4.6 Article

Comparison of the Hypotensive and Bradycardic Activity of Ginkgo, Garlic, and Onion Extracts

Journal

CLINICAL AND EXPERIMENTAL HYPERTENSION
Volume 33, Issue 2, Pages 95-99

Publisher

TAYLOR & FRANCIS INC
DOI: 10.3109/10641963.2010.531833

Keywords

Ginkgo biloba; Allium sativum; allium cepa; rat; arterial blood pressure; heart rate

Funding

  1. Ministry of Sciences and Technological Development of the Republic of Serbia [145081B, III41018]
  2. NIH/Fogarty International Center, USA [D43 TW00641]
  3. FOGARTY INTERNATIONAL CENTER [D43TW000641] Funding Source: NIH RePORTER

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The acute effect of ethanol extracts ginkgo (Ginkgo biloba L.), garlic (Allium sativum L.), and onion (Allium cepa L.) on arterial blood pressure (BP), and heart rate (HR) in anesthetized normotensive rats was examined and compared. Arterial BP was registered in the left carotid artery. The data showed that intravenous administration of the extracts produced dose-dependent and reversible hypotensive and bradycardic effects. The most effective in reducing arterial BP and HR is extract of garlic. There were statistically significant differences in bradycardic and hypotensive effects of the garlic and ginkgo extracts.

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