Mineralocorticoid receptor activation as an etiological factor in kidney diseases

Macrophage Mineralocorticoid Receptor Signaling Plays a Key Role in Aldosterone-Independent Cardiac Fibrosis

(2012) Laura A. Bienvenu et al.   ENDOCRINOLOGY

Oxidative Stress Causes Mineralocorticoid Receptor Activation in Rat Cardiomyocytes

(2012) Miki Nagase et al.   HYPERTENSION

Natriuretic Peptide Receptor Guanylyl Cyclase-A Protects Podocytes from Aldosterone-Induced Glomerular Injury

(2012) Y. Ogawa et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Angiotensin II- and Salt-Induced Kidney Injury through Rac1-Mediated Mineralocorticoid Receptor Activation

(2012) W. Kawarazaki et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Associations of kidney disease measures with mortality and end-stage renal disease in individuals with and without hypertension: a meta-analysis

(2012) Bakhtawar K Mahmoodi et al.   LANCET

Risk of coronary events in people with chronic kidney disease compared with those with diabetes: a population-level cohort study

(2012) Marcello Tonelli et al.   LANCET

Direct regulation of blood pressure by smooth muscle cell mineralocorticoid receptors

(2012) Amy McCurley et al.   NATURE MEDICINE

Oxidative Stress-Induced Glomerular Mineralocorticoid Receptor Activation Limits the Benefit of Salt Reduction in Dahl Salt-Sensitive Rats

(2012) Kento Kitada et al.   PLoS One

Mitochondrial Dysfunction Mediates Aldosterone-Induced Podocyte Damage

(2011) Chunhua Zhu et al.   AMERICAN JOURNAL OF PATHOLOGY

Cell Biology and Pathology of Podocytes

(2011) Anna Greka et al.   Annual Review of Physiology

Rac1 GTPase in rodent kidneys is essential for salt-sensitive hypertension via a mineralocorticoid receptor–dependent pathway

(2011) Shigeru Shibata et al.   JOURNAL OF CLINICAL INVESTIGATION

Mineralocorticoid receptor activation and blockade: an emerging paradigm in chronic kidney disease

(2011) Jean-Philippe Bertocchio et al.   KIDNEY INTERNATIONAL

Lower estimated GFR and higher albuminuria are associated with adverse kidney outcomes. A collaborative meta-analysis of general and high-risk population cohorts

(2011) Ron T. Gansevoort et al.   KIDNEY INTERNATIONAL

Lower estimated glomerular filtration rate and higher albuminuria are associated with mortality and end-stage renal disease. A collaborative meta-analysis of kidney disease population cohorts

(2011) Brad C. Astor et al.   KIDNEY INTERNATIONAL

Spironolactone inhibits hyperglycemia-induced podocyte injury by attenuating ROS production

(2011) J. Toyonaga et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Focal Segmental Glomerulosclerosis

(2011) Vivette D. D'Agati et al.   NEW ENGLAND JOURNAL OF MEDICINE

Diverse immunostaining patterns of mineralocorticoid receptor monoclonal antibodies

(2011) Celso E. Gomez-Sanchez et al.   STEROIDS

Activation of the aldosterone/mineralocorticoid receptor system in chronic kidney disease and metabolic syndrome

(2010) Miki Nagase   Clinical and Experimental Nephrology

Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts: a collaborative meta-analysis

(2010)   LANCET

Eplerenone in Patients with Systolic Heart Failure and Mild Symptoms

(2010) Faiez Zannad et al.   NEW ENGLAND JOURNAL OF MEDICINE

Aldosterone Antagonists for Preventing the Progression of Chronic Kidney Disease: A Systematic Review and Meta-analysis

(2009) S. D. Navaneethan et al.   Clinical Journal of the American Society of Nephrology

Deletion of Mineralocorticoid Receptors From Macrophages Protects Against Deoxycorticosterone/Salt-Induced Cardiac Fibrosis and Increased Blood Pressure

(2009) Amanda J. Rickard et al.   HYPERTENSION

Addition of Angiotensin Receptor Blockade or Mineralocorticoid Antagonism to Maximal Angiotensin-Converting Enzyme Inhibition in Diabetic Nephropathy

(2009) U. F. Mehdi et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Aldosterone antagonism or synthase inhibition reduces end-organ damage induced by treatment with angiotensin and high salt

(2009) William B. Lea et al.   KIDNEY INTERNATIONAL

Effects of mineralocorticoid and angiotensin II receptor blockers on proteinuria and glomerular podocyte protein expression in a model of minimal change nephrotic syndrome

(2009) AKIHIRO FUKUDA et al.   NEPHROLOGY

Aldosterone Induces Apoptosis in Rat Podocytes: Role of PI3-K/Akt and p38MAPK Signaling Pathways

(2009) Cheng Chen et al.   NEPHRON EXPERIMENTAL NEPHROLOGY

Aldosterone activates endothelial exocytosis

(2009) Y. Jeong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aldosterone-Stimulated SGK1 Activity Mediates Profibrotic Signaling in the Mesangium

(2008) Y. Terada et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Aldosterone Activates NF- B in the Collecting Duct

(2008) V. Leroy et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Spironolactone suppresses inflammation and prevents L-NAME–induced renal injury in rats

(2008) Hirofumi Ikeda et al.   KIDNEY INTERNATIONAL

Renal outcomes with telmisartan, ramipril, or both, in people at high vascular risk (the ONTARGET study): a multicentre, randomised, double-blind, controlled trial

(2008) Johannes FE Mann et al.   LANCET

Modification of mineralocorticoid receptor function by Rac1 GTPase: implication in proteinuric kidney disease

(2008) Shigeru Shibata et al.   NATURE MEDICINE

The role of aldosterone blockade in murine lupus nephritis

(2008) Seetha U Monrad et al.   ARTHRITIS RESEARCH & THERAPY