Article
Urology & Nephrology
Charles Ronsin, Marie Georges, Agnes Chapelet-Debout, Jean-Francois Augusto, Vincent Audard, Ludivine Lebourg, Sebastien Rubin, Thomas Quemeneur, Pierre Bataille, Alexandre Karras, Eric Daugas, Dimitri Titeca-Beauport, Jean-Jacques Boffa, Cecile Vigneau, Jean-Michel Halimi, Corinne Isnard-Bagnis, Sandrine Durault, Eric Renaudineau, Frank Bridoux, Angelo Testa, Moglie Le Quintrec, Karine Renaudin, Fadi Fakhouri
Summary: Within the spectrum of ANCA-negative PING, infection and malignancy-associated forms represent distinct clinical subsets. Despite immunosuppressive treatments, ANCA-negative PING remains a severe form of vasculitis with high morbidity and mortality rates.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2022)
Article
Pathology
Meral Uner, Bassam Alhasson, Jagdeep Obhrai, Serena M. Bagnasco
Summary: Cancer immunotherapy with immune checkpoint inhibitors has been successful in various cancer types, but specific side effects, such as immune-related adverse events (irAEs) in the kidney, are rare. This case report describes a patient treated with pembrolizumab for squamous cell carcinoma who developed infectious enterocolitis and ANCA-related diffuse necrotizing crescentic glomerulonephritis, potentially linked to the treatment.
Article
Multidisciplinary Sciences
Juan Irure-Ventura, Lara Belmar-Vega, Gema Fernandez-Fresnedo, Elena Gonzalez-Lopez, Carolina Castro-Hernandez, Emilio Rodrigo-Calabia, Milagros Heras-Vicario, Juan Carlos Ruiz San Millan, Marcos Lopez-Hoyost
Summary: An increase in the development of ANCA-associated vasculitis (AAV) has been observed in 2021, with most cases occurring after SARS-CoV-2 vaccination, particularly the second dose. The kidneys and respiratory tracts are the main organs affected.
Article
Immunology
Samy Hakroush, Bjoern Tampe
Summary: Continuous monitoring of COVID-19 vaccine safety is crucial as vaccination programs expand worldwide, particularly in detecting rare adverse events associated with vaccination.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Urology & Nephrology
Sophia Lionaki, Smaragdi Marinaki, George Liapis, Emmanuel Kalaitzakis, Sophia Fragkioudaki, Petros Kalogeropoulos, Ioannis Michelakis, Andreas Goules, Athanasios G. Tzioufas, John N. Boletis
Summary: Evidence suggests that low complement levels may be an independent predictor of treatment resistance in patients with pauci-immune glomerulonephritis, particularly in cases with higher histopathological activity at diagnosis. Treatment resistance is associated with factors such as low sC3 levels, high serum creatinine, acute dialysis requirement, and high chronicity score.
KIDNEY INTERNATIONAL REPORTS
(2021)
Article
Immunology
Samy Hakroush, Desiree Tampe, Philipp Stroebel, Peter Korsten, Bjoern Tampe
Summary: This study analyzed kidney biopsies of patients with ANCA GN and found that different types of immune cell infiltrates were associated with clinicopathological findings, particularly neutrophilic infiltrates were linked to glomerular necrosis and severe kidney injury, while eosinophilic infiltrates were associated with kidney injury and inflammation independent of glomerular lesions, suggesting distinct roles in inflammation and damage in ANCA GN. Plasma cell infiltrates and mononuclear cell infiltrates were also correlated with specific histopathological lesions and disease outcomes. The study suggests that different pathogenic mechanisms may be involved in MPO-ANCA versus PR3-ANCA GN, and may lead to potential new therapeutic targets for specific ANCA subtypes.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Medicine, General & Internal
Salem Almaani, Lynn A. Fussner, Sergey Brodsky, Alexa S. Meara, David Jayne
Summary: Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a group of small vessel vasculitides characterized by granulomatous and neutrophilic tissue inflammation, often associated with the production of antibodies that target neutrophil antigens. AAV involves multiple organ systems clinically, including the lungs, kidneys, skin, and nervous system. The prognosis of AAV has significantly improved due to advances in understanding its pathogenesis and treatment options.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Adam D. Morris, Camilo L. M. Morais, Kassio M. G. Lima, Daniel L. D. Freitas, Mark E. Brady, Ajay P. Dhaygude, Anthony W. Rowbottom, Francis L. Martin
Summary: This study demonstrates that attenuated total reflection Fourier-transform infrared spectroscopy can serve as a reliable biomarker to distinguish active and quiescent ANCA associated vasculitis with high accuracy. Plasma is the most suitable biofluid, with the predictive model showing high sensitivity and specificity.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Heejin Cho, Hyun Soon Lee, Su Hyun Kim, Jungho Shin, Jin Ho Hwang
Summary: This case report presents a patient who developed ANCA-negative pauci-immune crescentic glomerulonephritis (GN) with extrarenal involvement after receiving the COVID-19 mRNA vaccine. This is the first reported case of this type of GN associated with the COVID-19 vaccine.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Cristina Gluhovschi, Florica Gadalean, Silvia Velciov, Mirabela Nistor, Ligia Petrica
Summary: Immune mechanisms are crucial in the development of glomerulonephritis, where autoimmunity plays a key role in both primary and secondary forms. This review presents three autoimmune diseases mediated by different mechanisms and highlights the complexity of the relationship between immunopathologic mechanisms and their clinical expression. Treatment targeting immune mechanisms is essential in managing severe forms of glomerulonephritis, such as rapidly progressive crescentic glomerulonephritis.
Article
Immunology
Mi Tao, Yiqing He, Lijuan Li, Yuyan Li, Wenwen Liao, Haihang Nie, Ping Gao
Summary: This study investigated the association between NETosis and ANCA-associated Glomerulonephritis (ANCA-GN). Differential gene expression analysis and machine learning algorithms were employed to identify NETosis-related genes (NRGs) and develop a NETosisScore model for predicting high-risk patients. Enrichment analysis, immune cell infiltration analysis, and correlation analysis revealed the involvement of immune pathways and the potential biomarker roles of NRGs in ANCA-GN.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Urology & Nephrology
Muhammad Tariq Shakoor, Mark P. Birkenbach, Matthew Lynch
Summary: Severe acute respiratory syndrome coronavirus 2 (SAR S-CoV-2) is still spreading worldwide, driving the largest vaccination campaign in human history. Although the vaccines have been found to be safe and effective, rare side effects continue to arise. A case of new-onset renal-limited ANCA-associated vasculitis (AAV) in a 78-year-old woman post Pfizer-BioNTech COVID-19 vaccination highlights the need for ongoing surveillance for similar complications.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2021)
Review
Immunology
Kim M. O'Sullivan, Stephen R. Holdsworth
Summary: Understanding the role of cell death in autoimmune diseases can help define critical pathways in immunopathogenesis and identify new therapeutic targets. Neutrophils, crucial immune responder cells, play important roles in diseases like MPO-ANCA Microscopic Vasculitis in both host defense and autoimmunity.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Urology & Nephrology
Ling Hou, Lu Yin, Yubin Wu, Chengguang Zhao, Yue Du
Summary: This case report presents a 13-year-old girl diagnosed with ANCAs-negative PICGN, confirmed by renal biopsy. The patient was treated with methylprednisolone pulse therapy combined with an immunosuppressant, resulting in significant improvement in symptoms and a good prognosis.
Article
Urology & Nephrology
Jeremy Zaworski, Viviane Gnemmi, Pierre Bataille, Eric Hachulla, Francois Glowacki, Jean-Baptiste Gibier, Maite Daroux, Anderson Ratsimbazafy, Laura Bitton, Sarah Humez, Thomas Guincestre, Helene Behal, Raymond Azar, Maxime Hoffmann, Gerard Cardon, Franck Bourdon, Corinne Lemoine, Eric Auxenfant, Marie-Christine Copin, Cyrille Vandenbussche, Thomas Quemeneur
Summary: Renal involvement is a severe manifestation of antineutrophil cytoplasmic antibody-associated vasculitis, and early treatment can promote renal recovery. The percentage of cellular crescents is associated with early renal recovery.
AMERICAN JOURNAL OF NEPHROLOGY
(2022)
Article
Immunology
Joseph Calmette, Matthieu Bertrand, Mathias Vetillard, Mehdi Ellouze, Shaun Flint, Valerie Nicolas, Armelle Biola-Vidamment, Marc Pallardy, Eric Morand, Francoise Bachelerie, Veronique Godot, Geraldine Schlecht-Louf
JOURNAL OF IMMUNOLOGY
(2016)
Article
Surgery
S. M. Flint, R. G. Walker, C. Hogan, M. N. Haeusler, A. Robertson, D. M. A. Francis, R. Millar, M. Finlay, A. Landgren, S. J. Cohney
AMERICAN JOURNAL OF TRANSPLANTATION
(2011)
Article
Endocrinology & Metabolism
Ricardo C. Ferreira, Hui Guo, Richard M. R. Coulson, Deborah J. Smyth, Marcin L. Pekalski, Oliver S. Burren, Antony J. Cutler, James D. Doecke, Shaun Flint, Eoin F. McKinney, Paul A. Lyons, Kenneth G. C. Smith, Peter Achenbach, Andreas Beyerlein, David B. Dunger, David G. Clayton, Linda S. Wicker, John A. Todd, Ezio Bonifacio, Chris Wallace, Anette-G. Ziegler
Article
Urology & Nephrology
Ruth J. Pepper, Sally Hamour, Konstantia-Maria Chavele, Sarah K. Todd, Niels Rasmussen, Shaun Flint, Paul A. Lyons, Kenneth G. C. Smith, Charles D. Pusey, H. Terence Cook, Alan D. Salama
KIDNEY INTERNATIONAL
(2013)
Article
Urology & Nephrology
Shaun Flint, Emma Taylor, Jennifer Beavis, Gavin J. Becker, Eugenie Pedagogos
NEPHRON CLINICAL PRACTICE
(2009)
Article
Immunology
Amelie Bonaud, Pierre Larraufie, Melanie Khamyath, Ugo Szachnowski, Shaun M. Flint, Nadege Brunel-Meunier, Francois Delhommeau, Annie Munier, Tapio Loennberg, Claire Toffano-Nioche, Daniel Gautheret, Karl Balabanian, Marion Espeli
Summary: Using single cell RNAseq and in silico transinteractome analyses, the researchers identified Leptin receptor positive (LepR(+)) mesenchymal cells as the stromal cell subset most likely to interact with long-lived plasma cells (PCs) within the bone marrow. Furthermore, they found that PCs may use different sets of integrins and adhesion molecules to interact with these stromal cells based on their isotype. These findings provide new insights into the specific targeting of bone marrow PCs.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Shaun M. Flint, Joshua S. Davis, Jiunn-Yih Su, Erin P. Oliver-Landry, Benjamin A. Rogers, Aaron Goldstein, Jane H. Thomas, Uma Parameswaran, Colin Bigham, Kevin Freeman, Paul Goldrick, Steven Y. C. Tong
MEDICAL JOURNAL OF AUSTRALIA
(2010)
Article
Urology & Nephrology
Adam J. Hedley, Shaun Flint, Annabel Tuckfield, Rowan Walker, Solomon Cohney
CLINICAL KIDNEY JOURNAL
(2008)
Letter
Medicine, General & Internal
G Brown, J Torresi, S Flint
NEW ENGLAND JOURNAL OF MEDICINE
(2004)
Article
Rheumatology
Shaun M. Flint, Vojislav Jovanovic, Boon Wee Teo, Anselm Mak, Julian Thumboo, Eoin F. McKinney, James C. Lee, Paul MacAry, David M. Kemeny, David R. W. Jayne, Kok Yong Fong, Paul A. Lyons, Kenneth G. C. Smith
