Article
Biochemistry & Molecular Biology
Asadur Rahman, Tatsuya Sawano, Anupoma Sen, Akram Hossain, Nourin Jahan, Hideki Kobara, Tsutomu Masaki, Shinji Kosaka, Kento Kitada, Daisuke Nakano, Takeshi Imamura, Hiroyuki Ohsaki, Akira Nishiyama
Summary: Esaxerenone, a nonsteroidal and selective mineralocorticoid receptor blocker, improved survival and cardiac function, reduced blood pressure and cardiac remodeling in Dahl salt-sensitive rats fed a high-salt diet, indicating its potential in mitigating cardiac dysfunction in salt-induced myocardial injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Agriculture, Multidisciplinary
Li Zeng, Zerong Liu, Luxin Zhou, Meng Chen, Xuewei Zheng, Pengfei Yang, Xinrui Zhao, Zhongmin Tian
Summary: The study found that protein-rich almond supplementation can prevent salt-induced hypertension by regulating amino acid metabolism, increasing nitric oxide content, and alleviating oxidative stress.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Article
Peripheral Vascular Disease
Takahiro Miura, Akihiro Sakuyama, Lusi Xu, Jiahe Qiu, Asako Namai-Takahashi, Yoshiko Ogawa, Masahiro Kohzuki, Osamu Ito
Summary: This study aimed to investigate the mechanisms behind the antihypertensive and renal protective effects of the xanthine oxidoreductase inhibitor febuxostat. The results showed that febuxostat attenuated high salt diet-induced hypertension and renal damage in Dahl salt-sensitive rats by reducing renal oxidative stress. The antihypertensive effect of febuxostat may be partly mediated by its diuretic and natriuretic actions.
JOURNAL OF HYPERTENSION
(2022)
Article
Sport Sciences
Akihiro Sakuyama, Yoshiko Ogawa, Lusi Xu, Miwa Komatsu, Takahiro Miura, Asako Namai-Takahashi, Masahiro Kohzuki, Osamu Ito
Summary: Exercise training can alleviate renal dysfunction, glomerular injury, and renal RAS dysregulation caused by a high-salt diet in Dahl salt-sensitive rats.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2022)
Article
Nutrition & Dietetics
Ryoya Kawata, Yuji Hotta, Kotomi Maeda, Tomoya Kataoka, Kazunori Kimura
Summary: High salt intake may lead to urinary storage symptoms through abnormalities in detrusor muscle contraction and enhanced cholinergic signals. Excessive salt intake should be avoided to preserve bladder function.
Article
Cardiac & Cardiovascular Systems
Lusi Xu, Gaizun Hu, Jiahe Qiu, Yuxuan Fan, Yixuan Ma, Takahiro Miura, Masahiro Kohzuki, Osamu Ito
Summary: High-fructose diet induces hypertension and renal damage, which are exaggerated in salt-sensitive Dahl salt-sensitive rats through renal renin-angiotensin system activation. The effects can be controlled by renin-angiotensin system inhibitors.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Biochemistry & Molecular Biology
Pengfei Yang, Luxin Zhou, Meng Chen, Li Zeng, Yanan Ouyang, Xuewei Zheng, Xiangbo Chen, Zhe Yang, Zhongmin Tian
Summary: The study found that AO supplementation prevented high-salt diet-induced hypertension in SS rats by restoring the metabolic balance of the kidneys. Therefore, AO has the potential to become a functional food additive to improve salt-sensitive hypertension.
Article
Medicine, Research & Experimental
DongZhu Xu, Nobuyuki Murakoshi, Kazuko Tajiri, Feng Duo, Yuta Okabe, Yoshiko Murakata, Zixun Yuan, Siqi Li, Kazuhiro Aonuma, Zonghu Song, Yuzuno Shimoda, Haruka Mori, Akira Sato, Akihiko Nogami, Kazutaka Aonuma, Masaki Ieda
Summary: The XO inhibitor febuxostat, as well as allopurinol, could reduce hypertension-related increase in AF perpetuation by restoring Ca2+ handling and gap junction.
Article
Biochemistry & Molecular Biology
Ya-nan Ou-Yang, Meng-di Yuan, Zheng-mao Yang, Zhuo Min, Yue-xin Jin, Zhong-min Tian
Summary: Salt-induced renal metabolism dysfunction is a significant mechanism of salt-sensitive hypertension. This study aimed to investigate the extra-renal mechanism involving hepatic metabolism and gut microbiota, and the potential protective effects of curcumin. The results showed that a high-salt diet led to alterations in hepatic metabolic pathways and changes in gut microbial composition, which were associated with metabolic disorders. The dysfunction in hepatic metabolism was correlated with enhanced lipopolysaccharide (LPS) biosynthesis and apoptosis in gut microbes. Curcumin administration alleviated the salt-induced metabolic dysfunctions and protected against salt-sensitive hypertension.
Article
Pharmacology & Pharmacy
Edwin K. Jackson, Elizabeth V. Menshikova, Vladimir B. Ritov, Delbert G. Gillespie, Zaichuan Mi
Summary: This study investigates the biosynthesis pathway of 8-aminoguanine and finds that both pathway 1 and pathway 2 contribute to its formation. The increased level of 8-aminoguanine in Dahl rats is associated with the increased production of 8-nitroguanosine.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Jacqueline C. Potter, Shannon A. Whiles, Conor B. Miles, Jenna B. Whiles, Mark A. Mitchell, Brianna E. Biederman, Febronia M. Dawoud, Kevin F. Breuel, Geoffrey A. Williamson, Maria M. Picken, Aaron J. Polichnowski
Summary: The study found that high salt intake significantly increased blood pressure and exacerbated renal injury in salt-sensitive rats, while salt-resistant rats showed less severe symptoms. In consomic rats, high salt intake significantly decreased renal vascular resistance and increased renal blood flow, whereas these changes did not occur in salt-sensitive rats.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Medicine, Research & Experimental
Hongxia Du, Guangxu Xiao, Zhifeng Xue, Zhixiong Li, Shuang He, Xiaoli Du, Zhengchan Zhou, Linghua Cao, Yule Wang, Jian Yang, Xiaoying Wang, Yan Zhu
Summary: QiShenYiQi (QSYQ) has shown significant effects in treating ischemic stroke, blood pressure, and kidney injury in Dahl salt-sensitive hypertensive rat models. By regulating the expression of ADRA1D and SIK1 genes, QSYQ not only lowers blood pressure but also alleviates renal damage.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Prabhatchandra Dube, Vaishnavi Aradhyula, Apurva Lad, Fatimah K. Khalaf, Joshua D. Breidenbach, Eshita Kashaboina, Snigdha Gorthi, Shangari Varatharajan, Travis W. Stevens, Jacob A. Connolly, Sophia M. Soehnlen, Ambika Sood, Amulya Marellapudi, Meghana Ranabothu, Andrew L. Kleinhenz, Oliver Domenig, Lance D. Dworkin, Deepak Malhotra, Steven T. Haller, David J. Kennedy
Summary: This study demonstrates that a low-salt, oxalate-rich diet induces renal injury, dysfunction, hypertension, and activation of the renin-angiotensin-aldosterone system (RAAS) in SS rats. This novel diet-induced model provides a clinically relevant and reproducible approach to study hypertension and chronic kidney disease (CKD).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Li Zeng, Meng Chen, Hussain Ahmad, Xuewei Zheng, Yanan Ouyang, Pengfei Yang, Zhe Yang, Di Gao, Zhongmin Tian
Summary: Hypertension is a major factor in cardiovascular disease and high salt intake is a key risk factor. Dietary Momordica charantia may help prevent salt-induced hypertension by increasing the synthesis of nitric oxide and arginine. It also improves renal function and acts as an antioxidant to prevent oxidative stress.
PLANT FOODS FOR HUMAN NUTRITION
(2022)
Article
Medicine, Research & Experimental
Takashi Iwamoto, Kazumasa Torimoto, Daisuke Gotoh, Sayuri Onishi, Shunta Hori, Yousuke Morizawa, Yasushi Nakai, Makito Miyake, Kiyohide Fujimoto
Summary: This study aims to investigate the circadian expression changes of bladder clock genes in Dahl salt-sensitive rats following high salt intake. The results showed that high salt intake led to lower mRNA levels and reduced amplitude of circadian expression changes in bladder clock genes. However, reducing salt intake partially restored these rhythms.
Article
Surgery
Naoya Tada, Hideki Kobara, Noriko Nishiyama, Shintaro Fujihara, Tadayuki Takata, Kazuhiro Kozuka, Takanori Matsui, Nobuya Kobayashi, Taiga Chiyo, Koji Fujita, Joji Tani, Tatsuo Yachida, Akihito Tsuji, Keiichi Okano, Yasuyuki Suzuki, Daisuke Nakano, Akira Nishiyama, Tsutomu Masaki
Summary: This study concludes that the guidewire-assisted OTSC delivery (GOD) method is a feasible and safe technique for delivering OTSC to the small and proximal large intestine.
MINIMALLY INVASIVE THERAPY & ALLIED TECHNOLOGIES
(2022)
Article
Urology & Nephrology
Adriana Marton, Tatsuroh Kaneko, Jean-Paul Kovalik, Atsutaka Yasui, Akira Nishiyama, Kento Kitada, Jens Titze
Summary: SGLT2 inhibitors induce metabolic adaptations similar to aestivation, helping patients adapt to reduced energy availability and conserve water. These metabolic adjustments may contribute to the favorable cardiovascular and renal outcomes of SGLT2 inhibitor therapy.
NATURE REVIEWS NEPHROLOGY
(2021)
Review
Peripheral Vascular Disease
Satoshi Kidoguchi, Naoki Sugano, Gorou Tokudome, Takashi Yokoo, Yuichiro Yano, Kiyohiko Hatake, Akira Nishiyama
Summary: Due to aging populations, the prevalence of hypertension, cardiovascular events, and cancer is increasing globally. Small-molecule inhibitors used in cancer therapy have a positive impact on prognosis and survival of cancer patients, leading to a rapid increase in cancer survivors with hypertension. However, there is a lack of evidence on optimal blood pressure control for cancer patients with hypertension, highlighting the need for further research on the concept of onco-hypertension.
Article
Surgery
Nobuya Kobayashi, Hideki Kobara, Noriko Nishiyama, Shintaro Fujihara, Kazuhiro Kozuka, Naoya Tada, Takanori Matsui, Taiga Chiyo, Tadayuki Takata, Koji Fujita, Joji Tani, Tatsuo Yachida, Keiichi Okano, Daisuke Nakano, Akira Nishiyama, Hirohito Mori, Tsutomu Masaki
Summary: The study demonstrated that the WaRP method has a high technical success rate and safety in reducing post-ESD bleeding after gastric ESD, making it a simple and reliable approach.
MINIMALLY INVASIVE THERAPY & ALLIED TECHNOLOGIES
(2022)
Article
Surgery
Yasuhiro Goda, Hideki Kobara, Nobuya Kobayashi, Noriko Nishiyama, Shintaro Fujihara, Naoya Tada, Kazuhiro Kozuka, Takanori Matsui, Taiga Chiyo, Tingting Shi, Koji Fujita, Joji Tani, Tatsuo Yachida, Masashi Takata, Keiichi Okano, Daisuke Nakano, Akira Nishiyama, Hirohito Mori, Tsutomu Masaki
Summary: This study examined the clinical outcomes and long-term characteristics of patients treated with Over-The-Scope Clip (OTSC). The results showed a 100% clinical success rate and a 2.9% complication rate during the observation period. OTSC remains effective in the long-term.
MINIMALLY INVASIVE THERAPY & ALLIED TECHNOLOGIES
(2022)
Article
Physiology
Johannes Kovarik, Norihiko Morisawa, Johannes Wild, Adriana Marton, Kaoru Takase-Minegishi, Shintaro Minegishi, Steffen Daub, Jeff M. Sands, Janet D. Klein, James L. Bailey, Jean-Paul Kovalik, Manfred Rauh, Susanne Karbach, Karl F. Hilgers, Friedrich Luft, Akira Nishiyama, Daisuke Nakano, Kento Kitada, Jens Titze
Summary: Our study found that rats with 5/6 nephrectomy showed polyuria due to the inability of their kidneys to concentrate urine, but they were able to adapt physiologically by mobilizing nitrogen and energy from muscle, increasing norepinephrine and copeptin levels, and reducing skin blood flow to compensate for transepidermal water loss. This complex physiologic-metabolic adjustment across multiple organs allowed the rats to stabilize their body water content despite persisting renal water loss, although it led to hypertension and muscle catabolism.
Article
Surgery
Yohei Doi, Makoto Tsujita, Takayuki Hamano, Yoshitsugu Obi, Tomoko Namba-Hamano, Toshihide Tomosugi, Kenta Futamura, Manabu Okada, Takahisa Hiramitsu, Norihiko Goto, Akira Nishiyama, Asami Takeda, Shunji Narumi, Yoshihiko Watarai, Yoshitaka Isaka
Summary: Cholecalciferol supplementation did not significantly improve allograft outcomes in kidney transplant recipients, with no significant impact on eGFR change compared to placebo. However, it showed detrimental effects in patients with eGFR <45 mL/min/1.73 m(2).
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Biochemistry & Molecular Biology
Asadur Rahman, Tatsuya Sawano, Anupoma Sen, Akram Hossain, Nourin Jahan, Hideki Kobara, Tsutomu Masaki, Shinji Kosaka, Kento Kitada, Daisuke Nakano, Takeshi Imamura, Hiroyuki Ohsaki, Akira Nishiyama
Summary: Esaxerenone, a nonsteroidal and selective mineralocorticoid receptor blocker, improved survival and cardiac function, reduced blood pressure and cardiac remodeling in Dahl salt-sensitive rats fed a high-salt diet, indicating its potential in mitigating cardiac dysfunction in salt-induced myocardial injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Naoko Katagiri, Hirofumi Hitomi, Shin-Ichi Mae, Maki Kotaka, Li Lei, Takuya Yamamoto, Akira Nishiyama, Kenji Osafune
Summary: This study found that retinoic acid can enhance EPO production and potentially treat renal anemia. Combination treatment with RA and PHD inhibitors can improve renal anemia in vitamin A-depleted CKD model mice. This research using hiPSC-EPO cells and CKD model mice may provide insights into the mechanism of EPO production and aid in the development of efficient therapies for renal anemia.
SCIENTIFIC REPORTS
(2021)
Article
Hematology
Eri Muso, Soichi Sakai, Youske Ogura, Susumu Yukawa, Yoshiki Nishizawa, Noriaki Yorioka, Takao Saito, Masatoshi Mune, Satoshi Sugiyama, Yasuhiko Iino, Tsutomu Hirano, Motoshi Hattori, Tsuyoshi Watanabe, Hitoshi Yokoyama, Hiroshi Sato, Shunya Uchida, Takashi Wada, Tetsuo Shoji, Hiroaki Oda, Kiyoshi Mori, Hideki Kimura, Osamu Ito, Akira Nishiyama, Shoichi Maruyama, Reiko Inagi, Shoichi Fujimoto, Tatsuo Tsukamoto, Yusuke Suzuki, Hirokazu Honda, Tetsuya Babazono, Kazuhiko Tsuruya, Yukio Yuzawa
Summary: Many reports have demonstrated the therapeutic efficacy of LDL-Apheresis in improving heavy proteinuria and severely impaired renal function in cases of drug-resistant nephrotic syndrome. A post hoc analysis of the POLARIS study showed significant improvements in proteinuria and renal function in cases with normal and moderately impaired renal function, and a trend for improvement in severely impaired renal function. Most cases did not progress to end-stage renal disease within 2 years after LDL-A treatment.
THERAPEUTIC APHERESIS AND DIALYSIS
(2022)
Article
Biochemistry & Molecular Biology
Mai Hattori, Asadur Rahman, Satoshi Kidoguchi, Nourin Jahan, Yoshihide Fujisawa, Norihiko Morisawa, Hiroyuki Ohsaki, Hideki Kobara, Tsutomu Masaki, Akram Hossain, Akumwami Steeve, Akira Nishiyama
Summary: This study investigated the effects of the nonsteroidal mineralocorticoid receptor blocker esaxerenone on blood pressure and renal health in salt-loaded conditions. The results showed that esaxerenone significantly reduced blood pressure and attenuated renal damage induced by high salt intake. These effects were associated with the modulation of sodium homeostasis by esaxerenone.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Satoshi Kidoguchi, Kento Kitada, Yoshihide Fujisawa, Daisuke Nakano, Takashi Yokoo, Jens Titze, Akira Nishiyama
Summary: This study investigates the impact of pharmacological fluid loss induced by tolvaptan on water conservation. The findings reveal that tolvaptan-induced fluid loss activates the water conservation system through renal urea recycling.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Jose A. Godoy-Lugo, Max A. Thorwald, Dora A. Mendez, Ruben Rodriguez, Daisuke Nakano, Akira Nishiyama, Rudy M. Ortiz
Summary: This study found that long-term AT1 blockade can increase nuclear Nrf2 content and reduce the expression of antioxidant enzymes, thereby promoting the development of NAFLD. The angiotensin receptor blocker can alleviate the impact of hyperglycemia on Nrf2, suggesting its role in antioxidant defense.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Asadur Rahman, Nourin Jahan, Md Tanvir Rahman, Akira Nishiyama
Summary: Inappropriate mineralocorticoid receptor (MR) activation in cardiovascular cells has negative effects on cardiac remodeling and function. MR inhibition is an important strategy to overcome cardiovascular dysfunction, but the clinical application of steroidal MR antagonists is limited due to adverse effects. Newer non-steroidal MR antagonists show promise for clinical use, particularly in patients with type 2 diabetes and chronic kidney disease. Pre-clinical and clinical evidence supports the use of non-steroidal MR antagonists in treating cardiovascular disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Biochemistry & Molecular Biology
Rudy M. Ortiz, Ryousuke Satou, Jia L. Zhuo, Akira Nishiyama
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)