Role of simvastatin in tumor lymphangiogenesis and lymph node metastasis

Lymph node metastases can invade local blood vessels, exit the node, and colonize distant organs in mice

(2018) Ethel R. Pereira et al.   SCIENCE

Lymph node blood vessels provide exit routes for metastatic tumor cell dissemination in mice

(2018) M. Brown et al.   SCIENCE

Brief Report: Treatment of Tumor Necrosis Factor-Transgenic Mice With Anti-Tumor Necrosis Factor Restores Lymphatic Contractions, Repairs Lymphatic Vessels, and May Increase Monocyte/Macrophage Egress

(2017) Echoe M. Bouta et al.   Arthritis & Rheumatology

Rapamycin inhibition of CFA-induced lymphangiogenesis in PLN is independent of mast cells

(2014) Rui-Cheng Ji et al.   MOLECULAR BIOLOGY REPORTS

Hyaluronan: A simple polysaccharide with diverse biological functions

(2013) Kevin T. Dicker et al.   Acta Biomaterialia

Endothelial NO synthase and reactive oxygen species mediated effect of simvastatin on vessel structure and function: Pleiotropic and dose-dependent effect on tumor vascular stabilization

(2013) YESHAN CHEN et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Simvastatin reduces melanoma progression in a murine model

(2013) MARIO ZANFARDINO et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Can statins reduce the inflammatory response associated with preterm birth in an animal model?

(2012) Sanmaan K. Basraon et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Topical Simvastatin Accelerates Wound Healing in Diabetes by Enhancing Angiogenesis and Lymphangiogenesis

(2012) Jun Asai et al.   AMERICAN JOURNAL OF PATHOLOGY

Phenotype-based high-content chemical library screening identifies statins as inhibitors of in vivo lymphangiogenesis

(2012) M. M. P. Schulz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Macrophages are important mediators of either tumor- or inflammation-induced lymphangiogenesis

(2011) Rui-Cheng Ji   CELLULAR AND MOLECULAR LIFE SCIENCES

Markers for Microscopic Imaging of Lymphangiogenesis and Angiogenesis

(2008) Peter Baluk et al.   Annals of the New York Academy of Sciences

Simvastatin induces apoptosis in human colon cancer cells and in tumor xenografts, and attenuates colitis-associated colon cancer in mice

(2008) Soo-Jeong Cho et al.   INTERNATIONAL JOURNAL OF CANCER