Article
Pharmacology & Pharmacy
Tianhua Hou, Manshi Yang, Kun Yan, Xiaoye Fan, Xinxin Ci, Liping Peng
Summary: Amentoflavone (AMF) protects against pleurisy and lung injury by activating Nrf2, reducing inflammatory effusion and pathological injury. AMF also decreases oxidative stress markers and modulates proinflammatory pathways while increasing anti-inflammatory cytokines levels, all in a Nrf2-dependent manner.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ioana Boarescu, Paul-Mihai Boarescu, Raluca Maria Pop, Ioana Corina Bocsan, Dan Gheban, Ruxandra-Mioara Rajnoveanu, Armand Rajnoveanu, Adriana Elena Bulboaca, Anca Dana Buzoianu, Sorana D. Bolboaca
Summary: The study investigated the effects of curcumin nanoparticles combined with diclofenac sodium on local edema and oxidative stress parameters in rats. The results showed that curcumin nanoparticles, either alone or in combination with diclofenac sodium, effectively reduced paw edema and exhibited antioxidant effects. Curcumin nanoparticles could be a therapeutic option in acute inflammation, allowing for a reduction in drug dosage and potential limitation of side effects.
Article
Plant Sciences
Sithara K. Urumbil, Madhavan Nair Anilkumar
Summary: The study aimed to isolate and study the anti-inflammatory properties of endophytes from Emilia sonchifolia. In vitro and in vivo experiments confirmed the anti-inflammatory activity of the ethyl acetate extract of bacterial endophytes, particularly strain ES1 (Bacillus subtilis). Gene expression studies also confirmed the reduction in the expression of COX-2 and NfKb genes in the presence of ES1 extract.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Food Science & Technology
M. Reyzov, D. Pavlov, M. Novakovic, V. Tesevic, A. Georgieva, M. Eftimov, M. Todorova, S. Valcheva-Kuzmanova
Summary: This study aimed to assess the effect of the flavonoid fustin on carrageenan-induced acute paw inflammation in rats. The results showed that fustin treatment significantly reduced paw oedema, especially at 30 and 60 minutes after injection.
Article
Integrative & Complementary Medicine
Enaide Soares Santos, Geraldo Lucas Abrantes Coelho, Yan Kaue Saraiva Fontes Loula, Barbara Lourenco Saraiva Landim, Cicera Norma Fernandes Lima, Sara Tavares de Sousa Machado, Maria Janice Pereira Lopes, Aclessia Damiana Soares Gomes, Jose Galberto Martins da Costa, Irwin Rose Alencar de Menezes, Henrique Douglas Melo Coutinho, Bonglee Kim, Cicero Francisco Bezerra Felipe, Samya de Araujo Neves, Marta Regina Kerntopf
Summary: This study found that beta-pinene has hypoglycemic, hypolipidemic, and anti-inflammatory effects. Treatment with beta-pinene reduced blood glucose, triglyceride, and cholesterol levels, and also decreased inflammation. Additionally, the combined use of beta-pinene and glibenclamide enhanced the hypoglycemic and hypolipidemic effects.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Article
Plant Sciences
Johann Rohrl, Maria-Riera Pique-Borras, Manuela Jaklin, Markus Werner, Oliver Werz, Heinke Josef, Hubert Hoelz, Aldo Ammendola, Gerald Kunstle
Summary: We compared the anti-inflammatory properties of Arnicae planta tota and Arnicae flos extracts and found that Arnicae planta tota displayed a superior activity. It inhibited NF-kappa B reporter activation, decreased the expression of ALOX5 and PTGS2 genes, and inhibited the enzymatic activity of 5-LO and COX-2 more effectively than Arnicae flos. Topically applied Arnicae planta tota also reduced carrageenan-induced mouse paw oedema more efficiently.
Article
Immunology
Nada Fayez, Waleed Khalil, Essam Abdel-Sattar, Abdel-Fattah Mohamed Abdel-Fattah
Summary: Olive leaf extract demonstrates significant anti-inflammatory activity by reducing swelling, decreasing inflammatory markers, and inhibiting RBC membrane hemolysis.
INFLAMMOPHARMACOLOGY
(2023)
Article
Chemistry, Physical
Sara S. Awaad, Mona O. Sarhan, Walaa R. Mahmoud, Tamer Nasr, Riham F. George, Hanan H. Georgey
Summary: Two series of twenty benzothiazole amide derivatives were synthesized and screened for their anti-inflammatory activity and gastric ulcerogenicity. Compounds 3h and 6a showed the most potent anti-inflammatory activity with high gastrointestinal tolerability. In vitro selectivity testing demonstrated that compound 6a had the best selectivity index among the investigated compounds.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Environmental Sciences
Alaa Jameel A. Albarakati
Summary: This study confirmed the protective effect of protocatechuic acid on carrageenan-induced paw edema in mice, which may be attributed to its antioxidant and anti-inflammatory properties.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Mohammed H. Elkomy, Nabil K. Alruwaili, Mohammed Elmowafy, Khaled Shalaby, Ameeduzzafar Zafar, Naveed Ahmad, Izzeddin Alsalahat, Mohammed M. Ghoneim, Essam M. Eissa, Hussein M. Eid
Summary: In this study, chitosan-coated bilosomes containing berberine were developed to enhance transdermal delivery and manage inflammation of rheumatoid arthritis (RA). The optimized bilosomes showed good drug entrapment and surface charge, exhibited delayed release in vitro, and increased skin permeability. Animal experiments demonstrated that topical application of the bilosomes gel significantly reduced rat paw edema swelling in a RA model. Therefore, chitosan-coated bilosomes are a promising approach for the treatment of RA inflammation.
Article
Fisheries
Min Cao, Ningning Wang, Xu Yan, Ning Yang, Qiang Fu, Xiaoyan Zhang, Yong Zhang, Chao Li
Summary: This study identified TNFSF genes and their receptors in S. schlegelii through a genome-wide survey. The study found that these genes experienced duplication and whole genome duplication events, and performed clustering analysis through molecular phylogenetic analysis. Protein domain and motif analysis revealed the structural features of TNFSF and TNFRSF. Synteny analysis showed significant changes in neighboring genes of TNFSF and TNFRSF compared to other species. Additionally, qRT-PCR and protein-protein interaction network analysis demonstrated differential expression of these genes after infection. This study provides new insights into the characterization and evolution of TNFSF genes and their receptors in S. schlegelii.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Sanjukta Duarah, Manisha Sharma, Shuo Chen, Thomas K. Proft, Jacelyn Loh, Jingyuan Wen
Summary: A biodegradable microneedle-based transdermal delivery system was developed for sustained and effective delivery of dexamethasone. The microneedle arrays enhanced the permeation of dexamethasone and showed comparable anti-inflammatory efficacy to intravenous injection. This study suggests that microneedle arrays could be a safe, easy, effective and minimally invasive alternative to current delivery methods for dexamethasone.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Medicinal
Chunliu Wang, Qiqi Liu, Zhibiao Di, Hong Zhang, Ye Li, Jun Mu
Summary: This study focused on examining the analgesic and anti-inflammatory properties of the chloroform fraction of Alhagi sparsifolia Shap. (CASS). It was found that CASS was safe and had anti-inflammatory effects by downregulating the activation of IL-1 beta and TNF-alpha. Network pharmacology analysis revealed that the active ingredients of CASS could affect multiple targets and pathways, demonstrating complex regulatory effects.
PHARMACOGNOSY MAGAZINE
(2021)
Article
Immunology
Teklie Mengie, Solomon Mequanente, Dereje Nigussie, Belete Legesse, Eyasu Makonnen
Summary: The chloroform fraction of 80% methanol leaf extract of A. aspera showed significant wound healing and anti-inflammatory activities in rats.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Review
Gastroenterology & Hepatology
Cassandra Marie Townsend, Fiona Lovegrove, Reena Khanna, Aze Suzanne Wilson
Summary: This article reviews the evidence and provides a comprehensive guide for the management of paradoxical psoriasis in patients with inflammatory bowel disease (IBD). Paradoxical psoriasis is considered a contradictory effect of TNF antagonist therapy, with an underlying pathogenesis related to inflammatory cytokine imbalance. Treatment options should be tailored based on individual patient characteristics.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Health Care Sciences & Services
Rosaria De Luca, Carmela Rifici, Patrizia Pollicino, Marcella Di Cara, Sabrina Miceli, Giuseppina Sergi, Luisa Sorrenti, Michela Romano, Antonino Naro, Luana Billeri, Paola Lauria, Angelo Caminiti, Placido Bramanti, Michele Torrisi
Summary: This study aimed to investigate the effectiveness of online Skype therapy (OLST) in promoting cognitive and sensory-motor recovery in patients with severe acquired brain injury (SABI) and reducing caregiver distress. The results showed that OLST significantly reduced caregiver anxiety and burden, while improving trunk control, functional independence, cognitive functioning, and behavioral responsiveness in patients. The study also found significant changes in brain connectivity during the therapy. OLST could be a useful and complementary treatment for SABI patients and caregivers in the COVID-19 era.
JOURNAL OF TELEMEDICINE AND TELECARE
(2023)
Article
Cell Biology
Irene Paterniti, Alessia Filippone, Irina Naletova, Valentina Greco, Sebastiano Sciuto, Emanuela Esposito, Salvatore Cuzzocrea, Enrico Rizzarelli
Summary: Spinal cord injury (SCI) can cause severe motor dysfunction and nervous system abnormalities. The conjugation of trehalose with l-carnosine (Tre-car) has been found to reduce inflammation in vitro and in vivo models of SCI. Tre-car decreased early inflammatory effects, oxidative stress, and apoptosis, and stimulated the release of neurotrophic factors and influenced Zn2+ homeostasis. Tre-car may be a promising therapeutic agent for treating SCI.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Tiziana Genovese, Andrea Duranti, Francesco Monaco, Rosalba Siracusa, Roberta Fusco, Daniela Impellizzeri, Ramona D'Amico, Marika Cordaro, Salvatore Cuzzocrea, Rosanna Di Paola
Summary: Idiopathic pulmonary fibrosis (IPF), a deadly lung condition, worsens over time and has no known cause. Traditional treatments for IPF, such as corticosteroids and immunomodulatory drugs, often have noticeable side effects and are not very effective. By inhibiting the fatty acid amide hydrolase (FAAH) enzyme, which breaks down endocannabinoids, it is possible to increase the levels of these natural pain-relieving compounds and reduce inflammation. In our study, we used a bleomycin-induced IPF model and found that administering URB878, an FAAH inhibitor, reduced histological changes, cell infiltration, pro-inflammatory cytokine production, inflammation, and nitrosative stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Alessia Arangia, Ylenia Marino, Roberta Fusco, Rosalba Siracusa, Marika Cordaro, Ramona D'Amico, Francesco Macri, Emanuela Raffone, Daniela Impellizzeri, Salvatore Cuzzocrea, Rosanna Di Paola
Summary: The study investigated the beneficial effects of fisetin, a naturally occurring polyphenol, on endometriosis. Fisetin treatment reduced the size and volume of endometriotic implants, as well as histological alterations and inflammatory responses. It also decreased markers of oxidative stress and increased apoptosis in endometrial lesions. Fisetin may represent a potential therapeutic strategy for endometriosis by targeting inflammatory pathways and oxidative stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Giovanna Casili, Sarah Adriana Scuderi, Marika Lanza, Alessia Filippone, Deborah Mannino, Raffaella Giuffrida, Cristina Colarossi, Marzia Mare, Anna Paola Capra, Federica De Gaetano, Marco Portelli, Angela Militi, Salvatore Cuzzocrea, Irene Paterniti, Emanuela Esposito
Summary: This study evaluated the effect of the selective NLRP3 inflammasome inhibitor, BAY-117082, in an in vivo model of oral squamous cell carcinoma (OSCC) and its role in invasion and metastasis in neighboring organs. The results showed that BAY-117082 treatment reduced tumor presence and nuclear pleomorphism in tongue tissues and inhibited NLRP3 inflammasome pathway activation in tongue, lung, and spleen tissues. Furthermore, BAY-117082 treatment modulated the epithelial-mesenchymal transition (EMT) process and reduced the expression of matrix metalloproteinases (MMPs), markers of cell invasion and migration. Overall, BAY-117082 effectively reduced tumor area and metastasis through NLRP3 inflammasome pathway inhibition.
Review
Cell Biology
Alessio Ardizzone, Rossella Basilotta, Alessia Filippone, Lelio Crupi, Marika Lanza, Sofia Paola Lombardo, Cristina Colarossi, Dorotea Sciacca, Salvatore Cuzzocrea, Emanuela Esposito, Michela Campolo
Summary: Primary brain tumors are highly heterogeneous and invasive, leading to high mortality rates worldwide. Current therapies have improved survival rates, but new therapeutic strategies are needed. Immunotherapy approaches, targeting the immunosuppressive microenvironment, have shown promise in CNS tumors. Chemokines, a group of proteins that regulate immune cell recruitment and tumor growth, are examined as potential targets for immunotherapy in primary brain tumors.
Review
Cell Biology
Alessio Ardizzone, Valentina Bova, Giovanna Casili, Alberto Repici, Marika Lanza, Raffaella Giuffrida, Cristina Colarossi, Marzia Mare, Salvatore Cuzzocrea, Emanuela Esposito, Irene Paterniti
Summary: Cancer, the leading cause of death worldwide, requires successful strategies for treatment. Growth factors like VEGF, bFGF, and TGF-beta play significant roles in tumor growth, activating essential signaling pathways and promoting cell proliferation, angiogenesis, and metastasis. Specifically, bFGF is secreted by tumor cells and interacts with its receptors (FGFRs), leading to tumor cell proliferation, invasion, and upregulation of pro-inflammatory and anti-apoptotic proteins. Studies have focused on developing therapeutic strategies targeting the bFGF/FGFR axis, considering its involvement in oncogenesis. This review comprehensively examines the biological mechanisms of bFGF in the tumor microenvironment, available anticancer therapies targeting FGFRs, and the prognostic value of bFGF.
Article
Cell Biology
Alessia Filippone, Laura Cucinotta, Valentina Bova, Marika Lanza, Giovanna Casili, Irene Paterniti, Michela Campolo, Salvatore Cuzzocrea, Emanuela Esposito
Summary: Moderate traumatic brain injury (mTBI) is associated with emotional dysregulation. This study investigates the role of LRRK2 in reducing depression-related symptoms after mTBI and tests the antidepressant effects of LRRK2 inhibition by PF-06447475. The results show that mTBI promotes the development of depression-like behavior, but LRRK2 inhibition reduces histological damage and behavioral disturbances, suggesting an antidepressant effect.
Article
Biochemistry & Molecular Biology
Marco Calapai, Luisa Puzzo, Giuseppe Bova, Daniele Alfio Vecchio, Rosario Blandino, Alessia Barbagallo, Ilaria Ammendolia, Luigi Cardia, Maria De Pasquale, Fabrizio Calapai, Emanuela Esposito, Fabio Trimarchi, Debora Di Mauro, Gioacchino Calapai, Carmen Mannucci
Summary: The aim of this study was to evaluate the effects of physical activity on chronic pain in post-mastectomy women. The results showed that adequate physical activity can reduce pain intensity and interference, and is associated with a reduction in blood biomarkers of inflammation.
Article
Biochemistry & Molecular Biology
Alessio Ardizzone, Alberto Repici, Anna Paola Capra, Federica De Gaetano, Valentina Bova, Giovanna Casili, Michela Campolo, Emanuela Esposito
Summary: Atopic dermatitis (AD) is a common inflammatory skin disease that mainly affects children. This study evaluated the effects of a cream formulation containing tempol in a murine model of AD. The results demonstrated that tempol reduced histological damage, mast cell infiltration, and improved skin barrier function by restoring tight junctions and filaggrin. Furthermore, tempol modulated inflammation and oxidative stress through the NF-κB/Nrf2 signaling pathways.
Review
Biochemistry & Molecular Biology
Federica Rey, Clarissa Berardo, Erika Maghraby, Alessia Mauri, Letizia Messa, Letizia Esposito, Giovanna Casili, Sara Ottolenghi, Eleonora Bonaventura, Salvatore Cuzzocrea, Gianvincenzo Zuccotti, Davide Tonduti, Emanuela Esposito, Irene Paterniti, Cristina Cereda, Stephana Carelli
Summary: Oxygen imbalance can have detrimental effects on the brain, leading to various neurological disorders. The dysfunctions caused by oxygen imbalance in neurodegenerative and pediatric neurological disorders result from redox imbalance. This review focuses on the underlying dysfunction in redox and potential therapeutic strategies for these conditions.
Article
Biochemistry & Molecular Biology
Livia Interdonato, Ylenia Marino, Ramona D'Amico, Marika Cordaro, Rosalba Siracusa, Daniela Impellizzeri, Francesco Macri, Roberta Fusco, Salvatore Cuzzocrea, Rosanna Di Paola
Summary: This study investigates the molecular mechanisms underlying endometriosis and how they can be modulated by Actaea racemosa (AR). The findings show that AR can reduce the size and histological morphology of the lesions and suppress the disease development through regulating multiple pathways, including cell proliferation, apoptosis, antioxidant, and anti-inflammatory effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Alessia Arangia, Agnese Ragno, Marika Cordaro, Ramona D'Amico, Rosalba Siracusa, Roberta Fusco, Francesca Marino Merlo, Antonella Smeriglio, Daniela Impellizzeri, Salvatore Cuzzocrea, Giuseppina Mandalari, Rosanna Di Paola
Summary: The study evaluated the antioxidant and anti-inflammatory effects of almond skin extract (ASE) and found that it inhibited the formation of ROS and apoptosis in vitro, and restored tissue changes and decreased inflammation in an in vivo model. The mechanisms of action could be related to the inhibition of the pro-inflammatory nuclear factor NF-κB and activation of the Nrf2 antioxidant pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Integrative & Complementary Medicine
Giuseppa Maresca, Vanessa Nocito, Viviana Lo Buono, Desiree Latella, Marcella Di Cara, Caterina Formica, Lara Carnazza, Edoardo Sessa, Placido Bramanti, Francesco Corallo
Summary: This study conducted a systematic review on the symptoms of people with multiple sclerosis (MS), and found that hypnosis therapy has positive impacts on reducing pain, improving psychological well-being, and relieving fatigue in MS patients. Other nonpharmacological techniques did not have the same effects.
ALTERNATIVE THERAPIES IN HEALTH AND MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Livia Interdonato, Rosalba Siracusa, Roberta Fusco, Salvatore Cuzzocrea, Rosanna Di Paola
Summary: Endometriosis, an estrogen-dependent gynecologic illness, is potentially influenced by endocrine-disrupting chemicals (EDCs). This review examines human evidence on EDCs and endometriosis, specifically focusing on chemical amounts in women. Dioxins, BPA, Phthalates, and other EDCs are implicated as environmental causes of endometriosis, highlighting the need for prevention strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
