Promoting transplantation tolerance; adoptive regulatory T cell therapy

Cutting Edge: Foxp3-Mediated Induction of Pim 2 Allows Human T Regulatory Cells to Preferentially Expand in Rapamycin

(2014) Samik Basu et al.   JOURNAL OF IMMUNOLOGY

An Analysis of Lymphocyte Phenotype After Steroid Avoidance With Either Alemtuzumab or Basiliximab Induction in Renal Transplantation

(2012) A. Cherukuri et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Functionally distinct subsets of human FOXP3+ Treg cells that phenotypically mirror effector Th cells

(2012) T. Duhen et al.   BLOOD

Regulatory T-cell therapy for transplantation

(2012) Qizhi Tang et al.   Current Opinion in Organ Transplantation

Changes in Chemokine Receptor Expression of Regulatory T Cells After Ex Vivo Culture

(2012) Rikhia Chakraborty et al.   JOURNAL OF IMMUNOTHERAPY

High-Throughput 13-Parameter Immunophenotyping Identifies Shifts in the Circulating T-Cell Compartment Following Reperfusion in Patients with Acute Myocardial Infarction

(2012) Jedrzej Hoffmann et al.   PLoS One

Regulatory T cell migration during an immune response

(2012) Yaozhong Ding et al.   TRENDS IN IMMUNOLOGY

The Potency of Allospecific Tregs Cells Appears to Correlate With T Cell Receptor Functional Avidity

(2011) J. Y. S. Tsang et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Human FoxP3+ regulatory T cells in systemic autoimmune diseases

(2011) Makoto Miyara et al.   AUTOIMMUNITY REVIEWS

Human regulatory T cells in allogeneic stem cell transplantation

(2011) S. N. Ukena et al.   BLOOD

Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation

(2011) M. Di Ianni et al.   BLOOD

The Time is Crucial for Ex Vivo Expansion of T Regulatory Cells for Therapy

(2011) Natalia Marek et al.   CELL TRANSPLANTATION

Isolation strategies of regulatory T cells for clinical trials: Phenotype, function, stability, and expansion capacity

(2011) Sya N. Ukena et al.   EXPERIMENTAL HEMATOLOGY

Stability of human rapamycin-expanded CD4+CD25+ T regulatory cells

(2011) E. Tresoldi et al.   HAEMATOLOGICA

Human FoxP3+ CD4+ regulatory T cells: their knowns and unknowns

(2011) Makoto Miyara et al.   IMMUNOLOGY AND CELL BIOLOGY

Trans-Endocytosis of CD80 and CD86: A Molecular Basis for the Cell-Extrinsic Function of CTLA-4

(2011) O. S. Qureshi et al.   SCIENCE

Functional Regulatory T Cells Produced by Inhibiting Cyclic Nucleotide Phosphodiesterase Type 3 Prevent Allograft Rejection

(2011) G. Feng et al.   Science Translational Medicine

Human Regulatory T Cells with Alloantigen Specificity Are More Potent Inhibitors of Alloimmune Skin Graft Damage than Polyclonal Regulatory T Cells

(2011) P. Sagoo et al.   Science Translational Medicine

Immune Reconstitution Following Rabbit Antithymocyte Globulin

(2010) S. Gurkan et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Expression of CD39 by Human Peripheral Blood CD4+CD25+ T Cells Denotes a Regulatory Memory Phenotype

(2010) K. M. Dwyer et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics

(2010) C. G. Brunstein et al.   BLOOD

Cyclic adenosine monophosphate and IL-10 coordinately contribute to nTreg cell-mediated suppression of dendritic cell activation

(2010) Melanie Fassbender et al.   CELLULAR IMMUNOLOGY

Development of a cross-platform biomarker signature to detect renal transplant tolerance in humans

(2010) Pervinder Sagoo et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of Regulatory Foxp3+ Invariant NKT Cells Induced by TGF- 

(2010) M. Monteiro et al.   JOURNAL OF IMMUNOLOGY

Distinct Roles for CCR4 and CXCR3 in the Recruitment and Positioning of Regulatory T Cells in the Inflamed Human Liver

(2010) Y. H. Oo et al.   JOURNAL OF IMMUNOLOGY

In vivo prevention of transplant arteriosclerosis by ex vivo–expanded human regulatory T cells

(2010) Satish N Nadig et al.   NATURE MEDICINE

In vivo tracking of 'color-coded' effector, natural and induced regulatory T cells in the allograft response

(2010) Zhigang Fan et al.   NATURE MEDICINE

Ex Vivo–Expanded Human Regulatory T Cells Prevent the Rejection of Skin Allografts in a Humanized Mouse Model

(2010) Fadi Issa et al.   TRANSPLANTATION

Selective expression of latency-associated peptide (LAP) and IL-1 receptor type I/II (CD121a/CD121b) on activated human FOXP3+ regulatory T cells allows for their purification from expansion cultures

(2009) D. Q. Tran et al.   BLOOD

Ex vivo expanded human CD4+CD25+Foxp3+ regulatory T cells prevent lethal xenogenic graft versus host disease (GVHD)

(2009) Tinghua Cao et al.   CELLULAR IMMUNOLOGY

Immunomagnetic isolation of CD4+CD25+FoxP3+natural T regulatory lymphocytes for clinical applications

(2009) M. Di Ianni et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

First-in-man clinical results of the treatment of patients with graft versus host disease with human ex vivo expanded CD4+CD25+CD127− T regulatory cells

(2009) Piotr Trzonkowski et al.   CLINICAL IMMUNOLOGY

Loss of FOXP3 expression in natural human CD4+CD25+regulatory T cells upon repetitivein vitrostimulation

(2009) Petra Hoffmann et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Regulatory T Cells Sequentially Migrate from Inflamed Tissues to Draining Lymph Nodes to Suppress the Alloimmune Response

(2009) Nan Zhang et al.   IMMUNITY

Functional Delineation and Differentiation Dynamics of Human CD4+ T Cells Expressing the FoxP3 Transcription Factor

(2009) Makoto Miyara et al.   IMMUNITY

Direct Expansion of Human Allospecific FoxP3+CD4+ Regulatory T Cells with Allogeneic B Cells for Therapeutic Application

(2009) L. C. Chen et al.   JOURNAL OF IMMUNOLOGY

Mammalian Target of Rapamycin Inhibition and Alloantigen-Specific Regulatory T Cells Synergize To Promote Long-Term Graft Survival in Immunocompetent Recipients

(2009) G. Raimondi et al.   JOURNAL OF IMMUNOLOGY

CD39+Foxp3+ Regulatory T Cells Suppress Pathogenic Th17 Cells and Are Impaired in Multiple Sclerosis

(2009) J. M. Fletcher et al.   JOURNAL OF IMMUNOLOGY

Indefinite mouse heart allograft survival in recipient treated with CD4+CD25+ regulatory T cells with indirect allospecificity and short term immunosuppression

(2009) Julia Yuen-Shan Tsang et al.   TRANSPLANT IMMUNOLOGY

Noninvasive Prediction of Organ Graft Rejection and Outcome Using Gene Expression Patterns

(2009) Dany Anglicheau et al.   TRANSPLANTATION

Mechanisms regulating the development and function of natural regulatory T cells

(2008) Sonal Gupta et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Umbilical cord blood regulatory T-cell expansion and functional effects of tumor necrosis factor receptor family members OX40 and 4-1BB expressed on artificial antigen-presenting cells

(2008) K. L. Hippen et al.   BLOOD

Expansion of Human Regulatory T-Cells From Patients With Type 1 Diabetes

(2008) A. L. Putnam et al.   DIABETES

Regulatory T cells after organ transplantation: Where does their action take place?

(2008) I. Esmé Dijke et al.   HUMAN IMMUNOLOGY

Two Functional Subsets of FOXP3+ Regulatory T Cells in Human Thymus and Periphery

(2008) Tomoki Ito et al.   IMMUNITY

Clinical Grade Treg: GMP Isolation, Improvement of Purity by CD127pos Depletion, Treg Expansion, and Treg Cryopreservation

(2008) Jorieke H. Peters et al.   PLoS One