming threaten various species, especially fish. Understanding high-temperature tolerance in fish can help develop effective strategies for coping with global warming. This study investigated the effects of high temperature on Acipenser dabryanus, an ancient species of the Yangtze River, at different levels. The results showed damage to the intestine and liver tissues, increased cortisol levels and oxidative stress markers, and changes in gene and metabolite expression. The study provides insights into the heat stress response mechanisms in A. dabryanus, contributing to improved fish cultivation in response to global warming.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Environmental Sciences
He Huang, Min Wang, Lulu Hou, Xu Lin, Shifeng Pan, Peng Zheng, Qian Zhao
Summary: Lead is a toxic heavy metal that can damage male reproductive function. Selenium has the ability to counteract lead toxicity, and in this study, it was found that selenium can mitigate the reproductive toxicity of lead by enhancing antioxidant defense mechanisms in the spermatogonia and Leydig cells of chickens.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Horticulture
Adria Farras, Victor Lopez, Filippo Maggi, Giovanni Caprioli, Maria Pilar Vinardell, Montserrat Mitjans
Summary: This study screened polyphenolic compounds from Asplenium adiantum-nigrum L. fronds and evaluated their in vitro activities. The results showed that the extract had strong antioxidant and cytoprotective effects without cytotoxicity, and it did not cause phototoxicity under specific conditions.
Review
Plant Sciences
Noushina Iqbal, Shahid Umar, Nafees A. Khan, Francisco J. Corpas
Summary: Under heat stress, the interaction between ABA and NO affects plant adaptation and provides insights into developing heat stress-resistant varieties.
PLANT CELL REPORTS
(2021)
Article
Plant Sciences
T. Husain, M. Suhel, S. M. Prasad, V. P. Singh
Summary: Chromium toxicity to crops is a current scientific issue, and the study found that ethylene and hydrogen sulfide can alleviate the toxicity of Cr(VI) stress. The results indicate that although both ethylene and hydrogen sulfide can alleviate Cr(VI) stress, endogenous hydrogen sulfide is more effective.
Article
Plant Sciences
Wenxu Wang, Jiaojiao Zhang, Lijuan Ai, Dan Wu, Bing Li, Lingang Zhang, Liqun Zhao
Summary: This study demonstrates the relationship between CNGC6 and H2O2 in plant responses to heat shock, showing that CNGC6 may stimulate the accumulation of H2O2 in a manner dependent on an increase in cytosolic Ca2+. Additionally, CNGC6 enhances the gene transcription of HS factors and the accumulation of HS proteins via H2O2 to improve plant thermotolerance.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Agriculture, Dairy & Animal Science
Tori E. Rudolph, Crystal M. Roach, Lance H. Baumgard, Jason W. Ross, Aileen F. Keating, Josh T. Selsby
Summary: The study found that heat stress and Zearalenone exposure can induce oxidative stress in porcine skeletal muscle, with potentially different responses in muscle fiber types. However, the combination of heat stress and Zearalenone did not significantly increase oxidative stress levels compared to individual exposures.
JOURNAL OF ANIMAL SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Shuang Zhao, Xin Tang, Zian Miao, Yurong Chen, Jiawei Cao, Tianyu Song, Daiting You, Yanqing Zhong, Zhe Lin, Dan Wang, Zhiguang Shi, Xinlong Tang, Dongjin Wang, Shaoliang Chen, Liansheng Wang, Aihua Gu, Feng Chen, Liping Xie, Zhengrong Huang, Hong Wang, Yong Ji
Summary: Endothelial dysfunction is the initial process of atherosclerosis, and SNO-Hsp90 plays an important regulatory role in this process. The study found that SNO-Hsp90 levels increase in atherosclerotic human and rodent arteries as well as in oxLDL-treated ECs. Inhibition of iNOS or transfection with Hsp90 Cys521 mutation plasmid can reduce SNO-Hsp90 levels in oxLDL-cultured ECs. Additionally, SNO-Hsp90 at Cys521 disrupts the interaction between Hsp90 and AHA1, but promotes the association of Hsp90 and CDC37, thereby exacerbating atherosclerosis.
Review
Pharmacology & Pharmacy
Heng Liu, Miles N. Radford, Chun-tao Yang, Wei Chen, Ming Xian
BRITISH JOURNAL OF PHARMACOLOGY
(2019)
Article
Obstetrics & Gynecology
Yixing Wu, Chuntao Yang, Fuhui Meng, Fenglian Que, Wenxia Xiao, Huying Rao, Yan Wan, Hugh S. Taylor, Lingeng Lu
REPRODUCTIVE SCIENCES
(2019)
Review
Chemistry, Multidisciplinary
Shi Xu, Akil Hamsath, Deshka L. Neill, Yingying Wang, Chun-tao Yang, Ming Xian
CHEMISTRY-A EUROPEAN JOURNAL
(2019)
Article
Cell Biology
Chun-tao Yang, Li Chen, Wan-ling Chen, Na Li, Mei-ji Chen, Xiang Li, Xue Zheng, Yue-ze Zhao, Yi-xing Wu, Ming Xian, Jinbao Liu
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2019)
Article
Chemistry, Analytical
Huiling Wang, Yulin Xu, Li Rao, Chuntao Yang, Hong Yuan, Tingjuan Gao, Xin Chen, Hongyan Sun, Ming Xian, Chunrong Liu, Changlin Liu
ANALYTICAL CHEMISTRY
(2019)
Article
Chemistry, Multidisciplinary
Chun-tao Yang, Yingying Wang, Eizo Marutani, Tomoaki Ida, Xiang Ni, Shi Xu, Wei Chen, Hui Zhang, Takaaki Akaike, Fumito Ichinose, Ming Xian
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2019)
Article
Chemistry, Organic
Akil Hamsath, Yingying Wang, Chun-tao Yang, Shi Xu, Danica Canedo, Wei Chen, Ming Xian
Article
Biochemistry & Molecular Biology
Chun-tao Yang, Nelmi O. Devarie-Baez, Akil Hamsath, Xiao-dong Fu, Ming Xian
ANTIOXIDANTS & REDOX SIGNALING
(2020)
Article
Chemistry, Organic
Yingying Wang, Chun-tao Yang, Shi Xu, Wei Chen, Ming Xian
Article
Chemistry, Multidisciplinary
Wei Chen, Tetsuro Matsunaga, Deshka L. Neill, Chun-tao Yang, Takaaki Akaike, Ming Xian
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2019)
Article
Cell Biology
Qingzi Chen, Yubo Zhou, Lifen Zhou, Zhaodi Fu, Chuntao Yang, Lei Zhao, Shuni Li, Yan Chen, Yousen Wu, Zhenwei Ling, Yufeng Wang, Jianrong Huang, Jianhua Li
CELL DEATH & DISEASE
(2020)
Article
Oncology
Xiang Li, Na Li, Li Huang, Shi Xu, Xue Zheng, Akil Hamsath, Mei Zhang, Lijun Dai, Hui Zhang, Justin Jong-Leong Wong, Ming Xian, Chun-tao Yang, Jinbao Liu
FRONTIERS IN ONCOLOGY
(2020)
Article
Endocrinology & Metabolism
Yi-Xing Wu, Chun-Tao Yang, Na Li, Xue Zheng, Xiang Li, Hui Zhang, Jie Shen
ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
(2020)
Article
Endocrinology & Metabolism
Yupin Tan, Lili Zou, Na Li, Li Huang, Meiji Chen, Xuexiang Li, Xue Zheng, Wenkai Li, Yun Li, Chun-Tao Yang
Summary: This study revealed the effects of mast cells on gene expression in asthmatic lungs and the therapeutic effects of inhaled budesonide. Mast cell engraftment enhanced inflammation/immune response, while BUD treatment reduced serum IL-6 content and pulmonary inflammation, inhibiting mast cell degranulation. The study suggests that mast cell-induced pulmonary gene profile can be reversed through mast cell blockade or inhaled BUD.
ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
(2021)
Article
Pharmacology & Pharmacy
Ximing Zhang, Mianrong Chen, Xiang Ni, Yingying Wang, Xue Zheng, Hui Zhang, Shi Xu, Chun-tao Yang
FRONTIERS IN PHARMACOLOGY
(2020)