Article
Multidisciplinary Sciences
Linus G. Jansen, Payal Shah, Bettina Wabbels, Frank G. Holz, Robert P. Finger, Maximilian W. M. Wintergerst
Summary: The study evaluated the feasibility of upskilling alternative healthcare cadres in smartphone-based fundus imaging (SBFI) and found that with relatively short training, both ophthalmic assistants and ophthalmologists showed improved examination time, usable field-of-view, and image quality. The results suggest that SBFI is highly learnable and can produce comparable results across different healthcare cadres, aiding in the implementation and planning of future SBFI field studies.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Selina L. Liu, John R. Gonder, Ehsan Owrangi, Neil S. Klar, Irene M. Hramiak, Artem Uvarov, Jeffrey L. Mahon
Summary: This study examined whether nonmydriatic ultra-widefield screening on the day of a diabetes clinic visit improved detection of clinically important eye disease. The results showed that more eye diseases were detected in the on-site screening group compared to the usual screening group, demonstrating the effectiveness of nonmydriatic ultra-widefield screening in improving screening quality.
Article
Pediatrics
S. Grace Prakalapakorn, Lucy Greenberg, Erika M. Edwards, Danielle E. Y. Ehret
Summary: Analysis of data from US NICUs between 2008 and 2018 revealed an increased proportion of ROP screening among eligible infants, with a decrease in overall and severe ROP cases, retinal ablation procedures, and an increase in the use of anti-vascular endothelial growth factor treatment. Despite the overall improvements, 10% of infants were still not screened for ROP, indicating a potential for further enhancement in healthcare delivery.
Article
Health Care Sciences & Services
Longhui Li, Duoru Lin, Zhenzhe Lin, Mingyuan Li, Zhangkai Lian, Lanqin Zhao, Xiaohang Wu, Lixue Liu, Jiali Liu, Xiaoyue Wei, Mingjie Luo, Danqi Zeng, Anqi Yan, Wai Cheng Iao, Yuanjun Shang, Fabao Xu, Wei Xiang, Muchen He, Zhe Fu, Xueyu Wang, Yaru Deng, Xinyan Fan, Zhijun Ye, Meirong Wei, Jianping Zhang, Baohai Liu, Jianqiao Li, Xiaoyan Ding, Haotian Lin
Summary: We developed a deep learning-based system for assessing and enhancing the quality of infantile fundus images. The system accurately detects various quality defects and provides enhancement based on the assessment. Analysis of real-world fundus photographs revealed that a significant percentage of them had quality issues, with variations observed across different regions and hospitals. The system's application improved the diagnosis performance for retinopathy of prematurity and enhanced the model performance for detecting ROP.
NPJ DIGITAL MEDICINE
(2023)
Article
Health Care Sciences & Services
Emmanuel Kim, Kim-Huong Nguyen, Tim Donovan, Sisira Edirippulige, Nigel R. Armfield
Summary: This study compared the costs of the current screening program for retinopathy of prematurity (ROP) with two alternative telemedicine approaches, and found that telemedicine programs may improve cost efficiency of the health system and reduce the risk associated with infant transport.
JOURNAL OF TELEMEDICINE AND TELECARE
(2023)
Article
Ophthalmology
Susmit Das, Helen J. Kuht, Ian de Silva, Sundeep S. Deol, Lina Osman, Joyce Burns, Nagini Sarvananthan, Usman Sarodia, Bharat Kapoor, Tahir Islam, Raghavan Sampath, Alicia Poyser, Vasileios Konidaris, Rossella Anzidei, Frank A. Proudlock, Mervyn G. Thomas
Summary: This study compared the feasibility and clinical utility of five fundus cameras. The results showed that Remidio and Pictor achieved comparable results to the Zeiss table-top camera, while iNview and oDocs had lower performance. Zeiss performed best in cup:disc ratio estimates and diagnostic sensitivity. Therefore, Remidio and Pictor may be more cost-effective alternatives in certain clinical scenarios.
Article
Ophthalmology
Somya Kumari, Pradeep Venkatesh, Nikhil Tandon, Rohan Chawla, Brijesh Takkar, Atul Kumar
Summary: The study demonstrates that Selfie Fundus Imaging (SFI) is a feasible method, allowing patients to easily capture retinal images using smartphones with high sensitivity. SFI may help break the barriers of availability, accessibility, and affordability in diabetic retinopathy screening programs.
Review
Medicine, General & Internal
Piotr Kanclerz, Raimo Tuuminen, Ramin Khoramnia
Summary: This study reviewed the imaging modalities used for diabetic retinopathy screening, showing significantly different technical failure rates among various techniques. Smartphone-based imaging had a significantly higher publication bias factor compared to mydriatic and non-mydriatic digital fundus photography.
Article
Pediatrics
Gemma Mas-Dalmau, Carmen Villanueva Lopez, Pedro Gorrotxategi Gorrotxategi, Emma Arguelles Prendes, Oscar Espinazo Ramos, Teresa Valls Duran, Maria Encarnacion Gonzalo Alonso, Maria Pilar Cortes Viana, Tatiana Menendez Bada, Marta Esther Vazquez Fernandez, Ana Isabel Perez Hernandez, Laura Munoz Ortiz, Paul Little, Mariam de la Poza Abad, Pablo Alonso-Coello
Summary: The study found that there was no statistically significant difference in symptom duration or severity in children with uncomplicated respiratory infections who received delayed antibiotic prescription (DAP) compared to immediate antibiotic prescription (IAP) or no antibiotic prescription (NAP); however, DAP reduced antibiotic use and gastrointestinal adverse effects.
Article
Ophthalmology
Sara Tawfik, Ahmed Mansour, Norhan Lotfy Selim, Ahmed M. Habib, Yousef A. Fouad, Mohamed A. Tawfik, Mariam Al-Feky
Summary: The incidence of both ROP and AP-ROP in the Egyptian rural setting appears to be in the high end of global reported rates. Prevention measures should urgently be planned and implemented.
Article
Health Care Sciences & Services
Erika Maka, Gabor Kovacs, Laszlo Imre, Clare Gilbert, Miklos Szabo, Janos Nemeth, Zoltan Zsolt Nagy, Zsolt Somogyvari
Summary: The study evaluated the effectiveness of wide-field digital imaging (WFDI) and telemedicine-based screening compared to binocular indirect ophthalmoscopy (BIO) in preterm infants. The results showed lower sensitivity and specificity for any ROP compared to treatment-requiring retinopathy of prematurity (TR-ROP). The Premature Eye Rescue Program in Hungary successfully used WFDI for screening, preventing ROP-related blindness in screened preterm infants over a five-year period.
JOURNAL OF TELEMEDICINE AND TELECARE
(2021)
Article
Medicine, General & Internal
Jui-Yen Lin, Eugene Yu-Chuan Kang, Alay S. Banker, Kuan-Jen Chen, Yih-Shiou Hwang, Chi-Chun Lai, Jhen-Ling Huang, Wei-Chi Wu
Summary: This study compared the clinical performance of a smartphone-based fundus photography device and a contact imaging device for retinopathy of prematurity (ROP) screening. Results showed that the smartphone-based fundus photography device had moderate agreement in determining the presence or absence of plus disease, but could not identify the zone and stage of ROP.
Review
Ophthalmology
Kolbeinn Tumi Karason, Diana Vo, Jakob Grauslund, Malin Lundberg Rasmussen
Summary: Studies have shown that retinal imaging methods using <7SF and UWF provide similar results to 7SF, indicating acceptable performance for DR screening. However, non-mydriatic <7SF modalities may pose a clinical challenge due to a higher rate of ungradable images.
ACTA OPHTHALMOLOGICA
(2022)
Article
Biochemical Research Methods
Z. H. E. N. G. Y. U. DUAN, K. A. HUANG, Z. H. O. N. G. Z. H. O. U. LUO, K. E. MA, G. E. N. G. Y. U. A. N. WANG, X. I. A. O. D. O. N. G. HU, J. I. N. Z. E. ZHANG, X. I. A. O. L. I. N. G. LUO, Y. U. A. N. C. O. N. G. HUANG, G. A. N. G. J. U. N. LIU, X. I. A. O. Y. A. N. DING, P. E. N. G. XIAO, J. I. N. YUAN
Summary: We have developed a portable boom-type ophthalmic UHR-OCT system that can be used for high-resolution retinal examinations in pediatric, bedridden, and perioperative patients. The system integrates real-time iris display and automatic focusing, and has high mobility and stability.
BIOMEDICAL OPTICS EXPRESS
(2022)
Review
Biochemistry & Molecular Biology
Maxwell Mathias, Jill Chang, Marta Perez, Ola Saugstad
Summary: Oxygen is crucial for cell survival, but excessive oxygen delivery can disrupt growth and development, induce inflammation, and cause oxidative damage. Newborns, especially premature infants, are particularly susceptible to hyperoxic injury due to their immature antioxidant defense system.
Article
Biochemistry & Molecular Biology
Benjamin M. Nash, Christopher J. G. Watson, Edward Hughes, Alec L. Hou, To Ha Loi, Bruce Bennetts, Diana Jelovic, Philip J. Polkinghorne, Mark Gorbatov, John R. Grigg, Andrea L. Vincent, Robyn V. Jamieson
Summary: The COL9A3 gene variants are known to cause multiple epiphyseal dysplasia and Stickler syndrome, but this report is the first to link these variants to peripheral vitreoretinal lattice degeneration and retinal detachment.
EUROPEAN JOURNAL OF HUMAN GENETICS
(2021)
Article
Genetics & Heredity
Corina M. Chilibeck, Shaheen Shah, Heather C. Russell, Andrea L. Vincent
Summary: The study evaluated ocular features in NF1 patients and found that choroidal neurofibromas detected by NIR imaging are common, have early progression, and can serve as an additional tool for aiding NF1 diagnosis in young children.
OPHTHALMIC GENETICS
(2021)
Article
Genetics & Heredity
Haya H. Al-Ani, Leo Sheck, Andrea L. Vincent
Summary: This study aimed to investigate the prevalence and characteristics of peripheral pigmented retinal lesions in patients with pathogenic variants in the ABCA4 gene. The results showed that almost one-fifth of these patients had peripheral pigmented retinal lesions, which are associated with more severe disease and earlier onset, serving as a diagnostic aid. Compared to the control group, patients with ABCA4-associated retinopathy were more likely to have these lesions.
OPHTHALMIC GENETICS
(2021)
Article
Ophthalmology
Zhengyang Liu, Lauren n. Ayton, F. L. E. U. R. O'hare, J. A. N. A. N. Arslan, Monica l. Hu, Alexander p. Noar, Jiang-hui Wang, Doron g. Hickey, Myra b. Mcguinness, Andrea l. Vincent, Fred k. Chen, Thomas l. Edwards
Summary: This study evaluated the anatomic and functional symmetry between eyes in individuals with Bietti crystalline dystrophy (BCD) using clinical and multimodal imaging methods. The results showed high inter eye symmetry in terms of the number, area, and distribution of retinal crystalline deposits. This finding has important implications for future therapeutic trials and the care of BCD patients.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Lubica Dudakova, Stephen Tuft, Sek-Shir Cheong, Pavlina Skalicka, Jana Jedlickova, Marek Fichtl, Martin Hlozanek, Ales Filous, Manuela Vaneckova, Andrea L. Vincent, Alison J. Hardcastle, Alice E. Davidson, Petra Liskova
Summary: The study identified nine pathogenic or likely pathogenic variants and one variant of uncertain significance in the CHRDL1 gene, of which eight were novel. Some individuals with MGC1 showed ocular findings such as pigmentary glaucoma, unilateral posterior corneal vesicles, unilateral keratoconus, and unilateral Fuchs heterochromic iridocyclitis that were not previously associated with the condition. Additionally, some heterozygous female carriers of CHRDL1 pathogenic variants had reduced corneal thickness, indicating a possible mild phenotypic feature.
ACTA OPHTHALMOLOGICA
(2022)
Article
Genetics & Heredity
Kent W. Small, Lee M. Jampol, Benjamin Bakall, Leslie Small, Robert Wiggins, Steven Agemy, Nitin Udar, Jessica Avetisjan, Andrea Vincent, Fadi S. Shaya
Summary: Best Vitelliform Macular Dystrophy can mimic NCMD. There is significant clinical overlap between NCMD and BVMD, which may lead to diagnostic inaccuracies.
OPHTHALMIC GENETICS
(2022)
Article
Genetics & Heredity
Cam Loveridge-Easther, Gulunay Kiray, Sarah Hull, Andrea L. Vincent
Summary: Harboyan syndrome is a rare genetic disorder characterized by congenital hereditary endothelial dystrophy (CHED), with a later onset of sensorineural hearing loss.
OPHTHALMIC GENETICS
(2022)
Article
Multidisciplinary Sciences
Bernd Wissinger, Britta Baumann, Elena Buena-Atienza, Zeinab Ravesh, Artur Cideciyan, Katarina Stingl, Isabelle Audo, Isabelle Meunier, Beatrice Bocquet, Elias Traboulsi, Alison J. Hardcastle, Jessica C. Gardner, Michel Michaelides, Kari E. Branham, Thomas Rosenberg, Sten Andreasson, Helene Dollfus, David Birch, Andrea L. Vincent, Loreto Martorell, Jaume Catala Mora, Ulrich Kellner, Klaus Ruther, Birgit Lorenz, Markus N. Preising, Emanuela Manfredini, Yuri A. Zarate, Raymon Vijzelaar, Eberhart Zrenner, Samuel G. Jacobson, Susanne Kohl
Summary: Blue cone monochromacy (BCM) is an X-linked retinal disorder caused by mutations in the OPN1LW/OPN1MW gene cluster leading to impaired cone photoreceptor function. A study found that about one-third of BCM families carry submicroscopic structural variants (SVs), with deletions in the gene cluster being the most common. These SVs show diverse mechanisms and do not overlap, with 40 previously unreported SVs identified. The study also suggests that large gene arrays may predispose to SVs at this locus.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Ophthalmology
Shilpa E. Kuruvilla, Eileen Song, Naz Raoof, Katherine van Bysterveldt, Verity F. Oliver, Sheng Chiong Hong, Rasha Al-Taie, Graham Wilson, Andrea L. Vincent
Summary: This study aimed to establish the phenotypic and genotypic spectrum of XL-IRD in New Zealand. Among the 32 families observed, 26 unique pathogenic variants were identified. The study found that 31% of carrier females showed significant disease symptoms, and pathogenic variants in RPGR exon 1-14 occurred in 44% of the families, which is more frequent than previously described.
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Multidisciplinary Sciences
Pushkar Raj Silwal, Arier C. Lee, David Squirrell, Jinfeng Zhao, Matire Harwood, Andrea L. Vincent, Rinki Murphy, Shanthi Ameratunga, Jacqueline Ramke
Summary: The objective of this study was to assess the use of diabetes eye services in New Zealand among people aged >= 15 years. The study found that access to diabetes eye care is suboptimal, with disparities in screening and treatment services based on age, ethnicity, and level of deprivation. Efforts to improve access and quality of diabetes eye care services should focus on data collection and monitoring.
Article
Genetics & Heredity
Alexis Ceecee Britten-Jones, Heather G. G. Mack, Andrea L. L. Vincent, Lisa J. J. Hill, Thomas L. L. Edwards, Lauren N. N. Ayton
Summary: This cross-sectional survey evaluated the knowledge, attitudes, and concerns of optometrists in Australia and New Zealand regarding genetic testing and gene therapy for retinal diseases. The study found that optometrists have a high level of interest in ocular genetics topics, but there are knowledge gaps and perceived barriers to access. Addressing these issues can help promote genetic education in primary eye care.
Meeting Abstract
Ophthalmology
Andrea L. Vincent, Elena Edgar-Nemec, Sarah Hull
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Meeting Abstract
Ophthalmology
Sarah Hull, Andrea L. Vincent
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Meeting Abstract
Ophthalmology
Lachlan S. W. Knight, Jonathan B. Ruddle, Deepa A. Taranath, Ivan Goldberg, James E. Smith, Glen Gole, Mark Y. Chiang, Faren Willett, Guy D'Mellow, James Breen, Ayub Qassim, Sean Mullany, James E. Elder, Andrea L. Vincent, Sandra E. Staffieri, Lisa S. Kearns, David A. Mackey, Susie Luu, Owen M. Siggs, Emmanuelle Souzeau, Jamie E. Craig
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Meeting Abstract
Ophthalmology
Zhengyang Liu, Lauren N. Ayton, Fleur O'Hare, Janan Arslan, Monica L. Hu, Jiang-Hui Wang, Doron G. Hickey, Myra B. McGuinness, Andrea L. Vincent, Fred K. Chen, Thomas L. Edwards
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
