Inhibition of H3K27me3 demethylases attenuates asthma by reversing the shift in airway smooth muscle phenotype

Taxane-Platin-Resistant Lung Cancers Co-develop Hypersensitivity to JumonjiC Demethylase Inhibitors

(2017) Maithili P. Dalvi et al.   Cell Reports

Inhibition of H3K27me3 Histone Demethylase Activity Prevents the Proliferative Regeneration of Zebrafish Lateral Line Neuromasts

(2017) Beier Bao et al.   Frontiers in Molecular Neuroscience

Airway smooth muscle inflammation is regulated by microRNA-145 in COPD

(2016) Lawrence O'Leary et al.   FEBS LETTERS

The histone demethylase inhibitor GSK-J4 limits inflammation through the induction of a tolerogenic phenotype on DCs

(2016) Cristian Doñas et al.   JOURNAL OF AUTOIMMUNITY

PARP inhibition treatment in a nonconventional experimental mouse model of chronic asthma

(2016) Raffaela Zaffini et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Enhancer of Zeste Homolog 2 Inhibition Attenuates Renal Fibrosis by Maintaining Smad7 and Phosphatase and Tensin Homolog Expression

(2015) X. Zhou et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Epigenetic regulation of Smad2 and Smad3 by profilin-2 promotes lung cancer growth and metastasis

(2015) Yun-Neng Tang et al.   Nature Communications

HMGB1 contributes to allergen-induced airway remodeling in a murine model of chronic asthma by modulating airway inflammation and activating lung fibroblasts

(2014) Changchun Hou et al.   Cellular & Molecular Immunology

Fibroblast Growth Factor Maintains Chondrogenic Potential of Limb Bud Mesenchymal Cells by Modulating DNMT3A Recruitment

(2014) Deepak Kumar et al.   Cell Reports

High expression of trimethylated histone H3 at lysine 27 predicts better prognosis in non-small cell lung cancer

(2013) XIAOHUI CHEN et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Inactivation of TGF-β signaling and loss of PTEN cooperate to induce colon cancer in vivo

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Muscarinic receptor stimulation augments TGF-β1-induced contractile protein expression by airway smooth muscle cells

(2012) Tjitske A. Oenema et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Epigenetic mechanisms and the development of asthma

(2012) Ivana V. Yang et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Programmed cell death ligand 2 regulates TH9 differentiation and induction of chronic airway hyperreactivity

(2012) Jerome Kerzerho et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The histone H3K27 methylation mark regulates intestinal epithelial cell density-dependent proliferation and the inflammatory response

(2012) Naomie Turgeon et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response

(2012) Laurens Kruidenier et al.   NATURE

Emerging airway smooth muscle targets to treat asthma

(2012) Sana Siddiqui et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Phenotype modulation of airway smooth muscle in asthma

(2012) David B. Wright et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

In VivoRole of Platelet-Derived Growth Factor–BB in Airway Smooth Muscle Proliferation in Mouse Lung

(2011) Jeremy A. Hirota et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Protein kinase A and the exchange protein directly activated by cAMP (Epac) modulate phenotype plasticity in human airway smooth muscle

(2011) Sara S Roscioni et al.   BRITISH JOURNAL OF PHARMACOLOGY

Functional consequences of human airway smooth muscle phenotype plasticity

(2011) Bart GJ Dekkers et al.   BRITISH JOURNAL OF PHARMACOLOGY

Protection from Obesity and Diabetes by Blockade of TGF-β/Smad3 Signaling

(2011) Hariom Yadav et al.   Cell Metabolism

The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection

(2010) Takashi Satoh et al.   NATURE IMMUNOLOGY

Charting histone modifications and the functional organization of mammalian genomes

(2010) Vicky W. Zhou et al.   NATURE REVIEWS GENETICS

Quantitative High-Throughput Screening Identifies 8-Hydroxyquinolines as Cell-Active Histone Demethylase Inhibitors

(2010) Oliver N. F. King et al.   PLoS One

Inhaled house dust mite induces pulmonary T helper 2 cytokine production

(2009) L. G. Gregory et al.   CLINICAL AND EXPERIMENTAL ALLERGY

TGF-β1 Induces Human Bronchial Epithelial Cell-to-Mesenchymal Transition in Vitro

(2009) Min Zhang et al.   LUNG

Treating asthma means treating airway smooth muscle cells

(2008) S. Zuyderduyn et al.   EUROPEAN RESPIRATORY JOURNAL

Control of differentiation in a self-renewing mammalian tissue by the histone demethylase JMJD3

(2008) G. L. Sen et al.   GENES & DEVELOPMENT