Article
Pharmacology & Pharmacy
Tomislav Smoljo, Barbara Tomic, Hrvoje Lalic, Vilma Dembitz, Josip Batinic, Antonio Bedalov, Dora Visnjic
Summary: This study demonstrates that bone marrow stroma reduces differentiation of acute myeloid leukemia (AML) induced by low-dose cytarabine (LDAC). These findings provide insights into the limited occurrence of terminal differentiation observed in AML patients and suggest a potential explanation for this observation.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Cell Biology
Kevin Woods, Borhane Guezguez
Summary: Mesenchymal stromal cells (MSCs) are a diverse cell population known for their nutrient-producing and immunomodulatory functions, crucial in regulating hematopoietic stem cells (HSC) in the bone marrow for blood production and immunity. MSCs contribute to bone integrity and hormone supply by differentiating into osteoblasts and adipocytes, playing a key role in the complex interactions of the HSC niche.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Kevin Woods, Borhane Guezguez
Summary: MSCs are a heterogeneous cell population found in various tissues in the body, with important regulatory functions, especially in the bone marrow where they play a critical role in regulating HSCs. They contribute to maintaining bone integrity and hormonal nutrition supply, as well as regulating the homeostasis and differentiation of the HSC niche through differentiation into different cell types. Research on MSCs helps understand their role in regulating cell interactions and homeostasis in the body.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Martina Chiu, Giuseppe Taurino, Massimiliano G. Bianchi, Ovidio Bussolati
Summary: The close connection between hematopoietic cells and mesenchymal stromal cells in the bone marrow niche plays a crucial role in influencing the behavior and differentiation of both normal and malignant lymphoid and myeloid cells. Changes in cell metabolism, particularly in nutrient pools such as amino acids, are important components of the bidirectional communication between MSCs and hematological cancer cells. Furthermore, there is a direct nutritional interaction between MSCs and immune cells, with certain subpopulations of lymphocytes relying on specific amino acids for differentiation and competence.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zhenghai Zhang, Lulu Gong, Min Li, Guoshuai Wei, Yan Liu
Summary: This study investigated the effects of NF and FFF scaffolds on the behavior of hBMSCs using MFCS, IFS, and SVM, revealing that NF scaffolds induce the expression of more osteogenic-related genes in hBMSCs. Enrichment analysis of common genes suggests that NF scaffolds may enhance the osteogenic differentiation ability of hBMSCs.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Biology
Zheting Liao, Yu Jin, Yuhao Chu, Hansen Wu, Xiaoyu Li, Zhonghao Deng, Shuhao Feng, Nachun Chen, Ziheng Luo, Xiaoyong Zheng, Liangxiao Bao, Yongqing Xu, Hongbo Tan, Liang Zhao
Summary: A study using single-cell RNA sequencing explored the transcriptomic landscape of alcohol-induced osteonecrosis of the femoral head (ONFH). The study revealed the relevance of stromal and endothelial cells to the pathogenesis of the disease and provided resources for developing cell type-specific therapeutic strategies.
COMMUNICATIONS BIOLOGY
(2022)
Article
Materials Science, Biomaterials
Ziyan Wang, Feixue Mi, Jinchen Li, Dandan Chen, Minmin Lin, Xinyu Wang, Siying Wu, Changfeng Wu, Chao Liu
Summary: Bone marrow stromal cells (BMSCs) have great potential in bone defect repair. By using semiconducting polymer dots (Pdots) as markers, we successfully selected BMSCs and evaluated their therapeutic efficacy in a bone defect model.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Biochemistry & Molecular Biology
Hannah L. L. Smith, Juliet C. C. Gray, Stephen A. A. Beers, Janos M. M. Kanczler
Summary: Osteosarcoma, a bone cancer typically found in adolescents, is closely related to the conversion of bone marrow during adolescence. This study compared the differentiation potential of bone marrow cells from different regions with osteosarcoma cell lines. The results showed distinct differences in the differentiation abilities of hematopoietic and adipocyte-rich bone marrow, which correlated with specific characteristics of the osteosarcoma cell lines.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Anastasia M. M. Hughes, Vincent Kuek, Joyce Oommen, Grace-Alyssa Chua, Maria van Loenhout, Sebastien Malinge, Rishi S. S. Kotecha, Laurence C. C. Cheung
Summary: Components of the bone marrow microenvironment (BMM) play a significant role in the development, progression, and treatment response of acute lymphoblastic leukemia (B-ALL). This study investigated the cellular and transcriptome profiles of mesenchymal stem cells (MSCs) isolated from the BMM of an immunocompetent BCR-ABL1(+) model of B-ALL. The findings showed that leukemia-associated MSCs had reduced self-renewal capacity, upregulation of inflammatory signaling pathways, and downregulation of genes involved in extracellular matrix organization and osteoblastogenesis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Oncology
Csilla Kriston, Mark Hernadfoi, Mark Plander, Agnes Mark, Ferenc Takacs, Agnes Czeti, Gabor Szaloki, Orsolya Szabo, Andras Matolcsy, Gabor Barna
Summary: Lenalidomide has limited effect on BMSCs, increases apoptosis of CLL cells, decreases interaction with microenvironment, and enhances expression of certain cell molecules.
HEMATOLOGICAL ONCOLOGY
(2021)
Article
Cell Biology
Peng Chen, Ramanaiah Mamillapalli, Shutaro Habata, Hugh S. Taylor
Summary: Endometriosis-derived stromal cells promote the differentiation of BMDCs through paracrine signaling, leading to increased expression of T cell PD-1. Induction of PD-1 may require CXCL12.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Cell Biology
Wu Duan, Huajie Zou, Nan Zang, Dongxia Ma, Bo Yang, Lin Zhu
Summary: Bone marrow adipose tissue (MAT) can have both local and systemic effects on metabolic homeostasis. The effects of metformin, a first-line drug for type 2 diabetes, on MAT and bone marrow mesenchymal stem cell (BM-MSC) differentiation are conflicting. In vivo and in vitro experiments showed that metformin increased MAT in mice tibia and promoted both osteogenic and lipogenic gene expression in mouse bone marrow. However, metformin inhibited lipogenesis and promoted osteogenesis of MSC in vitro. The increased MAT may be attributed to the filling of adipose tissue after metformin-induced apoptosis of bone marrow stromal cells.
Article
Biotechnology & Applied Microbiology
Madhan Jeyaraman, Shiva Kumar Bingi, Sathish Muthu, Naveen Jeyaraman, Rathinavelpandian Perunchezhian Packkyarathinam, Rajni Ranjan, Shilpa Sharma, Saurabh Kumar Jha, Manish Khanna, Sree Naga Sowndary Rajendran, Ramya Lakshmi Rajendran, Prakash Gangadaran
Summary: Human bone marrow is a promising source of mesenchymal stromal cells (MSCs) for regenerative procedures involving cartilage and bone. However, the low proportion of MSCs in the bone marrow requires careful harvesting and processing techniques. There is currently a lack of consensus regarding the variables in the harvesting and processing technique of bone marrow aspiration concentrate (BMAC) and their impact on MSC yield.
BIOENGINEERING-BASEL
(2022)
Article
Biology
Zengdi Zhang, Zan Huang, Mohamed Awad, Mohammed Elsalanty, James Cray, Lauren E. Ball, Jason C. Maynard, Alma L. Burlingame, Hu Zeng, Kim C. Mansky, Hai-Bin Ruan
Summary: In mammals, the interaction between bone marrow stroma and hematopoietic progenitors contributes to bone-BM homeostasis, but the mechanisms and interactions between the development of skeletal and hematopoietic systems are largely unknown. This study reveals that the intracellular O-GlcNAc modification plays a role in dictating the fate and function of early BM stromal cells (BMSCs). O-GlcNAcylation promotes osteogenic differentiation of BMSCs and supports lymphopoiesis, while inhibiting adipogenesis and myelopoiesis. Impaired bone formation and defective hematopoiesis were observed when O-GlcNAc transferase (OGT) was ablated in BMSCs.
Article
Oncology
Ying Xie, Na Han, Feng Li, Lijuan Wang, Gerui Liu, Meilin Hu, Sheng Wang, Xuelei Wei, Jing Guo, Hongmei Jiang, Jingjing Wang, Xin Li, Yixuan Wang, Jingya Wang, Xiyun Bian, Zhongjiao Zhu, Hui Zhang, Chunhua Liu, Xiaozhi Liu, Zhiqiang Liu
Summary: This study found that melatonin levels decrease during aging, accompanied by downregulation of NSD2 expression in senescent BMSCs. Melatonin stimulates NSD2 expression through MT1/2-mediated signaling pathways, increasing chromatin accessibility of osteogenic genes to promote osteogenesis of BMSCs. Additionally, melatonin alleviates osteoporosis progression in aging mice and is negatively correlated with the severity of senile osteoporosis in humans.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Review
Oncology
Haige Ye, Aakash Desai, Dongfeng Zeng, Krystle Nomie, Jorge Romaguera, Makhdum Ahmed, Michael L. Wang
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2017)
Article
Hematology
D. F. Zeng, F. Chen, S. Wang, S. L. Chen, Y. Xu, M. Q. Shen, C. H. Du, C. Wang, P. Y. Kong, T. M. Cheng, Y. P. Su, J. P. Wang
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2018)
Review
Oncology
Haige Ye, Aakash Desai, Dongfeng Zeng, Jorge Romaguera, Michael L. Wang
Article
Hematology
Preetesh Jain, Rashmi Kanagal-Shamanna, Shaojun Zhang, Makhdum Ahmed, Ahmad Ghorab, Liang Zhang, Chi Young Ok, Shaoying Li, Frederick Hagemeister, Dongfeng Zeng, Tiejun Gong, Wendy Chen, Maria Badillo, Krystle Nomie, Luis Fayad, Leonard J. Medeiros, Sattva Neelapu, Nathan Fowler, Jorge Romaguera, Richard Champlin, Linghua Wang, Michael L. Wang
BRITISH JOURNAL OF HAEMATOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Hui Guo, Dongfeng Zeng, Hui Zhang, Taylor Bell, Jun Yao, Yang Liu, Shengjian Huang, Carrie J. Li, Elizabeth Lorence, Shouhao Zhou, Tiejun Gong, Changying Jiang, Makhdum Ahmed, Yixin Yao, Krystle J. Nomie, Liang Zhang, Michael Wang
Letter
Medical Laboratory Technology
Huan Xie, Zhongyue Zhao, Dongfeng Zeng
ANNALS OF LABORATORY MEDICINE
(2023)
Article
Cell Biology
Hai Yi, Qianjin Yu, Dongfeng Zeng, Zhaohua Shen, Jiali Li, Lidan Zhu, Xi Zhang, Quanhong Xu, Hu Song, Peiyan Kong
Summary: High-altitude polycythemia is a common aspect of chronic mountain sickness caused by hypoxia. Elevated inflammatory factors play a significant role in the pathogenesis of HAPC and high-altitude acclimation, potentially serving as new biomarkers.
MEDIATORS OF INFLAMMATION
(2021)
Article
Oncology
Haige Ye, Aakash Desai, Tiejun Gong, Dongfeng Zeng, Krystle Nomie, Wendy Chen, Wei Wang, Jorge Romaguera, Michael L. Wang
CANCER COMMUNICATIONS
(2018)