Article
Hematology
Stacy E. Croteau, Andrew L. Frelinger, Anja J. Gerrits, Alan D. Michelson
Summary: Decreased platelet surface phosphatidylserine expression measured by annexin V binding predicts increased bleeding in severe FVIII deficient patients on prophylaxis.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Biochemistry & Molecular Biology
Harriet Ghansah, Ildiko Beke Debreceni, Zsolt Fejes, Bela Nagy, Janos Kappelmayer
Summary: The study revealed that Bortezomib (BTZ) induces a procoagulant platelet phenotype, leading to increased phosphatidylserine (PS) and P-selectin expression levels, as well as depolarization of mitochondrial inner membrane potential in gel-filtered platelets (GFPs) compared to platelet-rich plasma (PRP). The presence of plasma proteins in PRP may attenuate the procoagulant effect of BTZ on platelets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Junaid Ansari, Felicity N. E. Gavins
Summary: Neutrophils and platelets play crucial roles in ischemic stroke, both promoting and resolving cerebrovascular inflammation to trigger ischemic events. These cells engage in pro- and anti-inflammatory functions in regulating cerebrovascular inflammation, highlighting their significance in stroke pathogenesis.
Article
Biochemistry & Molecular Biology
Jingyi Zhu, Xiangning Li, Wenling Gao, Jian Jing
Summary: In this study, a new antimelanoma tumor peptide, LbtA5, was successfully developed and synthesized. LbtA5 showed strong biological effects in inhibiting tumor cell viability and tumor tissue angiogenesis. This study provides a potential strategy for the treatment of various cancers, including malignant melanoma, using the recombinant fusion protein LbtA5.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Biomedical
Keerthana Chandrasekar, Brooke L. Farrugia, Lacey Johnson, Denese Marks, David Irving, Zehra Elgundi, Kieran Lau, Ha Na Kim, Jelena Rnjak-Kovacina, Marcela M. Bilek, John M. Whitelock, Megan S. Lord
Summary: This study explores the functionalization of PVC with rDV, and found that both physisorption and PIII treatment of rDV can reduce platelet adhesion and activation on PVC compared to pristine PVC. The two methods of tethering rDV have unique mechanisms in modulating platelet interactions, with physisorption hindering platelet adhesion by orienting the molecule to block integrin-binding region, while PIII treatment allows access to the integrin-binding region but inhibits adhesion through the GAG chain.
ADVANCED HEALTHCARE MATERIALS
(2021)
Review
Medical Laboratory Technology
Yong-Zhen Li, Yan-Yue Wang, Liang Huang, Yu-Yan Zhao, Lin-Hui Chen, Chi Zhang
Summary: Atherosclerosis, a chronic vascular pathology, is influenced by the AnxA family proteins.
CLINICA CHIMICA ACTA
(2022)
Article
Biochemistry & Molecular Biology
Rosa Suades, Alba Vilella-Figuerola, Teresa Padro, Sonia Mirabet, Lina Badimon
Summary: In this study, circulating extracellular microvesicles (cEVs) from chronic heart failure patients were phenotypically and quantitatively characterized. It was found that PS--cEVs were predominantly present in both chronic heart failure patients and non-HF subjects, but the proportions of PS-cEVs varied depending on the parental markers. PS+-cEVs were mainly derived from platelets and increased in the non-HF group, while PS--cEVs were mainly derived from endothelium and connexin 43-rich sources and significantly increased in chronic heart failure patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Milka Koupenova, Heather A. Corkrey, Olga Vitseva, Kahraman Tanriverdi, Mohan Somasundaran, Ping Liu, Shaukat Soofi, Rohan Bhandari, Matthew Godwin, Krishna Mohan Parsi, Alyssa Cousineau, Rene Maehr, Jennifer P. Wang, Scott J. Cameron, Jeffrey Rade, Robert W. Finberg, Jane E. Freedman
Summary: The study revealed that platelets in COVID-19 patients contain viral RNA and proteins, and that SARS-CoV-2 can directly influence platelet internalization and cell death, which may contribute to complications like thrombosis.
CIRCULATION RESEARCH
(2021)
Article
Hematology
Kristin M. Reddoch-Cardenas, Grant C. Peltier, Tiffani C. Chance, Prajeeda M. Nair, Michael A. Meledeo, Anand K. Ramasubramanian, Andrew P. Cap, James A. Bynum
Summary: The study found that cold storage of platelets in platelet additive solution can preserve mitochondrial integrity, reduce apoptosis, and maintain function for up to 15 days. Moreover, mitochondrial function and molecular analyses of cold-stored platelets revealed distinct differences from the well-known storage lesion of room temperature platelets, presenting a potential opportunity to extend storage duration.
Article
Biochemistry & Molecular Biology
Jingyi Zhu, Wenjuan Li, Jian Jing
Summary: Tumor tissues exhibit unique integrin receptor presentation during development, which can be targeted for antitumor therapy. A novel fusion protein called Echistatin-Annexin V (EAV) was developed, which showed strong inhibitory effects on melanoma tumor cells and angiogenesis in mouse models. The unique biological effects of EAV are based on its high selectivity for specific integrin receptors and its ability to bind to phosphatidylserine molecules. EAV-mediated tumor suppression provides a possible mechanism for the treatment of melanoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Brian Schnoor, Anne-Laure Papa
Summary: Lyophilized platelets, as a potential hemostatic agent, have long-term ambient storage capabilities and high biocompatibility, which make them a promising platform for drug delivery. The interactions between lyophilized platelets and fresh platelets have paradoxical effects on platelet adhesion and aggregation, which could have an impact for clinical applications.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Hematology
Xinlong Dong, Wei Liu, Yu Shen, Katie Houck, Mengchen Yang, Yuan Zhou, Zilong Zhao, Xiaoping Wu, Teri Blevins, Amanda L. Koehne, Tze-Chein Wun, Xiaoyun Fu, Min Li, Jianning Zhang, Jing-fei Dong
Summary: Severe traumatic brain injury can lead to a hypercoagulable state and consumptive coagulopathy. Targeting anionic phospholipid-expressing extracellular vesicles (EVs) with anticoagulation can prevent TBI-induced coagulopathy and improve outcomes. In a study using a fusion protein (ANV-6L15), it was found that reducing intracranial hematoma and improving neurological function in mice with severe TBI.
Article
Immunology
Silvie Kremserova, Anna Kocurkova, Michaela Chorvatova, Anna Klinke, Lukas Kubala
Summary: The study reveals that MPO plays a role in regulating PMN cell death by enhancing cell membrane permeabilization and phosphatidylserine surface exposure, thereby extending the lifespan of PMNs.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Analytical
Duong Song Thai Duong, Chang-Hyun Jang
Summary: In this study, a label-free liquid-crystal-mediated PS sensor was developed to detect the tumor biomarker phosphatidylserine (PS) in the bloodstream. The sensor showed high sensitivity and selectivity, making it a promising platform for clinical diagnostics and identification of low levels of PS in biological environments.
MICROCHEMICAL JOURNAL
(2023)
Article
Chemistry, Medicinal
Brent J. Tschirhart, Xiangru Lu, Janice Gomes, Arundhasa Chandrabalan, Gillian Bell, David A. Hess, Guangxin Xing, Hong Ling, Dylan Burger, Qingping Feng
Summary: Sepsis is a dysregulated immune response to infection and a leading cause of mortality. Recombinant human Annexin A5 (Anx5) treatment has been shown to inhibit pro-inflammatory cytokine production and improve survival in sepsis models. It blocks the inflammatory response induced by activated platelets and microvesicles in endothelial cells through phosphatidylserine binding.
Article
Materials Science, Multidisciplinary
Lidia Swiatek, Anna Olejnik, Jacek Grabarczyk, Anna Jedrzejczak, Anna Sobczyk-Guzenda, Marta Kaminska, Witold Jakubowski, Witold Szymanski, Dorota Bociaga
DIAMOND AND RELATED MATERIALS
(2016)
Article
Materials Science, Multidisciplinary
Dorota Bociaga, Marta Kaminska, Anna Sobczyk-Guzenda, Krzysztof Jastrzebski, Lidia Swiatek, Anna Olejnik
DIAMOND AND RELATED MATERIALS
(2016)
Article
Biotechnology & Applied Microbiology
Marta Kaminska, Slawomir Kuberski, Waldemar Maniukiewicz, Piotr Owczarz, Piotr Komorowski, Zofia Modrzejewska, Bogdan Walkowiak
JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS
(2017)
Article
Polymer Science
Agata Skwarczynska, Marta Kaminska, Piotr Owczarz, Nina Bartoszek, Bogdan Walkowiak, Zofia Modrzejewska
JOURNAL OF APPLIED POLYMER SCIENCE
(2018)
Article
Biochemistry & Molecular Biology
Justyna Fraczyk, Wojciech Lipinski, Agata Chaberska, Joanna Wasko, Kamil Rozniakowski, Zbigniew J. Kaminski, Maciej Bogun, Zbigniew Draczynski, Elzbieta Menaszek, Ewa Stodolak-Zych, Marta Kaminska, Beata Kolesinska
Article
Engineering, Biomedical
Piotr Komorowski, Malgorzata Siatkowska, Tomasz Wasiak, Katarzyna Dzialoszynska, Sylwia Kotarba, Kinga Kadziola, Nina Bartoszek, Paulina Sokolowska, Marcin Elgalal, Anna Sobol-Pacyniak, Krzysztof Makowski, Bogdan Walkowiak
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2019)
Article
Chemistry, Analytical
Beata Polak, Adam Traczuk, Marta Kaminska, Malgorzata Kozyra
JOURNAL OF ANALYTICAL METHODS IN CHEMISTRY
(2019)
Article
Biochemistry & Molecular Biology
Wojciech Lipinski, Joanna Wasko, Malgorzata Walczak, Justyna Fraczyk, Zbigniew J. Kaminski, Krystian Galecki, Zbigniew Draczynski, Izabella Krucinska, Marta Kaminska, Beata Kolesinska
CHEMISTRY & BIODIVERSITY
(2019)
Article
Materials Science, Multidisciplinary
Barbara Burnat, Patrycja Olejarz, Damian Batory, Michal Cichomski, Marta Kaminska, Dorota Bociaga
Article
Chemistry, Physical
Joanna Wasko, Justyna Fraczyk, Angelika Becht, Zbigniew J. Kaminski, Sandra Flincec Grgac, Anita Tarbuk, Marta Kaminska, Mariusz Dudek, Eulalia Gliscinska, Zbigniew Draczynski, Beata Kolesinska
Article
Chemistry, Physical
Piotr Komorowski, Malgorzata Siatkowska, Marta Kaminska, Witold Jakubowski, Marta Walczynska, Magdalena Walkowiak-Przybylo, Witold Szymanski, Katarzyna Piersa, Patryk Wielowski, Paulina Sokolowska, Kamila Bialkowska, Krzysztof Makowski, Marcin Elgalal, Agnieszka Kierzkowska, Lechoslaw Ciupik, Bogdan Walkowiak
Article
Materials Science, Ceramics
Anna Laska-Lesniewicz, Patrycja Szczepanska, Marta Kaminska, Magdalena Nowosielska, Anna Sobczyk-Guzenda
Summary: This study manufactured and characterized hydroxyapatite (HAp) powder that can be successfully incorporated into a PMMA-based matrix and improve the final properties of composite bone cement. The surface modification technique significantly increased the dispersion of the filler in the polymer matrix, and biological studies confirmed the biocompatibility of the tested material.
CERAMICS INTERNATIONAL
(2022)
Article
Engineering, Biomedical
Marta Kaminska, Aleksandra Jastrzebska, Magdalena Walkowiak-Przybylo, Marta Walczynska, Piotr Komorowski, Bogdan Walkowiak
Summary: Laser surface modification of metallic implants is a promising alternative to other surface modification techniques. Different alloyed metallic biomaterials were studied, and it was found that the number of adhered platelets on the surfaces of the four tested biomaterials did not significantly differ regardless of the type of modification. However, the surface of medical steel and cobalt-chromium-molybdenum alloy had a significantly higher number of platelet aggregates compared to the titanium alloy surfaces. In addition, in-depth analysis revealed small but statistically significant differences in platelet interaction with the tested surfaces of metallic biomaterials for different types of modification.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Article
Endocrinology & Metabolism
Agnieszka Los, Joanna Wojcik-Odyniec, Anna Sobol-Pacyniak, Katarzyna Cypryk
CLINICAL DIABETOLOGY
(2018)
Proceedings Paper
Nanoscience & Nanotechnology
Karolina Boruvkova, Jakub Wiener, Marta Kaminska, Marcela Kolinova
NANOCON 2015: 7TH INTERNATIONAL CONFERENCE ON NANOMATERIALS - RESEARCH & APPLICATION
(2015)
